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Latest & greatest articles for rheumatoid arthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on rheumatoid arthritis or other clinical topics then use Trip today.
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Risk of Biologics and Glucocorticoids in Patients With RheumatoidArthritis Undergoing Arthroplasty: A Cohort Study. Patients with rheumatoidarthritis (RA) are at increased risk for infection after arthroplasty, yet risks of specific biologic medications are unknown.To compare risk for postoperative infection among biologics and to evaluate the risk associated with glucocorticoids.Retrospective cohort study.Medicare and Truven MarketScan administrative data from January 2006 through September
Effects of the anti-RANKL antibody denosumab on joint structural damage in patients with rheumatoidarthritis treated with conventional synthetic disease-modifying antirheumatic drugs (DESIRABLE study): a randomised, double-blind, placebo-controlled phase To evaluate the efficacy of denosumab in suppressing joint destruction when added to conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy in patients with rheumatoidarthritis (RA).This was a multi-centre, randomised
Gradual tapering TNF inhibitors versus conventional synthetic DMARDs after achieving controlled disease in patients with rheumatoidarthritis: first-year results of the randomised controlled TARA study The aim of this study is to evaluate the effectiveness of two tapering strategies after achieving controlled disease in patients with rheumatoidarthritis (RA), during 1 year of follow-up.In this multicentre single-blinded (research nurses) randomised controlled trial, patients with RA were
Neuromuscular Electrical Stimulation Compared to Volitional Exercise for Improving Muscle Function in RheumatoidArthritis: A Randomized Pilot Study The aim of this study was to compare the feasibility and effectiveness of neuromuscular electrical stimulation (NMES) with that of high-intensity volitional resistance training for improving muscle structure and function and physical function in patients with rheumatoidarthritis (RA). We also compared pre-intervention and post-intervention values
Adalimumab (Idacio) - Arthritis, Rheumatoid, Arthritis, Juvenile Rheumatoid, Psoriasis, Arthritis, Psoriatic, Spondylitis, Ankylosing, Uveitis, Hidradenitis Suppurativa, Colitis, Ulcerative, Crohn Disease EMA/85985/2019 EMEA/H/C/004475 Idacio (adalimumab) An overview of Idacio and why it is authorised in the EU What is Idacio and what is it used for? Idacio is a medicine that acts on the immune system (the body’s natural defences) and is used to treat the following conditions: • plaque (...) psoriasis (a disease causing red, scaly patches on the skin); • psoriatic arthritis (a disease causing red, scaly patches on the skin with inflammation of the joints); • rheumatoidarthritis (a disease causing inflammation of the joints); • axial spondyloarthritis (inflammation of the spine causing back pain), including ankylosing spondylitis and when there are clear signs of inflammation but X-ray does not show disease; • polyarticular juvenile idiopathic arthritis and active enthesitis-related
Risk of serious infections in tocilizumab versus other biologic drugs in patients with rheumatoidarthritis: a multidatabase cohort study To investigate the rate of serious bacterial, viral or opportunistic infection in patients with rheumatoidarthritis (RA) starting tocilizumab (TCZ) versus tumour necrosis factor inhibitors (TNFi) or abatacept.Using claims data from US Medicare from 2010 to 2015, and IMS and MarketScan from 2011 to 2015, we identified adults with RA who initiated TCZ or TNFi
Adjustment of the multi-biomarker disease activity score to account for age, sex and adiposity in patients with rheumatoidarthritis To develop and evaluate an adjusted score for the multi-biomarker disease activity (MBDA) test to account for the effects of age, sex and adiposity in patients with RA.Two models were developed to adjust MBDA score for age, sex and adiposity, using either serum leptin concentration or BMI as proxies for adiposity. Two cohorts were studied. A cohort of 325 781 RA
Effect of Magnetic Resonance Imaging vs Conventional Treat-to-Target Strategies on Disease Activity Remission and Radiographic Progression in RheumatoidArthritis: The IMAGINE-RA Randomized Clinical Trial. Whether using magnetic resonance imaging (MRI) to guide treatment in patients with rheumatoidarthritis (RA) improves disease activity and slows joint damage progression is unknown.To determine whether an MRI-guided treat-to-target strategy vs a conventional clinical treat-to-target strategy
Risk of serious infections in patients with rheumatoidarthritis treated in routine care with abatacept, rituximab and tocilizumab in Denmark and Sweden To estimate (1) crude and age-and gender-adjusted incidence rates (IRs) of serious infections (SI) and (2) relative risks (RR) of SI in patients with rheumatoidarthritis (RA) initiating treatment with abatacept, rituximab or tocilizumab in routine care.This is an observational cohort study conducted in parallel in Denmark and Sweden including
