Latest & greatest articles for proton pump inhibitors

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Top results for proton pump inhibitors

161. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding

Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could (...) not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Proton pump inhibitor (PPI) treatment may be an effective treatment for peptic ulcer bleeding in those patients with high-risk endoscopic findings. {{author}} {{($index An error has occurred in processing the XML document An error has occurred in processing the XML document

2007 NIHR HTA programme

162. Does clopidogrel rather than aspirin plus a proton-pump inhibitor reduce the frequency of gastrointestinal complications after cardiac surgery?

Does clopidogrel rather than aspirin plus a proton-pump inhibitor reduce the frequency of gastrointestinal complications after cardiac surgery? BestBets: Does clopidogrel rather than aspirin plus a proton-pump inhibitor reduce the frequency of gastrointestinal complications after cardiac surgery? Does clopidogrel rather than aspirin plus a proton-pump inhibitor reduce the frequency of gastrointestinal complications after cardiac surgery? Report By: Maren Ziegelin, Andreas Hoschtitzky, Joel (...) to aspirin and a proton-pump inhibitor] for the prevention of [gastrointestinal bleeding or complications or peptic ulcers]? Clinical Scenario You are seeing a 72 year old man 8 days post-CABG. He had some melaena on day 2 and endoscopy showed a duodenal ulcer, which was injected. He has had no more symptoms or signs of continued bleeding and you would like to resume anti-platelet therapy. You have heard that clopidogrel is better for your stomach and decide to restart this instead of aspirin, but later

2007 BestBETS

163. Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study. (PubMed)

Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study. BACKGROUND & AIMS: Use of proton pump inhibitors (PPIs) has been associated with elevated levels of serum gastrin. Because hypergastrinemia increases colorectal mucosa proliferation and has been associated with risk of colorectal cancer (CRC) in human beings, we conducted a large population-based study in Denmark to assess whether PPI use is associated with CRC risk. METHODS: We conducted

2007 EvidenceUpdates

164. Systematic review: maintenance treatment of gastro-oesophageal reflux disease with proton pump inhibitors taken `on-demand` (Full text)

Systematic review: maintenance treatment of gastro-oesophageal reflux disease with proton pump inhibitors taken `on-demand` BACKGROUND: Proton pump inhibitors (PPI) therapy 'on-demand' is often used as an alternative to continuous maintenance therapy in gastro-oesophageal reflux disease (GERD). AIM: We conducted a systematic review with the specific objectives to ascertain whether on-demand PPI therapy was effective in preventing symptomatic relapse and to assess the relative efficacy

2007 EvidenceUpdates PubMed

165. Review: insufficient evidence exists on the effectiveness of proton pump inhibitors for adults with prolonged non-specific cough associated with gastro-oesophageal reflux

Review: insufficient evidence exists on the effectiveness of proton pump inhibitors for adults with prolonged non-specific cough associated with gastro-oesophageal reflux Review: insufficient evidence exists on the effectiveness of proton pump inhibitors for adults with prolonged non-specific cough associated with gastro-oesophageal reflux | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your (...) of proton pump inhibitors for adults with prolonged non-specific cough associated with gastro-oesophageal reflux Article Text Treatment Review: insufficient evidence exists on the effectiveness of proton pump inhibitors for adults with prolonged non-specific cough associated with gastro-oesophageal reflux Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service

2007 Evidence-Based Nursing

166. Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial. (PubMed)

Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial. Guidelines on pain management recommend that patients at risk of ulcers receive either a cyclo-oxygenase (COX 2) inhibitor or a non-steroidal anti-inflammatory drug (NSAID) with a proton-pump inhibitor (PPI). These two treatments have similar effectiveness, but they are insufficient for protection of patients at very (...) high risk for ulcer bleeding. We aimed to test the hypothesis that in patients with previous ulcer bleeding induced by non-selective NSAIDs, combined treatment with the COX 2 inhibitor celecoxib and the PPI esomeprazole would be better than celecoxib alone for prevention of recurrent ulcer bleeding.441 consecutively presenting patients who were taking non-selective NSAIDs for arthritis were recruited to our single-centre, prospective, randomised, double-blind trial after admission to hospital

