Latest & greatest articles for pulmonary embolism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on pulmonary embolism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on pulmonary embolism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for pulmonary embolism

341. Cost-effectiveness of ultrasound in preventing femoral venous catheter-associated pulmonary embolism

Cost-effectiveness of ultrasound in preventing femoral venous catheter-associated pulmonary embolism Cost-effectiveness of ultrasound in preventing femoral venous catheter-associated pulmonary embolism Cost-effectiveness of ultrasound in preventing femoral venous catheter-associated pulmonary embolism Cox C E, Carson S S, Biddle A K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Two strategies to prevent femoral venous catheter-associated pulmonary embolism (PE) were compared. The strategies were physical examination alone without ultrasound and lower extremity unilateral Doppler ultrasound-based screening, performed after 7 days of catheterisation. The ultrasound strategy included unilateral duplex Doppler examination

2003 NHS Economic Evaluation Database.

342. Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. Full Text available with Trip Pro

Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. The standard initial treatment of hemodynamically stable patients with pulmonary embolism is intravenous unfractionated heparin, requiring laboratory monitoring and hospitalization.We conducted a randomized, open-label trial involving 2213 patients with acute symptomatic pulmonary embolism to compare the efficacy and safety of the synthetic antithrombotic agent fondaparinux (...) in an international normalized ratio above 2.0. The primary efficacy outcome was the three-month incidence of the composite end point of symptomatic, recurrent pulmonary embolism (nonfatal or fatal) and new or recurrent deep-vein thrombosis.Forty-two of the 1103 patients randomly assigned to receive fondaparinux (3.8 percent) had recurrent thromboembolic events, as compared with 56 of the 1110 patients randomly assigned to receive unfractionated heparin (5.0 percent), for an absolute difference of -1.2 percent

2003 NEJM Controlled trial quality: predicted high

343. Diagnostic strategy for patients with suspected pulmonary embolism: a prospective multicentre outcome study. (Abstract)

Diagnostic strategy for patients with suspected pulmonary embolism: a prospective multicentre outcome study. We designed a prospective multicentre outcome study to evaluate a diagnostic strategy based on clinical probability, spiral CT, and venous compression ultrasonography of the legs in patients with suspected pulmonary embolism (PE). The main aim was to assess the safety of withholding anticoagulant treatment in patients with low or intermediate clinical probability of PE and negative (...) findings on spiral CT and ultrasonography.1041 consecutive inpatients and outpatients with suspected PE were included. Patients with negative spiral CT and ultrasonography and clinically assessed as having a low or intermediate clinical probability were left untreated. Those with high clinical probability underwent lung scanning, pulmonary angiography, or both. All patients were followed up for 3 months.PE was diagnosed in 360 (34.6%) patients; 55 had positive ultrasonography despite negative spiral CT

2002 Lancet

344. Comparison of contrast-enhanced magnetic resonance angiography and conventional pulmonary angiography for the diagnosis of pulmonary embolism: a prospective study. (Abstract)

Comparison of contrast-enhanced magnetic resonance angiography and conventional pulmonary angiography for the diagnosis of pulmonary embolism: a prospective study. Diagnostic strategies for pulmonary embolism are complex and consist of non-invasive diagnostic tests done to avoid conventional pulmonary angiography as much as possible. We aimed to assess the diagnostic accuracy of magnetic resonance angiography (MRA) for the diagnosis of pulmonary embolism, using conventional pulmonary (...) angiography as a reference method.In a prospective study, we enrolled 141 patients with suspected pulmonary embolism and an abnormal perfusion scan. Patients underwent MRA before conventional pulmonary angiography. Two reviewers, masked with respect to the results of conventional pulmonary angiography, assessed MRA images independently. Statistical analyses used chi(2) and 95% CI.MRA was contraindicated in 13 patients (9%), and images were not interpretable in eight (6%). MRA was done in two patients

2002 Lancet

345. Echocardiography in the management of pulmonary embolism. (Abstract)

Echocardiography in the management of pulmonary embolism. Echocardiography is not recommended as a routine imaging test to diagnose suspected pulmonary embolism. However, it is useful for identifying patients with pulmonary embolism who may have a poor prognosis. It can be used for rapid and accurate risk assessment. Moderate or severe right ventricular hypokinesis, persistent pulmonary hypertension, a patent foramen ovale, and free-floating right-heart thrombus are echocardiographic markers (...) that identify patients at risk for death or recurrent thromboembolism. Such patients warrant consideration for thrombolysis or embolectomy. Serial imaging of right ventricular function can help physicians monitor the effect of treatment and judge whether the selected management strategy is successful. Further research will clarify and define more precisely the utility and limitations of echocardiography in the management of pulmonary embolism.

