Latest & greatest articles for pulmonary embolism

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Top results for pulmonary embolism

1. Thrombolytics for Patients with Acute or Massive Pulmonary Embolisms: Clinical Effectiveness and Guidelines

Thrombolytics for Patients with Acute or Massive Pulmonary Embolisms: Clinical Effectiveness and Guidelines Thrombolytics for Patients with Acute or Massive Pulmonary Embolisms: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Thrombolytics for Patients with Acute or Massive Pulmonary Embolisms: Clinical Effectiveness and Guidelines Thrombolytics for Patients with Acute or Massive Pulmonary Embolisms: Clinical Effectiveness and Guidelines Last updated: August 27 (...) , 2019 Project Number: RB1385-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of thrombolytics for the treatment of adults with acute or emergent massive pulmonary embolism? What are the evidence-based guidelines regarding thrombolytics in managing adult patients with acute or emergent massive pulmonary embolism? Key Message Three systematic reviews with meta-analyses, seven meta-analyses, five randomized

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

2. Diagnosis and Management of Acute Pulmonary Embolism

Diagnosis and Management of Acute Pulmonary Embolism 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS) | European Heart Journal | Oxford Academic ') We use cookies to enhance your experience on our website.By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Search Account Menu Menu Navbar Search Filter Mobile Microsite (...) Search Term Close search filter search input Article Navigation Close mobile search navigation Article Navigation Article Contents Article Navigation 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC) Stavros V Konstantinides Chairperson Germany/Greece Corresponding authors: Stavros

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2019 European Society of Cardiology

3. Could the YEARS algorithm be used to exclude pulmonary embolism during pregnancy? Data from the CT-PE-pregnancy study

Could the YEARS algorithm be used to exclude pulmonary embolism during pregnancy? Data from the CT-PE-pregnancy study The recently proposed YEARS algorithm was shown to safely exclude pulmonary embolism (PE) and reduce the use of computed tomography pulmonary angiography (CTPA) among pregnant women with suspected PE. Our aim was to externally validate this finding.We performed a post hoc analysis of a prospective management outcome study for PE diagnosis in pregnant women. PE was diagnosed

2019 EvidenceUpdates

4. Hospital volume and outcomes for acute pulmonary embolism: multinational population based cohort study. (PubMed)

Hospital volume and outcomes for acute pulmonary embolism: multinational population based cohort study. To evaluate the association between experience in the management of acute pulmonary embolism, reflected by hospital case volume, and mortality.Multinational population based cohort study using data from the Registro Informatizado de la Enfermedad TromboEmbólica (RIETE) registry between 1 January 2001 and 31 August 2018.353 hospitals in 16 countries.39 257 consecutive patients with confirmed (...) diagnosis of acute symptomatic pulmonary embolism.Pulmonary embolism related mortality within 30 days after diagnosis of the condition.Patients with acute symptomatic pulmonary embolism admitted to high volume hospitals (>40 pulmonary embolisms per year) had a higher burden of comorbidities. A significant inverse association was seen between annual hospital volume and pulmonary embolism related mortality. Admission to hospitals in the highest quarter (that is, >40 pulmonary embolisms per year

2019 BMJ

5. Patent Foramen Ovale and Ischemic Stroke in Patients With Pulmonary Embolism: A Prospective Cohort Study. (PubMed)

Patent Foramen Ovale and Ischemic Stroke in Patients With Pulmonary Embolism: A Prospective Cohort Study. Pulmonary embolism (PE) is associated with increased risk for ischemic stroke, but the underlying mechanism remains unclear. The authors hypothesized that paradoxical embolism through patent foramen ovale (PFO) should be the main mechanism.To determine the frequency of recent ischemic stroke in patients with symptomatic PE according to whether PFO was detected.Prospective cohort study (...) was more frequent in the PFO group than in the non-PFO group (9 of 42 patients [21.4%] vs. 15 of 273 patients [5.5%]; difference in proportions, 15.9 percentage points [95% CI, 4.7 to 30.7 percentage points]).Because of inconclusive contrast TTE or MRI, 46 patients were excluded from analysis.Frequency of recent ischemic stroke in patients with symptomatic PE was higher in patients with PFO than in those without PFO. This finding supports the hypothesis that paradoxical embolism is an important

2019 Annals of Internal Medicine

6. A novel electrocardiographic parameter for diagnosis of acute pulmonary embolism: RS time: RS time in acute pulmonary embolism

