Latest & greatest articles for proton pump inhibitors

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Top results for proton pump inhibitors

141. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. (PubMed)

Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. Proton-pump inhibitors (PPIs) are often prescribed in combination with thienopyridines. Conflicting data exist as to whether PPIs diminish the efficacy of clopidogrel. We assessed the association between PPI use, measures of platelet function, and clinical outcomes for patients treated with clopidogrel or prasugrel.In the PRINCIPLE-TIMI 44

2009 Lancet

142. Cost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis. (Full text)

Cost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis. To investigate the cost effectiveness of cyclo-oxygenase-2 (COX 2) selective inhibitors and traditional non-steroidal anti-inflammatory drugs (NSAIDs), and the addition of proton pump inhibitors to these treatments, for people with osteoarthritis.An economic evaluation using a Markov model and data from a systematic review was conducted (...) . Subgroup analyses were conducted for people at high risk of gastrointestinal or cardiovascular adverse events. Comparators Licensed COX 2 selective inhibitors (celecoxib and etoricoxib) and traditional NSAIDs (diclofenac, ibuprofen, and naproxen) for which suitable data were available were compared. Paracetamol was also included, as was the possibility of adding a proton pump inhibitor (omeprazole) to each treatment.The main outcome measure was cost effectiveness, which was based on quality adjusted

2009 BMJ PubMed

143. Proton pump inhibitors for the prevention of stress-related mucosal disease in critically-ill patients: a meta-analysis

Proton pump inhibitors for the prevention of stress-related mucosal disease in critically-ill patients: a meta-analysis Proton pump inhibitors for the prevention of stress-related mucosal disease in critically-ill patients: a meta-analysis Proton pump inhibitors for the prevention of stress-related mucosal disease in critically-ill patients: a meta-analysis Pongprasobchai S, Kridkratoke S, Nopmaneejumruslers C CRD summary The review found a significantly lower rate of clinically important (...) bleeding when using proton pump inhibitors rather than histamine-2 receptor antagonists in the prevention of stress-related mucosal disease in critically ill patients. Rates of nosocomial pneumonia were similar. The reliability of the authors’ conclusions is unclear due to some methodological weaknesses and differences between the small number of studies. Authors' objectives To evaluate the effectiveness of proton pump inhibitors compared to histamine-2 receptor antagonists in the prevention of stress

2009 DARE.

144. The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis

The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis Gill SK, O'Brien L, Einarson TR, Koren G CRD summary This review concluded that proton pump inhibitor use during early pregnancy was not associated with an increased risk for major congenital birth defects, spontaneous abortions and preterm delivery. In light of uncertainty (...) over generalisability and parts of the review process, plus the potential influence of one large study, the reliability of the authors' conclusions is unclear. Authors' objectives To determine the foetal safety of proton pump inhibitors (PPIs) during early pregnancy. Searching MEDLINE, EMBASE, International Pharmaceutical Abstracts, EBM Reviews and CINAHL were searched without language restrictions from inception to July 2008; search terms were reported. Reference lists of relevant articles were

2009 DARE.

145. Concomitant use of proton pump inhibitors with clopidogrel may increase risk of readmission after discharge for acute MI

Concomitant use of proton pump inhibitors with clopidogrel may increase risk of readmission after discharge for acute MI Concomitant use of proton pump inhibitors with clopidogrel may increase risk of readmission after discharge for acute MI | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using (...) your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Concomitant use of proton pump inhibitors with clopidogrel may increase risk of readmission after discharge for acute MI Article Text Aetiology

2009 Evidence-Based Medicine (Requires free registration)

146. The effect of ranitidine versus proton pump inhibitors on gastric secretions: a meta-analysis of randomised control trials

The effect of ranitidine versus proton pump inhibitors on gastric secretions: a meta-analysis of randomised control trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

147. Systematic review: standard- and double-dose proton pump inhibitors for the healing of severe erosive oesophagitis - a mixed treatment comparison of randomized controlled trials

Systematic review: standard- and double-dose proton pump inhibitors for the healing of severe erosive oesophagitis - a mixed treatment comparison of randomized controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

148. Cost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis

Cost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 NHS Economic Evaluation Database.

