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Testosterone and Cardiovascular Health: Safety of Treatment of Hypogonadism. Controversy has arisen over the issue of the cardiovascular safety of testosterone.The aim of this article is to examine the evidence as to the cardiovascular safety involved with the administration of testosterone.A literature review was performed with regard to cardiovascular safety of testosterone.The main outcome measure was to evaluate the available evidence as to cardiovascular safety and risk of testosterone.A (...) handful of recently published and widely discussed manuscripts have suggested that administration of testosterone replacement therapy increases the frequency of adverse cardiovascular events. In contrast, there have been recent clinical reports suggesting that testosterone is either safe or actually reduces cardiovascular events and mortality. All of these studies-both those suggesting that testosterone has adverse effects, as well as those suggesting it has positive effects on the cardiovascular
The Effectiveness of Clomiphene Citrate Compared to Exogenous Testosterone Therapy in Adult Males "The Effectiveness of Clomiphene Citrate Compared to Exogenous Testoste" by Eric J. Krinsky < > > > > > Title Author Date of Graduation Summer 8-8-2015 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor David Keene, PA-C, MPAS Second Advisor Annjanette Sommers, PA-C, MS Rights . Abstract Background: Low testosterone (T) in men is a common medical (...) condition affecting approximately 5 million men in the United States. Low T caused by primary hypogonadism is treatable with exogenous testosterone in the form of direct injection or topical gels. However, low T due to secondary hypogonadism is amenable to treatment with exogenous testosterone forms, as well as selective estrogen receptor modulators (SERMs), such as clomiphene citrate (Clomid; CC).There are significant side effects and increased cost with exogenous testosterone therapy (mentioned above
The Effect of Testosterone Therapy on the Mortality Rate in Men Suffering From Diabetes Mellitus "The Effect of Testosterone Therapy on the Mortality Rate in Men Suffer" by Deion Tran < > > > > > Title Author Date of Graduation Summer 8-8-2015 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Saje Davis-Risen, PA-C, MS Rights . Abstract Background: Low testosterone level is common with aging men and is associated with many adverse outcomes (...) like diabetes mellitus (DM). In addition, men with low testosterone and DM have increased mortality risk. This review looks at the effect of testosterone therapy on mortality in men suffering from DM. Methods: An exhaustive literature search of available databases using Medline-OVID, CINAHL and Web of Science was conducted using the following keywords: testosterone, diabetes mellitus, and mortality. Results : The initial search of the databases yielded 58 articles. A total of two articles, both
Testosterone testing Final Testosterone Testing: Findings & Decision Page 1 of 3 Health Technology Clinical Committee Final Findings and Decision Topic: Testosterone Testing Meeting Date: March 20, 2015 Final Adoption: May 15, 2015 Meeting materials and transcript are available on the HTA website: www.hca.wa.gov/hta/meetingmaterials/Forms/ExtMeetingMaterials.aspx Number and Coverage Topic: 20150320A – Testosterone Testing HTCC Coverage Determination: Testosterone testing is a covered benefit (...) of testosterone therapy Non-covered Indicators: N/A This decision does not apply to females, males under age 18, or transgender persons. Agency Contact Information: Agency Phone Number Labor and Industries 1-800-547-8367 Public Employees Health Plan 1-800-200-1004 Washington State Medicaid 1-800-562-3022 WA - Health Technology Assessment March 20, 2015 Final Testosterone Testing: Findings & Decision Page 2 of 3 HTCC Coverage Vote and Formal Action Committee Decision Based on the deliberations of key health
Effect of Testosterone Treatment on Glucose Metabolism in men With Type 2 Diabetes: A Randomized Controlled Trial To determine whether testosterone therapy improves glucose metabolism in men with type 2 diabetes (T2D) and lowered testosterone.We conducted a randomized, double-blind, parallel, placebo-controlled trial in 88 men with T2D, aged 35-70 years with an HbA1c ≤8.5% (69 mmol/mol), and a total testosterone level, measured by immunoassay, of ≤12.0 nmol/L (346 ng/dL). Participants were (...) randomly assigned to 40 weeks of intramuscular testosterone undecanoate (n = 45) or matching placebo (n = 43). All study subjects were included in the primary analysis. Seven men assigned to testosterone and six men receiving placebo did not complete the study. Main outcome measures were insulin resistance by homeostatic model assessment (HOMA-IR, primary outcome) and glycemic control by HbA1c (secondary outcome).Testosterone therapy did not improve insulin resistance (mean adjusted difference [MAD
