Latest & greatest articles for sepsis

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Top results for sepsis

121. Maternal and child health: Procalcitonin-guided decision-making results in a significant reduction of antibiotic therapy and hospital stay in neonates with suspected early-onset sepsis

Maternal and child health: Procalcitonin-guided decision-making results in a significant reduction of antibiotic therapy and hospital stay in neonates with suspected early-onset sepsis Procalcitonin-guided decision-making results in a significant reduction of antibiotic therapy and hospital stay in neonates with suspected early-onset sepsis | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings (...) in a significant reduction of antibiotic therapy and hospital stay in neonates with suspected early-onset sepsis Article Text Commentary Maternal and child health Procalcitonin-guided decision-making results in a significant reduction of antibiotic therapy and hospital stay in neonates with suspected early-onset sepsis Meret Merker 1 , 2 , Rebekka Bolliger 1 , 2 , Philipp Schuetz 1 , 2 Statistics from Altmetric.com Commentary on : Stocker M, van Herk W, El Helou S, et al . Procalcitonin-guided decision making

2018 Evidence-Based Medicine (Requires free registration)

122. Recognition and Diagnosis of Sepsis in Rural or Remote Areas: Clinical and Cost-Effectiveness and Guidelines

Recognition and Diagnosis of Sepsis in Rural or Remote Areas: Clinical and Cost-Effectiveness and Guidelines Recognition and Diagnosis of Sepsis in Rural or Remote Areas: Clinical and Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Recognition and Diagnosis of Sepsis in Rural or Remote Areas: Clinical and Cost-Effectiveness and Guidelines Recognition and Diagnosis of Sepsis in Rural or Remote Areas: Clinical and Cost-Effectiveness and Guidelines Published on: January (...) 23, 2018 Project Number: RA0945-000 Product Line: Research Type: Other Diagnostics Report Type: Reference List Result type: Report Question What is the clinical effectiveness of processes used for the assessment for and recognition of sepsis in adults with suspected sepsis in rural or remote areas? What is the clinical effectiveness of tests used for sepsis diagnosis in adults with suspected sepsis in rural or remote areas? What is the cost-effectiveness of tests used for sepsis diagnosis

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

123. Recognition and Diagnosis of Sepsis in Adults: Evidence-Based Guidelines

Recognition and Diagnosis of Sepsis in Adults: Evidence-Based Guidelines Recognition and Diagnosis of Sepsis in Adults: Evidence-Based Guidelines | CADTH.ca Find the information you need Recognition and Diagnosis of Sepsis in Adults: Evidence-Based Guidelines Recognition and Diagnosis of Sepsis in Adults: Evidence-Based Guidelines Last updated: January 24, 2018 Project Number: RB1186-000 Product Line: Research Type: Other Diagnostics Report Type: Summary of Abstracts Result type: Report (...) Question What are the evidence-based guidelines regarding the use of tests or procedures for the recognition and diagnosis of sepsis in adults with suspected sepsis? Key Message One evidence based guideline was identified regarding the use of tests or procedures for the recognition and diagnosis of sepsis in adults with suspected sepsis. Files Rapid Response Summary of Abstracts Published : January 24, 2018 Related Content Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

124. CRACKCast E138 – Sepsis Syndromes

CRACKCast E138 – Sepsis Syndromes CRACKCast E138 - Sepsis Syndromes - CanadiEM CRACKCast E138 – Sepsis Syndromes In by Chris Lipp December 25, 2017 This episode of CRACKCast covers Rosen’s Chapter 138, Sepsis Syndromes. Sepsis is a topic that has undergone a lot of change in the last 15 years since the Rivers paper was published. This episode covers the original definitions of SIRS and sepsis, while also covering more recent evidence & the newest evidence-based treatment protocols. Shownotes (...) – Key Points Sepsis is a progression of disease due to a dysregulated inflammatory cascade, leading to organ dysfunction and circulatory compromise in severe cases. Sepsis is subtle and often difficult to detect, so the emergency clinician should maintain a high index of suspicion when assessing patients in the ED. Older adults, immunocompromised and neutropenic patients, and patients with multiple comorbidities are at increased risk for the development of sepsis syndromes. A thorough history

