Latest & greatest articles for warfarin

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on warfarin or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on warfarin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for warfarin

181. Oral anticoagulation with warfarin - 4th edition

Oral anticoagulation with warfarin - 4th edition Guidelines on oral anticoagulation with warfarin – fourth edition - Keeling - 2011 - British Journal of Haematology - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term The full text of this article hosted at iucr.org is unavailable due to technical difficulties. guideline Free Access Guidelines on oral anticoagulation with warfarin – fourth edition (...) of this article with your friends and colleagues. Copy URL Share a link ). The guidance is updated with reference to relevant publications since 2005. Publications known to the writing group were supplemented with additional papers identified by searching PubMed for publications in the last 5 years using the key word warfarin and limits clinical trial, randomized control trial, meta‐analysis, humans, core clinical journals, and English language. The writing group produced the draft guideline, which

Full Text available with Trip Pro

2011 British Committee for Standards in Haematology

182. Performance of stroke risk scores in older people with atrial fibrillation not taking warfarin: comparative cohort study from BAFTA trial. (PubMed)

Performance of stroke risk scores in older people with atrial fibrillation not taking warfarin: comparative cohort study from BAFTA trial. To compare the predictive power of the main existing and recently proposed schemes for stratification of risk of stroke in older patients with atrial fibrillation.Comparative cohort study of eight risk stratification scores.Trial of thromboprophylaxis in stroke, the Birmingham Atrial Fibrillation in the Aged (BAFTA) trial.665 patients aged 75 or over (...) with atrial fibrillation based in the community who were randomised to the BAFTA trial and were not taking warfarin throughout or for part of the study period.Events rates of stroke and thromboembolism.54 (8%) patients had an ischaemic stroke, four (0.6%) had a systemic embolism, and 13 (2%) had a transient ischaemic attack. The distribution of patients classified into the three risk categories (low, moderate, high) was similar across three of the risk stratification scores (revised CHADS(2), NICE, ACC

Full Text available with Trip Pro

2011 BMJ

183. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. (PubMed)

Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. The use of warfarin reduces the rate of ischemic stroke in patients with atrial fibrillation but requires frequent monitoring and dose adjustment. Rivaroxaban, an oral factor Xa inhibitor, may provide more consistent and predictable anticoagulation than warfarin.In a double-blind trial, we randomly assigned 14,264 patients with nonvalvular atrial fibrillation who were at increased risk for stroke to receive either rivaroxaban (...) (at a daily dose of 20 mg) or dose-adjusted warfarin. The per-protocol, as-treated primary analysis was designed to determine whether rivaroxaban was noninferior to warfarin for the primary end point of stroke or systemic embolism.In the primary analysis, the primary end point occurred in 188 patients in the rivaroxaban group (1.7% per year) and in 241 in the warfarin group (2.2% per year) (hazard ratio in the rivaroxaban group, 0.79; 95% confidence interval [CI], 0.66 to 0.96; P<0.001 for noninferiority

Full Text available with Trip Pro

2011 NEJM

184. Apixaban versus warfarin in patients with atrial fibrillation. (PubMed)

Apixaban versus warfarin in patients with atrial fibrillation. Vitamin K antagonists are highly effective in preventing stroke in patients with atrial fibrillation but have several limitations. Apixaban is a novel oral direct factor Xa inhibitor that has been shown to reduce the risk of stroke in a similar population in comparison with aspirin.In this randomized, double-blind trial, we compared apixaban (at a dose of 5 mg twice daily) with warfarin (target international normalized ratio, 2.0 (...) , as compared with 1.60% per year in the warfarin group (hazard ratio with apixaban, 0.79; 95% confidence interval [CI], 0.66 to 0.95; P<0.001 for noninferiority; P=0.01 for superiority). The rate of major bleeding was 2.13% per year in the apixaban group, as compared with 3.09% per year in the warfarin group (hazard ratio, 0.69; 95% CI, 0.60 to 0.80; P<0.001), and the rates of death from any cause were 3.52% and 3.94%, respectively (hazard ratio, 0.89; 95% CI, 0.80 to 0.99; P=0.047). The rate

2011 NEJM

185. Randomised controlled trial: In people with atrial fibrillation unsuitable for warfarin, apixaban reduces the risk of stroke compared with aspirin, with no difference in major bleeding

