mucositis cancer ozono
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- Answered 3 Sep 2019 Conflict of interest declaration: None Q re-worded to "Is ozone effective in the treatment of oral mucositis?" (after correspondence with the initial question asker)! We found very little on this topic, certainly nothing to instil confidence in it as an intervention! A 2013 paper “The effect of subgingival ozone and/or hydrogen peroxide on the development of peri-implant mucositis: a double-blind randomized controlled trial”  reported on a small trial (20 subjects and 80 implants) and concluded: “Ozone showed great potential for management of peri-implant mucositis.” We also found a 2011 case study “Gaseous and Aqueous Ozone Therapy for Treatment of Mucositis Secondary to Chemotherapy/Radiotherapy: A Case Report” which we highlight due to its relevance . A 2013 paper “Ozone applications in dentistry: an overview”  reports: “Ozone could also help in healing wounds, treatment of radiation-induced mucositis and osteoradionecrosis by increasing the blood supply and through modulation of inflammatory mediators. Despite of these advantages, therapeutic ozone’s application in dentistry is limited because of its possible side effects on upper respiratory system.” We found two reviews [4, 5] both of which give ambiguous support for ozone. References 1) https://www.ncbi.nlm.nih.gov/pubmed/24278915 2) https://www.stardent.fr/attachments/057_Ozone%20and%20Mucositis%20(2).pdf 3) http://eprints.manipal.edu/136604/ 4) https://www.sciencedirect.com/science/article/pii/S2352003516300260#b0245 5) http://www.aihbonline.com/article.asp?issn=2321-8568;year=2016;volume=6;issue=2;spage=66;epage=72;aulast=Gholizadeh#ref26