Latest & greatest articles for sepsis

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Top results for sepsis

81. Efficacy of alkaline phosphatase on patients with sepsis-associated acute kidney injury: a systematic review and meta-analysis of randomized clinical trials

Efficacy of alkaline phosphatase on patients with sepsis-associated acute kidney injury: a systematic review and meta-analysis of randomized clinical trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

82. Sepsis demographics, aetiology and outcomes in sub-Saharan Africa: a systematic review

Sepsis demographics, aetiology and outcomes in sub-Saharan Africa: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

83. Qinwen Baidu decoction for sepsis

Qinwen Baidu decoction for sepsis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2019 PROSPERO

84. Machine learning tools for diagnosing and predicting sepsis: a systematic review and meta-analysis of diagnostic test accuracy

Machine learning tools for diagnosing and predicting sepsis: a systematic review and meta-analysis of diagnostic test accuracy Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

85. Short-course versus prolonged-course antibiotic therapy for sepsis in adults: systematic review and meta-analysis

Short-course versus prolonged-course antibiotic therapy for sepsis in adults: systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2019 PROSPERO

86. The association between proteomic and metabolomic profiles and outcomes in patients with sepsis and septic shock: a systematic review

The association between proteomic and metabolomic profiles and outcomes in patients with sepsis and septic shock: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2019 PROSPERO

87. Sepsis associated acute kidney injury in patients admitted to the ICU: a systematic review and meta-analysis

Sepsis associated acute kidney injury in patients admitted to the ICU: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

88. General medicine: Subduing the killer - sepsis; through simulation

General medicine: Subduing the killer - sepsis; through simulation Subduing the killer - sepsis; through simulation | BMJ Evidence-Based Medicine Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name (...) or password? You are here Subduing the killer - sepsis; through simulation Article Text EBM Learning General medicine Subduing the killer - sepsis; through simulation Statistics from Altmetric.com You do not have access to the full text of this article, the first page of the of this article appears above. Footnotes Competing interests None declared. Patient consent Not required. Provenance and peer review Not commissioned; externally peer reviewed. Request Permissions If you wish to reuse any or all

2019 Evidence-Based Medicine

89. Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock. Full Text available with Trip Pro

Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock. Sepsis and septic shock are potentially life-threatening complications of infection that are associated with high morbidity and mortality in adults and children. Fluid therapy is regarded as a crucial intervention during initial treatment of sepsis. Whether conservative or liberal fluid therapy can improve clinical outcomes in patients with sepsis and septic shock remains unclear.To determine whether (...) liberal versus conservative fluid therapy improves clinical outcomes in adults and children with initial sepsis and septic shock.We searched CENTRAL, MEDLINE, Embase, intensive and critical care conference abstracts, and ongoing clinical trials on 16 January 2018, and we contacted study authors to try to identify additional studies.We planned to include all randomized controlled trials (RCTs), quasi-RCTs, and cluster RCTs comparing liberal fluid therapy versus conservative fluid therapy for adults

2018 Cochrane

90. The anticoagulant treatment for sepsis induced disseminated intravascular coagulation; network meta-analysis Full Text available with Trip Pro

The anticoagulant treatment for sepsis induced disseminated intravascular coagulation; network meta-analysis The benefits and harm caused by anticoagulant treatments for sepsis induced disseminated intravascular coagulation (DIC) remain unclear. Therefore, we performed a network meta-analysis to assess the effect of available anticoagulant treatments on patient mortality, DIC resolution and the incidence of bleeding complication in patients with septic DIC.We considered all studies from four

2018 EvidenceUpdates

91. A trial of probiotics for treating sepsis in very premature babies poses more questions than it answers

A trial of probiotics for treating sepsis in very premature babies poses more questions than it answers A trial of probiotics for treating sepsis in very premature babies poses more questions than it answers Discover Portal Discover Portal A trial of probiotics for treating sepsis in very premature babies poses more questions than it answers Published on 23 December 2015 doi: Contrary to a previous review of trials, this large, NIHR-funded trial found that probiotic treatment did not prevent (...) two common life-threatening conditions in very premature babies. The conditions were necrotising enterocolitis, which is a severe gut inflammation/infection that can result in the death of intestinal tissue, and sepsis (blood poisoning) from bacteria that have crossed from the gut into the bloodstream. This trial used a single strain of a harmless bacterium, known as a “probiotic”, prepared to high quality standards fit for medicines, and chosen because it is commonly used in dietary supplements

