Latest & greatest articles for traumatic brain injury

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Top results for traumatic brain injury

141. A prospective study on employment outcome 3 years after moderate to severe traumatic brain injury (PubMed)

A prospective study on employment outcome 3 years after moderate to severe traumatic brain injury To evaluate the employment outcome in patients with moderate to severe traumatic brain injury (TBI) and to identify which patients are at risk of unemployment 3 years after injury.Prospective cohort study.Patients with moderate and severe TBI discharged from the neurosurgery departments of 3 level 1 trauma centers in The Netherlands.Patients aged 18 to 65 years (N=113; mean age ± SD, 33.2±13.1y; 73 (...) % men) who were hospitalized with moderate (26% of patients) to severe (74% of patients) TBI.Not applicable.The main outcome measure was employment status. Potential predictors included patient characteristics, injury severity factors, functional outcome measured at discharge from the acute hospital with the Glasgow Outcome Scale (GOS), Barthel Index (BI), and FIM, and cognitive functioning measured with the Functional Assessment Measure (FAM).Ninety-four patients (83%) completed the 3-year follow

2012 EvidenceUpdates

142. Systematic review of head cooling in adults after traumatic brain injury and stroke

Systematic review of head cooling in adults after traumatic brain injury and stroke Systematic review of head cooling in adults after traumatic brain injury and stroke Journals Library An error has occurred in processing the XML document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you (...) need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Study found insufficient published evidence to establish whether or not head cooling in patients with traumatic brain injury or stroke improves functional outcome or has benefits and fewer side effects compared with systemic cooling or no cooling. {{author}} {{($index An error has occurred in processing the XML document An error has occurred in processing the XML document {{metadata.Journal

2012 NIHR HTA programme

143. Early management of severe traumatic brain injury. (PubMed)

Early management of severe traumatic brain injury. Severe traumatic brain injury remains a major health-care problem worldwide. Although major progress has been made in understanding of the pathophysiology of this injury, this has not yet led to substantial improvements in outcome. In this report, we address present knowledge and its limitations, research innovations, and clinical implications. Improved outcomes for patients with severe traumatic brain injury could result from progress (...) in pharmacological and other treatments, neural repair and regeneration, optimisation of surgical indications and techniques, and combination and individually targeted treatments. Expanded classification of traumatic brain injury and innovations in research design will underpin these advances. We are optimistic that further gains in outcome for patients with severe traumatic brain injury will be achieved in the next decade.Copyright © 2012 Elsevier Ltd. All rights reserved.

2012 Lancet

144. Specialized neurocritical care units for traumatic brain injury

Specialized neurocritical care units for traumatic brain injury Specialized neurocritical care units for traumatic brain injury Specialized neurocritical care units for traumatic brain injury Mitchell MD, Williams K Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mitchell MD, Williams K. Specialized neurocritical care units for traumatic brain injury (...) . Philadelphia: Center for Evidence-based Practice (CEP). 2012 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Brain Injuries; Critical Cares; Intensive Care Units; Outcome and Process Assessment (Health Care) Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence Center for Evidence-based Practice, University of Pennsylvania Health System, 3535 Market St. Suite 50, Philadelphia PA 19104

2012 Health Technology Assessment (HTA) Database.

145. WITHDRAWN: Antiepileptic drugs for preventing seizures following acute traumatic brain injury. (PubMed)

WITHDRAWN: Antiepileptic drugs for preventing seizures following acute traumatic brain injury. Seizure activity in the early post-traumatic period following head injury may cause secondary brain damage as a result of increased metabolic demands, raised intracranial pressure and excess neurotransmitter release.To determine the effects of prophylactic anti-epileptic agents for acute traumatic head injury.We searched the Cochrane Injuries Group specialised register, MEDLINE and the registers (...) of the Cochrane Stroke Group and Cochrane Epilepsy Group. We contacted pharmaceutical companies who manufacture anti-epileptic agents, the National Institute of Neurological Disorders and Stroke, Epilepsy Division, and the United States' National Institute of Health.All randomised trials of anti-epileptic agents, in which study participants had a clinically defined acute traumatic head injury of any severity. Trials in which the intervention was started more than eight weeks after injury were excluded.Two

