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Latest & greatest articles for traumatic brain injury
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Out-of-hospital hypertonic resuscitation following severe traumaticbraininjury: a randomized controlled trial. Hypertonic fluids restore cerebral perfusion with reduced cerebral edema and modulate inflammatory response to reduce subsequent neuronal injury and thus have potential benefit in resuscitation of patients with traumaticbraininjury (TBI).To determine whether out-of-hospital administration of hypertonic fluids improves neurologic outcome following severe TBI.Multicenter, double
Hyperbaric oxygen therapy for traumaticbraininjury (TBI) and post traumatic stress disorder (PTSD) Hyperbaric oxygen therapy for traumaticbraininjury (TBI) and post traumatic stress disorder (PTSD) Hyperbaric oxygen therapy for traumaticbraininjury (TBI) and post traumatic stress disorder (PTSD) Adams E Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA (...) database. Citation Adams E. Hyperbaric oxygen therapy for traumaticbraininjury (TBI) and post traumatic stress disorder (PTSD) Boston: VA Technology Assessment Program (VATAP). 2010 Authors' conclusions Conclusions: Traumaticbraininjury. The systematic reviews by McDonagh (2003) and Bennett (2004) provide the most rigorous and current information on the status of the clinical research for the use of HBO2 in TBI. Subsequent reviews identified these two reviews as the primary basis
Prophylactic hypothermia for traumaticbraininjury: a quantitative systematic review Prophylactic hypothermia for traumaticbraininjury: a quantitative systematic review Prophylactic hypothermia for traumaticbraininjury: a quantitative systematic review Fox JL, Vu EN, Doyle-Waters M, Brubacher JR, Abu-Laban R, Hu Z CRD summary The review found that early prophylactic mild to moderate hypothermia improved mortality and functional outcomes after severe traumaticbraininjury, especially when (...) a long-term or goal-directed cooling strategy was used. In view of limitations in the review, including poor quality studies and possible publication bias (both acknowledged by the authors), some caution may be required in interpreting the findings. Authors' objectives To evaluate the use of prophylactic hypothermia for traumaticbraininjury. Searching MEDLINE, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews, PapersFirst
Cost-effectiveness analysis of intravenous levetiracetam versus intravenous phenytoin for early onset seizure prophylaxis after neurosurgery and traumaticbraininjury Cost-effectiveness analysis of intravenous levetiracetam versus intravenous phenytoin for early onset seizure prophylaxis after neurosurgery and traumaticbraininjury Cost-effectiveness analysis of intravenous levetiracetam versus intravenous phenytoin for early onset seizure prophylaxis after neurosurgery and traumaticbrain (...) after neurosurgery or traumaticbraininjury, in the intensive care unit setting. The authors concluded that, from the perspective of the hospital, levetiracetam could be cost-effective compared with phenytoin. The methods were valid and the study was generally well presented. The authors’ conclusions seem robust. Type of economic evaluation Cost-effectiveness analysis Study objective This study examined the cost-effectiveness of intravenous levetiracetam, compared with conventional intravenous
Nursing management of adults with severe traumaticbraininjury. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund You are here Guidelines and Measures Funding for the National
Brain tissue oxygen and outcome after severe traumaticbraininjury: a systematic review In this study, available medical literature were reviewed to determine whether brain hypoxia as measured by brain tissue oxygen (Bto2) levels is associated with increased risk of poor outcome after traumaticbraininjury (TBI). A secondary objective was to examine the safety profile of a direct BtO2 probe. DATA SOURCE AND EXTRACTION: Clinical studies published between 1993 and 2008 were identified from (...) electronic databases, Index Medicus, bibliographies of pertinent articles, and expert consultation. The following inclusion criteria were applied for outcome analysis: 1) more than 10 patients described, 2) use of a direct Bto2 monitor, 3) brain hypoxia defined as Bto2 <10 mm Hg for >15 or 30 minutes, 4) 6-month outcome data, and 5) clear reporting of patient outcome associated with Bto2. For the analysis, each selected article had to have adequate data to determine odds ratios (ORs) and confidence