2018 NIHR Dissemination Centre

92. Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT

Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1

2018 NIHR HTA programme

93. Are qSOFA Criteria Better Than the Systemic Inflammatory Response Syndrome Criteria for Diagnosing Sepsis and Predicting Inhospital Mortality? (SRS Prognosis)

Are qSOFA Criteria Better Than the Systemic Inflammatory Response Syndrome Criteria for Diagnosing Sepsis and Predicting Inhospital Mortality? (SRS Prognosis) TAKE-HOME MESSAGE Systemic in?ammatory response syndrome (SIRS) criteria are more sensitive for diagnosing sepsis, while quickSequential[Sepsis-related]Organ Failure Assessment (qSOFA) criteria are marginally more accurate for predicting inhospital mortality among patients identi?ed with sepsis. AreqSOFACriteriaBetterThantheSystemic (...) In?ammatoryResponseSyndromeCriteriafor DiagnosingSepsisandPredictingInhospitalMortality? EBEM Commentators Brit Long, MD Michael D. April, MD, DPhil Department of Emergency Medicine San Antonio Uniformed Services Health Education Consortium Fort Sam, Houston, TX Results Results of included trials. Outcome: SIRS vs qSOFA No. of Studies No. of Subjects Standard Mean Difference (95% CI) Favors Heterogeneity (I 2 ), % Sensitivity for diagnosis of sepsis 7 228,105 1.32 (0.40–2.24) SIRS 100 AUROC for hospital mortality 7 226,677 0.03

2018 Annals of Emergency Medicine Systematic Review Snapshots

94. Is Early Goal-Directed Therapy or Standard Therapy More Effective in Decreasing Mortality Among Patients With Sepsis?

Is Early Goal-Directed Therapy or Standard Therapy More Effective in Decreasing Mortality Among Patients With Sepsis? TAKE-HOME MESSAGE Time to antibiotic administration is the main factor explaining mortality differences between sepsis patients treated with early goal-directed therapy versus standard care in recent observational trials. Early goal-directed therapy was associated with increased mortality risk in patients with severe sepsis. IsEarlyGoal-DirectedTherapyorStandardTherapy More (...) Effective in Decreasing Mortality Among Patients With Sepsis? EBEM Commentators Melinda J. Morton Hamer, MD, MPH Department of Emergency Medicine George Washington University School of Medicine Washington, DC Department of Emergency Medicine Fort Belvoir Community Hospital Fort Belvoir, VA Sara K. Faught, DO Department of Emergency Medicine Fort Belvoir Community Hospital Fort Belvoir, VA Results In the systematic review, 19,998 patients were included from 6 randomized trials (n¼4,342) and 31

2018 Annals of Emergency Medicine Systematic Review Snapshots

95. Validation of a Host Response Assay, SeptiCyte LAB, for Discriminating Sepsis from Systemic Inflammatory Response Syndrome in the ICU Full Text available with Trip Pro

Validation of a Host Response Assay, SeptiCyte LAB, for Discriminating Sepsis from Systemic Inflammatory Response Syndrome in the ICU A molecular test to distinguish between sepsis and systemic inflammation of noninfectious etiology could potentially have clinical utility.This study evaluated the diagnostic performance of a molecular host response assay (SeptiCyte LAB) designed to distinguish between sepsis and noninfectious systemic inflammation in critically ill adults.The study employed (...) a prospective, observational, noninterventional design and recruited a heterogeneous cohort of adult critical care patients from seven sites in the United States (n = 249). An additional group of 198 patients, recruited in the large MARS (Molecular Diagnosis and Risk Stratification of Sepsis) consortium trial in the Netherlands ( www.clinicaltrials.gov identifier NCT01905033), was also tested and analyzed, making a grand total of 447 patients in our study. The performance of SeptiCyte LAB was compared

