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Latest & greatest articles for acetaminophen
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Single dose dextropropoxyphene, alone and with paracetamol (acetaminophen), for postoperative pain. Patient surveys have shown that postoperative pain is often not managed well, and there is a need to assess the efficacy and safety of commonly used analgesics as newer treatments become available. Dextropropoxyphene is one example of an opioid analgesic in current use, and is widely prescribed for pain relief in combination with paracetamol under names such as Co-proxamol and Distalgesic.To (...) determine the analgesic efficacy and adverse effects of single dose oral Dextropropoxyphene alone and in combination with paracetamol (acetaminophen) for moderate to severe postoperative pain.Published reports were identified from: Medline (1966 - November 1996), Biological Abstracts (1985 - 1996), Embase (1980 - 1996), the Cochrane Library (Issue 4 1996), and the Oxford Pain Relief Database (1954 - 1994). Additional studies were identified from the reference lists of retrieved reports. Date of the most
Single dose paracetamol (acetaminophen), with and without codeine, for postoperative pain. Patient surveys have shown that postoperative pain is often not managed well, and there is a need to assess the efficacy and safety of commonly used analgesics as newer treatments become available. Paracetamol (acetaminophen) is an important non-opiate analgesic, commonly prescribed, as well as being available for retail sale. This review seeks to examine the efficacy of paracetamol alone (...) and in combination with codeine, and also considers adverse effects.To assess the analgesic efficacy and adverse effects of a single dose of oral paracetamol (acetaminophen) alone and in combination with codeine for moderate to severe postoperative pain.Published trials were identified from: Medline (1966 to May 1996), Embase (1980 to 1996), Cochrane Library (Issue 2 1996) and the Oxford Pain Relief Database (1950 to 1994). Additional trials were identified from reference lists of retrieved studies. Date of most
Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review Dart R C, Kuffner E K, Rumack B H Authors' objectives To evaluate whether the administration of therapeutic doses of paracetamol cause hepatic injury in the alcoholic patient (...) with long-term use of non-steroidal anti-inflammatory agents. Research: The authors did not state any implications for further research. Bibliographic details Dart R C, Kuffner E K, Rumack B H. Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. American Journal of Therapeutics 2000; 7(2): 123-134 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Acetaminophen /adverse effects; Alcoholism /complications; Analgesics, Non-Narcotic
Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria. Routine antipyretic therapy in children with infectious diseases has long been the source of controversy. Each year, in addition to antimalarial medication, millions of children with Plasmodium falciparum malaria receive paracetamol to reduce fever. However, the usefulness of this practice has not been proven.In a randomised trial in Lambaréné, Gabon, 50 children with P falciparum malaria were treated (...) with intravenous quinine, and received either mechanical antipyresis alone, or in combination with paracetamol. Rectal body temperature and parasitaemia were recorded every 6 h for 4 days. Plasma concentrations and inducible concentrations of tumour necrosis factor (TNF) and interleukin-6 were measured every 24 h. In addition, production of oxygen radicals was measured in both groups.The mean fever clearance time was 32 h for children treated with paracetamol and 43 h for those who received mechanical
. Bibliographic details Li Wan Po A, Zhang W Y. Systematic overview of co-proxamol to assess analgesic effects of addition of dextropropoxyphene to paracetamol. BMJ 1997; 315: 1565-1571 PubMedID Original Paper URL Other publications of related interest DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88. Indexing Status Subject indexing assigned by NLM MeSH Acetaminophen /adverse effects /therapeutic use; Analgesics, Non-Narcotic /adverse effects /therapeutic use (...) Systematic overview of co-proxamol to assess analgesic effects of addition of dextropropoxyphene to paracetamol Systematic overview of co-proxamol to assess analgesic effects of addition of dextropropoxyphene to paracetamol Systematic overview of co-proxamol to assess analgesic effects of addition of dextropropoxyphene to paracetamol Li Wan Po A, Zhang W Y Authors' objectives To evaluate the comparative efficacy and tolerability of paracetamol-dextropropoxyphene combination and paracetamol
