What is the evidence for vitamin B6 in premenstrual syndrome?Original question: P-5-P for treating PMS
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- Answered 28 Oct 2019 Conflict of interest declaration: None It appears P-5-P is Pyridoxal 5 Phosphate which appears to be the active form of vitamin B6 . I am unsure what the difference is between P-5-P and vitamin B6 so searched for them both . CKS have a very recent guideline on PMS  and this reports: “Advise that there is limited evidence to support the use of complementary treatments and dietary supplements, including reflexology, acupuncture, calcium and vitamin D, ginkgo biloba, evening primrose oil, vitamin B6, and magnesium.” They later report “Mixed results for vitamin B6, magnesium, isoflavones, and St John’s Wort” and reference the 2016 RCOG guideline “Management of premenstrual syndrome” . Within that guideline they list vitamin B6 as a first line treatment. In 2017 JBI conducted the systematic review “The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review”  which reported: “The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review” I also found two – small trials – published from 2016 which I include for interest [6, 7] References 1) https://en.wikipedia.org/wiki/Pyridoxal_phosphate 2) https://www.tripdatabase.com/search?criteria=premenstrual+syndrome+AND+%28pyridoxal+OR+%22vitamin+B6%22%29 3) https://cks.nice.org.uk/premenstrual-syndrome#!scenario 4) https://www.rcog.org.uk/globalassets/documents/guidelines/gt48managementpremensturalsyndrome.pdf 5) https://www.ncbi.nlm.nih.gov/pubmed/28178022 6) https://www.ncbi.nlm.nih.gov/pubmed/29033988 7) https://www.ncbi.nlm.nih.gov/pubmed/26989667