Latest & greatest articles for statin

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Top results for statin

541. Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials

Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials LaRosa J C, He J, Vupputuri S Authors' objectives To estimate the reduced risk of coronary heart disease and total mortality associated with statin drug treatment, particularly in elderly individuals and women (...) . Searching MEDLINE was searched from 1966 to December 1998 using the following MeSH: 'hydroxy-methyl-glutaryl-CoA reductase inhibitors', 'simvastin', 'lovastatin', 'pravastatin', 'coronary disease' and 'myocardial infarction'. In addition, the keywords 'statin' and 'coronary heart disease' were used. The search was restricted to those studies conducted in human participants, published in English language journals, and classified as clinical trials in the MEDLINE database. A manual search was also

1999 DARE.

542. What role for statins: a review and economic model

What role for statins: a review and economic model What role for statins: a review and economic model What role for statins: a review and economic model Ebrahim S, Davey Smith G, McCabe C, Payne N, Pickin M, Sheldon T A, Lampe F, Sampson F, Ward S, Wannamethee G Authors' objectives The review aimed to answer the following questions: 1. By how much do low fat and other diets reduce blood cholesterol? And how effective are such effects in reducing coronary heart disease (CHD) risk? 2. Does (...) treatment with statins reduce CHD events and are relative reductions in these events independent of the level of CHD risk? 3. How effective are non-cholesterol lowering drug treatments (i.e. aspirin, beta-blockers, and antihypertensives) for reducing CHD risk relative to dietary modifications and cholesterol lowering drug treatments? 4. What is the relative cost-effectiveness of different approaches to reducing cholesterol and/or CHD? Searching MEDLINE and the Cochrane CENTRAL Register were searched

1999 DARE.

543. Cost effectiveness of HMG-CoA reductase inhibitor (statin) treatment related to the risk of coronary heart disease and cost of drug treatment

Cost effectiveness of HMG-CoA reductase inhibitor (statin) treatment related to the risk of coronary heart disease and cost of drug treatment Cost effectiveness of HMG-CoA reductase inhibitor (statin) treatment related to the risk of coronary heart disease and cost of drug treatment Cost effectiveness of HMG-CoA reductase inhibitor (statin) treatment related to the risk of coronary heart disease and cost of drug treatment Pickin D M, McCabe C J, Ramsay L E, Payne N, Haq I U, Yeo W W, Jackson P (...) R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin) treatment in subgroups of the population at different levels of coronary heart disease (CHD) risk. Type

1999 NHS Economic Evaluation Database.

544. Clinical outcomes in statin treatment trials: a meta-analysis

Clinical outcomes in statin treatment trials: a meta-analysis Clinical outcomes in statin treatment trials: a meta-analysis Clinical outcomes in statin treatment trials: a meta-analysis Ross S D, Allen I E, Connelly J E, Korenblat B M, Smith M E, Bishop D, Luo D Authors' objectives To determine the risk of cardiovascular events and death in patients receiving statin treatment for cholesterol regulation. Searching The authors searched MEDLARS using the search terms: 'anticholesterolemic agents (...) , French, German, Spanish or Italian. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs) with parallel design and duration of at least one year. Eligible studies had to have at least 10 participants per group and one group receiving a monotherapy statin agent versus at least one concurrent control arm that used placebo or no pharmacologic treatment for cholesterol regulation. Specific interventions included in the review Statin treatment (lovostatin

1999 DARE.

545. What role for statins? A review and economic model

What role for statins? A review and economic model What role for statins? A review and economic model Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1

1999 NIHR HTA programme

546. The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group. (PubMed)

The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group. The high-density lipoprotein (HDL) cholesterol concentration is inversely related to the risk of coronary artery disease. The cholesteryl ester transfer protein (CETP) has a central role in the metabolism of this lipoprotein and may therefore alter the susceptibility to atherosclerosis.The DNA of 807 men

1998 NEJM

547. Cost-effectiveness of statins

Cost-effectiveness of statins Cost-effectiveness of statins Cost-effectiveness of statins Huse D M, Russell M W, Miller J D, Kraemer D F, D'Agostino R B, Ellison R C, Hartz S C Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology (...) use data were collected from studies published between 1992 and 1998. Cost data were collected from studies published between 1986 and 1998. The price year was not reported. Source of effectiveness data Effectiveness data were derived from a review of the literature. Coronary heart disease event occurrence was derived from the Framingham Heart Study (using coronary health risk appraisal functions). The effectiveness of statin therapy was derived using approved US Food and Drug Administration

1998 NHS Economic Evaluation Database.

548. Cholesterol lowering with statin drugs, risk of stroke, and total mortality: an overview of randomized trials

Cholesterol lowering with statin drugs, risk of stroke, and total mortality: an overview of randomized trials Cholesterol lowering with statin drugs, risk of stroke, and total mortality: an overview of randomized trials Cholesterol lowering with statin drugs, risk of stroke, and total mortality: an overview of randomized trials Hebert P R, Gaziano J M, Chan K S, Hennekens C H Authors' objectives To assess the effectiveness of statin drugs to reduce the risk of stroke and total mortality (...) . Searching A computerised literature search was performed from 1985 to 1995. Data from the Cholesterol and Recurrent Events (CARE) Trial was added when the report was published in late 1996. The search was limited to English language articles. Principal researchers of the included trials and their respective funding bodies were contacted for details of unpublished reports. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs) testing statin drugs

1997 DARE.

549. Stroke, statins, and cholesterol: a meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors

Stroke, statins, and cholesterol: a meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors Stroke, statins, and cholesterol: a meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors Stroke, statins, and cholesterol: a meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors Blauw G J, Lagaay A M, Smelt A H, Westendorp R G Authors' objectives To estimate (...) the effect of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors ('statins') on stroke risk. Searching MEDLINE was searched from 1980 to 1996, and Current Contents (Life Sciences) from January through May 1996. The search strategy used the terms 'HMG-CoA reductase inhibitor', 'lovastatin', 'simvastatin', 'pravastatin', 'fluvastatin', 'atorvastatin', 'randomized controlled trial' (RCT), and 'double-blind method', both as MeSH and textwords. Reviews and preliminary reports were searched

1997 DARE.

550. Cost effectiveness of lowering cholesterol concentration with statins in patients with and without pre-existing coronary heart disease: life table method applied to health authority population

Cost effectiveness of lowering cholesterol concentration with statins in patients with and without pre-existing coronary heart disease: life table method applied to health authority population Cost effectiveness of lowering cholesterol concentration with statins in patients with and without pre-existing coronary heart disease: life table method applied to health authority population Cost effectiveness of lowering cholesterol concentration with statins in patients with and without pre-existing (...) coronary heart disease: life table method applied to health authority population Pharoah P D, Hollingworth W Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of statins to lower cholesterol concentration in patients

1996 NHS Economic Evaluation Database.