A novel electrocardiographic parameter for diagnosis of acute pulmonary embolism: RS time: RS time in acute pulmonary embolism Pulmonary embolism (PE) is one of the leading causes of cardiovascular mortality worldwide. Electrocardiography (ECG) may provide useful information for patients with acute PE. In this study, we aimed to investigate the diagnostic value of the QRS duration and RS time in inferolateral leads in patients admitted to the emergency department, and pre-diagnosed with acute (...) PE.We retrospectively enrolled 136 consecutive patients, admitted to the emergency department, pre-diagnosed with the clinical suspicion of acute PE, and underwent computerized tomographic pulmonary angiography (CTPA) to confirm the PE diagnosis. The study subjects were divided into two groups according to the presence or absence of PE, and the independent predictors of PE were investigated.Sixty-eight patients (50%) had PE. Patients with PE had a longer RS time. Among the ECG parameters, only RS

2019 EvidenceUpdates

7. Tofacitinib (Xeljanz): restriction of 10 mg twice-daily dose in patients at high risk of pulmonary embolism while safety review is ongoing

Tofacitinib (Xeljanz): restriction of 10 mg twice-daily dose in patients at high risk of pulmonary embolism while safety review is ongoing Tofacitinib (Xeljanz▼): restriction of 10 mg twice-daily dose in patients at high risk of pulmonary embolism while safety review is ongoing - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Tofacitinib (Xeljanz▼): restriction of 10 mg twice-daily dose in patients at high risk of pulmonary embolism while safety review is ongoing Following (...) observation in a clinical study of an increased risk of pulmonary embolism and overall mortality with tofacitinib 10 mg twice-daily in rheumatoid arthritis, a safety review has started and new contraindications introduced. The 10 mg twice-daily dose of tofacitinib (authorised for ulcerative colitis) must not be used in patients at high risk of pulmonary embolism. Published 17 May 2019 From: Therapeutic area: , , , A European safety review of tofacitinib ( ) has begun following results from an ongoing

2019 MHRA Drug Safety Update

8. Outpatient versus inpatient treatment for acute pulmonary embolism. (PubMed)

Outpatient versus inpatient treatment for acute pulmonary embolism. Pulmonary embolism (PE) is a common life-threatening cardiovascular condition, with an incidence of 23 to 69 new cases per 100,000 people each year. For selected low-risk patients with acute PE, outpatient treatment might provide several advantages over traditional inpatient treatment, such as reduction of hospitalisations, substantial cost savings, and improvements in health-related quality of life. This is an update

2019 Cochrane

9. The Prognostic Value of Renal Function in Acute Pulmonary Embolism-A Multi-Centre Cohort Study

The Prognostic Value of Renal Function in Acute Pulmonary Embolism-A Multi-Centre Cohort Study  Haemodynamic alterations caused by acute pulmonary embolism (PE) may affect multi-organ function including kidneys. This multi-centre, multinational cohort study aimed to validate the prognostic significance of estimated glomerular filtration rate (eGFR) and its potential additive value to the current PE risk assessment algorithms. The post hoc analysis of pooled prospective cohort studies: 2,845

2019 EvidenceUpdates

10. Rapid blood test helps exclude pulmonary embolism for low risk patients

Rapid blood test helps exclude pulmonary embolism for low risk patients Rapid blood test helps exclude pulmonary embolism for low risk patients Discover Portal Discover Portal Rapid blood test helps exclude pulmonary embolism for low risk patients Published on 25 October 2016 doi: An inexpensive blood test can help quickly rule out pulmonary embolism for low risk patients attending hospital outpatient or emergency departments, especially in people with early symptoms. This review looked (...) diagnostic imaging. Overall a change in the management pathway for suspected pulmonary embolism (PE) have potential to be cost saving and provide better care. Commissioners, will be interested in the overall pathway costs but unfortunately these were not researched here. Share your views on the research. Why was this study needed? In the UK, 47,734 cases of PE were reported between 2014 and 2015. Emergency admissions for PE increased by 30% between 2008 and 2012. A pulmonary embolism is a blockage

2019 NIHR Dissemination Centre

11. Inhaled nitric oxide to treat intermediate risk pulmonary embolism: A multicenter randomized controlled trial. (PubMed)

Inhaled nitric oxide to treat intermediate risk pulmonary embolism: A multicenter randomized controlled trial. To test the hypothesis that adjunctive inhaled NO would improve RV function and viability in acute PE.This was a randomized, placebo-controlled, double blind trial conducted at four academic hospitals. Eligible patients had acute PE without systemic arterial hypotension but had RV dysfunction and a treatment plan of standard anticoagulation. Subjects received either oxygen plus

