Latest & greatest articles for side effects

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Top results for side effects

101. Review: new generation antipsychotics do not induce fewer extrapyramidal side effects than low potency antipsychotics (Full text)

Review: new generation antipsychotics do not induce fewer extrapyramidal side effects than low potency antipsychotics Review: new generation antipsychotics do not induce fewer extrapyramidal side effects than low potency antipsychotics | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: new generation antipsychotics do not induce fewer extrapyramidal side effects than low potency antipsychotics Article Text Therapeutics Review

2004 Evidence-Based Medicine (Requires free registration) PubMed

102. Selenoprotein synthesis and side-effects of statins. (PubMed)

Selenoprotein synthesis and side-effects of statins. Statins are possibly the most effective drugs for the prevention and treatment of hypercholesterolaemia and coronary heart disease. They are generally well tolerated, however, they do cause some unusual side-effects with potentially severe consequences, most prominently myopathy or rhabdomyolysis and polyneuropathy. We noted that the pattern of side-effects associated with statins resembles the pathology of selenium deficiency, and postulated (...) that the mechanism lay in a well established, but often overlooked, biochemical pathway--the isopentenylation of selenocysteine-tRNA([Ser]Sec). A negative effect of statins on selenoprotein synthesis does seem to explain many of the enigmatic effects and side-effects of statins, in particular, statin-induced myopathy.

2004 Lancet

103. Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects

Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects Shekelle P, Morton S, Maglione M Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation Shekelle P, Morton S, Maglione M. Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Report/Technology Assessment No. 76. 2003 Authors' objectives This report aims to assess the efficacy of herbal ephedra-containing dietary supplements and ephedrine on weight loss and athletic performance, through

2003 Health Technology Assessment (HTA) Database.

104. Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review

Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review McNicol E, Horowicz-Mehler N, Fisk R A, Bennett K, Gialeli-Goudas M, Chew P W, Lau J, Carr D CRD summary The authors concluded that they found limited evidence to support diverse interventions (...) for the management of opioid-related side-effects, as well as the general approach of opioid rotation, and that there is a need for higher quality research. These conclusions appear justified on the basis of the evidence reported in the review, though it is possible that relevant evidence may have been available that was not included in the review. Authors' objectives To assess the management of opioid side-effects in the context of cancer pain management or, in the event that no evidence was available

2003 DARE.

105. Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects

Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects Shekelle P, Morton S, Maglione M, Hardy M, Suttorp M, Roth E, Jungvig L, Mojica WA, Gagne J, Rhodes S, McKinnon E CRD summary This review assessed the effectiveness (...) and safety of using ephedrine or ephedra for weight loss or improving athletic performance. The authors concluded that ephedra and ephedrine provide modest, short-term improvements in weight loss, but that they are associated with increased rates of side-effects. These conclusions reflected the limited evidence available and are likely to be reliable. Authors' objectives To assess the efficacy and safety of ephedra and ephedrine on weight loss and athletic performance. Searching MEDLINE, EMBASE, BIOSIS

2003 DARE.

106. The efficacy of behavioral interventions for cancer treatment-related side effects

The efficacy of behavioral interventions for cancer treatment-related side effects The efficacy of behavioral interventions for cancer treatment-related side effects The efficacy of behavioral interventions for cancer treatment-related side effects Mundy E A, DuHamel K N, Montgomery G H CRD summary This review found that behavioural interventions could reduce anticipatory nausea and vomiting in people undergoing chemotherapy and decrease anxiety related to cancer diagnosis and treatment (...) for studies published in English. The search terms were reported. Study selection Study designs of evaluations included in the review Published randomised controlled trials (RCTs), within-subject cohort studies and case reports were eligible for inclusion. Review articles and sub-samples of data from larger studies were excluded. Specific interventions included in the review Studies were eligible for inclusion in the review if they assessed a behavioural intervention for side-effects related to cancer

2003 DARE.

107. Impact of side-effects of atypical antipsychotics on non-compliance, relapse and cost

Impact of side-effects of atypical antipsychotics on non-compliance, relapse and cost Impact of side-effects of atypical antipsychotics on non-compliance, relapse and cost Impact of side-effects of atypical antipsychotics on non-compliance, relapse and cost Mortimer A, Williams P, Meddis D Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) outcomes was derived from a review of published studies and reviews. It was supplemented by a two-round Delphi study, in which a panel of 25 experts on schizophrenia assessed the impact of different side effect profiles on non-compliance. Modelling A state-transition model was used to represent the relationship between compliance and relapse over a 1-year period following recovery from an episode of schizophrenia. This technique involved identifying clinically important events and defining them

