Latest & greatest articles for sepsis

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Top results for sepsis

101. Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis.

Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis. PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2018 PedsCCM Evidence-Based Journal Club

102. Neutrophil-to-lymphocyte Ratio Relation to Sepsis Severity Scores and Inflammatory Biomarkers in Patients with Community-acquired Pneumonia: A Case Series (PubMed)

Neutrophil-to-lymphocyte Ratio Relation to Sepsis Severity Scores and Inflammatory Biomarkers in Patients with Community-acquired Pneumonia: A Case Series Neutrophil to lymphocyte ratio (NLR) as calculated from the white cell differential blood count is considered a promising marker for the prognosis of patients with various diseases, including sepsis. This study was designed to assess the possible use of neutrophil-to-lymphocyte ratio in the prediction of survival outcomes in patients (...) with community acquired pneumonia (CAP). A secondary objective was to compare the prognostic accuracy of NLR with the commonly used severity scores of sepsis SOFA, APACHE II and SAPS II.This was a retrospective study based on data extracted from 26 patients suffering from acute CAP. The study period was from February 01, 2017 until April 30, 2017. All patients with CAP were presented in the Emergency Department (ED) of the University Hospital of Patras, Greece and were treated after admission in the Internal

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2018 Journal of translational internal medicine

103. Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice (PubMed)

Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice Thrombocytopenia impairs host defense and hemostasis in sepsis. However, the mechanisms of how platelets regulate host defense are not fully understood. High-mobility group box 1 (HMGB1), a danger-associated molecular pattern protein, is released during infection and contributes to the pathogenesis of sepsis. Platelets express HMGB1, which is released on activation and has been shown to play (...) a critical role in thrombosis, monocyte recruitment, and neutrophil extracellular trap (NET) production. However, the contribution of platelet HMGB1 to host defense is unknown. To determine the role of platelet HMGB1 in polymicrobial sepsis, platelet-specific HMGB1 knockout (HMGB1 platelet factor 4 [PF4]) mice were generated and were subjected to cecal ligation and puncture (CLP), a clinically relevant intra-abdominal sepsis model. Compared with HMGB1 Flox mice and wild-type (WT) mice, HMGB1 PF4 mice

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2018 Blood advances

104. Evidence Underpinning the U.S. Government-Mandated Hemodynamic Interventions for Sepsis: A Systematic Review. (PubMed)

Evidence Underpinning the U.S. Government-Mandated Hemodynamic Interventions for Sepsis: A Systematic Review. This article has been corrected. To see what has changed, please read the Letter to the Editor and the authors' response. The original version (PDF) is appended to this article as a Supplement.The Severe Sepsis and Septic Shock Early Management Bundle (SEP-1), the sepsis performance measure introduced in 2015 by the Centers for Medicare & Medicaid Services (CMS), requires the reporting (...) of up to 5 hemodynamic interventions, as many as 141 tasks, and 3 hours to document for a single patient.To evaluate whether moderate- or high-level evidence shows that use of the 2015 SEP-1 or its hemodynamic interventions improves survival in adults with sepsis.PubMed, Embase, Scopus, Web of Science, and ClinicalTrials.gov from inception to 28 November 2017 with no language restrictions.Randomized and observational studies of death among adults with sepsis who received versus those who did

2018 Annals of Internal Medicine

105. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG 2016) (PubMed)

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG 2016) The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 in Japanese. An English-language version

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2018 Acute medicine & surgery

106. Development and External Validation of an Automated Computer-Aided Risk Score for Predicting Sepsis in Emergency Medical Admissions Using the Patient`s First Electronically Recorded Vital Signs and Blood Test Results