Randomised controlled trial: In people with atrial fibrillation unsuitable for warfarin, apixaban reduces the risk of stroke compared with aspirin, with no difference in major bleeding In people with atrial fibrillation unsuitable for warfarin, apixaban reduces the risk of stroke compared with aspirin, with no difference in major bleeding | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via (...) for warfarin, apixaban reduces the risk of stroke compared with aspirin, with no difference in major bleeding Article Text Therapeutics Randomised controlled trial In people with atrial fibrillation unsuitable for warfarin, apixaban reduces the risk of stroke compared with aspirin, with no difference in major bleeding Renato D Lopes 1 , David A Garcia 2 Statistics from Altmetric.com Commentary on: Connolly SJ , Eikelboom J , Joyner C , et al . Apixaban in patients with atrial fibrillation. Context Atrial

2011 Evidence-Based Medicine (Requires free registration)

186. Cost-Effectiveness of Dabigatran Compared With Warfarin for Stroke Prevention in Atrial Fibrillation. (PubMed)

Cost-Effectiveness of Dabigatran Compared With Warfarin for Stroke Prevention in Atrial Fibrillation. Warfarin reduces the risk for ischemic stroke in patients with atrial fibrillation (AF) but increases the risk for hemorrhage. Dabigatran is a fixed-dose, oral direct thrombin inhibitor with similar or reduced rates of ischemic stroke and intracranial hemorrhage in patients with AF compared with those of warfarin.To estimate the quality-adjusted survival, costs, and cost-effectiveness (...) of dabigatran compared with adjusted-dose warfarin for preventing ischemic stroke in patients 65 years or older with nonvalvular AF.Markov decision model.The RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial and other published studies of anticoagulation. The cost of dabigatran was estimated on the basis of pricing in the United Kingdom.Patients aged 65 years or older with nonvalvular AF and risk factors for stroke (CHADS₂ score ≥1 or equivalent) and no contraindications

2010 Annals of Internal Medicine

187. Cytochrome P450 gene test to establish the correct warfarin dose in patients requiring oral anti-coagulant therapyCytochrome P450 gene test to establish the correct warfarin dose in patients requiring oral anti-coagulant therapy

Cytochrome P450 gene test to establish the correct warfarin dose in patients requiring oral anti-coagulant therapyCytochrome P450 gene test to establish the correct warfarin dose in patients requiring oral anti-coagulant therapy Horizon Scanning Technology Prioritising Summary Cytochrome P450 gene test to establish the correct warfarin dose in patients requiring oral anti-coagulant therapy March 2010 2 Genetic test for correct warfarin dose: April 2010 © Commonwealth of Australia 2010 ISBN (...) . This Horizon scanning prioritising summary was prepared by Linda Mundy and Professor Janet Hiller from the National Horizon Scanning Unit, Adelaide Health Technology Assessment, Discipline of Public Health, School of Population Health and Clinical Practice, Mail Drop DX 650 545, University of Adelaide, Adelaide, SA, 5005. Genetic test for correct warfarin dose: April 2010 1 PRIORITISING SUMMARY REGISTER ID: 000439 NAME OF TECHNOLOGY: CYTOCHROME P450 GENE TEST PURPOSE AND TARGET GROUP: TO ESTABLISH

2010 Australia and New Zealand Horizon Scanning Network

188. Fibrate/statin initiation in warfarin users and gastrointestinal bleeding risk (PubMed)

Fibrate/statin initiation in warfarin users and gastrointestinal bleeding risk To evaluate whether initiation of a fibrate or statin increases the risk of hospitalization for gastrointestinal bleeding in warfarin users.We used Medicaid claims data (1999-2003) to perform an observational case-control study nested within person-time exposed to warfarin in those > or =18 years (n=353,489). Gastrointestinal bleeding cases were matched to 50 controls based on index date and state.Chronic warfarin

Full Text available with Trip Pro

2010 EvidenceUpdates

189. Morbidity and Mortality With Warfarin Therapy Use in Elderly Patients With Atrial Fibrillation: A Systematic Review

Morbidity and Mortality With Warfarin Therapy Use in Elderly Patients With Atrial Fibrillation: A Systematic Review "Morbidity and Mortality With Warfarin Therapy Use in Elderly Patients " by Kristi M. Crowell < > > > > > Title Author Date of Graduation 8-14-2010 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Mark Pedemonte, MD Second Advisor Annjanette Sommers MS, PAC Third Advisor Rob Rosenow PharmD, OD Rights . Abstract Background (...) : Atrial fibrillation (AF) is the most common dysrhythmia among elderly patients. A co-morbidity associated with this disease process is embolic stroke. In an effort to reduce the potential morbidity and mortality associated with stroke, patients are often placed on the anticoagulant warfarin. While warfarin has been statistically proven to reduce the rate of embolic stroke in patients with AF, it potentiates increased risk of bleeding. The elderly population has an elevated level of AF and increased

2010 Pacific University EBM Capstone Project

190. Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. (PubMed)

Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. Effectiveness and safety of warfarin is associated with the time in therapeutic range (TTR) with an international normalised ratio (INR) of 2·0-3·0. In the Randomised Evaluation of Long-term Anticoagulation Therapy (RE-LY) trial, dabigatran versus warfarin reduced both stroke and haemorrhage. We aimed (...) to investigate the primary and secondary outcomes of the RE-LY trial in relation to each centre's mean TTR (cTTR) in the warfarin population.In the RE-LY trial, 18 113 patients at 951 sites were randomly assigned to 110 mg or 150 mg dabigatran twice daily versus warfarin dose adjusted to INR 2·0-3·0. Median follow-up was 2·0 years. For 18 024 patients at 906 sites, the cTTR was estimated by averaging TTR for individual warfarin-treated patients calculated by the Rosendaal method. We compared the outcomes

2010 Lancet

191. Cytochrome P450 gene test to establish the correct warfarin dose in patients requiring oral anti-coagulant therapy

Cytochrome P450 gene test to establish the correct warfarin dose in patients requiring oral anti-coagulant therapy Cytochrome P450 gene test to establish the correct warfarin dose in patients requiring oral anti-coagulant therapy Cytochrome P450 gene test to establish the correct warfarin dose in patients requiring oral anti-coagulant therapy Mundy L, Hiller JE Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation Mundy L, Hiller JE. Cytochrome P450 gene test to establish the correct warfarin dose in patients requiring oral anti-coagulant therapy. Adelaide: Adelaide Health Technology Assessment (AHTA). Horizon Scanning Prioritising Summary Volume 26. 2010 Authors' conclusions Polymerase chain reaction is an accurate means of identifying genetic mutations. All techniques discussed in this summary use PCR and other molecular techniques

2010 Health Technology Assessment (HTA) Database.

192. Modeling the cost-effectiveness of prothrombin complex concentrate compared with fresh frozen plasma in emergency warfarin reversal in the United Kingdom

Modeling the cost-effectiveness of prothrombin complex concentrate compared with fresh frozen plasma in emergency warfarin reversal in the United Kingdom Modeling the cost-effectiveness of prothrombin complex concentrate compared with fresh frozen plasma in emergency warfarin reversal in the United Kingdom Modeling the cost-effectiveness of prothrombin complex concentrate compared with fresh frozen plasma in emergency warfarin reversal in the United Kingdom Guest JF, Watson HG, Limaye S Record (...) Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study examined the cost-effectiveness of using prothrombin complex concentrate, compared with fresh frozen plasma, for emergency warfarin reversal in patients with a life-threatening

2010 NHS Economic Evaluation Database.

193. Warfarin vs. Aspirin For Atrial Fibrillation Stroke Prevention

Warfarin vs. Aspirin For Atrial Fibrillation Stroke Prevention Warfarin vs. Aspirin For Atrial Fibrillation Stroke Prevention – TheNNTTheNNT Oral anticoagulants versus antiplatelet agents in non-valvular atrial fibrillation for stroke prevention (and no prior stroke) 60 for prevented stroke In Summary, for those who took warfarin instead of aspirin (for 1.9 years): Benefits in NNT 98.8% saw no benefit 1.6% were helped by preventing 1 stroke 0.3% were helped by avoiding a systemic embolism 1 (...) . The overall risk of stroke ranges from 2.5% to 4% per year. Both anti-platelet agents and oral anticoagulants reduce this risk, but both also increase the risk of hemorrhagic stroke and other bleeding. The review compared anti-platelet agents to anticoagulants in patients with atrial fibrillation but no history of stroke or transient ischemic attack. Eight randomized trials with 9598 subjects were included, with most examining warfarin versus aspirin (75 to 325 mg/day). The target INR range for subjects

2010 theNNT

194. Warfarin for Atrial Fibrillation Stroke Prevention

Warfarin for Atrial Fibrillation Stroke Prevention Warfarin for Atrial Fibrillation Stroke Prevention – TheNNTTheNNT Oral anticoagulants in non-valvular atrial fibrillation for primary stroke prevention (no prior stroke) 25 for prevented stroke In Summary, for those who took the warfarin (for 1.5 years): Benefits in NNT 96% saw no benefit 4% were helped by preventing 1 stroke 2.4% were helped by avoiding death 1 in 25 were helped (preventing stroke ) 1 in 42 were helped (preventing death from (...) factor for strokes. The overall risk ranges from 2.5% to 4% per year. Oral anticoagulants (OAC) reduce this risk, but also increase the risk of hemorrhagic stroke and major bleeding. The review compared warfarin with placebo for prevention of stroke in patients with atrial fibrillation but no history of strokes (or transient ischemic attacks). Five high quality trials with 2313 participant were included, most examining warfarin versus placebo. The warfarin group achieved a mean INR between 2.0