Interventions for apathy after traumaticbraininjury. Apathy is a deficiency in overt behavioural, emotional and cognitive components of goal-directed behaviour. It is a common occurrence after traumaticbraininjury (TBI), with widespread impact. We have systematically reviewed studies examining the effectiveness of interventions for apathy in the TBI population.To investigate the effectiveness of interventions for apathy in adults who have sustained a TBI. This was evaluated by changes (...) in behavioural, cognitive and emotional measures of apathy.We searched the following databases up to January 2008: CENTRAL (The Cochrane Library 2008, Issue 1), Database of Abstracts of Reviews of Effects, ACP Journal Club, MEDLINE (1950 to Jan 2008), EMBASE (1980 to Jan 2008), PsycINFO (1806 to Jan 2008), CINAHL (1982 Jan 2008), PsycBITE, AMED (1985 to Jan 2008), www.controlled-trials.com, www.clinicaltrials.gov and www.actr.org.au.The Cochrane Injuries Group's Specialised Register was searched to Jan 2009
A critical comparison of clinical decision instruments for computed tomographic scanning in mild closed traumaticbraininjury in adolescents and adults A number of clinical decision aids have been introduced to limit unnecessary computed tomographic scans in patients with mild traumaticbraininjury. These aids differ in the risk factors they use to recommend a scan. We compare the instruments according to their sensitivity and specificity and recommend ones based on incremental benefit (...) of correctly classifying patients as having surgical, nonsurgical, or no intracranial lesions.We performed a secondary analysis of prospectively collected database from 7,955 patients aged 10 years or older with mild traumaticbraininjury to compare sensitivity and specificity of 6 common clinical decision strategies: the Canadian CT Head Rule, the Neurotraumatology Committee of the World Federation of Neurosurgical Societies, the New Orleans, the National Emergency X-Radiography Utilization Study II
Longitudinal trajectories of postconcussive symptoms in children with mild traumaticbraininjuries and their relationship to acute clinical status We examined whether mild traumaticbraininjuries in children and adolescents, especially when associated with acute clinical features reflecting more severe injury, result in different postinjury trajectories of postconcussive symptoms compared with mild orthopedic injuries.Participants in this prospective and longitudinal cohort study were 8 (...) - to 15-year-old children, 186 with mild traumaticbraininjuries and 99 with mild orthopedic injuries, who were recruited from consecutive admissions to emergency departments in 2 large children's hospitals. Parents rated current postconcussive symptoms within 3 weeks of injury and at 1, 3, and 12 months after injury. At the initial assessment, parents also provided retrospective ratings of preinjury symptoms, and children with mild traumaticbraininjuries received MRI of the brain. Clinical
Long-term risk of epilepsy after traumaticbraininjury in children and young adults: a population-based cohort study. The risk of epilepsy shortly after traumaticbraininjury is high, but how long this high risk lasts is unknown. We aimed to assess the risk of epilepsy up to 10 years or longer after traumaticbraininjury, taking into account sex, age, severity, and family history.We identified 1 605 216 people born in Denmark (1977-2002) from the Civil Registration System. We obtained (...) information on traumaticbraininjury and epilepsy from the National Hospital Register and estimated relative risks (RR) with Poisson analyses.Risk of epilepsy was increased after a mild braininjury (RR 2.22, 95% CI 2.07-2.38), severe braininjury (7.40, 6.16-8.89), and skull fracture (2.17, 1.73-2.71). The risk was increased more than 10 years after mild braininjury (1.51, 1.24-1.85), severe braininjury (4.29, 2.04-9.00), and skull fracture (2.06, 1.37-3.11). RR increased with age at mild and severe
Visual problems in traumaticbraininjury Visual problems in traumaticbraininjury Visual problems in traumaticbraininjury Adams E Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Adams E. Visual problems in traumaticbraininjury. Boston: VA Technology Assessment Program (VATAP). 2009 Authors' conclusions Mild TBI Overall, the findings (...) from this qualitative systematic review provide moderately suggestive evidence for a range of vision sequelae primarily in the acute stages of mild TBI in younger clinically-based adult populations. The evidence is limited by small sample size and heterogeneity in the selection of cases and controls, injury severity criteria and outcome measures. In the acute stages following mild TBI, photosensitivity is a common complaint particularly in the Veteran population. The evidence suggests that while