2002 Annals of Internal Medicine

346. The accuracy of the enzyme-linked immunosorbent assay D-dimer test in the diagnosis of pulmonary embolism: a meta-analysis

The accuracy of the enzyme-linked immunosorbent assay D-dimer test in the diagnosis of pulmonary embolism: a meta-analysis The accuracy of the enzyme-linked immunosorbent assay D-dimer test in the diagnosis of pulmonary embolism: a meta-analysis The accuracy of the enzyme-linked immunosorbent assay D-dimer test in the diagnosis of pulmonary embolism: a meta-analysis Brown M D, Rowe B H, Reeves M J, Bermingham J M, Goldhaber S Z Authors' objectives The primary objective was to determine (...) the accuracy of the enzyme-linked immunosorbent assay (ELISA) D-dimer test in the diagnosis of pulmonary embolism (PE) in adults in the hospital emergency department (ED). A secondary objective was to determine whether the test performance is affected by covariates such as age, co-morbidity and duration of symptoms. Searching MEDLINE (from January 1980 to January 1 2001) and EMBASE were searched; the search terms were reported. The reference lists of articles identified by the search, and those of previous

2002 DARE.

347. Thrombolytic therapy of pulmonary embolism: a meta-analysis

Thrombolytic therapy of pulmonary embolism: a meta-analysis Thrombolytic therapy of pulmonary embolism: a meta-analysis Thrombolytic therapy of pulmonary embolism: a meta-analysis Thabut G, Thabut D, Myers R P, Bernard-Chabert B, Marrash-Chahla R, Mal H, Fournier M Authors' objectives To assess the safety and efficacy of thrombolytic treatment in people with acute pulmonary embolism (PE). Searching MEDLINE (from 1967 to 2000), EMBASE (from 1974 to 2000) and Current Contents were searched (...) . Bibliographic details Thabut G, Thabut D, Myers R P, Bernard-Chabert B, Marrash-Chahla R, Mal H, Fournier M. Thrombolytic therapy of pulmonary embolism: a meta-analysis. Journal of the American College of Cardiology 2002; 40(9): 1660-1667 PubMedID Original Paper URL Other publications of related interest Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1-12. Indexing

2002 DARE.

348. Anticoagulation therapy as prophylaxis for prevention of DVT or pulmonary embolism in neurosurgery

Anticoagulation therapy as prophylaxis for prevention of DVT or pulmonary embolism in neurosurgery Anticoagulation therapy as prophylaxis for prevention of DVT or pulmonary embolism in neurosurgery Anticoagulation therapy as prophylaxis for prevention of DVT or pulmonary embolism in neurosurgery Abdulwadud O Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation (...) Abdulwadud O. Anticoagulation therapy as prophylaxis for prevention of DVT or pulmonary embolism in neurosurgery. Clayton, Victoria: Centre for Clinical Effectiveness (CCE) 2002: 12 Authors' objectives This aim of this critical appraisal was to assess the effectiveness of anticoagulation therapy as prophylaxis for prevention of deep vein thrombosis (DVT) or pulmonary embolism in neurosurgery. Project page URL Indexing Status Subject indexing assigned by CRD MeSH Anticoagulants; Neurosurgery; Pulmonary

2002 Health Technology Assessment (HTA) Database.

349. Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. Full Text available with Trip Pro

Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. The use of thrombolytic agents in the treatment of hemodynamically stable patients with acute submassive pulmonary embolism remains controversial.We conducted a study of patients with acute pulmonary embolism and pulmonary hypertension or right ventricular dysfunction but without arterial hypotension or shock. The patients were randomly assigned in double-blind fashion to receive heparin plus 100 (...) -plus-alteplase group and 2.2 percent in the heparin-plus-placebo group, P=0.71). Treatment with heparin plus placebo was associated with almost three times the risk of death or treatment escalation that was associated with heparin plus alteplase (P=0.006). No fatal bleeding or cerebral bleeding occurred in patients receiving heparin plus alteplase.When given in conjunction with heparin, alteplase can improve the clinical course of stable patients who have acute submassive pulmonary embolism and can