2007 Lancet

167. The clinical- and cost-effectiveness of proton pump inhibitors in acute upper gastro-intestinal bleeding

The clinical- and cost-effectiveness of proton pump inhibitors in acute upper gastro-intestinal bleeding Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding Leontiadis GI, Sreedharan A, Dorward S, Barton P, Delaney B, Howden CW, Orhewere M, Gisbert J, sharma VK, Rostom (...) A, Moayyedi P, Forman D Record Status This is a bibliographic record of an ongoing health technology assessment being undertaken by a member of INAHTA. Links to the published report and any other relevant documentation will be added when available. Citation Leontiadis GI, Sreedharan A, Dorward S, Barton P, Delaney B, Howden CW, Orhewere M, Gisbert J, sharma VK, Rostom A, Moayyedi P, Forman D. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper

2007 Health Technology Assessment (HTA) Database.

168. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy initiated prior to endoscopy

Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy initiated prior to endoscopy Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy initiated prior to endoscopy Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal (...) bleeding: PPI therapy initiated prior to endoscopy Leontiadis G I, Sreedharan A, Dorward S, Barton P, Delaney B, Howden C W, Orhewere M, Gisbert J, Sharma V K, Rostom A, Moayyedi P, Forman D CRD summary This review found limited evidence that proton pump inhibitor (PPI) therapy prior to endoscopy for upper gastrointestinal bleeding may reduce the incidence of stigmata of recent haemorrhage, but not other outcomes. Despite some concerns about potential differences between studies and the risk

2007 DARE.

169. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori eradication therapy

Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori eradication therapy Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori eradication therapy Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori (...) ' conclusions H. pylori eradication therapy reduced rates of bleeding compared to non-eradication antisecretory therapy, including proton pump inhibitors (PPI), with or without subsequent long-term maintenance antisecretory therapy. It was not possible to draw conclusions for the comparison of different types of antisecretory therapies with each other or placebo, particularly in H. pylori negative patients, due to a paucity of evidence. CRD commentary The review question was clear and was supported by clear

2007 DARE.

170. Systematic review: rebound acid hypersecretion after therapy with proton pump inhibitors (Full text)

Systematic review: rebound acid hypersecretion after therapy with proton pump inhibitors Systematic review: rebound acid hypersecretion after therapy with proton pump inhibitors Systematic review: rebound acid hypersecretion after therapy with proton pump inhibitors Hunfeld N G, Geus W P, Kuipers E J CRD summary This review evaluated the incidence of rebound acid hypersecretion after the discontinuation of proton-pump inhibitors (PPIs). The authors concluded that the available evidence is too (...) limited to confirm a clinically relevant acid hypersecretion after the withdrawal of PPIs. This review has some methodological weaknesses, but the authors' cautious conclusions seem to reflect the limited evidence presented and are likely to be reliable. Authors' objectives To evaluate the incidence of rebound acid hypersecretion after the discontinuation of proton-pump inhibitors (PPIs). Searching PubMed, EMBASE and the Cochrane CENTRAL Register were searched to October 2005 for published trials

2007 DARE. PubMed

171. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori eradication versus proton pump inhibitors

Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori eradication versus proton pump inhibitors Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: H. pylori eradication versus proton pump inhibitors Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper (...) gastrointestinal bleeding: H. pylori eradication versus proton pump inhibitors Leontiadis G I, Sreedharan A, Dorward S, Barton P, Delaney B, Howden C W, Orhewere M, Gisbert J, Sharma V K, Rostom A, Moayyedi P, Forman D CRD summary This review found no direct evidence to determine whether long-term aspirin or non-aspirin NSAID use prevented further upper gastrointestinal bleeding. There were no treatment differences between proton pump inhibitor and H. pylori eradication therapy in patients diagnosed with H

2007 DARE.

172. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: Prophylactic PPI therapy

Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: Prophylactic PPI therapy Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: Prophylactic PPI therapy Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: Prophylactic PPI therapy (...) Leontiadis G I, Sreedharan A, Dorward S, Barton P, Delaney B, Howden C W, Orhewere M, Gisbert J, Sharma V K, Rostom A, Moayyedi P, Forman D CRD summary This review concluded that H 2 RAs effectively reduced the risk of gastric and/or duodenal ulcers resulting from NSAID use, but standard-dose H 2 RAs were inferior to proton pump inhibitors and misoprostol. The authors' conclusions appeared to reflect the evidence presented, but the reliability of the conclusions is unclear due to limitations of the data