Safety and tolerability of subcutaneous sarilumab and intravenous tocilizumab in patients with rheumatoidarthritis Safety and efficacy of mAbs blocking the IL-6 receptor have been established in RA. This is the first analysis examining safety and tolerability of sarilumab and tocilizumab administered as single or multiple doses in patients with RA within the same study.In ASCERTAIN, patients were randomized 1: 1: 2 to 24 weeks' double-blind sarilumab 150 or 200 mg every 2 weeks s.c
Stopping biological drugs for rheumatoidarthritis can lead to twice the relapse rate Stopping biological drugs for rheumatoidarthritis can lead to twice the relapse rate Discover Portal Discover Portal Stopping biological drugs for rheumatoidarthritis can lead to twice the relapse rate Published on 24 January 2018 doi: It seems safer to reduce the dose of biological drugs, rather than to stop them if people with rheumatoidarthritis and their doctors want to avoid relapse. Stopping (...) these powerful drugs caused the disease to recur in 58% of people compared with 29% who continued them. Reducing the dose also led to more relapses for people in remission, but did not cause those with low-grade disease activity to worsen. Rheumatoidarthritis is a chronic disease which causes pain, swelling and stiffness in the small joints of the hands and feet. It can cause more widespread inflammation. The disease has episodes of improvement and deterioration so judging the effects of treatment can
Existing drugs for rheumatoidarthritis may also improve associated fatigue Existing drugs for rheumatoidarthritis may also improve associated fatigue Discover Portal Discover Portal Existing drugs for rheumatoidarthritis may also improve associated fatigue Published on 23 August 2016 doi: Biological treatments for moderate to severe rheumatoidarthritis appear to reduce fatigue as well as other symptoms. Although existing studies looking at effectiveness have focused on symptoms such as pain (...) be an important consideration for patients and prescribers. Share your views on the research. Why was this study needed? Rheumatoidarthritis affects around 400,000 people in the UK. It is an autoimmune disease in which the person’s own immune system attacks their body, in this case mainly the joints, causing inflammation, swelling, stiffness, pain and irreversible joint damage. There is no cure for rheumatoidarthritis. Treatments such as anti-inflammatory painkillers aim to relieve symptoms while drugs
Comparative effectiveness of rituximab, abatacept, and tocilizumab in adults with rheumatoidarthritis and inadequate response to TNF inhibitors: prospective cohort study. To compare the effectiveness and safety of three non-tumour necrosis factor (TNF) α inhibitors (rituximab, abatacept, and tocilizumab) in the treatment of rheumatoid arthritis.Population based prospective study.53 university and 54 non-university clinical centres in France.3162 adults (>18 years) with rheumatoidarthritis (...) according to 1987 American College of Rheumatology criteria, enrolled in one of the three French Society of Rheumatology registries; who had no severe cardiovascular disease, active or severe infections, or severe immunodeficiency, with follow-up of at least 24 months.Initiation of intravenous rituximab, abatacept, or tocilizumab for rheumatoid arthritis.The primary outcome was drug retention without failure at 24 months. Failure was defined as all cause death; discontinuation of rituximab, abatacept
Effectiveness of a Referral Program for rheumatoidarthritis and axial spondyloarthritis Diagnosis at Primary Care Centers in Portugal - SIARA STUDY. Early diagnosis and treatment of RheumatoidArthritis (RA) and axial Spondylarthritis (axial SpA) can limit the impact of disease outcomes. This study evaluated the effectiveness of a referral program on the identification of patients with RA and axial SpA.This was an observational, prospective, randomized (by clusters) study conducted in Portugal (...) or axial SpA cases confirmed by the rheumatologist of the reference hospital.RA-Substudy: A total of 340 patients were recruited (144 in the RSA-exposed group; 196 in the control). RA diagnosis confirmation was 7.3% (95%CI, 2.1-12.5%) in RSA group versus 2.7% (95%CI, 0.0-5.7%) in control group RSA effect was positive but moderate (4.6%) and not statistically significant (95% CI, 0.0%-11.8%; p=0.222, adjusted for clustering effect). Rate of confirmed arthritis of any type was 16.9% (n=14/83) in the RSA
Effects of B-cell directed therapy on the preclinical stage of rheumatoidarthritis: the PRAIRI study We explored the effects of B-cell directed therapy in subjects at risk of developing autoantibodypositive rheumatoidarthritis (RA), who never experienced inflammatory arthritis before, and explored biomarkers predictive of arthritis development.Individuals positive for both anti-citrullinated peptide antibodies and rheumatoid factor but without arthritis were included in a randomised, double (...) -blind, placebo-controlled study to receive a single infusion of 1000 mg rituximab or placebo.Eighty-one individuals received treatment and were followed up for a mean of 29.0 (0-54) months, during which 30/81 (37%) individuals developed arthritis. The observed risk of developing arthritis in the placebo-treated group was 40%, which was decreased by 55% (HR 0.45, 95% CI 0.154 to 1.322) in the rituximab-treated group at 12 months. Rituximab treatment caused a delay in arthritis development of 12