149. Clinical trial: Radiofrequency energy delivery in proton pump inhibitor-dependent gastro-oesophageal reflux disease patients (Full text)

Clinical trial: Radiofrequency energy delivery in proton pump inhibitor-dependent gastro-oesophageal reflux disease patients Radiofrequency (RF) energy delivery is an endoscopic procedure developed for the treatment of gastro-oesophageal reflux disease.To compare RF and a proton pump inhibitor strategy (PPI) in PPI-dependent patients by carrying out a prospective, randomized trial.Patients with PPI-dependent typical reflux symptoms were randomly allocated to either RF or PPI regimen alone

2008 EvidenceUpdates PubMed

150. Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: `on` or `off` proton pump inhibitor? (PubMed)

Esophageal pH-impedance monitoring in patients with therapy-resistant reflux symptoms: `on` or `off` proton pump inhibitor? In patients with proton pump inhibitor (PPI)-resistant symptoms, ambulatory 24-h pH-impedance monitoring can be used to assess whether a relationship exists between symptoms and reflux episodes. Until now, it is unclear whether combined pH-impedance monitoring in these patients should be performed on or off PPI.Thirty patients with symptoms of heartburn, chest pain

2008 EvidenceUpdates

151. Meta-analysis: high-dose proton pump inhibitors vs. standard dose in triple therapy for Helicobacter pylori eradication (Full text)

Meta-analysis: high-dose proton pump inhibitors vs. standard dose in triple therapy for Helicobacter pylori eradication The evidence on whether high-dose proton pump inhibitors (PPIs) increase cure rates of Helicobacter pylori treatment has not been previously assessed.To evaluate the evidence on the usefulness of high-dose PPI in standard triple therapy by performing a systematic review and a meta-analysis.A systematic search was performed in multiple databases and in the abstracts submitted

2008 EvidenceUpdates PubMed

152. Proton-pump inhibitor use and the risk for community-acquired pneumonia. (PubMed)

Proton-pump inhibitor use and the risk for community-acquired pneumonia. Recent studies suggest that proton-pump inhibitors (PPIs) may increase the risk for community-acquired pneumonia (CAP).To examine the association between PPI use and CAP in adults followed in general practices in the United Kingdom.Nested case-control study.The General Practice Research Database (1987 to 2002) in the United Kingdom.Patients age 18 years or older with at least 6 months of initial pneumonia-free follow-up (...) matched case-control analysis, which included the 3 strongest confounders as additional matching factors, yielded similar results as the primary analysis (adjusted OR, 0.96 [CI, 0.91 to 1.02]).Adherence to PPI prescription was assumed to be 100%. No radiographic evidence was available to corroborate a diagnosis of CAP.Proton-pump inhibitor therapy started within the past 30 days was associated with an increased risk for CAP, whereas longer-term current use was not.

2008 Annals of Internal Medicine

153. Review: prokinetics, histamine H2 receptor antagonists, antimuscarinics, and proton pump inhibitors improve global symptoms in non-ulcer dyspepsia

Review: prokinetics, histamine H2 receptor antagonists, antimuscarinics, and proton pump inhibitors improve global symptoms in non-ulcer dyspepsia Review: prokinetics, histamine H2 receptor antagonists, antimuscarinics, and proton pump inhibitors improve global symptoms in non-ulcer dyspepsia | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about (...) inhibitors improve global symptoms in non-ulcer dyspepsia Article Text Therapeutics Review: prokinetics, histamine H 2 receptor antagonists, antimuscarinics, and proton pump inhibitors improve global symptoms in non-ulcer dyspepsia Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse

2008 Evidence-Based Medicine (Requires free registration)

154. Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: multicentre randomised controlled trial (MRC-CUBE trial). (Full text)

Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: multicentre randomised controlled trial (MRC-CUBE trial). To determine the cost effectiveness of Helicobacter pylori "test and treat" compared with empirical acid suppression in the initial management of patients with dyspepsia in primary care.Randomised controlled trial.80 general practices in the United Kingdom.699 patients aged 18-65 who presented to their general practitioner (...) with epigastric pain, heartburn, or both without "alarm symptoms" for malignancy.H pylori 13C urea breath test plus one week of eradication treatment if positive or proton pump inhibitor alone; subsequent management at general practitioner's discretion.Cost effectiveness in cost per quality adjusted life year (QALY) (EQ-5D) and effect on dyspeptic symptoms at one year measured with short form Leeds dyspepsia questionnaire.343 patients were randomised to testing for H pylori, and 100 were positive

2008 BMJ PubMed

155. Meta-analysis: high-dose proton pump inhibitors vs. standard dose in triple therapy for Helicobacter pylori eradication (Full text)

