Latest & greatest articles for rheumatoid arthritis

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Top results for rheumatoid arthritis

1. Olumiant - baricitinib - Arthritis, Rheumatoid

Olumiant - baricitinib - Arthritis, Rheumatoid baricitinib | CADTH.ca Find the information you need baricitinib baricitinib Last Updated: September 12, 2019 Result type: Reports Project Number: SR0597-000 Product Line: Generic Name: baricitinib Brand Name: Olumiant Manufacturer: Eli Lilly Canada Inc. Indications: Arthritis, Rheumatoid Manufacturer Requested Reimbursement Criteria 1 : In combination with methotrexate (MTX), indicated for reducing the signs and symptoms of moderate to severe (...) rheumatoid arthritis (RA) in adult patients who have responded inadequately to one or more disease-modifying anti-rheumatic drugs (DMARDs).Olumiant may be used as monotherapy in cases of intolerance to MTX. Submission Type: New Project Status: Complete Biosimilar: No Companion Diagnostics: No Date Recommendation Issued: August 2, 2019 Recommendation Type: Reimburse with clinical criteria and/or conditions Fee Schedule: Schedule A The requested reimbursement criteria are provided by the applicant and do

2019 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

2. Upadacitinib (TBC) - Arthritis, Rheumatoid

Upadacitinib (TBC) - Arthritis, Rheumatoid upadacitinib | CADTH.ca Find the information you need upadacitinib upadacitinib Last Updated: October 4, 2019 Result type: Reports Project Number: SR0614-000 Product Line: Generic Name: upadacitinib Brand Name: TBC Manufacturer: AbbVie Indications: Arthritis, Rheumatoid Manufacturer Requested Reimbursement Criteria 1 : Upadacitinib to be listed for the treatment of moderate to severe active rheumatoid arthritis in adult patients who have responded (...) recommendation, if applicable. Key Milestones 2 Call for patient input posted May 31, 2019 Patient group input closed July 22, 2019 Clarification: - Patient input submission received from the Arthritis Consumer Experts, Canadian Arthritis Patient Alliance (CAPA) & The Arthritis Society Patient input summary sent for review to patient input groups July 30, 2019 Patient group comments on input summary closed August 07, 2019 Clarification: - Patient input summary feedback received Submission received July 04

2019 Canadian Agency for Drugs and Technologies in Health - Common Drug Review

3. Triple Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs for the Management of Rheumatoid Arthritis

Triple Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs for the Management of Rheumatoid Arthritis Triple Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs for the Management of Rheumatoid Arthritis | CADTH.ca Find the information you need Triple Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs for the Management of Rheumatoid Arthritis Triple Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs for the Management of Rheumatoid Arthritis Last (...) updated: March 26, 2019 Project Number: RC1087-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the cost-effectiveness of triple conventional synthetic disease-modifying anti-rheumatic drugs compared with other pharmacologic options for the management of rheumatoid arthritis? Key Message Two relevant publications comprising cost-effectiveness analyses were identified; one involved patients with rheumatoid arthritis (RA) that could

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4. Benefit assessment of biotechnologically produced drugs for the treatment of rheumatoid arthritis

Benefit assessment of biotechnologically produced drugs for the treatment of rheumatoid arthritis 1 Translation of Chapters 1 to 6 of the final report A16-70 Biotechnologisch hergestellte Wirkstoffe bei rheumatoider Arthritis (Version 1.0; Status: 23 July 2019 [German original], 16 September 2019 [English translation]). Please note: This document is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally (...) binding. Extract IQWiG Reports – Commission No. A16-70 Biologics for rheumatoid arthritis 1 Extract of final report A16-70 Version 1.0 Biologics for rheumatoid arthritis 23 July 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Biologics for rheumatoid arthritis Commissioning agency: Federal Joint Committee Commission awarded on: 24 November 2016 Internal Commission No.: A16-70 Address

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

5. Rituximab as Maintenance Treatment in Rheumatoid Arthritis

Rituximab as Maintenance Treatment in Rheumatoid Arthritis Rituximab as Maintenance Treatment in Rheumatoid Arthritis | CADTH.ca Find the information you need Rituximab as Maintenance Treatment in Rheumatoid Arthritis Rituximab as Maintenance Treatment in Rheumatoid Arthritis Last updated: March 29, 2019 Project Number: HO0002-000 - HE0021-000 Product Line: Technology Review Result type: Report This project reviewed the evidence on the administration of repeated courses of rituximab