2007 DARE.

173. Meta-analysis: duration of first-line proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication

Meta-analysis: duration of first-line proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication Meta-analysis: duration of first-line proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication Meta-analysis: duration of first-line proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication Fuccio L, Minardi M E, Zagari R M, Grilli D, Magrini N, Bazzoli F CRD summary This well-conducted review concluded that extending proton-pump (...) inhibitor-based triple therapy beyond 7 days for the eradication of Helicobacter pylori is unlikely to be clinically useful. This conclusion is supported by the data presented, but it may not be reliable given the poor methodological quality of the included studies. Authors' objectives To evaluate the efficacy of different durations of proton-pump inhibitor (PPI)-based triple therapy for the eradication of Helicobacter pylori (H. pylori). Searching PubMed, EMBASE and the Cochrane Library were searched

2007 DARE.

174. Review: on-demand maintenance therapy with proton pump inhibitors is as effective as continuous therapy for non-erosive GORD

Review: on-demand maintenance therapy with proton pump inhibitors is as effective as continuous therapy for non-erosive GORD Review: on-demand maintenance therapy with proton pump inhibitors is as effective as continuous therapy for non-erosive GORD | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: on-demand maintenance therapy with proton pump inhibitors is as effective as continuous therapy for non-erosive GORD Article Text

2007 Evidence-Based Medicine (Requires free registration)

175. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy in patients with endoscopically documented acute bleeding from a peptic ulcer

Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy in patients with endoscopically documented acute bleeding from a peptic ulcer Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy in patients with endoscopically documented acute bleeding from a peptic ulcer Systematic reviews of the clinical (...) effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding: PPI therapy in patients with endoscopically documented acute bleeding from a peptic ulcer Leontiadis G I, Sreedharan A, Dorward S, Barton P, Delaney B, Howden C W, Orhewere M, Gisbert J, Sharma V K, Rostom A, Moayyedi P, Forman D CRD summary The authors concluded that proton pump inhibitors reduced re-bleeding; no overall effect was observed on mortality. Overall, this was a well-conducted review

2007 DARE.

176. Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials

Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2007 DARE.

177. Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux disease

Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux disease Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2007 DARE.

178. Long-term proton pump inhibitor therapy and risk of hip fracture. (Full text)

Long-term proton pump inhibitor therapy and risk of hip fracture. Proton pump inhibitors (PPIs) may interfere with calcium absorption through induction of hypochlorhydria but they also may reduce bone resorption through inhibition of osteoclastic vacuolar proton pumps.To determine the association between PPI therapy and risk of hip fracture.A nested case-control study was conducted using the General Practice Research Database (1987-2003), which contains information on patients in the United

2006 JAMA PubMed

179. Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding. (Full text)

Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding. There is conflicting evidence regarding the clinical efficacy of proton pump inhibitors (PPI) initiated prior to endoscopy in patients with upper gastrointestinal bleeding.We aimed to systematically review evidence from randomised controlled trials (RCTs) that studied PPI treatment initiated before endoscopy in patients with upper gastrointestinal bleeding.A search was undertaken

2006 Cochrane PubMed

180. Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease. (Full text)

Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease. Approximately 25% of adults experience heartburn, the cardinal feature of gastro-oesophageal reflux disease (GORD), at least monthly. The evaluation and treatment of patients with suspected GORD is associated with a substantial economic burden. Most patients are treated empirically (without specific diagnostic (...) evaluation). They include a wide range of underlying oesophageal injury. The severity of oesophageal injury can only be established in those who have undergone upper endoscopy. Patients without visible damage to the oesophagus have been referred to as having endoscopy negative reflux disease (ENRD). The pathogenesis of ENRD as well as its response to treatment may differ from GORD with oesophagitis.Summarise, quantify and compare the efficacy of the short-term use of proton pump inhibitors (PPI), H2

2006 Cochrane PubMed