Latest & greatest articles for stroke

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Top results for stroke

2401. Double-blind randomised trial of Org 10172 low-molecular-weight heparinoid in prevention of deep-vein thrombosis in thrombotic stroke. (PubMed)

Double-blind randomised trial of Org 10172 low-molecular-weight heparinoid in prevention of deep-vein thrombosis in thrombotic stroke. In a double-blind, randomised trial Org 10172 low-molecular-weight (LMW) heparinoid was compared with placebo in the prevention of deep-vein thrombosis in patients with acute thrombotic stroke. Prophylaxis was started within 7 days of the onset of stroke with a loading dose of 1000 anti-factor-Xa units intravenously followed by a fixed dose of 750 anti-factor-Xa

1987 Lancet

2402. The European Stroke Prevention Study (ESPS). Principal end-points. The ESPS Group. (PubMed)

The European Stroke Prevention Study (ESPS). Principal end-points. The ESPS Group. In a multicentre double-blind trial, 2500 patients with a clinical diagnosis of a recent cerebrovascular event of atherothrombotic origin (transient ischaemic attack, reversible ischaemic neurological deficit, or stroke) were randomised to receive either dipyridamole 75 mg plus acetylsalicylic acid 325 mg (DP-ASA, 1250 patients) or placebo (1250 patients) thrice daily. Follow-up was twenty-four months (...) . On intention-to-treat analysis, 473 patients reached an end-point (stroke or death from any cause), 190 on DP-ASA and 283 on placebo. Survival curves for end-points showed 33% benefit in favour of the DP-ASA group (p less than 0.001). 108 patients died in the DP-ASA group and 156 in the placebo group (p less than 0.01). Results of an explanatory analysis were similar.

1987 Lancet

2403. Is a controlled trial of long-term oral anticoagulants in patients with stroke and non-rheumatic atrial fibrillation worthwhile? (PubMed)

Is a controlled trial of long-term oral anticoagulants in patients with stroke and non-rheumatic atrial fibrillation worthwhile? A controlled randomised trial large enough to assess the value of anticoagulating stroke patients in atrial fibrillation would be difficult to conduct in the UK and the results would be applicable to only a small proportion of stroke patients. It would be more worthwhile to organise a trial that also assessed the value of other treatments that are simpler (...) and applicable to all stroke patients. A trial that assessed the value of aspirin and beta-blockers against control in all stroke patients would not cost much more than one restricted to comparing anticoagulants against control in patients with stroke and atrial fibrillation but would provide information of more relevance to the management of patients with stroke in the UK.

1986 Lancet

2404. Controlled trial of a home-care service for acute stroke patients. (PubMed)

Controlled trial of a home-care service for acute stroke patients. In a controlled trial of a home-care service available for the first 6 months after acute stroke, 440 patients received the new service and 417 patients were in the control group. The trial group used more hospital bed days, had a slightly higher admission rate, and did not show better emotional adjustment to stroke than the control group. There was no difference between the 2 groups in stress on relatives. Functional recovery

1985 Lancet

2405. Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke. Results of an international randomized trial. The EC/IC Bypass Study Group. (PubMed)

Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke. Results of an international randomized trial. The EC/IC Bypass Study Group. To determine whether bypass surgery would benefit patients with symptomatic atherosclerotic disease of the internal carotid artery, we studied 1377 patients with recent hemisphere strokes, retinal infarction, or transient ischemic attacks who had atherosclerotic narrowing or occlusion of the ipsilateral internal carotid or middle (...) cerebral artery. Of these, 714 were randomly assigned to the best medical care, and 663 to the same regimen with the addition of bypass surgery joining the superficial temporal artery and the middle cerebral artery. The patients were followed for an average of 55.8 months. Thirty-day surgical mortality and major stroke morbidity rates were 0.6 and 2.5 per cent, respectively. The postoperative bypass patency rate was 96 per cent. Nonfatal and fatal stroke occurred both more frequently and earlier

1985 NEJM

2406. Nortriptyline treatment of post-stroke depression: a double-blind study. (PubMed)

Nortriptyline treatment of post-stroke depression: a double-blind study. The efficacy of nortriptyline in the treatment of post-stroke depression was assessed by a double-blind study in thirty-four patients. Half of the patients had major depression. There was a significantly greater improvement in depression in patients treated with nortriptyline than in a similar group of placebo-treated patients. Depression was measured by the Hamilton depression scale, Zung depression scale, present state (...) examination, and an overall depression scale. Successfully treated patients had serum nortriptyline levels in the therapeutic range. Post-stroke depressions are common, severe, and longstanding, and the demonstrated efficacy of nortriptyline provides an important addition to the treatments available for stroke patients.