2018 EvidenceUpdates

96. Valuable prognostic indicators for severe burn sepsis with inhalation lesion: age, platelet count, and procalcitonin Full Text available with Trip Pro

Valuable prognostic indicators for severe burn sepsis with inhalation lesion: age, platelet count, and procalcitonin Severe burn sepsis can lead to high mortality. We explored the valuable prognostic indicators for severe burn sepsis with inhalation lesion.Thirty-eight severe burn patients with sepsis who were admitted to the Third Affiliated Hospital of Soochow University from August 2014 to December 2017 were retrospectively analyzed. Among them, 22 patients were assigned to the death group (...) and 16 patients to the survival group. Their general information, vital signs, and blood index including serum procalcitonin (PCT) and C-reactive protein (CRP) levels at admission, diagnosis of sepsis, and 1-week post-diagnosis of sepsis were compared.Patients in the death group were older and had lower platelet count (PLT) at diagnosis of sepsis and 1-week post-diagnosis as well as higher PCT level at 1-week post-diagnosis than patients in the survival group (all p < 0.05). According to receiver

2018 Burns & trauma

97. Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial. Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes and survival. Administration of the detoxifying enzyme alkaline phosphatase may improve kidney function and survival.To determine the optimal therapeutic dose, effect on kidney function, and adverse effects of a human recombinant alkaline (...) phosphatase in patients who are critically ill with sepsis-associated AKI.The STOP-AKI trial was an international (53 recruiting sites), randomized, double-blind, placebo-controlled, dose-finding, adaptive phase 2a/2b study in 301 adult patients admitted to the intensive care unit with a diagnosis of sepsis and AKI. Patients were enrolled between December 2014 and May 2017, and follow-up was conducted for 90 days. The final date of follow-up was August 14, 2017.In the intention-to-treat analysis, in part

2018 JAMA Controlled trial quality: predicted high

98. Sepsis in adults

Sepsis in adults Sepsis in adults - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Sepsis in adults Last reviewed: February 2019 Last updated: October 2018 Important updates 18 Sep 2018 Corticosteroids reduce mortality but increase neuromuscular weakness in sepsis and septic shock Corticosteroids reduce mortality (by approximately 2%) but increase the risk of neuromuscular weakness in patients with sepsis or septic (...) shock, according to an international panel that reviewed conflicting recent evidence. The panel concluded that the overall body of evidence offers weak support for the use of corticosteroids in patients with sepsis with or without shock but said a no-steroid approach remained reasonable. Patient values and preferences may help guide the decision on whether or not to use corticosteroids. Patients who would prioritise living over quality-of-life would likely choose to have corticosteroid treatment

2018 BMJ Best Practice

99. Sepsis in children

Sepsis in children Sepsis in children - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Sepsis in children Last reviewed: February 2019 Last updated: October 2018 Summary Initial clinical presentation may be non-specific (especially in younger age groups). Given the time-critical nature of severe sepsis and septic shock, when sepsis is suspected on clinical grounds it is usually best to initiate sepsis investigations (...) and treatment, including administering antibiotics and fluid resuscitation. These should continue until sepsis has been excluded. Progression to organ failure and shock is often very rapid, so early recognition and treatment is crucial. Empirical broad-spectrum antibiotic therapy (based on the most probable pathogens) should be administered as soon as possible, and always within the first hour following recognition. Other treatments are primarily supportive, and should be delivered according

2018 BMJ Best Practice

100. Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis. Full Text available with Trip Pro

Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis. Acute kidney injury is the most frequent complication in patients with septic shock and is an independent risk factor for death. Although renal-replacement therapy is the standard of care for severe acute kidney injury, the ideal time for initiation remains controversial.In a multicenter, randomized, controlled trial, we assigned patients with early-stage septic shock who had severe acute kidney injury

2018 NEJM Controlled trial quality: predicted high