2019 Publication 4890897

6. Leflunomide for the Management of Rheumatoid Arthritis: Comparative Clinical Effectiveness

Leflunomide for the Management of Rheumatoid Arthritis: Comparative Clinical Effectiveness Leflunomide for the Management of Rheumatoid Arthritis: Comparative Clinical Effectiveness | CADTH.ca Find the information you need Leflunomide for the Management of Rheumatoid Arthritis: Comparative Clinical Effectiveness Leflunomide for the Management of Rheumatoid Arthritis: Comparative Clinical Effectiveness Last updated: January 15, 2019 Project Number: RA0999-000 Product Line: Research Type: Drug (...) Report Type: Reference List Result type: Report Question What is the clinical effectiveness of leflunomide compared with other disease modifying antirheumatic drugs for the management of rheumatoid arthritis? Key Message One randomized controlled trial was identified regarding the clinical effectiveness of leflunomide for rheumatoid arthritis management. Files Rapid Response Reference List Published : January 15, 2019 Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

7. Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): A multicentre, open-label, randomised controlled trial

Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): A multicentre, open-label, randomised controlled trial The inflammatory contribution to type 2 diabetes (T2D) has suggested new therapeutic targets using biologic drugs designed for rheumatoid arthritis (RA). On this basis, we aimed at investigating whether interleukin-1 (IL-1) inhibition with anakinra, a recombinant human IL-1 receptor antagonist, could improve both glycaemic and inflammatory (...) haemoglobin (HbA1c%) (EudraCT: 2012-005370-62 ClinicalTrial.gov: NCT02236481). In total, 41 participants with RA and T2D were randomised, and 39 eligible participants were treated (age 62.72 ± 9.97 years, 74.4% female sex). The majority of participants had seropositive RA disease (rheumatoid factor and/or anticyclic citrullinated peptide antibody [ACPA] 70.2%) with active disease (Disease Activity Score-28 [DAS28]: 5.54 ± 1.03; C-reactive protein 11.84 ± 9.67 mg/L, respectively). All participants had T2D

2019 EvidenceUpdates

8. Group cognitive behavioural programme to reduce the impact of rheumatoid arthritis fatigue: the RAFT RCT with economic and qualitative evaluations

Group cognitive behavioural programme to reduce the impact of rheumatoid arthritis fatigue: the RAFT RCT with economic and qualitative evaluations Group cognitive behavioural programme to reduce the impact of rheumatoid arthritis fatigue: the RAFT RCT with economic and qualitative evaluations Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from (...) the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} CBT plus usual care, delivered by clinical rheumatology teams, reduced fatigue impact in rheumatoid arthritis at 26 weeks beyond usual care alone, but with uncertain cost-effectiveness. {{author}} {{($index , , , , , , , , , , , , , & . Sarah Hewlett 1, * , Celia Almeida 1 , Nicholas Ambler 2 , Peter S Blair 3 , Ernest Choy 4

2019 NIHR HTA programme

9. Tai Chi for rheumatoid arthritis. (PubMed)

Tai Chi for rheumatoid arthritis. Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory, autoimmune disease that results in joint deformity and immobility of the musculoskeletal system. The major goals of treatment are to relieve pain, reduce inflammation, slow down or stop joint damage, prevent disability, and preserve or improve the person's sense of well-being and ability to function. Tai Chi, interchangeably known as Tai Chi Chuan, is an ancient Chinese health-promoting martial art (...) form that has been recognized in China as an effective arthritis therapy for centuries. This is an update of a review published in 2004.To assess the benefits and harms of Tai Chi as a treatment for people with rheumatoid arthritis (RA).We updated the search of CENTRAL, MEDLINE, Embase, and clinical trial registries from 2002 to September 2018.We selected randomized controlled trials and controlled clinical trials examining the benefits (ACR improvement criteria or pain, disease progression