2017 CandiEM

125. Retrospective analysis of cancer patients admitted to a tertiary centre with suspected neutropenic sepsis: Are C-reactive protein and neutrophil count useful prognostic biomarkers? (Full text)

Retrospective analysis of cancer patients admitted to a tertiary centre with suspected neutropenic sepsis: Are C-reactive protein and neutrophil count useful prognostic biomarkers? Historically, neutropenic sepsis has been associated with high mortality rates. However, there has been limited research into cancer patients admitted with suspected sepsis who are found to be non-neutropenic. C-reactive protein has been shown to be raised in cancer patients for reasons other than infection (...) and there have been limited studies to look as its utility as a prognostic biomarker in suspected sepsis in this population. This study looked at 749 patients admitted to a tertiary cancer centre between January 2015 and February 2016 with suspected sepsis. The neutrophil count and C-reactive protein level was taken in all these patients on admission and at 72 h and compared to the primary outcome of 30-day all-cause mortality rates and hospital length of stay. There were 49 patients who died within 30 days

2017 Journal of the Intensive Care Society PubMed

126. A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis

A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

127. Natural history of anorectal sepsis

Natural history of anorectal sepsis Progression from anorectal abscess to fistula is poorly described and it remains unclear which patients develop a fistula following an abscess. The aim was to assess the burden of anorectal abscess and to identify risk factors for subsequent fistula formation.The Hospital Episode Statistics database was used to identify all patients presenting with new anorectal abscesses. Cox regression analysis was undertaken to identify factors predictive of fistula (...) at time of first abscess 41-60 years (HR 1·85 versus less than 20 years; P < 0·001), and intersphincteric (HR 1·53; P < 0·001) or ischiorectal (HR 1·48; P < 0·001) abscess location compared with perianal. Some 2·9 per cent of all patients presenting with a new abscess were subsequently diagnosed with Crohn's disease; the median time to diagnosis was 14 months.The burden of anorectal sepsis is high, with subsequent fistula formation nearly three times more common in Crohn's disease than idiopathic

2017 EvidenceUpdates

128. A combined preventive strategy could reduce late sepsis in the premature child

A combined preventive strategy could reduce late sepsis in the premature child A combined preventive strategy could reduce late sepsis in the premature child - Evidencias en pediatría Searching, please wait Show menu Library Management You did not add any article to your library yet. | Search Evidence-Based decision making Evidence-Based decision making Show menu Library Management You did not add any article to your library yet. × User Password Log in × Reset password If you need to reset your (...) password please enter your email and click the Send button. You will receive an email to complete the process. Email Send × Library Management × September 2017. Volume 13. Number 3 A combined preventive strategy could reduce late sepsis in the premature child Rating: 0 (0 Votes) | Newsletter Free Subscription Regularly recieve most recent articles by e-mail Subscribe × Newsletter subscription: Email Confirm email I accept the journal’s privacy policy. Subscribe × Warnings and privacy policy To whom

2017 Evidencias en Pediatría

129. Raised cardiac troponin in intensive care patients with sepsis, in the absence of angiographically documented coronary artery disease: A systematic review. (Full text)

Raised cardiac troponin in intensive care patients with sepsis, in the absence of angiographically documented coronary artery disease: A systematic review. Elevated cardiac troponin in the critically ill has been associated with increased hospital mortality. However, in critically ill patients with sepsis the results are heterogeneous and less easy to interpret. The objectives of this systematic review were to describe the pathophysiology, clinical relevance and prognostic significance (...) of raised troponin in intensive care patients with sepsis. Articles were identified through a detailed MEDLINE search and additional references were retrieved from the selected studies. A growing body of clinical evidence suggests that although troponins are sensitive biomarkers with prognostic value, they are not independent predictors of mortality. However, vigilance for objective evidence of coronary artery disease is required and patients with atherosclerotic risk factors and elevated troponins may

2017 Journal of the Intensive Care Society PubMed

130. Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial. (Full text)

Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial. The effect of an early resuscitation protocol on sepsis outcomes in developing countries remains unknown.To determine whether an early resuscitation protocol with administration of intravenous fluids, vasopressors, and blood transfusion decreases mortality among Zambian adults with sepsis and hypotension compared with usual care.Randomized clinical trial (...) of 212 adults with sepsis (suspected infection plus ≥2 systemic inflammatory response syndrome criteria) and hypotension (systolic blood pressure ≤90 mm Hg or mean arterial pressure ≤65 mm Hg) presenting to the emergency department at a 1500-bed referral hospital in Zambia between October 22, 2012, and November 11, 2013. Data collection concluded December 9, 2013.Patients were randomized 1:1 to either (1) an early resuscitation protocol for sepsis (n = 107) that included intravenous fluid bolus

2017 JAMA PubMed

131. Adaptation and Validation of a Pediatric Sequential Organ Failure Assessment Score and Evaluation of the Sepsis-3 Definitions in Critically Ill Children (Full text)

Adaptation and Validation of a Pediatric Sequential Organ Failure Assessment Score and Evaluation of the Sepsis-3 Definitions in Critically Ill Children The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) uses the Sequential Organ Failure Assessment (SOFA) score to grade organ dysfunction in adult patients with suspected infection. However, the SOFA score is not adjusted for age and therefore not suitable for children.To adapt and validate a pediatric version (...) of the SOFA score (pSOFA) in critically ill children and to evaluate the Sepsis-3 definitions in patients with confirmed or suspected infection.This retrospective observational cohort study included all critically ill children 21 years or younger admitted to a 20-bed, multidisciplinary, tertiary pediatric intensive care unit between January 1, 2009 and August 1, 2016. Data on these children were obtained from an electronic health record database. The pSOFA score was developed by adapting the original SOFA

2017 EvidenceUpdates PubMed

132. Assessment of Sepsis-3 criteria and quick SOFA in patients with cirrhosis and bacterial infections

Assessment of Sepsis-3 criteria and quick SOFA in patients with cirrhosis and bacterial infections Patients with cirrhosis have a high risk of sepsis, which confers a poor prognosis. The systemic inflammatory response syndrome (SIRS) criteria have several limitations in cirrhosis. Recently, new criteria for sepsis (Sepsis-3) have been suggested in the general population (increase of Sequential Organ Failure Assessment (SOFA) ≥2 points from baseline). Outside the intensive care unit (ICU (...) ), the quick SOFA (qSOFA (at least two among alteration in mental status, systolic blood pressure ≤100 mm Hg or respiratory rate ≥22/min)) was suggested to screen for sepsis. These criteria have never been evaluated in patients with cirrhosis. The aim of the study was to assess the ability of Sepsis-3 criteria in predicting in-hospital mortality in patients with cirrhosis and bacterial/fungal infections.259 consecutive patients with cirrhosis and bacterial/fungal infections were prospectively included

2017 EvidenceUpdates

133. A Rapid Test for Microbial Identification in Patients With Suspected Sepsis

A Rapid Test for Microbial Identification in Patients With Suspected Sepsis A Rapid Test for Microbial Identification in Patients With Suspected Sepsis | CADTH.ca CADTH Document Viewer A Rapid Test for Microbial Identification in Patients With Suspected Sepsis Table of Contents Search this document A Rapid Test for Microbial Identification in Patients With Suspected Sepsis September 2017 Summary The FilmArray Blood Culture Identification (FA-BCID) panel is a multiplex polymerase chain reaction (...) –based rapid diagnostic test that can detect 24 sepsis-related pathogens (bacteria and yeast) and three antimicrobial resistance genes in patients with suspected sepsis. An initial blood culture is still required, as the FA-BCID panel must be performed on blood cultures that have tested positive (indicating initial microbial growth). The FA-BCID panel can identify specific pathogens from positive blood cultures with a turnaround time of approximately one hour; this is significantly faster than

2017 CADTH - Issues in Emerging Health Technologies

134. Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014. (Full text)

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014. Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may lack clinical fidelity and can be affected by changing diagnosis and coding practices over time.To estimate the US national incidence of sepsis and trends using detailed clinical data from the electronic health record (EHR) systems (...) of diverse hospitals.Retrospective cohort study of adult patients admitted to 409 academic, community, and federal hospitals from 2009-2014.Sepsis was identified using clinical indicators of presumed infection and concurrent acute organ dysfunction, adapting Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) criteria for objective and consistent EHR-based surveillance.Sepsis incidence, outcomes, and trends from 2009-2014 were calculated using regression models and compared