Natesto (testosterone) Nasal Gel Drug Approval Package: Brand Name (Generic Name) NDA # Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Natesto (testosterone) Nasal Gel Company: Trimel Biopharma, Inc. Application No.: 205488 Approval Date: 5/28/2014 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date created
Testosterone for low sexual desire in nonsurgically postmenopausal women Testosterone for low sexual desire in nonsurgically postmenopausal women Testosterone for low sexual desire in nonsurgically postmenopausal women Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Testosterone for low sexual desire in nonsurgically postmenopausal women. Lansdale: HAYES, Inc (...) .. Directory Publication. 2013 Authors' conclusions Endogenous androgens such as testosterone are thought to play a role in the regulation of sexual desire, and the goal of testosterone therapy for nonsurgically postmenopausal women is to increase sexual desire. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Females; Libido; Postmenopause; Sexual Dysfunctions, Psychological; Testosterone Language Published English Country of organisation United
Medicalization of aging and the testosterone deficiency syndrome Servicio Navarro de Salud / Osasunbidea Plaza de la Paz, s/n - 31002 Pamplona T 848429047 - F 848429010 email@example.com Drug and Therapeutics Bulletin of Navarre. Spain abstract n Objective: to carry out a critical appraisal of the Testosterone Deficit Syndrome (TDS), also known as low testosterone or T-low, its diagnosis and management. Materials and methods: a bibliographic search was carried out in the TRIP (...) database and PubMed with the following key words: “testosterone deficiency”, “late-onset hypogonadism”, “male andropause” and “androgen deficiency in aging males” filtered by the type of study (clinical practice guidelines, systematic reviews, meta-analyses or clinical trials). Information on consumption and sales was obtained from invoiced prescriptions in Navarre from 2001 upto 2011. Results: many of the signs and symptoms that define this syndrome overlap with those produced by other health problems
What Is Andropause? Is Testosterone Supplementation the Answer in Older Men? What Is Andropause? Is Testosterone Supplementation the Answer in Older Men? – Clinical Correlations Search What Is Andropause? Is Testosterone Supplementation the Answer in Older Men? September 20, 2012 5 min read By Kylie Birnbaum Faculty Peer Reviewed Women have long bemoaned menopause and its physiological, psychological, and sexual effects. Fortunately, hormone replacement therapy has provided relief (...) for symptomatic women. Less attention is paid to men, who also experience declines in their sex hormones. Decreased testosterone may explain many symptoms experienced by elderly men, such as poor sexual function and libido, decreased bone mineral density, fatigue, and decreased muscle mass and strength. Should physicians treat elderly men with testosterone replacement therapy? Late-onset hypogonadism, or “andropause,” is the gradual decline in testosterone levels in aging men. It differs from menopause
Effect of testosterone supplementation with and without a dual 5Î±-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial. Steroid 5α-reductase inhibitors are used to treat benign prostatic hyperplasia and androgenic alopecia, but the role of 5α-dihydrotestosterone (DHT) in mediating testosterone's effects on muscle, sexual function, erythropoiesis, and other androgen-dependent processes remains poorly understood.To determine whether (...) testosterone's effects on muscle mass, strength, sexual function, hematocrit level, prostate volume, sebum production, and lipid levels are attenuated when its conversion to DHT is blocked by dutasteride (an inhibitor of 5α-reductase type 1 and 2).The 5α-Reductase Trial was a randomized controlled trial of healthy men aged 18 to 50 years comparing placebo plus testosterone enthanate with dutasteride plus testosterone enanthate from May 2005 through June 2010.Eight treatment groups received 50, 125, 300
Effect of 1 Week of Sleep Restriction on Testosterone Levels in Young Healthy MenFREE 21632481 2011 06 03 2018 11 13 1538-3598 305 21 2011 Jun 01 JAMA JAMA Effect of 1 week of sleep restriction on testosterone levels in young healthy men. 2173-4 10.1001/jama.2011.710 Leproult Rachel R Department of Medicine, University of Chicago, Chicago, Illinois, USA. Van Cauter Eve E eng P60DK-020595 DK NIDDK NIH HHS United States 5R01HL72694-5 HL NHLBI NIH HHS United States M01 RR000055 RR NCRR NIH HHS (...) United States MO1-RR-00055 RR NCRR NIH HHS United States R01 HL072694 HL NHLBI NIH HHS United States P60 DK020595 DK NIDDK NIH HHS United States Journal Article Research Support, N.I.H., Extramural United States JAMA 7501160 0098-7484 3XMK78S47O Testosterone WI4X0X7BPJ Hydrocortisone AIM IM Adult Fatigue Humans Hydrocortisone blood Male Sleep Deprivation physiopathology Testosterone blood deficiency Young Adult 2011 6 3 6 0 2011 6 3 6 0 2011 6 4 6 0 ppublish 21632481 305/21/2173 10.1001/jama.2011.710