2012 Cochrane

146. Use of a mild traumatic brain injury guideline to reduce inpatient hospital imaging and charges

Use of a mild traumatic brain injury guideline to reduce inpatient hospital imaging and charges Use of a mild traumatic brain injury guideline to reduce inpatient hospital imaging and charges Use of a mild traumatic brain injury guideline to reduce inpatient hospital imaging and charges Goldberg J, McClaine RJ, Cook B, Garcia VF, Brown RL, Crone K, Falcone RA Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study evaluated the impact of guidelines for the treatment of mild traumatic brain injury in paediatric patients, in reducing hospital charges and computed tomography (CT) scans. The implementation of the guideline resulted in a significant reduction in CT scans, length of stay, and patient charges. There were

2012 NHS Economic Evaluation Database.

147. CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury - a nested randomised, placebo-controlled trial

CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury - a nested randomised, placebo-controlled trial CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury - a nested randomised, placebo-controlled trial Journals Library An error has occurred in processing the XML (...) document An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Study to evaluate the effect of tranexamic acid in traumatic brain injury patients found that neither moderate benefits nor

2012 NIHR HTA programme

148. Decompressive Craniectomy in Diffuse Traumatic Brain Injury

Decompressive Craniectomy in Diffuse Traumatic Brain Injury PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2012 PedsCCM Evidence-Based Journal Club

149. Sedation for critically ill adults with severe traumatic brain injury: a systematic review of randomized controlled trials (PubMed)

Sedation for critically ill adults with severe traumatic brain injury: a systematic review of randomized controlled trials To summarize randomized controlled trials on the effects of sedative agents on neurologic outcome, mortality, intracranial pressure, cerebral perfusion pressure, and adverse drug events in critically ill adults with severe traumatic brain injury.PubMed, MEDLINE, EMBASE, the Cochrane Database, Google Scholar, two clinical trials registries, personal files, and reference (...) hrs) was addressed in six studies, whereas a bolus dose, short infusion, or doubling of plasma drug concentration was investigated in remaining trials. Most trials did not describe baseline traumatic brain injury prognostic factors or important cointerventions. Eight trials possibly or definitely concealed allocation and six were blinded. Insufficient data exist regarding the effects of sedative agents on neurologic outcome or mortality. Although their effects are likely transient, bolus doses

2012 EvidenceUpdates

150. The use of Levetiracetam and Phenytoin for Seizure Prophylaxis in the Setting of Severe Traumatic Brain Injury

The use of Levetiracetam and Phenytoin for Seizure Prophylaxis in the Setting of Severe Traumatic Brain Injury "The use of Levetiracetam and Phenytoin for Seizure Prophylaxis in the " by Gregg V. Kosloff < > > > > > Title Author Date of Graduation Summer 8-11-2012 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Mark Pedemonte, MD Second Advisor Annjanette Sommers, PA-C, MS Rights . Abstract Background: Each year in the United States (...) an estimated 1.7 million people suffer a traumatic brain injury (TBI). Current standard of care for these patients is seven days of phenytoin (PHT) for seizure prophylaxis. Given the known side effect profile and drug interactions associated with the use of PHT, levetiracetam (LEV) has been proposed as an alternative for seizure prophylaxis. This systematic review examined available literature to determine whether or not there is sufficient evidence to recommend the use of LEV in lieu of PHT. Method