2017 JAMA PubMed

135. Extracorporeal cytokine haemadsorption in patients with sepsis or SIRS

Extracorporeal cytokine haemadsorption in patients with sepsis or SIRS Extracorporeal cytokine haemadsorption in patients with sepsis or SIRS Extracorporeal cytokine haemadsorption in patients with sepsis or SIRS Hawlik K, Wild C Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Hawlik K, Wild C. Extracorporeal cytokine haemadsorption (...) in patients with sepsis or SIRS. Vienna: Ludwig Boltzmann Institut fuer Health Technology Assessment (LBIHTA). Decision Support Document. 2017 Authors' objectives Extracorporeal cytokine adsorption therapy (ECAT) aims to reduce the cytokine concentration in the blood, thereby stabilising the overall immune response in sepsis and SIRS (Systemic Inflammatory Response Syndrome). We investigated the efficacy and safety of ECAT in its two main indications: to treat sepsis and to prevent SIRS during

2017 Health Technology Assessment (HTA) Database.

136. Association Between Early Lactate Levels and 30-Day Mortality in Clinically Suspected Sepsis in Children

Association Between Early Lactate Levels and 30-Day Mortality in Clinically Suspected Sepsis in Children PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

137. Sepsis in the burn patient: a different problem than sepsis in the general population (Full text)

Sepsis in the burn patient: a different problem than sepsis in the general population Sepsis has recently been defined as "life-threatening organ dysfunction caused by a dysregulated host response to infection". A great amount of effort has been made to develop early treatments for sepsis through the Surviving Sepsis Campaign. There are similar but slightly different recommendations for the treatment of sepsis in the pediatric population. These international efforts have led to earlier (...) diagnosis and treatments for sepsis that have led to improvements in survival. Sepsis is also the leading cause of death in the burn patient but most clinical sepsis studies have excluded burns. The reason for the exclusion is that the sepsis found in burn patients is different than that of the general population. The early treatment strategies, such as those directed by the Surviving Sepsis Campaign, focus on patients presenting to hospitals with recent signs of infection. Burn patients lose

2017 Burns & trauma PubMed

138. Investigating the Impact of Different Suspicion of Infection Criteria on the Accuracy of Quick Sepsis-Related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores

Investigating the Impact of Different Suspicion of Infection Criteria on the Accuracy of Quick Sepsis-Related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores Studies in sepsis are limited by heterogeneity regarding what constitutes suspicion of infection. We sought to compare potential suspicion criteria using antibiotic and culture order combinations in terms of patient characteristics and outcomes. We further sought to determine the impact (...) of differing criteria on the accuracy of sepsis screening tools and early warning scores.Observational cohort study.Academic center from November 2008 to January 2016.Hospitalized patients outside the ICU.None.Six criteria were investigated: 1) any culture, 2) blood culture, 3) any culture plus IV antibiotics, 4) blood culture plus IV antibiotics, 5) any culture plus IV antibiotics for at least 4 of 7 days, and 6) blood culture plus IV antibiotics for at least 4 of 7 days. Accuracy of the quick Sepsis

2017 EvidenceUpdates

139. Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis

Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

140. Early evaluation of severity in patients with severe sepsis: a comparison with “septic shock” — subgroup analysis of the Japanese Association for Acute Medicine Sepsis Registry (JAAM‐SR) (Full text)

Early evaluation of severity in patients with severe sepsis: a comparison with “septic shock” — subgroup analysis of the Japanese Association for Acute Medicine Sepsis Registry (JAAM‐SR) The purpose of this subgroup analysis of a Japanese multicenter registry, the Japanese Association for Acute Medicine Sepsis Registry Advanced (JAAM-SR-Advanced), was to identify early outcome indicators for severe sepsis that are useful and more objective than "septic shock."Among 624 patients (...) with severe sepsis registered in JAAM-SR-Advanced, 554 with valid serum lactate data were retrospectively studied. Hypotension before and after fluid resuscitation and the highest lactate values over the initial 24 h were compared for their ability to predict in-hospital mortality.Of the study group, 155 (28.0%) patients were non-survivors and had significantly lower systolic blood pressures and higher lactate peaks. The mortality of 364 patients with initial hypotension was higher than those patients

2017 Acute medicine & surgery PubMed