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Latest & greatest articles for sepsis
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The Effect of Selenium Therapy on Mortality in Patients With Sepsis Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
Association Among Blood Transfusion, Sepsis, and Decreased Long-term Survival After Colon Cancer Resection To investigate the potential additive effects of blood transfusion and sepsis on colon cancer disease-specific survival, cardiovascular disease-specific survival, and overall survival after colon cancer surgery.Perioperative blood transfusions are associated with infectious complications and increased risk of cancer recurrence through systemic inflammatory effects. Furthermore, recent (...) studies have suggested an association among sepsis, subsequent systemic inflammation, and adverse cardiovascular outcomes. However, no study has investigated the association among transfusion, sepsis, and disease-specific survival in postoperative patients.The New York State Cancer Registry and Statewide Planning and Research Cooperative System were queried for stage I to III colon cancer resections from 2004 to 2011. Propensity-adjusted survival analyses assessed the association of perioperative
Continuous versus Intermittent beta-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials Optimization of β-lactam antibiotic dosing for critically ill patients is an intervention that may improve outcomes in severe sepsis.In this individual patient data meta-analysis of critically ill patients with severe sepsis, we aimed to compare clinical outcomes of those treated with continuous versus intermittent infusion of β-lactam antibiotics.We identified (...) relevant randomized controlled trials comparing continuous versus intermittent infusion of β-lactam antibiotics in critically ill patients with severe sepsis. We assessed the quality of the studies according to four criteria. We combined individual patient data from studies and assessed data integrity for common baseline demographics and study endpoints, including hospital mortality censored at 30 days and clinical cure. We then determined the pooled estimates of effect and investigated factors
Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial. Although frequently used in treating intensive care unit (ICU) patients with sepsis, empirical antifungal therapy, initiated for suspected fungal infection, has not been shown to improve outcome.To determine whether empirical micafungin reduces invasive fungal infection (IFI)-free survival (...) at day 28.Multicenter double-blind placebo-controlled study of 260 nonneutropenic, nontransplanted, critically ill patients with ICU-acquired sepsis, multiple Candida colonization, multiple organ failure, exposed to broad-spectrum antibacterial agents, and enrolled between July 2012 and February 2015 in 19 French ICUs.Empirical treatment with micafungin (100 mg, once daily, for 14 days) (n = 131) vs placebo (n = 129).The primary end point was survival without proven IFI 28 days after randomization
Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis. Levosimendan is a calcium-sensitizing drug with inotropic and other properties that may improve outcomes in patients with sepsis.We conducted a double-blind, randomized clinical trial to investigate whether levosimendan reduces the severity of organ dysfunction in adults with sepsis. Patients were randomly assigned to receive a blinded infusion of levosimendan (at a dose of 0.05 to 0.2 μg per kilogram of body weight per (...) likely than those in the placebo group to be successfully weaned from mechanical ventilation over the period of 28 days (hazard ratio, 0.77; 95% CI, 0.60 to 0.97; P=0.03). More patients in the levosimendan group than in the placebo group had supraventricular tachyarrhythmia (3.1% vs. 0.4%; absolute difference, 2.7 percentage points; 95% CI, 0.1 to 5.3; P=0.04).The addition of levosimendan to standard treatment in adults with sepsis was not associated with less severe organ dysfunction or lower
Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis: The HYPRESS Randomized Clinical Trial. Adjunctive hydrocortisone therapy is suggested by the Surviving Sepsis Campaign in refractory septic shock only. The efficacy of hydrocortisone in patients with severe sepsis without shock remains controversial.To determine whether hydrocortisone therapy in patients with severe sepsis prevents the development of septic shock.Double-blind, randomized clinical trial conducted (...) from January 13, 2009, to August 27, 2013, with a follow-up of 180 days until February 23, 2014. The trial was performed in 34 intermediate or intensive care units of university and community hospitals in Germany, and it included 380 adult patients with severe sepsis who were not in septic shock.Patients were randomly allocated 1:1 either to receive a continuous infusion of 200 mg of hydrocortisone for 5 days followed by dose tapering until day 11 (n = 190) or to receive placebo (n = 190
Prediction of Sepsis in the Intensive Care Unit With Minimal Electronic Health Record Data: A Machine Learning Approach Sepsis is one of the leading causes of mortality in hospitalized patients. Despite this fact, a reliable means of predicting sepsis onset remains elusive. Early and accurate sepsis onset predictions could allow more aggressive and targeted therapy while maintaining antimicrobial stewardship. Existing detection methods suffer from low performance and often require time (...) -consuming laboratory test results.To study and validate a sepsis prediction method, InSight, for the new Sepsis-3 definitions in retrospective data, make predictions using a minimal set of variables from within the electronic health record data, compare the performance of this approach with existing scoring systems, and investigate the effects of data sparsity on InSight performance.We apply InSight, a machine learning classification system that uses multivariable combinations of easily obtained patient
Evaluation of optimized continuous venovenous hemodiafiltration therapy efficiency in severe burn patients with sepsis. As an initial factor, sepsis and multiple organ dysfunction syndrome (MODS) caused by sepsis are the principal causes of death in burned patients. In this report, we measured the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-8 in severely burned patients with sepsis after the initiation of continuous vein-vein hemodiafiltration (CVVHDF) to evaluate (...) the clinical usefulness of CVVHDF on the removal of key mediators. The vital sign indices, such as the heart rate (HR), respiration (R) and central venous pressure (CVP), were recorded at 0 and 42 h in each group. Further, the laboratory examinations indexes, such as the white blood cell count, blood sugar, serum sodium, blood urea nitrogen and serum creatinine, were detected in venous blood samples. Twenty-two severely burned patients suffering from sepsis were randomized into the control group (A, n = 11
Practice Patterns and Outcomes Associated With Use of Anticoagulation Among Patients With Atrial Fibrillation During Sepsis Atrial fibrillation (AF) during sepsis is associated with an increased risk of ischemic stroke during hospitalization, but risks and benefits associated with anticoagulation for AF during sepsis are unclear.To determine clinician practice patterns and patient risk of stroke and bleeding associated with use of anticoagulation for AF during sepsis.A retrospective cohort (...) study using enhanced administrative claims data from approximately 20% of patients hospitalized in the United States July 1, 2010, to June 30, 2013, examined patients with AF during sepsis who did not have additional indications for therapeutic anticoagulation. Propensity score and instrumental variable analyses were used to evaluate risks of in-hospital stroke and bleeding associated with anticoagulation during sepsis.Parenteral anticoagulants administered in doses greater than those used
Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype The Pediatric Sepsis Biomarker Risk Model (PERSEVERE), a pediatric sepsis risk model, uses biomarkers to estimate baseline mortality risk for pediatric septic shock. It is unknown how PERSEVERE performs within distinct septic shock phenotypes. We tested PERSEVERE in children with septic shock and thrombocytopenia-associated multiple organ failure (TAMOF), and in those
Effect of intravenous immunoglobulins in critically ill adults with sepsis: a meta-analysis. 27518520 2016 08 17 2016 08 13 0832-610X 53 4 2006 Apr Canadian journal of anaesthesia = Journal canadien d'anesthesie Can J Anaesth Effect of intravenous immunoglobulins in critically ill adults with sepsis: a meta-analysis. A415-6 10.1007/BF03022511 Turgeon Alexis F AF Centre for Transfusion and Critical Care Research, Critical Care Medicine Program, University of Ottawa, Ottawa, Canada. Hutton Brian