2002 NEJM Controlled trial quality: predicted high

350. Severe pulmonary embolism associated with air travel. (Abstract)

Severe pulmonary embolism associated with air travel. Air travel is believed to be a risk factor for pulmonary embolism, but the relation between pulmonary embolism and distance flown has not been documented. The aim of this study was to investigate whether the duration of air travel is related to the risk of pulmonary embolism.From November 1993 to December 2000, we systematically reviewed all cases of pulmonary embolism requiring medical care on arrival at France's busiest international (...) airport. Data on the geographic origins of all flights and the numbers of passengers were collected in order to evaluate the incidence of pulmonary embolism per 1 million passenger arrivals as a function of the distance traveled.A total of 135.29 million passengers from 145 countries or other areas arrived at Charles de Gaulle Airport during the period of the study, of whom 56 had confirmed pulmonary embolism. The incidence of pulmonary embolism was much higher among passengers traveling more than

2001 NEJM

351. Strategies incorporating spiral CT for the diagnosis of acute pulmonary embolism: a cost-effectiveness analysis

Strategies incorporating spiral CT for the diagnosis of acute pulmonary embolism: a cost-effectiveness analysis Strategies incorporating spiral CT for the diagnosis of acute pulmonary embolism: a cost-effectiveness analysis Strategies incorporating spiral CT for the diagnosis of acute pulmonary embolism: a cost-effectiveness analysis Paterson D I, Schwartzman K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Seven strategies for the diagnosis of pulmonary embolism (PE) were considered in the study. All the strategies were obtained from different combinations of the following diagnostic techniques: ventilation-perfusion (V/Q) scans, duplex ultrasound of the legs (US), spiral computed tomography (CT), and conventional

2001 NHS Economic Evaluation Database.

352. Cost-effectiveness of currently accepted strategies for pulmonary embolism diagnosis

Cost-effectiveness of currently accepted strategies for pulmonary embolism diagnosis Cost-effectiveness of currently accepted strategies for pulmonary embolism diagnosis Cost-effectiveness of currently accepted strategies for pulmonary embolism diagnosis Hull R D, Pineo G F, Stein P D, Mah A F, Butcher R S Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Three alternative diagnostic strategies for diagnosing pulmonary embolism (PE) were evaluated. All strategies began with a ventilation-perfusion scan, and were then followed by a variety of different strategies in patients with a nondiagnostic result: ventilation-perfusion scans and pulmonary angiography; ventilation-perfusion scans, single noninvasive leg test, and pulmonary

2001 NHS Economic Evaluation Database.

353. Excluding Pulmonary Embolism at the Bedside without Diagnostic Imaging: Management of Patients with Suspected Pulmonary Embolism Presenting to the Emergency Department by Using a Simple Clinical Model and D-dimer

Excluding Pulmonary Embolism at the Bedside without Diagnostic Imaging: Management of Patients with Suspected Pulmonary Embolism Presenting to the Emergency Department by Using a Simple Clinical Model and D-dimer PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2001 PedsCCM Evidence-Based Journal Club

354. Effect of D-dimer testing on the diagnostic strategy of suspected pulmonary embolism: an observational study of practice patterns and costs

Effect of D-dimer testing on the diagnostic strategy of suspected pulmonary embolism: an observational study of practice patterns and costs Effect of D-dimer testing on the diagnostic strategy of suspected pulmonary embolism: an observational study of practice patterns and costs Effect of D-dimer testing on the diagnostic strategy of suspected pulmonary embolism: an observational study of practice patterns and costs Lebrun E, Maitre B, Grenier-Sennelier C, Katsahian S, Gouault-Heilmann M (...) , Vasile N, Meignan M, Housset B, Durand-Zaleski I Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of D-dimer testing for the diagnosis of suspected pulmonary embolism. Type of intervention Diagnosis. Economic study type Cost

2000 NHS Economic Evaluation Database.

355. The role of spiral volumetric computed tomography in the diagnosis of pulmonary embolism

The role of spiral volumetric computed tomography in the diagnosis of pulmonary embolism The role of spiral volumetric computed tomography in the diagnosis of pulmonary embolism The role of spiral volumetric computed tomography in the diagnosis of pulmonary embolism Mullins M D, Becker D M, Hagspiel K D, Philbrick J T Authors' objectives To evaluate the evidence for the use of spiral volumetric computed tomography (SVCT) in the diagnosis of acute pulmonary embolism (PE). Searching MEDLINE (from (...) a large multi-centre trial and specific investigation of the sensitivity of SVCT in the detection of small subsegmental emboli'. Bibliographic details Mullins M D, Becker D M, Hagspiel K D, Philbrick J T. The role of spiral volumetric computed tomography in the diagnosis of pulmonary embolism. Archives of Internal Medicine 2000; 160(3): 293-298 PubMedID Original Paper URL Other publications of related interest Remy-Jardin M, Wattinne L, Giraud F. Central pulmonary thromboembolism: diagnosis