2019 Cochrane

10. Upadacitinib Versus Placebo or Adalimumab in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate: Results of a Phase III, Double-Blind, Randomized Controlled Trial

Upadacitinib Versus Placebo or Adalimumab in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate: Results of a Phase III, Double-Blind, Randomized Controlled Trial To evaluate the efficacy, including capacity for inhibition of radiographic progression, and safety of upadacitinib, a JAK1-selective inhibitor, as compared to placebo or adalimumab in patients with rheumatoid arthritis (RA) who have experienced an inadequate response to methotrexate (MTX).In total, 1,629 RA

2019 EvidenceUpdates

11. Efficacy of Atlantoaxial Joint Glucocorticoid Injection in Patients with Rheumatoid Arthritis: A Randomized Trial

Efficacy of Atlantoaxial Joint Glucocorticoid Injection in Patients with Rheumatoid Arthritis: A Randomized Trial The atlantoaxial joint (AAJ) plays a pivotal role in the cervical spine motion. Unfortunately, it is the most common cervical spine joint that is affected in patients with rheumatoid arthritis. Inflammation of the AAJ results in neck disability, nerve root compression, and finally spinal cord compression.We aim to evaluate the efficacy of intraarticular triamcinolone injection (...) of the AAJ on neck pain and disability.A prospective randomized, controlled clinical trial.An interventional pain unit in a tertiary center at a university hospital in Egypt.Sixty patients with rheumatoid arthritis complaining of AAJ arthritis were randomized into 2 groups. Group AAJI (n = 30) received AAJ injection with 1.0 mL of a mixture of 0.5 mL of bupivacaine 0.5% and 0.5 mL of 20 mg of triamcinolone, in addition to oral placebo tablets (2 tablets every 8 hours for one week). Group SS (n = 30

2019 EvidenceUpdates

12. A Multicenter, Randomized, Placebo-Controlled Trial of Atorvastatin for the Primary Prevention of Cardiovascular Events in Patients With Rheumatoid Arthritis

A Multicenter, Randomized, Placebo-Controlled Trial of Atorvastatin for the Primary Prevention of Cardiovascular Events in Patients With Rheumatoid Arthritis Rheumatoid arthritis (RA) is associated with increased cardiovascular event (CVE) risk. The impact of statins in RA is not established. We assessed whether atorvastatin is superior to placebo for the primary prevention of CVEs in RA patients.A randomized, double-blind, placebo-controlled trial was designed to detect a 32% CVE risk (...) %). The rates of adverse events in the atorvastatin group (n = 298 [19.8%]) and placebo group (n = 292 [19.5%]) were similar.Atorvastatin 40 mg daily is safe and results in a significantly greater reduction of LDL cholesterol level than placebo in patients with RA. The 34% CVE risk reduction is consistent with the Cholesterol Treatment Trialists' Collaboration meta-analysis of statin effects in other populations.© 2019, The Authors. Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf

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2019 EvidenceUpdates

13. Cardiovascular Safety During Treatment With Baricitinib in Rheumatoid Arthritis

Cardiovascular Safety During Treatment With Baricitinib in Rheumatoid Arthritis To assess the frequency of cardiovascular and venous thromboembolic events in clinical studies of baricitinib, an oral, selective JAK1 and JAK2 inhibitor approved in more than 50 countries for the treatment of moderately-to-severely active rheumatoid arthritis (RA).Data were pooled from 9 RA studies. Placebo comparison up to 24 weeks included data from 6 studies. Randomized dose comparison between baricitinib doses (...) . Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology.

2019 EvidenceUpdates

14. Efficacy and safety of switching from rituximab to biosimilar CT-P10 in rheumatoid arthritis: 72-week data from a randomized Phase 3 trial

Efficacy and safety of switching from rituximab to biosimilar CT-P10 in rheumatoid arthritis: 72-week data from a randomized Phase 3 trial To evaluate the efficacy and safety of CT-P10, a rituximab biosimilar after a single switch, during a multinational, randomized, double-blind Phase 3 trial involving patients with RA.Patients received 48 weeks' treatment with CT-P10 or United States- or European Union-sourced reference rituximab (US-RTX and EU-RTX, respectively). Patients entering