searched: MEDLINE from 1966 to May 1996, EMBASE from 1980 to 1996, the Cochrane Library (March 1996), and the Oxford Pain Relief Database from 1950 to 1994. The words 'paracetamol', 'acetaminophen' and 'trial' were used in a free text search for studies published in any language. Additional reports were identified from reference lists of retrieved articles, review articles and textbooks. Neither pharmaceutical companies nor authors of papers were contacted for unpublished reports. Abstracts and review (...) Paracetamol with and without codeine in acute pain: a quantitative systematic review Paracetamol with and without codeine in acute pain: a quantitative systematic review Paracetamol with and without codeine in acute pain: a quantitative systematic review Moore A, Collins S, Carroll D, McQuay H Authors' objectives To assess the analgesic effect obtained from single oral doses of paracetamol alone, and in combination with codeine, in post-operative pain. Searching The following sources were
Analgesic efficacy of paracetamol and its combination with codeine and caffeine in surgical pain: a meta-analysis Analgesic efficacy of paracetamol and its combination with codeine and caffeine in surgical pain: a meta-analysis Analgesic efficacy of paracetamol and its combination with codeine and caffeine in surgical pain: a meta-analysis Zhang W Y, Li Wan Po A Authors' objectives To quantify the analgesic efficacy of paracetamol and its combination with codeine or caffeine. Searching MEDLINE (...) (RCTs) were included. Specific interventions included in the review Paracetamol, codeine and caffeine. Participants included in the review Partici[ants were in the age range 13 to 87 years with a mean weight ranging from 46 to 81 kg. All had severe pain before taking the study drug or placebo (mean baseline pain score 0.54 to 0.87%); pain could originate from episiotomy, postpartum uterine cramp, dental or miscellaneous post-operative pain. Outcomes assessed in the review Total pain relief (TOTPAR
Craen A J, Di Giulio G, Lampe-Schoenmaechers A J, Kessels A G, Kleijnen J. Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic review. BMJ 1996; 313: 321-325 PubMedID Original Paper URL Other publications of related interest DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88. Indexing Status Subject indexing assigned by NLM MeSH Acetaminophen /administration & Analgesia; Analgesics /administration (...) Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic review Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic review Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic review de Craen A J, Di Giulio G, Lampe-Schoenmaechers A J, Kessels A G, Kleijnen J Authors' objectives To assess the safety and analgesic effects of paracetamol plus
n of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis. To evaluate the efficacy of paracetamol and a non-steroidal anti-inflammatory drug for symptom relief in osteoarthritis.Double blind, randomised, controlled trials in individual patients (n of 1 trials). Three treatment cycles with two weeks' each of paracetamol (1 g twice daily) and diclofenac (50 mg twice daily) prepared in identical gelatin capsules.General practices in metropolitan Sydney (...) of the 20 patients found no clear difference, symptoms being adequately controlled by paracetamol; five indicated a clear preference for the non-steroidal anti-inflammatory drug; two showed control of symptoms after their initial two weeks of the non-steroidal anti-inflammatory drug which continued throughout subsequent treatment changes; in five the non-steroidal anti-inflammatory drug may have been better but neither agent gave satisfactory control. After three months nine of the 20 patients had
Acetaminophen ingestion in childhood: cost and relative risk of alternative referral strategies Acetaminophen ingestion in childhood: cost and relative risk of alternative referral strategies Acetaminophen ingestion in childhood: cost and relative risk of alternative referral strategies Bond G R, Krenzelok E P, Normann S A, Tendler J D, Morriskukoski C L, Mccoy D J,Thompson M W, McCarthy T, Roblez J, Taylor C, Dolan M A, Requa R K, Curry S C Record Status This is a critical abstract (...) of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Management of acetaminophen ingestion in childhood. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Children who ingested acetaminophen, aged one to six years and referred
Risks and benefits of paracetamol antipyresis in young children with fever of presumed viral origin. To examine whether antipyretic therapy in young children is associated with potential risks (interference with enhanced host defences at febrile temperatures) or benefits (improved comfort and behaviour), a randomised, double-blind, placebo-controlled trial of paracetamol was conducted among 225 children 6 months to 6 years of age who presented with acute (less than or equal to 4 days) fever (...) (greater than or equal to 38 degrees C per rectum) without evident bacterial focus of infection. Parents were asked to give paracetamol liquid 10-15 mg/kg or placebo every 4 h as needed for fever and to avoid bathing, sponging, or other pharmacological agents. Parents kept temperature and symptom diaries and recorded changes in child comfort and behaviour according to a pretested, 5-category Likert-type questionnaire 1-2 h after every dose. There were no significant differences between treated