1984 Lancet

2407. Effectiveness of speech therapy for aphasic stroke patients. A randomised controlled trial. (PubMed)

Effectiveness of speech therapy for aphasic stroke patients. A randomised controlled trial. Aphasic stroke patients were randomly allocated to either a speech therapy group receiving treatment twice a week for 24 weeks or a no-treatment control group. Patients in both groups improved and there were no significant differences in language recovery between the 104 patients allocated to the treatment group and the 87 allocated to the no-treatment group. This treatment regimen, which (...) is representative of clinical practice, is ineffective for most aphasic stroke patients.

1984 Lancet

2408. A randomized trial of aspirin and sulfinpyrazone in threatened stroke. The Canadian Cooperative Study Group. (PubMed)

A randomized trial of aspirin and sulfinpyrazone in threatened stroke. The Canadian Cooperative Study Group. Five hundred and eighty-five patients with threatened stroke were followed in a randomized clinical trial for an average of 26 months to determine whether aspirin or sulfinpyrazone, singly or in combination, influence the subsequent occurrence of continuing transient ischemic attacks, stroke or death. Eighty-five subjects went on to stroke, and 42 died. Aspirin reduced the risk (...) of continuing ischemic attacks, stroke or death by 19 per cent (P less than 0.05) and also reduced risk for the "harder," more important events of stroke or death by 31 percent (P less than 0.05), but this effect was sex-dependent: among men, the risk reduction for stroke or death was 48 per cent (P less than 0.005), whereas no significant trend was observed among women. For sulfinpyrazone, no risk reduction of ischemic attacks was observed, and the 10 per cent risk reduction of stroke or death

1978 NEJM

2409. Low-dose heparin as a prophylaxis against deep-vein thrombosis after acute stroke. (PubMed)

Low-dose heparin as a prophylaxis against deep-vein thrombosis after acute stroke. A trial of subcutaneous low-dose heparin in the prevention of deep-vein thrombosis was carried out in elderly patients admitted to hospital after an acute stroke. A statistically significant reduction was observed in deep-vein thrombosis as assessed by isotope leg scanning.

1977 Lancet

2410. Double-blind trial of glycerol therapy in early stroke. (PubMed)

Double-blind trial of glycerol therapy in early stroke. The effects of intravenous glycerol and intravenous dextrose were compared using a double-blind trial in twenty-seven patients with acute stroke. Administration continued for up to 6 days. A standard scoring system was used for neurological evaluation. There was no difference in mortality or in improvement in neurological score between the two groups.

1976 Lancet

2411. Effect of antihypertensive treatment on stroke recurrence. Hypertension-Stroke Cooperative Study Group. (PubMed)

Effect of antihypertensive treatment on stroke recurrence. Hypertension-Stroke Cooperative Study Group. 4599980 1974 08 30 2016 10 17 0098-7484 229 4 1974 Jul 22 JAMA JAMA Effect of antihypertensive treatment on stroke recurrence. Hypertension-Stroke Cooperative Study Group. 409-18 eng Clinical Trial Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Antihypertensive Agents 0 Placebos AIM IM Adult African Continental Ancestry Group Aged Antihypertensive Agents

1974 JAMA

2412. Joint study of extracranial arterial occlusion. VI. Racial differences in hospitalized patients with ischemic stroke. (PubMed)

Joint study of extracranial arterial occlusion. VI. Racial differences in hospitalized patients with ischemic stroke. 4678681 1973 03 05 2016 11 22 0098-7484 222 3 1972 Oct 16 JAMA JAMA Joint study of extracranial arterial occlusion. VI. Racial differences in hospitalized patients with ischemic stroke. 285-9 Heyman A A Fields W S WS Keating R D RD eng Clinical Trial Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 AIM IM Adult African Continental Ancestry Group

1973 JAMA

2413. Treatment of acute stroke with dextran 40. (PubMed)

Treatment of acute stroke with dextran 40. 5394364 1969 11 26 2016 11 22 0098-7484 210 2 1969 Oct 13 JAMA JAMA Treatment of acute stroke with dextran 40. 293-8 Gilroy J J Barnhart M I MI Meyer J S JS eng Clinical Trial Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Carbon Isotopes 0 Dextrans AIM IM Blood Platelets cytology drug effects Blood Viscosity drug effects Carbon Isotopes Cerebrovascular Disorders drug therapy Dextrans therapeutic use Humans

1969 JAMA