Latest & greatest articles for side effects

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Top results for side effects

21. Adverse side effects of dexamethasone in surgical patients. (PubMed)

Adverse side effects of dexamethasone in surgical patients. In the perioperative period, dexamethasone is widely and effectively used for prophylaxis of postoperative nausea and vomiting (PONV), for pain management, and to facilitate early discharge after ambulatory surgery.Long-term treatment with steroids has many side effects, such as adrenal insufficiency, increased infection risk, hyperglycaemia, high blood pressure, osteoporosis, and development of diabetes mellitus. However, whether (...) a single steroid load during surgery has negative effects during the postoperative period has not yet been studied.To assess the effects of a steroid load of dexamethasone on postoperative systemic or wound infection, delayed wound healing, and blood glucose change in adult surgical patients (with planned subgroup analysis of patients with and without diabetes).We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), in the Cochrane Library, and the Web of Science

2018 Cochrane

22. Safety and Side Effects of Rifampin versus Isoniazid in Children. (PubMed)

Safety and Side Effects of Rifampin versus Isoniazid in Children. The treatment of latent infection with Mycobacterium tuberculosis is important in children because of their vulnerability to life-threatening forms of tuberculosis disease. The current standard treatment - 9 months of isoniazid - has been associated with poor adherence and toxic effects, which have hampered the effectiveness of the drug. In adults, treatment with 4 months of rifampin has been shown to be safer and to have higher (...) completion rates than 9 months of isoniazid.In this multicenter, open-label trial, we randomly assigned 844 children (<18 years of age) with latent M. tuberculosis infection to receive either 4 months of rifampin or 9 months of isoniazid. The primary outcome was adverse events of grade 1 to 5 that resulted in the permanent discontinuation of a trial drug. Secondary outcomes were treatment adherence, side-effect profile, and efficacy. Independent review panels whose members were unaware of trial-group

2018 NEJM

23. Side effects

Side effects Top results for side effects - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for side effects The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms

2018 Trip Latest and Greatest

24. Second-generation antipsychotics and metabolic side-effects: Canadian population-based study (PubMed)

Second-generation antipsychotics and metabolic side-effects: Canadian population-based study Use of second-generation antipsychotics (SGA) has increased in recent years; however, their use and effect on metabolic outcomes has been poorly characterised in population-level studies.AimsThis study aimed to determine the associations between SGA use and metabolic indicators in a general population.We used data from the Canadian Health Measures Survey, a cross-sectional survey of Canadian households

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2018 BJPsych open

25. Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial

Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial We compared the analgesic efficacy and incidence of side effects when low-dose (0.3 mg/kg) ketamine (LDK) is administered as a slow infusion (SI) over 15 minutes versus an intravenous push (IVP) over 1 minute.This was a prospective, randomized, double-blind, double-dummy, placebo-controlled trial of adult ED patients presenting with moderate (...) to severe pain (numerical rating scale [NRS] score ≥ 5). Patients received 0.3 mg/kg ketamine administered either as a SI or a IVP. Our primary outcome was the proportion of patients experiencing any psychoperceptual side effect over 60 minutes. A secondary outcome was incidence of moderate or greater psychoperceptual side effects. Additional outcomes included reduction in pain NRS scores at 60 minutes and percent maximum summed pain intensity difference (%SPID).Fifty-nine participants completed

2018 EvidenceUpdates

26. Inducing labour mechanically can be as effective as the recommended drugs and may have fewer side effects

Inducing labour mechanically can be as effective as the recommended drugs and may have fewer side effects Inducing labour mechanically can be as effective as the recommended drugs and may have fewer side effects Discover Portal Discover Portal Inducing labour mechanically can be as effective as the recommended drugs and may have fewer side effects Published on 8 November 2016 doi: Double-balloon catheters seem to be as effective as vaginal prostaglandin drugs for inducing labour, while also (...) avoiding overstimulation of the womb. The catheter is a device inserted through the cervix, where inflated balloons put pressure on the cervix helping it to “ripen” and start contractions. Prostaglandin drugs are the current recommended induction method, but uterine (womb) overstimulation, where contractions become too frequent or long, is a recognised side effect. This trial found that with either method half of women went on to a vaginal delivery within 24 hours and avoided the need for a caesarean

2018 NIHR Dissemination Centre

27. Early and Late Onset Side Effects of Photodynamic Therapy (PubMed)

Early and Late Onset Side Effects of Photodynamic Therapy Photodynamic Therapy (PDT) is a non-invasive treatment successfully used for neoplastic, inflammatory and infectious skin diseases. One of its strengths is represented by the high safety profile, even in elderly and/or immuno-depressed subjects. PDT, however, may induce early and late onset side effects. Erythema, pain, burns, edema, itching, desquamation, and pustular formation, often in association with each other, are frequently