2010 theNNT

195. Uninterrupted warfarin for periprocedural anticoagulation in catheter ablation of typical atrial flutter: a safe and cost-effective strategy

Uninterrupted warfarin for periprocedural anticoagulation in catheter ablation of typical atrial flutter: a safe and cost-effective strategy Uninterrupted warfarin for periprocedural anticoagulation in catheter ablation of typical atrial flutter: a safe and cost-effective strategy Uninterrupted warfarin for periprocedural anticoagulation in catheter ablation of typical atrial flutter: a safe and cost-effective strategy Finlay M, Sawhney V, Schilling R, Thomas G, Duncan E, Hunter R, Virdi G (...) , Abrams D, Sporton S, Dhinoja M, Earley M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The objective was to examine the clinical and economic impact of warfarin versus heparin for patients undergoing catheter ablation for typical atrial

2010 NHS Economic Evaluation Database.

196. Long-term effect of chronic oral anticoagulation with warfarin after acute myocardial infarction

Long-term effect of chronic oral anticoagulation with warfarin after acute myocardial infarction Long-term effect of chronic oral anticoagulation with warfarin after acute myocardial infarction Long-term effect of chronic oral anticoagulation with warfarin after acute myocardial infarction Haq SA, Heitner JF, Sacchi TJ, Brener SJ CRD summary This review concluded that long-term oral anticoagulation with warfarin did not reduce mortality or reinfarction after myocardial infarction, although (...) there was a significantly higher rate of bleeding balanced by a reduction in the rate of stroke. These conclusions follow from the presented evidence but, given limitations in the conduct and reporting of the review, they may not be reliable. Authors' objectives To evaluate the risk and benefit of long-term oral anticoagulation with warfarin after myocardial infarction. Searching PubMed and Ovid SR were searched for relevant evidence published in any language. Search terms were reported, but search dates were

2010 DARE.

197. A policy model to evaluate the benefits, risks and costs of warfarin pharmacogenomic testing

A policy model to evaluate the benefits, risks and costs of warfarin pharmacogenomic testing A policy model to evaluate the benefits, risks and costs of warfarin pharmacogenomic testing A policy model to evaluate the benefits, risks and costs of warfarin pharmacogenomic testing Meckley LM, Gudgeon JM, Anderson JL, Williams MS, Veenstra DL Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study examined the cost-effectiveness of genetic testing to adjust the warfarin dose, using a model based on the international normalised ratio, for patients with atrial fibrillation who had just started long-term warfarin therapy. The authors concluded that warfarin pharmacogenomic testing provided some clinical benefit, but with significant

2010 NHS Economic Evaluation Database.

198. Effectiveness of pharmacist-participated warfarin therapy management: a systematic review and meta-analysis

Effectiveness of pharmacist-participated warfarin therapy management: a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

199. The net clinical benefit of warfarin anticoagulation in atrial fibrillation. (PubMed)

The net clinical benefit of warfarin anticoagulation in atrial fibrillation. Guidelines recommend warfarin use in patients with atrial fibrillation solely on the basis of risk for ischemic stroke without antithrombotic therapy. These guidelines rely on ischemic stroke rates observed in older trials and do not explicitly account for increased risk for hemorrhage.To quantify the net clinical benefit of warfarin therapy in a cohort of patients with atrial fibrillation.Mixed retrospective (...) prevented by warfarin minus intracranial hemorrhages attributable to warfarin, multiplied by an impact weight. The base-case impact weight was 1.5, reflecting the greater clinical impact of intracranial hemorrhage versus thromboembolism.Patients accumulated more than 66 000 person-years of follow-up. The adjusted net clinical benefit of warfarin for the cohort overall was 0.68% per year (95% CI, 0.34% to 0.87%). Adjusted net clinical benefit was greatest for patients with a history of ischemic stroke

Full Text available with Trip Pro

2009 Annals of Internal Medicine

200. Should we be applying warfarin pharmacogenetics to clinical practice? No, not now. (PubMed)

Should we be applying warfarin pharmacogenetics to clinical practice? No, not now. The U.S. Food and Drug Administration modified warfarin labeling in 2007 to suggest, but not mandate, pharmacogenetic testing. Genetic analysis is now commercially available. However, results predict only one third of all dosing variation, the value of testing in reducing bleeding and thrombosis rates remains unproved, and cost-effectiveness is not established. Careful consideration of clinical factors (...) that influence dosing, conscientious prothrombin time monitoring, and sage dosage adjustment remain paramount in warfarin management. Further study is required before routine warfarin pharmacogenetic testing can be recommended.

2009 Annals of Internal Medicine