2019 Nitric oxide : biology and chemistry

12. The clinical net benefit of thrombolysis in the management of submassive pulmonary embolism: systematic review and meta-analysis

The clinical net benefit of thrombolysis in the management of submassive pulmonary embolism: systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

13. Applying rigorous eligibility criteria to studies evaluating prognostic utility of serum biomarkers in patients with pulmonary embolism: a systematic review and meta-analysis

Applying rigorous eligibility criteria to studies evaluating prognostic utility of serum biomarkers in patients with pulmonary embolism: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

14. Prognostic value of RV/LV ratio on computed tomography pulmonary angiography in patients with pulmonary embolism: a systematic review and meta-analysis

Prognostic value of RV/LV ratio on computed tomography pulmonary angiography in patients with pulmonary embolism: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

15. Efficacy of rivaroxaban for pulmonary embolism (PE): an updated systematic review protocol of randomized controlled trial

Efficacy of rivaroxaban for pulmonary embolism (PE): an updated systematic review protocol of randomized controlled trial Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

16. Systematic review to assess the effectiveness and safety of extra-corporeal life support in patients with complicated pulmonary embolism

Systematic review to assess the effectiveness and safety of extra-corporeal life support in patients with complicated pulmonary embolism Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2019 PROSPERO

17. A comparison of the unstructured clinician gestalt, the Wells score, and the revised Geneva score for the estimation of pretest probability in suspected pulmonary embolism

A comparison of the unstructured clinician gestalt, the Wells score, and the revised Geneva score for the estimation of pretest probability in suspected pulmonary embolism Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2019 PROSPERO

18. Thrombolytic therapy for pulmonary embolism. (PubMed)

Thrombolytic therapy for pulmonary embolism. Thrombolytic therapy is usually reserved for patients with clinically serious or massive pulmonary embolism (PE). Evidence suggests that thrombolytic agents may dissolve blood clots more rapidly than heparin and may reduce the death rate associated with PE. However, there are still concerns about the possible risk of adverse effects of thrombolytic therapy, such as major or minor haemorrhage. This is the third update of the Cochrane review first (...) of treatment. None of the included studies reported on post-thrombotic syndrome or compared the costs of different treatments.Low-quality evidence suggests that thrombolytics reduce death following acute pulmonary embolism compared with heparin. The included studies used a variety of thrombolytic drugs. Thrombolytic therapy may be helpful in reducing the recurrence of pulmonary emboli but may cause major and minor haemorrhagic events and stroke. More high-quality, blinded randomised controlled trials

2018 Cochrane

19. Increasing Safe Outpatient Management of Emergency Department Patients With Pulmonary Embolism: A Controlled Pragmatic Trial. (PubMed)

Increasing Safe Outpatient Management of Emergency Department Patients With Pulmonary Embolism: A Controlled Pragmatic Trial. Many low-risk patients with acute pulmonary embolism (PE) in the emergency department (ED) are eligible for outpatient care but are hospitalized nonetheless. One impediment to home discharge is the difficulty of identifying which patients can safely forgo hospitalization.To evaluate the effect of an integrated electronic clinical decision support system (CDSS

2018 Annals of Internal Medicine

20. Can Echocardiography Be Used to Diagnose Pulmonary Embolism at the Bedside?

Can Echocardiography Be Used to Diagnose Pulmonary Embolism at the Bedside? TAKE-HOME MESSAGE When pretest probability for pulmonary embolism is high, abnormalities in right ventricular function detected on echocardiogram strongly support the diagnosis; however, a normal echocardiogram cannot be used to rule out pulmonary embolism. Can Echocardiography Be Used to Diagnose Pulmonary Embolism at the Bedside? EBEM Commentators Robert R. Ehrman, MD Mark J. Favot, MD Department of Emergency Medicine (...) by cardiologists, and 1 unclear)andatthepointofcarein 7 studies; 7 studies were con- ducted solely in the ED. The authors identi?ed 9 unique echocardiographic signs of pulmo- nary embolism, as well as the unde?ned ?nding of “right-sided heart strain.” Overall, the signs of pulmonary embolism were moder- atelyspeci?c(range61%to99%)but poorly sensitive (range 5% to 80%). Test characteristics were slightly improved when echocardiograms were performed by physicians. In the pooled and subgroup analyses, McConnell’s

2018 Annals of Emergency Medicine Systematic Review Snapshots