Reduction in 24-hour plasma testosterone levels in subjects who showered 15 or 30 minutes after application of testosterone gel. To investigate whether showering, to prevent the involuntary transfer of testosterone to others through skin contact, either 15 or 30 minutes after application of testosterone gel would significantly affect plasma testosterone levels.Prospective 3-way crossover trial.University hospital in the Netherlands.Ten agonadal female-to-male transsexuals who had sex (...) -reassignment surgery at least 3 months earlier.Subjects were randomized to one of three application regimens for testosterone gel 50 mg/day, each lasting 7 days: testosterone application after showering (standard regimen), shower was taken 30 minutes after testosterone application, or shower was taken 15 minutes after testosterone application. Subjects then crossed over to each of the other two application regimens for a total of 21 days of study participation.On day 7 of each application regimen, mean
Effects of Exogenous Testosterone Replacement Therapy on Time to ST Segment Depression and Myocardial Ischemia in Men With Chronic Stable Angina "Effects of Exogenous Testosterone Replacement Therapy on Time to ST Se" by Tanya N. Nestvogel < > > > > > Title Author Date of Graduation Spring 2-2011 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Torry Cobb, DHSc, MPH, PA-C Second Advisor Mary E. Von, DHEd, PA-C, DFAAPA Rights . Abstract (...) Background : Testosterone levels in men decline with age and low testosterone levels or hypogonadism can cause multiple negative effects and symptoms. Studies have shown that exogenous testosterone replacement therapy at physiological levels has a number of beneficial and protective effects on mood, libido, strength, lean body mass, bone health and cardiovascular health. One of the many cardiovascular benefits of testosterone therapy is its action as a vasodilator and effect on angina and exercise
Incomplete testosterone suppression in prostate cancer. 21067409 2010 11 30 2013 11 21 1533-4406 363 20 2010 Nov 11 The New England journal of medicine N. Engl. J. Med. Incomplete testosterone suppression in prostate cancer. 1976 10.1056/NEJMc1010187 Crawford E David ED Rove Kyle O KO eng Letter United States N Engl J Med 0255562 0028-4793 0 Androgen Antagonists 33515-09-2 Gonadotropin-Releasing Hormone 3XMK78S47O Testosterone AIM IM Androgen Antagonists pharmacology therapeutic use (...) Gonadotropin-Releasing Hormone agonists antagonists & inhibitors Humans Male Prostatic Neoplasms blood drug therapy mortality Testosterone blood 2010 11 12 6 0 2010 11 12 6 0 2010 12 14 6 0 ppublish 21067409 10.1056/NEJMc1010187
The Effect of Testosterone on Metabolic Syndrome and Type 2 Diabetes "The Effect of Testosterone on Metabolic Syndrome and Type 2 Diabetes" by Alison Quammen < > > > > > Title Author Date of Graduation 8-14-2010 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Mary Von PA-C Second Advisor Annjanette Sommers MS, PAC Third Advisor Rob Rosenow PharmD, OD Rights . Abstract Background: Metabolic syndrome (MetS) and diabetes type 2 (DM2 (...) a link between hypogonadism and metabolic syndrome and the next step is to evaluate if raising a man’s testosterone levels back to physiologic norms has any benefit in the treatment of metabolic syndrome or DM2. Methods: A comprehensive review of the literature was performed using the data bases: CINAHL, ovid - Medline, EBMR Multifile, Web of Science, PubMed and Google scholar. This produced a number of studies and the following exclusion criteria were applied to limit the search. Exclusion criteria
Fortesta (testosterone) Gel for topical use Drug Approval Package: Fortesta (testosterone) NDA #021463 Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Fortesta (testosterone) Gel for topical use, 10 mg of testosterone per pump actuation Company: Endo Pharmaceuticals, Inc. Application No.: 021463 Approval Date: 12/29/2010 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF
Adverse events associated with testosterone administration. Testosterone supplementation has been shown to increase muscle mass and strength in healthy older men. The safety and efficacy of testosterone treatment in older men who have limitations in mobility have not been studied.Community-dwelling men, 65 years of age or older, with limitations in mobility and a total serum testosterone level of 100 to 350 ng per deciliter (3.5 to 12.1 nmol per liter) or a free serum testosterone level of less (...) than 50 pg per milliliter (173 pmol per liter) were randomly assigned to receive placebo gel or testosterone gel, to be applied daily for 6 months. Adverse events were categorized with the use of the Medical Dictionary for Regulatory Activities classification. The data and safety monitoring board recommended that the trial be discontinued early because there was a significantly higher rate of adverse cardiovascular events in the testosterone group than in the placebo group.A total of 209 men (mean