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2019 EvidenceUpdates

15. Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy: The FINCH 2 Randomized Clinical Trial. (PubMed)

Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy: The FINCH 2 Randomized Clinical Trial. Patients with active rheumatoid arthritis (RA) despite treatment with biologic disease-modifying antirheumatic drug (bDMARD) therapy need treatment options.To evaluate the effects of filgotinib vs placebo on the signs and symptoms of RA in a treatment-refractory population.A 24-week

2019 JAMA

16. Therapeutic monitoring of TNF-alpha inhibitors in rheumatoid arthritis

Therapeutic monitoring of TNF-alpha inhibitors in rheumatoid arthritis Ther Therapeutic monitoring of TNF-alpha apeutic monitoring of TNF-alpha inhibitors in rheumatoid arthritis inhibitors in rheumatoid arthritis Diagnostics guidance Published: 10 July 2019 www.nice.org.uk/guidance/dg36 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility This guidance represents the view of NICE (...) possible. Therapeutic monitoring of TNF-alpha inhibitors in rheumatoid arthritis (DG36) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 36Contents Contents 1 Recommendations 4 2 Clinical need and practice 5 The problem addressed 5 The condition 6 The care pathways 6 3 The diagnostic tests 8 The interventions 8 The comparator 9 4 Evidence 11 Clinical effectiveness 11 Cost effectiveness 17 5 Committee discussion 25

2019 National Institute for Health and Clinical Excellence - Diagnostics Guidance

17. Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study. (PubMed)

Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study. Upadacitinib, an oral Janus kinase (JAK)1-selective inhibitor, showed efficacy in combination with stable background conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) in patients with rheumatoid arthritis who had an inadequate response to DMARDs. We aimed to evaluate the safety (...) and efficacy of upadacitinib monotherapy after switching from methotrexate versus continuing methotrexate in patients with inadequate response to methotrexate.SELECT-MONOTHERAPY was conducted at 138 sites in 24 countries. The study enrolled adults (≥18 years) who fulfilled the 2010 American College of Rheumatology (ACR)-European League Against Rheumatism (EULAR) classification criteria for rheumatoid arthritis. Patients with active rheumatoid arthritis despite stable methotrexate were randomly assigned 2:2

2019 Lancet

18. Impact of Janus kinase inhibitors on risk of cardiovascular events in patients with rheumatoid arthritis: systematic review and meta-analysis of randomised controlled trials

Impact of Janus kinase inhibitors on risk of cardiovascular events in patients with rheumatoid arthritis: systematic review and meta-analysis of randomised controlled trials To investigate the effect of Janus kinase inhibitors (Jakinibs) on cardiovascular risk in adult patients with rheumatoid arthritis (RA) via a meta-analysis of randomised controlled trials (RCTs).PubMed, Embase and Cochrane library were thoroughly searched for RCTs reporting safety issues in patients with RA receiving

2019 EvidenceUpdates

19. How do biosimilar medications compare to their corresponding originator biologic medications in treating patients with conditions like rheumatoid arthritis or inflammatory bowel disease?

How do biosimilar medications compare to their corresponding originator biologic medications in treating patients with conditions like rheumatoid arthritis or inflammatory bowel disease? Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,800 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives (...) for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca May 27, 2019 It’s all in the details... or is it? Biosimilars versus biologics for inflammatory conditions. Clinical Question: How do biosimilar medications compare to their corresponding originator biologic medications in treating patients with conditions like rheumatoid arthritis or inflammatory bowel disease? Bottom Line: For patients with rheumatoid arthritis, other inflammatory

2019 Tools for Practice

20. Down-titration and discontinuation strategies of tumour necrosis factor-blocking agents for rheumatoid arthritis in patients with low disease activity. (PubMed)

Down-titration and discontinuation strategies of tumour necrosis factor-blocking agents for rheumatoid arthritis in patients with low disease activity. Anti-tumour necrosis factor (TNF) agents are effective in treating people with rheumatoid arthritis (RA), but are associated with (dose-dependent) adverse effects and high costs. To prevent overtreatment, several trials have assessed the effectiveness of down-titration compared with continuation of the standard dose. This is an update

2019 Cochrane