Meta-analysis: high-dose proton pump inhibitors vs. standard dose in triple therapy for Helicobacter pylori eradication Meta-analysis: high-dose proton pump inhibitors vs. standard dose in triple therapy for Helicobacter pylori eradication Meta-analysis: high-dose proton pump inhibitors vs. standard dose in triple therapy for Helicobacter pylori eradication Villoria A, Garcia P, Calvet X, Gisbert JP, Vergara M CRD summary This review concluded that high-dose proton pump inhibitors appeared more (...) effective than standard-dose as part of a seven-day triple therapy regimen for eradication of Helicobacter pylori infection. These conclusions may not be reliable due a risk of missing data, apparent methodological weaknesses in the included studies and the borderline significance of many of the findings. Authors' objectives To compare the effectiveness of high-dose proton pump inhibitors (PPI) with standard in triple therapy for the eradication of Helicobacter pylori . Searching PubMed, Web

2008 DARE. PubMed

156. Systematic review: proton pump inhibitors for the treatment of gastroesophageal reflux in infants

Systematic review: proton pump inhibitors for the treatment of gastroesophageal reflux in infants Systematic review: proton pump inhibitors for the treatment of gastroesophageal reflux in infants Systematic review: proton pump inhibitors for the treatment of gastroesophageal reflux in infants Gieruszczak-Bialek D, Skorka A, Szajewska H CRD summary The review evaluated the safety and effectiveness of proton pump inhibitors in the treatment of gastro-oesophageal reflux disease in infants (...) and found limited evidence that omeprazole significantly reduced reflux. The review was generally well conducted. The authors’ conclusion that there was insufficient evidence for the use of proton pump inhibitors for treatment of gastro-oesophageal reflux disease in infants seems reliable. Authors' objectives To evaluate the safety and effectiveness of proton pump inhibitors in the treatment of gastro-oesophageal reflux disease (GORD) in infants. Searching MEDLINE (1966-2007), EMBASE (1980-2007

2008 DARE.

157. Cost-effectiveness of proton pump inhibitor cotherapy in patients taking long-term, low-dose aspirin for secondary cardiovascular prevention

Cost-effectiveness of proton pump inhibitor cotherapy in patients taking long-term, low-dose aspirin for secondary cardiovascular prevention Cost-effectiveness of proton pump inhibitor cotherapy in patients taking long-term, low-dose aspirin for secondary cardiovascular prevention Cost-effectiveness of proton pump inhibitor cotherapy in patients taking long-term, low-dose aspirin for secondary cardiovascular prevention Saini S D, Schoenfeld P, Fendrick A M, Scheiman J Record Status (...) This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study examined the cost-effectiveness of long-term therapy with low-dose aspirin (ASA) plus proton-pump inhibitor (PPI) co-therapy, compared with ASA alone, for the prevention of upper gastrointestinal bleeding

2008 NHS Economic Evaluation Database.

158. The Stretta procedure versus proton pump inhibitors and laparoscopic Nissen fundoplication in the management of gastroesophageal reflux disease: a cost-effectiveness analysis

The Stretta procedure versus proton pump inhibitors and laparoscopic Nissen fundoplication in the management of gastroesophageal reflux disease: a cost-effectiveness analysis The Stretta procedure versus proton pump inhibitors and laparoscopic Nissen fundoplication in the management of gastroesophageal reflux disease: a cost-effectiveness analysis The Stretta procedure versus proton pump inhibitors and laparoscopic Nissen fundoplication in the management of gastroesophageal reflux disease (...) with the proton-pump inhibitor (PPI) omeprazole and laparoscopic Nissen fundoplication in the management of patients with long-term gastro-oesophageal reflux disease. The authors concluded that PPIs were the cost-effective option when symptom-free months and quality-adjusted life-years were used as benefit measures. In summary, with a few exceptions, the methods were transparent and clearly reported. The authors’ conclusions appear to be appropriate. Type of economic evaluation Cost-effectiveness analysis

2008 NHS Economic Evaluation Database.

159. Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: multicentre randomised controlled trial (MRC-CUBE trial)

Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: multicentre randomised controlled trial (MRC-CUBE trial) Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2008 NHS Economic Evaluation Database.

160. Helicobacter pylori eradication in long-term proton pump inhibitor users is highly cost-effective: economic analysis of the HELPUP trial

Helicobacter pylori eradication in long-term proton pump inhibitor users is highly cost-effective: economic analysis of the HELPUP trial Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2008 NHS Economic Evaluation Database.