1991LancetControlled trial quality: predicted high
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. The optimal short-term, symptomatic therapy for osteoarthritis of the knee has not been fully determined. Accordingly, we compared the efficacy of a nonsteroidal antiinflammatory drug, ibuprofen, given in either an antiinflammatory dose (high dose) or an analgesic dose (low dose), with that of acetaminophen, a pure analgesic.In (...) a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day. They were evaluated after a washout period of three to seven days before the beginning of the study, and again after four weeks of treatment. The major measures of outcome included scores on the pain and disability scales of the Stanford Health Assessment Questionnaire (range of possible scores, 0 to 3), scores on the visual
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. To see whether intravenous acetylcysteine would improve outcome in patients with fulminant hepatic failure after paracetamol overdose.A prospective randomised controlled study.The Institute of Liver Studies, King's College Hospital, London.50 consecutive patients (21 male) aged 16-60 with fulminant hepatic failure after paracetamol overdose who had not previously received (...) acetylcysteine.Conventional intensive liver care plus either acetylcysteine (25 patients) in the same dose regimen as used early after a paracetamol overdose, except that the infusion was continued until recovery from encephalopathy or death, or an equivalent volume of 5% dextrose (25 patients).Survival; incidence of cerebral oedema, renal failure, and hypotension requiring inotropic support; liver function as assessed by prolongation of the prothrombin time; and degree of encephalopathy.The rate of survival
Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol. To determine the part played by altered gastric emptying in the modification of glucose absorption by gel fibres, glucose tolerance tests were done in seven healthy volunteers with and without the addition of pectin to the ingested glucose solution and after pharmacological inhibition of gastric emptying with propantheline. Compared with the controls, pectin significantly reduced blood-glucose. Propantheline had (...) a similar but more pronounced effect. Pectin and guar gum did not substantially alter glucose tolerance in a patient who had had total gastrectomy. In a further investigation, gastric emptying and paracetamol absorption were studied simultaneously in fourteen subjects. In eight of these the study was repeated after addition of guar gum and pectin to the ingested paracetamol. Both gastric emptying and paracetamol absorption were slower after gel fibre but the total absorption of the drug, reflected
Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. The feasibility of determining the exact site and amount of drug-induced gastric bleeding was tested. Fourteen patients with rheumatoid arthritis received equivalent therapeutic doses of the antinflammatory drugs aspirin, 4 gm/day, and fenoprofen calcium, 2.4 gm/day, in randomized order for seven days. Acetaminophen (...) was given for 14 days just prior to each of these periods. By fiberoptic gastroscopy, antral ulceration and acute mucosal lesions were found in seven patients following aspirin ingestion, in one taking fenoprofen, and in none taking acetaminophen. Fecal blood loss in four-day stool collections, quantitated by autologous chromium 51-labeled erythrocytes shed into the stool averaged 5.0 ml/day while taking aspirin, 2.2 ml/day while taking fenoprofen calcium, and 0.8 ml/day while taking acetaminophen
Controlled trial of cysteamine in treatment of acute paracetamol (acetaminophen) poisoning. A randomised controlled trial of the use of intravenous cysteamine in the treatment of severe paracetamol poisoning has been performed. Thirty-eight patients presenting 3-17 h after ingestion were admitted to the trial; of these eighteen received cysteamine. Two patients died from hepatic failure, one in each treatment group. Analysis of the series as a whole showed no advantage of cysteamine (...) in preventing biochemical abnormalities of liver function except for aspartate aminotranferase and serum ferritin levels, which were significantly less after cysteamine therapy. Separate analysis of the patients treated within 9 h of paractamol ingestion and of those treated 9-17 h after paracetamol ingesion similarly showed no definite advantage of cysteamine. Histological evidence of liver damage showed a possible beneficial effect of cysteamine. Cysteamine therapy did not prevent renal or pancreatic