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2018 Biomedicines

28. Half-Side Application for Transdermal Patches: Clinical Effectiveness and Guidelines

Half-Side Application for Transdermal Patches: Clinical Effectiveness and Guidelines Half-Side Application for Transdermal Patches: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Half-Side Application for Transdermal Patches: Clinical Effectiveness and Guidelines Half-Side Application for Transdermal Patches: Clinical Effectiveness and Guidelines Last updated: March 22, 2018 Project Number: RB1203-000 Product Line: Research Type: Drug Report Type: Summary (...) of Abstracts Result type: Report Question What is the clinical effectiveness of the administration of transdermal patches using the half-side application procedure for any patient? What are the evidence-based guidelines regarding the administration of transdermal patches for any patient? Key Message No relevant literature was identified regarding the administration of transdermal patches using the half-side application procedure for any patient. Files Rapid Response Summary of Abstracts Published : March

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

29. Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness

Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness | CADTH.ca Find the information you need Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness Last updated: August 14, 2018 Project Number: RA0963-000 Product Line: Research Type: Drug Report Type: Reference List Result type (...) : Report Question What is the clinical effectiveness of 'side-effect-free' chemotherapy for the treatment of any type of cancer? Key Message No relevant literature was identified regarding the clinical effectiveness of 'side-effect-free' chemotherapy for the treatment of any type of cancer. Files Rapid Response Reference List Published : August 16, 2018 Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter:

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

30. “Side effects affected my daily activities a lot”: a qualitative exploration of the impact of contraceptive side effects in Bangladesh (PubMed)

“Side effects affected my daily activities a lot”: a qualitative exploration of the impact of contraceptive side effects in Bangladesh In a country like Bangladesh that has made great progress in contraceptive use with one of the lowest levels of fertility and highest levels of contraceptive use, understanding what factors influence women's decisions to discontinue a contraceptive method and not switch to a new method is critical in designing interventions and programs that will help enable (...) Bangladesh to reach its FP2020 goals. Research on side effects has focused on physical manifestations like headaches, moodiness, abdominal pain, and menstrual irregularities. While physical effects alone may stop women from continuing a contraceptive method, less is known about how side effects influence women's daily activities and lives. The purpose of this study is to understand the ways that side effects affect Bangladeshi women's participation in different social settings.Thirty-five in-depth

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2017 Open access journal of contraception

31. e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns

e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns - GOV.UK GOV.UK uses cookies to make the site simpler. Search e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns Use the Yellow Card Reporting Scheme to support the safety of e-cigarettes and refill containers (e-liquids). Published 21 June 2017 From (...) : Contents What and how to report Members of the public and healthcare professionals can use the to report any suspected side effects or safety concerns with e-cigarettes and the e-liquids used for vaping. These issues could include: • suspected side-effects that occurred after the use of e-cigarettes and e-liquids • harm to children or non-users, including accidental poisoning • safety issues or defects with e-cigarette devices Your information will aid us in identifying previously unrecognised side

2017 MHRA Drug Safety Update

32. [How to evaluate side effects in a clinical trial?] (PubMed)

[How to evaluate side effects in a clinical trial?] Adverse effects of psychotropic medications must be systematically assessed during a clinical trial. This systematic and mandatory evaluation, for the patient safety first, will also allow to establish for the tested molecule, an efficiency/tolerance ratio which could be compared to preexisting medications, and guide the clinician prescriptions. These side effects are closely related to the pharmacological profile of the tested molecule (...) , in particular its monoamine binding profile. Antipsychotics are taken as an example, with a focus on classical clinical side effects related to each monoamine transmission blocking.© L’Encéphale, Paris, 2016.

2017 L'Encephale

33. Evidence of ocular side effects of SSRIs and new warnings

Evidence of ocular side effects of SSRIs and new warnings Evidence of ocular side effects of SSRIs and new warnings | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name (...) or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Evidence of ocular side effects of SSRIs and new warnings Article Text Outcomes Evidence of ocular side effects of SSRIs and new warnings Julia Kirkham , Dallas Seitz Statistics from Altmetric.com ABSTRACT FROM: Chen H , Lin C , Lai S , et al . Association of selective

2017 Evidence-Based Mental Health

34. Are side effects reduced if practice nurses administer the intramuscular (IM) contraceptive injection via the ventrogluteal site compared to the dorsogluteal site?