Development and External Validation of an Automated Computer-Aided Risk Score for Predicting Sepsis in Emergency Medical Admissions Using the Patient`s First Electronically Recorded Vital Signs and Blood Test Results To develop a logistic regression model to predict the risk of sepsis following emergency medical admission using the patient's first, routinely collected, electronically recorded vital signs and blood test results and to validate this novel computer-aided risk of sepsis model (...) , using data from another hospital.Cross-sectional model development and external validation study reporting the C-statistic based on a validated optimized algorithm to identify sepsis and severe sepsis (including septic shock) from administrative hospital databases using International Classification of Diseases, 10th Edition, codes.Two acute hospitals (York Hospital - development data; Northern Lincolnshire and Goole Hospital - external validation data).Adult emergency medical admissions discharged

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2018 EvidenceUpdates

107. Utility of Early-Onset Sepsis Risk Calculator for Neonates Born to Mothers with Chorioamnionitis

Utility of Early-Onset Sepsis Risk Calculator for Neonates Born to Mothers with Chorioamnionitis To evaluate the performance of the early-onset sepsis (EOS) risk calculator in a cohort of neonates born to mothers with clinical chorioamnionitis, and to compare the diagnostic utility of the EOS calculator, clinical signs, and laboratory evaluations for correctly identifying EOS in this cohort.This was a retrospective study of neonates born at ≥35 weeks of gestation to mothers

2018 EvidenceUpdates

108. Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis

Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis Sepsis is a leading cause of mortality in noncoronary ICUs. Although immediate start of antibiotics reduces sepsis-related mortality, antibiotics are often administered for too long, leading to suboptimal treatment and, importantly, contributes to antimicrobial resistance. Prior literature suggests that procalcitonin correlates with infection and thus may help (...) to guide the decision on when to stop antibiotic treatment. This study was conducted as part of a regulatory submission to the U.S. Food and Drug Administration and aimed to summarize the evidence of procalcitonin guidance on efficacy and safety outcomes in adult patients with sepsis.PubMed and the Cochrane Database of Systematic Reviews.English-language randomized controlled trials evaluating procalcitonin use among adult patients with suspected or confirmed sepsis published between January 2004

2018 EvidenceUpdates

109. Economic burden of neonatal sepsis in sub-Saharan Africa (PubMed)

Economic burden of neonatal sepsis in sub-Saharan Africa The third Sustainable Development Goal for child health, which aims to end preventable deaths of newborns and children less than 5 years of age by 2030, cannot be met without substantial reduction of infection-specific neonatal mortality in the developing world. Neonatal infections are estimated to account for 26% of annual neonatal deaths, with mortality rates highest in sub-Saharan Africa (SSA). Reliable and comprehensive estimates (...) of the incidence and aetiology surrounding neonatal sepsis in SSA remain incompletely available. We estimate the economic burden of neonatal sepsis in SSA.Data available through global health agencies and in the medical literature were used to determine population demographics in SSA, as well as to determine the incidence, disease burden, mortality and resulting disabilities associated with neonatal sepsis. The disability-adjusted life years (DALY) associated with successful treatment or prevention of neonatal

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2018 BMJ global health

110. Enhancing Recovery From Sepsis: A Review. (PubMed)

Enhancing Recovery From Sepsis: A Review. Survival from sepsis has improved in recent years, resulting in an increasing number of patients who have survived sepsis treatment. Current sepsis guidelines do not provide guidance on posthospital care or recovery.Each year, more than 19 million individuals develop sepsis, defined as a life-threatening acute organ dysfunction secondary to infection. Approximately 14 million survive to hospital discharge and their prognosis varies. Half of patients (...) stress disorder (44%). About 40% of patients are rehospitalized within 90 days of discharge, often for conditions that are potentially treatable in the outpatient setting, such as infection (11.9%) and exacerbation of heart failure (5.5%). Compared with patients hospitalized for other diagnoses, those who survive sepsis (11.9%) are at increased risk of recurrent infection than matched patients (8.0%) matched patients (P < .001), acute renal failure (3.3% vs 1.2%, P < .001), and new cardiovascular

2018 JAMA

111. Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial

Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2018 PedsCCM Evidence-Based Journal Club

112. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2018 PedsCCM Evidence-Based Journal Club

113. New Sepsis Definition (Sepsis-3) and Community-acquired Pneumonia Mortality. A Validation and Clinical Decision-Making Study

New Sepsis Definition (Sepsis-3) and Community-acquired Pneumonia Mortality. A Validation and Clinical Decision-Making Study The Sepsis-3 Task Force updated the clinical criteria for sepsis, excluding the need for systemic inflammatory response syndrome (SIRS) criteria. The clinical implications of the proposed flowchart including the quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA) and SOFA scores are unknown.To perform a clinical decision-making analysis of Sepsis-3 (...) -65 for mortality, whereas mSOFA seemed more applicable when considering mortality/intensive care unit admission. Sepsis-3 flowchart resulted in better identification of patients at high risk of mortality.qSOFA and CRB outperformed SIRS and presented better clinical usefulness as prompt tools for patients with community-acquired pneumonia in the emergency department. Among the tools for a comprehensive patient assessment, PSI had the best decision-aid tool profile.

2018 EvidenceUpdates

114. Sepsis in adults

Sepsis in adults Sepsis in adults - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Sepsis in adults Last reviewed: February 2019 Last updated: October 2018 Important updates 18 Sep 2018 Corticosteroids reduce mortality but increase neuromuscular weakness in sepsis and septic shock Corticosteroids reduce mortality (by approximately 2%) but increase the risk of neuromuscular weakness in patients with sepsis or septic (...) shock, according to an international panel that reviewed conflicting recent evidence. The panel concluded that the overall body of evidence offers weak support for the use of corticosteroids in patients with sepsis with or without shock but said a no-steroid approach remained reasonable. Patient values and preferences may help guide the decision on whether or not to use corticosteroids. Patients who would prioritise living over quality-of-life would likely choose to have corticosteroid treatment

2018 BMJ Best Practice

115. Sepsis in children

Sepsis in children Sepsis in children - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Sepsis in children Last reviewed: February 2019 Last updated: October 2018 Summary Initial clinical presentation may be non-specific (especially in younger age groups). Given the time-critical nature of severe sepsis and septic shock, when sepsis is suspected on clinical grounds it is usually best to initiate sepsis investigations (...) and treatment, including administering antibiotics and fluid resuscitation. These should continue until sepsis has been excluded. Progression to organ failure and shock is often very rapid, so early recognition and treatment is crucial. Empirical broad-spectrum antibiotic therapy (based on the most probable pathogens) should be administered as soon as possible, and always within the first hour following recognition. Other treatments are primarily supportive, and should be delivered according

2018 BMJ Best Practice

116. Management of Neonates Born at ?34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis

Management of Neonates Born at ?34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis Management of Neonates Born at ≤34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis | From the American Academy of Pediatrics | Pediatrics '); document.write(''); } function OAS_AD(pos) { if (OAS_version >= 11 && typeof(OAS_RICH)!='undefined') { OAS_RICH(pos); } else { OAS_NORMAL(pos); } } //--> Search for this keyword Source User menu Sections Sign up (...) for highlighting editor-chosen studies with the greatest impact on clinical care. Management of Neonates Born at ≤34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis Karen M. Puopolo , William E. Benitz , Theoklis E. Zaoutis , COMMITTEE ON FETUS AND NEWBORN , COMMITTEE ON INFECTIOUS DISEASES Abstract Early-onset sepsis (EOS) remains a serious and often fatal illness among infants born preterm, particularly among newborn infants of the lowest gestational age. Currently, most preterm