2012 Pacific University EBM Capstone Project

151. Traumatic brain injury (TBI) ? Coordination of outpatient rehabilitative care

Traumatic brain injury (TBI) ? Coordination of outpatient rehabilitative care Occupational and Physical Therapy/Traumatic Brain Injury/Rehabilitative Care/BESt 142 Best Evidence Statement (BESt) Copyright © 2012 Cincinnati Children's Hospital Medical Center; all rights reserved Page 1 of 7 Date: 12/20/12 Title: Coordination of Outpatient Rehabilitative Care for patients with Traumatic Brain Injury (TBI) and their Families Clinical Question: P (Population/Problem) Among children who have (...) sustained a traumatic brain injury (TBI) who have been discharged from an inpatient rehabilitation unit I (Intervention) does participation in a coordinated multi-disciplinary* program for outpatient rehabilitation C O (Comparison) (Outcome) versus a non-formalized multi-disciplinary* approach affect quality of life, caregiver satisfaction, and/or functional performance skills*? Definitions for terms marked with * may be found in the Supporting Information section. Target Population

2012 Cincinnati Children's Hospital Medical Center

152. Acupuncture for acute management and rehabilitation of traumatic brain injury. (PubMed)

Acupuncture for acute management and rehabilitation of traumatic brain injury. Traumatic brain injury (TBI) can be life threatening depending on the severity of the insult to the brain. It can also cause a range of debilitating sequelae which require cognitive, motor, communication, emotional, or behavioral rehabilitation of varying intensity and duration. A number of studies conducted and published in China have suggested that acupuncture may be beneficial in the acute treatment (...) and rehabilitation of TBI.To determine the efficacy and safety of acupuncture in the acute management or rehabilitation (or both) of patients with a TBI, including cognitive, neurological, motor, communication, emotional, or behavioral complications, or a combination of such complications.We searched the Cochrane Injuries Group Specialised Register, Cochrane Central Register of Controlled Trials (The Cochrane Library),MEDLINE, EMBASE, CINAHL, AMED, PsycINFO and others. We also searched the Chinese Acupuncture

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2012 Cochrane

153. Mild traumatic brain injury

Mild traumatic brain injury Mild traumatic brain injury - Vos - 2012 - European Journal of Neurology - Wiley Online Library The full text of this article hosted at iucr.org is unavailable due to technical difficulties.

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2012 European Academy of Neurology

154. Multidisciplinary Postacute Rehabilitation for Moderate to Severe Traumatic Brain Injury in Adults

Multidisciplinary Postacute Rehabilitation for Moderate to Severe Traumatic Brain Injury in Adults Multidisciplinary Postacute Rehabilitation for Moderate to Severe Traumatic Brain Injury in Adults Comparative Effectiveness Review Number 72Comparative Effectiveness Review Number 72 Multidisciplinary Postacute Rehabilitation for Moderate to Severe Traumatic Brain Injury in Adults Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 540 Gaither (...) to Severe Traumatic Brain Injury in Adults. (Prepared by the Minnesota Evidence-based Practice Center under Contract No. 290-2007-10064-I.) AHRQ Publication No. 12-EHC101-EF. Rockville, MD: Agency for Healthcare Research and Quality; June 2012. www.effectivehealthcare.ahrq.gov/reports/final.cfm. None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report. iii Preface The Agency for Healthcare Research and Quality (AHRQ) conducts

2012 Effective Health Care Program (AHRQ)

155. Multidisciplinary postacute rehabilitation for moderate to severe traumatic brain injury in adults

Multidisciplinary postacute rehabilitation for moderate to severe traumatic brain injury in adults Multidisciplinary postacute rehabilitation for moderate to severe traumatic brain injury in adults Multidisciplinary postacute rehabilitation for moderate to severe traumatic brain injury in adults Brasure M, Lamberty GJ, Sayer NA, Nelson NW, MacDonald R, Ouellette J, Tacklind J, Grove M, Rutks IR, Butler ME, Kane RL, Wilt TJ Record Status This is a bibliographic record of a published health (...) technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Brasure M, Lamberty GJ, Sayer NA, Nelson NW, MacDonald R, Ouellette J, Tacklind J, Grove M, Rutks IR, Butler ME, Kane RL, Wilt TJ. Multidisciplinary postacute rehabilitation for moderate to severe traumatic brain injury in adults. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 72. 2012 Authors' objectives