Direct brain tissue oxygen monitoring for traumaticbraininjury Direct brain tissue oxygen monitoring for traumaticbraininjury Direct brain tissue oxygen monitoring for traumaticbraininjury Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Report may be purchased from . Citation Direct brain tissue oxygen monitoring for traumaticbraininjury . Lansdale: HAYES, Inc (...) .. 2009 Authors' objectives Direct brain tissue oxygen monitoring is used in conjunction with other monitoring modalities to better detect evolving braininjury and thereby avoid secondary brain insults before they cause irreversible damage. Direct brain tissue oxygen monitoring is accomplished by placing a small, oxygen-sensitive catheter directly into the brain tissue. The probe measures the partial pressure of oxygen in the interstitial brain tissue, which is reflective of the balance between
The use of hypothermia as a treatment for traumaticbraininjury The use of hypothermia as a treatment for traumaticbraininjury The use of hypothermia as a treatment for traumaticbraininjury Rupich K CRD summary This review evaluated hypothermia to treat traumaticbraininjuries and concluded that there may be benefits of hypothermia treatment for some patients with severe traumatic head injuries. Insufficient information was presented about the conduct of the review, quality (...) of the included studies and results, so it was difficult to draw any conclusions about the reliability of the author's conclusions. Authors' objectives To evaluate the use of hypothermia as a treatment for traumaticbraininjury. Searching MEDLINE, CINAHL, EMBASE and PubMed were searched from 2000 to 2006 for English-language studies. Search terms were reported. Study selection Controlled trials of therapeutic hypothermia used for at least 24 hours compared to normothermia in adults with a closed traumatic
Approaches to vocational rehabilitation after traumaticbraininjury: a review of the evidence Approaches to vocational rehabilitation after traumaticbraininjury: a review of the evidence Approaches to vocational rehabilitation after traumaticbraininjury: a review of the evidence Fadyl JK, McPherson KM CRD summary The authors concluded that there was little clear evidence to suggest the best practice approach to vocational rehabilitation in people with traumaticbraininjury. Although (...) there were some limitations in reporting of the review, the authors’ conclusions appeared to reflect the limited evidence from a small number of flawed studies. Authors' objectives To evaluate the effectiveness of different approaches to vocational rehabilitation for people after traumaticbraininjury. Searching MEDLINE, PsycINFO, CINAHL, AMED, Health and Psychosocial Instruments, EBM databases and Web of Science were searched for studies published in English between 1999 and July 2007. Search terms
TraumaticBrainInjury and PTSD: A Synthesis of the Evidence Management Briefs Enter search terms Button to search HSRD ® Inside VA Budget and Performance Inside the News Room National Observances Special Events » » » » » Management Briefs Health Services Research & Development Management Briefs Management eBriefs: Provide VA senior managers with results from VA Health Services Research in a concise and timely manner. , April 2019, Issue 152 , March 2019, Issue 151 , March 2019, Issue 150
The economic impact of S-100B as a pre-head CT screening test on emergency department management of adult patients with mild traumaticbraininjury The economic impact of S-100B as a pre-head CT screening test on emergency department management of adult patients with mild traumaticbraininjury The economic impact of S-100B as a pre-head CT screening test on emergency department management of adult patients with mild traumaticbraininjury Ruan S, Noyes K, Bazarian JJ Record Status (...) This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study estimated the cost reduction associated with serum-100B testing to determine whether a computed tomography (CT) scan was required for adults with an isolated mild traumaticbraininjury. The authors
Towards an understanding of sex differences in functional outcome following moderate to severe traumaticbraininjury: a systematic review A clear understanding of the impact sex differences play in clinical traumaticbraininjury (TBI) outcome remains elusive. Animal research suggests that females have better functional outcomes following TBI than males. Therefore, this paper aims to systematically review all studies that have examined sex differences in functional outcome measures following (...) measures and lack of appropriate statistical information, a qualitative analysis was performed. More than half of the papers were considered high quality. Strong evidence was found to suggest that women do not have better functional outcome than men following moderate to severe TBI.The results of this review are contrary to the suggestions from animal literature. Consideration of factors such as the woman patient's hormonal status at the time of injury and other sources of heterogeneity such as age
Systematic review of the literature on pain in patients with polytrauma including traumaticbraininjury Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Treatment for depression after traumaticbraininjury: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.