Are side effects reduced if practice nurses administer the intramuscular (IM) contraceptive injection via the ventrogluteal site compared to the dorsogluteal site? Getting Evidence in Clinical Practice: General Practice Nurse Evidence Based Practice (CAT group) Date: May 2017 CAT Lead: Gwenllian Wynne-Jones and Katherine Gatensbury Date CAT completed: May 2017 Email: g.wynne-jones@keele.ac.uk Date CAT to be reviewed: May 2018 Clinical bottom line There is no evidence regarding side effects (...) ? The use of intramuscular injections is very common in nursing practice, and is the standard method for the administration of the contraceptive injection. However, there is little guidance relating to the most appropriate intramuscular injection site and debate on whether the dorsogluteal or ventrogluteal site is associated with fewer side effects. Search timeframe From each databases inception to March 2017. Inclusion criteria Description Search terms Population and setting Adult women wanting to use

2017 Home Modification Information Clearinghouse

35. Molecular mechanisms involved in the side effects of fatty acid amide hydrolase inhibitors: a structural phenomics approach to proteome-wide cellular off-target deconvolution and disease association (PubMed)

Molecular mechanisms involved in the side effects of fatty acid amide hydrolase inhibitors: a structural phenomics approach to proteome-wide cellular off-target deconvolution and disease association Fatty acid amide hydrolase (FAAH) is a promising therapeutic target for the treatment of pain and CNS disorders. However, the development of potent and safe FAAH inhibitors is hindered by their off-target mediated side effect that leads to brain cell death. Its physiological off-targets (...) and their associations with phenotypes may not be characterized using existing experimental and computational techniques as these methods fail to have sufficient proteome coverage and/or ignore native biological assemblies (BAs; i.e., protein quaternary structures). To understand the mechanisms of the side effects from FAAH inhibitors and other drugs, we develop a novel structural phenomics approach to identifying the physiological off-targets binding profile in the cellular context and on a structural proteome

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2016 NPJ systems biology and applications

36. Use of acupuncture to alleviate side effects in radiation oncology: Current evidence and future directions (PubMed)

Use of acupuncture to alleviate side effects in radiation oncology: Current evidence and future directions Several reports have shown that acupuncture is an effective method of complementary medicine; however, only a few of these reports have focused on oncological patients treated with radiation therapy. Most of these studies discuss a benefit of acupuncture for side-effect reduction; however, not all could demonstrate significant improvements. Thus, innovative trial designs are necessary (...) to confirm that acupuncture can alleviate side effects related to radiation therapy. In the present manuscript, we perform a broad review and discuss pitfalls and limitations of acupuncture in parallel with standard radiation therapy, which lead the way to novel treatment concepts.

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2016 Advances in radiation oncology

37. Apomorphine with domperidone: minimising risk of cardiac side effects

Apomorphine with domperidone: minimising risk of cardiac side effects Apomorphine with domperidone: minimising risk of cardiac side effects - GOV.UK GOV.UK uses cookies to make the site simpler. Search Apomorphine with domperidone: minimising risk of cardiac side effects Patients receiving apomorphine and domperidone require an assessment of cardiac risk factors and ECG monitoring to reduce the risk of serious arrhythmia related to QT-prolongation. Published 18 April 2016 From: Therapeutic area (...) : , Contents Advice for healthcare professionals: Before starting treatment, carefully consider whether the benefits of concomitant apomorphine and domperidone treatment outweigh the small increased risk of cardiac side effects Discuss the benefits and risks of apomorphine with patients and carers and advise them to contact their doctor immediately if they develop palpitations or syncopal symptoms during treatment Check the QT-interval before starting domperidone, during the apomorphine initiation phase

2016 MHRA Drug Safety Update

38. Changes in Proteinuria and Side Effects of Corticosteroids Alone or in Combination with Azathioprine at Different Stages of IgA Nephropathy (PubMed)

Changes in Proteinuria and Side Effects of Corticosteroids Alone or in Combination with Azathioprine at Different Stages of IgA Nephropathy Time-average proteinuria (TAp) is the strongest predictor of renal survival in IgA nephropathy (IgAN). Little is known about the utility and safety of corticosteroids (CS) to obtain TAp<1 g/d in patients with advanced IgAN. This study sought to evaluate TAp at different degree of baseline renal function and histologic severity during CS use

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2016 EvidenceUpdates

39. Improving symptoms and side effects in older patients with schizophrenia with decreasing dopamine D2/3 receptor occupancy following risperidone and olanzapine dose reduction

Improving symptoms and side effects in older patients with schizophrenia with decreasing dopamine D2/3 receptor occupancy following risperidone and olanzapine dose reduction Improving symptoms and side effects in older patients with schizophrenia with decreasing dopamine D2/3 receptor occupancy following risperidone and olanzapine dose reduction | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie (...) settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Improving symptoms and side effects

2015 Evidence-Based Mental Health

40. Effects of vertical and side-alternating vibration training on fall risk factors and bone turnover in older people at risk of falls (PubMed)

Effects of vertical and side-alternating vibration training on fall risk factors and bone turnover in older people at risk of falls whole-body vibration training may improve neuromuscular function, falls risk and bone density, but previous studies have had conflicting findings.this study aimed to evaluate the influence of vertical vibration (VV) and side-alternating vibration (SV) on musculoskeletal health in older people at risk of falls.single-blind, randomised, controlled trial comparing

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2014 EvidenceUpdates