2012 Health Technology Assessment (HTA) Database.

156. A trial of intracranial-pressure monitoring in traumatic brain injury. (PubMed)

A trial of intracranial-pressure monitoring in traumatic brain injury. Intracranial-pressure monitoring is considered the standard of care for severe traumatic brain injury and is used frequently, but the efficacy of treatment based on monitoring in improving the outcome has not been rigorously assessed.We conducted a multicenter, controlled trial in which 324 patients 13 years of age or older who had severe traumatic brain injury and were being treated in intensive care units (ICUs) in Bolivia (...) was higher in the imaging-clinical examination group than in the pressure-monitoring group (4.8 vs. 3.4, P=0.002). The distribution of serious adverse events was similar in the two groups.For patients with severe traumatic brain injury, care focused on maintaining monitored intracranial pressure at 20 mm Hg or less was not shown to be superior to care based on imaging and clinical examination. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number, NCT01068522.).

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2012 NEJM

157. Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). (PubMed)

Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). Traumatic brain injury (TBI) is a serious public health problem in the United States, yet no treatment is currently available to improve outcome after TBI. Approved for use in TBI in 59 countries, citicoline is an endogenous substance offering potential neuroprotective properties as well as facilitated neurorepair post injury.To determine (...) ). At the 180-day evaluation, the citicoline and placebo groups did not differ significantly with respect to the primary outcome (global OR, 0.87 [95% CI, 0.72-1.04]).Among patients with traumatic brain injury, the use of citicoline compared with placebo for 90 days did not result in improvement in functional and cognitive status.clinicaltrials.gov Identifier: NCT00545662.

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2012 JAMA

158. Placebo-controlled trial of amantadine for severe traumatic brain injury. (PubMed)

Placebo-controlled trial of amantadine for severe traumatic brain injury. Amantadine hydrochloride is one of the most commonly prescribed medications for patients with prolonged disorders of consciousness after traumatic brain injury. Preliminary studies have suggested that amantadine may promote functional recovery.We enrolled 184 patients who were in a vegetative or minimally conscious state 4 to 16 weeks after traumatic brain injury and who were receiving inpatient rehabilitation. Patients (...) (difference in slope, 0.30 points per week; P=0.02). The overall improvement in DRS scores between baseline and week 6 (2 weeks after treatment was discontinued) was similar in the two groups. There were no significant differences in the incidence of serious adverse events.Amantadine accelerated the pace of functional recovery during active treatment in patients with post-traumatic disorders of consciousness. (Funded by the National Institute on Disability and Rehabilitation Research; ClinicalTrials.gov

2012 NEJM

159. Effect on behavior problems of teen online problem-solving for adolescent traumatic brain injury (PubMed)

Effect on behavior problems of teen online problem-solving for adolescent traumatic brain injury To report the results of a randomized clinical trial of teen online problem-solving (TOPS) meant to improve behavioral outcomes of adolescents with traumatic brain injury (TBI).A randomized clinical trial was conducted to compare the efficacy of TOPS with access to Internet resources in teenagers with TBI in improving parent and self-reported behavior problems and parent-teen conflicts. Participants (...) included 41 adolescents aged 11 to 18 years (range: 11.47-17.90 years) who had sustained a moderate-to-severe TBI between 3 and 19 months earlier. Teens in the TOPS group received 10 to 14 online sessions that provided training in problem-solving, communication skills, and self-regulation. Outcomes were assessed before treatment and at a follow-up assessment an average of 8 months later. Groups were compared on follow-up scores after we controlled for pretreatment levels. Injury severity

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2011 EvidenceUpdates