2018 American Academy of Pediatrics

117. Comparison of SIRS, qSOFA, and NEWS for the early identification of sepsis in the Emergency Department

Comparison of SIRS, qSOFA, and NEWS for the early identification of sepsis in the Emergency Department The increasing use of sepsis screening in the Emergency Department (ED) and the Sepsis-3 recommendation to use the quick Sepsis-related Organ Failure Assessment (qSOFA) necessitates validation. We compared Systemic Inflammatory Response Syndrome (SIRS), qSOFA, and the National Early Warning Score (NEWS) for the identification of severe sepsis and septic shock (SS/SS) during ED triage.This (...) was a retrospective analysis from an urban, tertiary-care academic center that included 130,595 adult visits to the ED, excluding dispositions lacking adequate clinical evaluation (n = 14,861, 11.4%). The SS/SS group (n = 930) was selected using discharge diagnoses and chart review. We measured sensitivity, specificity, and area under the receiver-operating characteristic (AUROC) for the detection of sepsis endpoints.NEWS was most accurate for triage detection of SS/SS (AUROC = 0.91, 0.88, 0.81), septic shock

2018 EvidenceUpdates

118. Survey: There is an urgent need for evidence-based internationally agreed guidelines for the assessment of neonates at risk of developing early-onset sepsis

Survey: There is an urgent need for evidence-based internationally agreed guidelines for the assessment of neonates at risk of developing early-onset sepsis There is an urgent need for evidence-based internationally agreed guidelines for the assessment of neonates at risk of developing early-onset sepsis | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more (...) for the assessment of neonates at risk of developing early-onset sepsis Article Text Child health Survey There is an urgent need for evidence-based internationally agreed guidelines for the assessment of neonates at risk of developing early-onset sepsis Siba Prosad Paul , Kerrie Richardson Statistics from Altmetric.com Commentary on: Mukhopadhyay S, Taylor JA, Von Kohorn I, et al . Variation in sepsis evaluation across a national network of nurseries. Pediatr 2017;139:e20162845. Implications for practice

2018 Evidence-Based Nursing

119. Sepsis: recognition, diagnosis and early management

Sepsis: recognition, diagnosis and early management Sepsis: recognition, diagnosis and early management bpac nz guidelines www.bpac.org.nz/guidelines June 20182 SEPSIS: RECOGNITION, DIAGNOSIS AND EARLY MANAGEMENT www.bpac.org.nz/guidelines/4 This is a bpac nz contextualisation of NICE Guideline NG51 © NICE 2015 2 Contents Introduction 4 Overview 6 Purpose of this guideline 6 Who is it for 6 1. Recommendations 7 1.1 Identifying people with suspected sepsis 7 1.2 Risk factors for sepsis 8 1.3 (...) Face-to-face assessment of people with suspected sepsis 9 1.4 Stratifying risk of severe illness or death from sepsis 10 1.5 Managing suspected sepsis outside acute hospital settings 18 1.6 Managing and treating suspected sepsis in acute hospital settings 18 1.7 Antibiotic treatment in people with suspected sepsis 26 1.8 Intravenous fluids in people with suspected sepsis 26 1.9 Using oxygen in people with suspected sepsis 27 1.10 Finding the source of infection in people with suspected sepsis 27

2018 Best Practice Advocacy Centre New Zealand

120. Can corticosteroids reduce the mortality of patients with severe sepsis? A systematic review and meta-analysis

Can corticosteroids reduce the mortality of patients with severe sepsis? A systematic review and meta-analysis The effects of corticosteroids on clinical outcomes of patients with sepsis remains controversial. We aimed to further determine the effectiveness of corticosteroids in reducing mortality in adult patients with severe sepsis by comparison with placebo.Pubmed, Embase, Medline, Cochrane Central Register of Controlled Trials (CENTRAL) as well as the Information Sciences Institute (ISI (...) ) Web of Science were searched for all controlled studies that compared corticosteroids and placebo in adult patients with severe sepsis. The primary outcome was the mortality 28-day mortality and the secondary outcomes were mortality at longest follow up, occurrence, and reoccurrence of septic shock.A total of 19 trials involving 7035 patients were pooled in our final analyses. No significant heterogeneity was found in any of the outcome measures. Compared with placebo, corticosteroids were

2018 EvidenceUpdates