Recognition and Diagnosis of Sepsis in Rural or Remote Areas: A Review of Clinical and Cost-Effectiveness and Guidelines Recognition and Diagnosis of Sepsis in Rural or Remote Areas: A Review of Clinical and Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Recognition and Diagnosis of Sepsis in Rural or Remote Areas: A Review of Clinical and Cost-Effectiveness and Guidelines Recognition and Diagnosis of Sepsis in Rural or Remote Areas: A Review of Clinical and Cost (...) -Effectiveness and Guidelines Published on: August 11, 2016 Project Number: RC0804-000 Product Line: Research Type: Other Diagnostics Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of processes used for the assessment for and recognition of sepsis in adults with suspected sepsis in rural or remote areas? What is the clinical effectiveness of tests used for sepsis diagnosis in adults with suspected sepsis in rural or remote areas? What is the cost
Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial High-dose intravenous administration of sodium selenite has been proposed to improve outcome in sepsis by attenuating oxidative stress. Procalcitonin-guided antimicrobial therapy may hasten the diagnosis of sepsis, but effect on outcome is unclear.To determine whether high-dose intravenous sodium selenite treatment and procalcitonin (...) -guided anti-infectious therapy in patients with severe sepsis affect mortality.The Placebo-Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis (SISPCT), a multicenter, randomized, clinical, 2 × 2 factorial trial performed in 33 intensive care units in Germany, was conducted from November 6, 2009, to June 6, 2013, including a 90-day follow-up period.Patients were randomly assigned to receive an initial intravenous loading dose of sodium selenite, 1000 µg
Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Risk Stratification of Acute Kidney Injury in Patients With Sepsis To examine the performance of the urinary biomarker panel tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in patients with sepsis at ICU admission. To investigate the effect of nonrenal organ dysfunction on tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding (...) protein 7 in this population.In this ancillary analysis, we included patients with sepsis who were enrolled in either of two trials including 39 ICUs across Europe and North America. The primary endpoint was moderate-severe acute kidney injury (equivalent to Kidney Disease Improving Global Outcome stage 2-3) within 12 hours of enrollment. We assessed biomarker performance by calculating the area under the receiver operating characteristic curve, sensitivity, specificity, and negative and positive
Clinical Criteria to Identify Patients With Sepsis 27458952 2016 08 22 2018 12 02 1538-3598 316 4 2016 Jul 26 JAMA JAMA Clinical Criteria to Identify Patients With Sepsis. 453 10.1001/jama.2016.6407 Makam Anil N AN Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. Nguyen Oanh Kieu OK Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. eng KL2 TR001103 TR NCATS NIH HHS United States R24 HS022418 HS AHRQ HHS United (...) States Letter Comment United States JAMA 7501160 0098-7484 AIM IM JAMA. 2016 Jul 26;316(4):454 27458955 JAMA. 2016 Feb 23;315(8):762-74 26903335 Female Hospital Mortality Humans Male Organ Dysfunction Scores Sepsis diagnosis mortality 2016 7 27 6 0 2016 7 28 6 0 2016 8 23 6 0 ppublish 27458952 2536624 10.1001/jama.2016.6407 PMC5349293 NIHMS850954 Circulation. 2007 Feb 20;115(7):928-35 17309939 Circ Cardiovasc Qual Outcomes. 2014 Sep;7(5):778-9 25097213 JAMA. 2016 Feb 23;315(8):762-74 26903335 JAMA
Sepsis: the LightCycler SeptiFast Test MGRADE, SepsiTest and IRIDICA BAC BSI assay for rapidly identifying bloodstream bacteria and fungi ? a systematic review and economic evaluation Sepsis: the LightCycler SeptiFast Test MGRADE®, SepsiTest and IRIDICA BAC BSI assay for rapidly identifying bloodstream bacteria and fungi a systematic review and economic evaluation Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404
Hypopyon and Klebsiella Sepsis. 27355556 2016 07 07 2016 06 30 1533-4406 374 26 2016 Jun 30 The New England journal of medicine N. Engl. J. Med. IMAGES IN CLINICAL MEDICINE. Hypopyon and Klebsiella Sepsis. e33 10.1056/NEJMicm1509932 Mustafa Osama M OM Alfaisal University, Riyadh, Saudi Arabia firstname.lastname@example.org. Aduriz-Lorenzo Patricio M PM Dubai Hospital, Dubai, United Arab Emirates. eng Case Reports Journal Article United States N Engl J Med 0255562 0028-4793 AIM IM Anterior Eye Segment