2003 NHS Economic Evaluation Database.

108. Provision of information about drug side-effects to patients. (PubMed)

Provision of information about drug side-effects to patients. To make informed decisions about taking medicinal drugs, people need accurate information about side-effects. A European Union guideline now recommends use of qualitative descriptions for five bands of risk, ranging from very rare (affecting <0.01% of the population), to very common (>10%). We did four studies of more than 750 people, whom we asked to estimate the probability of having a side-effect on the basis of qualitative

2002 Lancet

109. Nonspecific medication side effects and the nocebo phenomenon. (PubMed)

Nonspecific medication side effects and the nocebo phenomenon. Patients taking active medications frequently experience adverse, nonspecific side effects that are not a direct result of the specific pharmacological action of the drug. Although this phenomenon is common, distressing, and costly, it is rarely studied and poorly understood. The nocebo phenomenon, in which placebos produce adverse side effects, offers some insight into nonspecific side effect reporting. We performed a focused (...) review of the literature, which identified several factors that appear to be associated with the nocebo phenomenon and/or reporting of nonspecific side effects while taking active medication: the patient's expectations of adverse effects at the outset of treatment; a process of conditioning in which the patient learns from prior experiences to associate medication-taking with somatic symptoms; certain psychological characteristics such as anxiety, depression, and the tendency to somatize

2002 JAMA

110. Meta-analysis of effects and side effects of low dosage tricyclic antidepressants in depression: systematic review. (Full text)

Meta-analysis of effects and side effects of low dosage tricyclic antidepressants in depression: systematic review. To compare the effects and side effects of low dosage tricyclic antidepressants with placebo and with standard dosage tricyclics in acute phase treatment of depression.Systematic review of randomised trials comparing low dosage tricyclics (< or =100 mg/day) with placebo or with standard dosage tricyclics in adults with depression.Relative risk of response in depression (random (...) effects model), according to the original authors' definition but usually defined as 50% or greater reduction in severity of depression. Relative risks of overall dropouts and dropouts due to side effects.35 studies (2013 participants) compared low dosage tricyclics with placebo, and six studies (551 participants) compared low dosage tricyclics with standard dosage tricyclics. Low dosage tricyclics, mostly between 75 and 100 mg/day, were 1.65 (95% confidence interval 1.36 to 2.0) and 1.47 (1.12

2002 BMJ PubMed

111. Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation: a systematic review of the literature

Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation: a systematic review of the literature Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation: a systematic review of the literature Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation: a systematic review of the literature Raaijmakers E, Engelen A M Authors' objectives The authors appear to study the effects (...) . Is sensorineural hearing loss a possible side effect of nasopharyngeal and parotid irradiation: a systematic review of the literature. Radiotherapy and Oncology 2002; 65(1): 1-7 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Hearing /radiation effects; Hearing Loss, Sensorineural /etiology; Humans; Nasopharyngeal Neoplasms /radiotherapy; Parotid Neoplasms /radiotherapy; Radiation Injuries /etiology AccessionNumber 12003000015 Date bibliographic record published 28/02/2005 Date abstract record

2002 DARE.

112. Behavioral intervention for cancer treatment side effects

Behavioral intervention for cancer treatment side effects Behavioral intervention for cancer treatment side effects Behavioral intervention for cancer treatment side effects Redd W H, Montgomery G H, DuHamel K N Authors' objectives To evaluate the clinical impact of behavioural interventions in patients undergoing cancer treatment. Searching PubMed and PsycLIT were searched from 1979 to January 2000 for reports published in the English language, using the following search terms in combination (...) patients). Nausea and vomiting (23 studies, including 13 RCTs with 401 patients). Studies supported the effectiveness of behavioural interventions in controlling anticipatory nausea and vomiting. Twelve of the 13 RCTs reported a statistically-significant benefit from behavioural interventions when compared with a no treatment or attention control interventions. Modest results were found in the 4 studies that assessed behavioural interventions in post-chemotherapy side-effects. Anxiety and distress (19

2001 DARE.

113. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. (PubMed)

Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. To assess the effects of folic acid and folinic acid in reducing the mucosal and gastrointestinal (GI) and haematologic side effects of low-dose of Methotrexate (MTX) in patients with Rheumatoid Arthritis (RA) and to determine whether or not folate supplementation alters MTX efficacy.We searched the Cochrane Controlled Clinical Trial's Register (CCTR), the Cochrane Musculoskeletal (...) criteria. The total sample included 307 patients, of which 147 were treated with folate supplementation, 80 patients with folinic acid and 67 patients with folic acid. A 79% reduction in mucosal and GI side effects was observed for folic acid [OR = 0.21 (95% CI 0.10 to 0.44)]. For folinic acid, a clinically but non-statistically significant reduction of 43% was found [OR = 0. 57 (95% CI 0.28 to 1.15)]. No major differences were observed between low and high doses of folic or folinic acid. Haematologic

2000 Cochrane

114. The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction

The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction HS Osman, HI Rashid, N Sathananthan, MC Parker Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study evaluated the cost-effectiveness of self-expanding metal stents to treat acute left-sided large bowel obstruction in colorectal carcinoma. The authors concluded that stenting showed reduction in hospital stay and costs, but further analysis was necessary due to small sample size

2000 NHS Economic Evaluation Database.

115. Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: a randomised trial. (PubMed)

Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: a randomised trial. Radical radiotherapy is commonly used to treat localised prostate cancer. Late chronic side-effects limit the dose that can be given, and may be linked to the volume of normal tissues irradiated. Conformal radiotherapy allows a smaller amount of rectum and bladder to be treated, by shaping the high-dose volume to the prostate. We assessed the ability of this new technology (...) to lessen the risk of radiation-related effects in a randomised controlled trial of conformal versus conventional radiotherapy.We recruited men with prostate cancer for treatment with a standard dose of 64 Gy in daily 2 Gy fractions. The men were randomly assigned conformal or conventional radiotherapy treatment. The primary endpoint was the development of late radiation complications (> 3 months after treatment) measured with the Radiation Therapy and Oncology Group (RTOG) score. Indicators of disease

1999 Lancet

116. Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice

Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice Honig A, Arts B M, Ponds R W, Riedel W J Authors' objectives To investigate whether lithium gives rise to cognitive side-effects and affects (...) with lithium who present themselves with memory problems and mental slowness in order to rule out lithium intoxication. Patients should be given psycho-education about cognitive deficits in an attempt to make them aware of implications of these deficits for their ability to drive, thereby decreasing the risk of road accidents'. Bibliographic details Honig A, Arts B M, Ponds R W, Riedel W J. Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily

1999 DARE.

117. Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials

Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials Efficacy and extrapyramidal side-effects of the new (...) of drop-outs is considered in detail. The very nature of the patient population and the side-effects of the drugs means that drop-outs in these types of trials are often very common. In view of the data presented the authors' findings would appear to be valid and their suggestions for future research would seem reasonable. However, the above comments should be borne in mind when interpreting the findings. 95% CI are often not reported for individual studies and pooled effect sizes. Implications

1999 DARE.

118. Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects

Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects Hindmarch I, Shamsi Z Authors' objectives The primary aim was to identify the test which are most sensitive to the effects of antihistamines, to identify a test-battery which (...) and other side-effects. Clinical and Experimental Allergy 1999; 29(Supplement 3): 133-142 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Cognition /drug effects; Histamine Antagonists /adverse effects; Humans; Hypnotics and Sedatives /adverse effects; Psychomotor Performance /drug effects AccessionNumber 11999001555 Date bibliographic record published 31/12/2000 Date abstract record published 31/12/2000 Record Status This is a critical abstract of a systematic review that meets

1999 DARE.

119. Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects

Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Curatolo M, Petersen-Felix S, Scaramozzino P, Zbinden A M (...) in the review Patients undergoing surgery (orthopaedic or lower abdominal) with planned epidural block, without general analgesia. Women in labour were not included unless they were having Caesarean section. Outcomes assessed in the review Inadequate analgesia and the occurrence of side-effects were assessed. Inadequate analgesia was defined as pain at any intensity at the site of surgery, occurring during operation. The side-effects included respiratory depression, nausea/vomiting, pruritis, sedation

1998 DARE.

120. Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients

Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients Cantarovich M, Besner J G, Fitchett D H, Latter D A Record Status This is a critical abstract of an economic evaluation (...) progressively decreased since its introduction into clinical practice as side-effects such as hypertension and renal dysfunction were frequently reported after heart transplantation. You, as a user of this database, should consider whether this is a widely used health technology in your own setting. Validity of estimate of measure of benefit No summary benefit measure was used in the analysis and as such the principal benefits centred around reductions in dose and therefore cost. The data have not been used

1997 NHS Economic Evaluation Database.