2000 DARE.

356. Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial. (Abstract)

Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial. Previous trials of antiplatelet therapy for the prevention of venous thromboembolism have individually been inconclusive, but a meta-analysis of their results indicated reductions in the risks of deep-vein thrombosis and of pulmonary embolism in various high-risk groups. The aim of this large randomised placebo-controlled trial was to confirm or refute these apparent (...) the patients with hip fracture, allocation to aspirin produced proportional reductions in pulmonary embolism of 43% (95% CI 18-60; p=0.002) and in symptomatic deep-vein thrombosis of 29% (3-48; p=0.03). Pulmonary embolism or deep-vein thrombosis was confirmed in 105 (1.6%) of 6679 patients assigned aspirin compared with 165 (2.5%) of 6677 assigned placebo, which represents an absolute reduction of 9 (SE 2) per 1000 and a proportional reduction of 36% (19-50; p=0.0003). Similar proportional effects were

2000 Lancet Controlled trial quality: predicted high

357. Thrombolytic therapy of pulmonary embolism: a comprehensive review of current evidence

Thrombolytic therapy of pulmonary embolism: a comprehensive review of current evidence Thrombolytic therapy of pulmonary embolism: a comprehensive review of current evidence Thrombolytic therapy of pulmonary embolism: a comprehensive review of current evidence Arcasoy SM, Kreit JW Authors' objectives To provide a comprehensive and systematic review of studies evaluating thrombolytic therapy of patients with pulmonary embolism (PE). Seven objectives were identified: 1. What are the proven (...) terms and textwords: thrombolytic therapy, thrombolysis, fibrinolyses, urokinase (UK), streptokinase (SK), recombinant tissue-type plasminogen activator (rt-PA), and pulmonary embolism. The reference lists of all articles were examined to identify additional studies. No attempt was made to evaluate unpublished data. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs) are the focus of the review, but non-randomised, uncontrolled trials and case

1999 DARE.

358. Risk of fatal pulmonary embolism in patients with treated venous thromboembolism. (Abstract)

Risk of fatal pulmonary embolism in patients with treated venous thromboembolism. The most serious complication of deep vein thrombosis (DVT) or nonfatal pulmonary embolism (PE) is fatal PE. However, reliable estimates as to the risk of fatal PE in patients with treated DVT or PE are lacking.To provide reliable estimates of the risk of fatal PE and the case-fatality rate of recurrent DVT or PE among patients presenting with symptomatic DVT or PE, during and following 3 months of anticoagulant

1998 JAMA

359. Acute pulmonary embolism: cost-effectiveness analysis of the effect of artificial neural networks on patient care

Acute pulmonary embolism: cost-effectiveness analysis of the effect of artificial neural networks on patient care Acute pulmonary embolism: cost-effectiveness analysis of the effect of artificial neural networks on patient care Acute pulmonary embolism: cost-effectiveness analysis of the effect of artificial neural networks on patient care Tourassi G D, Floyd C E, Coleman R E Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED (...) . Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of an artificial neural network (ANN) to diagnose and determine treatment strategies in patients with suspected acute pulmonary embolism. The network was trained to predict the probability of pulmonary embolism by using physicians' findings from ventilation-perfusion lung scans and chest

1998 NHS Economic Evaluation Database.

360. Cost-effective diagnostic algorithms in pulmonary embolism: an updated analysis

Cost-effective diagnostic algorithms in pulmonary embolism: an updated analysis Cost-effective diagnostic algorithms in pulmonary embolism: an updated analysis Cost-effective diagnostic algorithms in pulmonary embolism: an updated analysis van Erkel A R, Pattynama P M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed (...) critical assessment on the reliability of the study and the conclusions drawn. Health technology Diagnosis of pulmonary embolism (PE). Type of intervention Diagnosis. Economic study type Cost-effectiveness analysis. Study population Persons with suspected PE. Setting The setting was Leiden University Medical Centre, Leiden, The Netherlands. Dates to which data relate Effectiveness data were collected from studies previously published between 1985 and 1997. The dates of resource use data and the price

1998 NHS Economic Evaluation Database.