Latest & greatest articles for acetaminophen

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Top results for acetaminophen

21. Randomized Clinical Trial of Intravenous Acetaminophen as an Analgesic Adjunct for Older Adults With Acute Severe Pain (Abstract)

Randomized Clinical Trial of Intravenous Acetaminophen as an Analgesic Adjunct for Older Adults With Acute Severe Pain Older adults are at risk for undertreatment of pain. We examined intravenous (IV) acetaminophen as an analgesic adjunct to IV opioids in the care of older emergency department (ED) patients with acute severe pain.This was a randomized clinical trial conducted in two EDs in the Bronx, New York. Eligible adults aged 65 years and older with acute severe pain were randomized to 0.5 (...) mg of IV hydromorphone and 1 g of IV acetaminophen or 0.5 mg of IV hydromorphone and 100 mL of normal saline placebo. The primary outcome was the between group difference in improvement of numerical rating scale (NRS) pain scores at 60 minutes. Secondary outcomes were the between-group differences in the proportion of patients who chose to forgo additional pain medications at 60 minutes; the proportion who developed side effects; the proportion who required rescue analgesia; and between-group

2019 EvidenceUpdates

22. Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand

Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand | The Medical Journal of Australia search Use the for more specific terms. Title contains Body contains Date range from Date range to Article type Author's surname Volume First page doi: 10.5694/mja__.______ Search Reset  close Individual Login Purchase options Connect person_outline Login keyboard_arrow_down (...) Individual Login Purchase options menu search Article types Advertisement close Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand Angela L Chiew, David Reith, Adam Pomerleau, Anselm Wong, Katherine Z Isoardi, Jessamine Soderstrom and Nicholas A Buckley Med J Aust 2020; 212 (4): . || doi: 10.5694/mja2.50428 Published online: 2 December 2019 Topics Abstract Introduction: Paracetamol is a common agent taken in deliberate self‐poisoning and in accidental overdose

2019 MJA Clinical Guidelines

23. Acetaminophen and Febrile Seizure Recurrences During the Same Fever Episode Full Text available with Trip Pro

Acetaminophen and Febrile Seizure Recurrences During the Same Fever Episode To confirm the safety of using acetaminophen for febrile seizures (FSs) and to assess its efficacy in preventing FS recurrence during the same fever episode.In this single-center, prospective, open, randomized controlled study, we included children and infants (age range: 6-60 months) with FSs who visited our hospital between May 1, 2015, and April 30, 2017. The effectiveness of acetaminophen was examined by comparing (...) the recurrence rates of patients in whom rectal acetaminophen (10 mg/kg) was administered every 6 hours until 24 hours after the first convulsion (if the fever remained >38.0°C) to the rates of patients in whom no antipyretics were administered. No placebo was administered to controls. The primary outcome measure was FS recurrence during the same fever episode.We evaluated 423 patients; of these, 219 were in the rectal acetaminophen group, and 204 were in the no antipyretics group. In the univariate analysis

2018 EvidenceUpdates

24. Randomized Controlled Trial of Intravenous Acetaminophen Versus Intravenous Hydromorphone for the Treatment of Acute Pain in the Emergency Department Full Text available with Trip Pro

Randomized Controlled Trial of Intravenous Acetaminophen Versus Intravenous Hydromorphone for the Treatment of Acute Pain in the Emergency Department As clinicians look to nonnarcotic analgesics in the emergency department (ED), it is essential to understand the effectiveness and adverse effects of nonopioid medications in comparison with existing opioid treatments. Studies of intravenous acetaminophen for acute pain in the ED demonstrate mixed results and suffer from small sample sizes (...) and methodological limitations. This study compares intravenous hydromorphone with intravenous acetaminophen in adult ED patients presenting with acute pain.This was a prospective, randomized, clinical trial comparing 1 g intravenous acetaminophen with 1 mg intravenous hydromorphone for treatment of adults with severe, acute pain in the ED. The primary outcome was between-group difference in change in numeric rating scale from baseline to 60 minutes postadministration of study medication. Secondary outcomes

2018 EvidenceUpdates

25. Paracetamol overdose

. The definition of hepatotoxicity after paracetamol overdose is a serum AST concentration at least 1000 IU/L. Paracetamol is known as acetaminophen in some countries. History and exam attempted self-harm repeated non-prescription analgesic use for pain relief asymptomatic presentation nausea, vomiting, or abdominal pain right upper quadrant pain and tenderness jaundice confusion, decreased consciousness level, and/or asterixis history of self-harm history of frequent or repeated use of medications for pain (...) Paracetamol overdose Paracetamol overdose - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Paracetamol overdose Last reviewed: February 2019 Last updated: September 2018 Summary Overdose may occur after an acute single ingestion of a large amount of paracetamol or paracetamol-containing medication, or repeated ingestion of an amount exceeding recommended dosage. Patients are often asymptomatic or have only mild

2018 BMJ Best Practice

26. Acetaminophen

of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Top results for acetaminophen 1. Paracetamol ( acetaminophen ) for patent ductus arteriosus in preterm or low birth weight infants. BACKGROUND: In preterm newborns, the ductus arteriosus frequently fails to close and the infants require medical or surgical closure of the patent ductus arteriosus (PDA). A PDA can be treated surgically; or medically with one of two prostaglandin inhibitors, indomethacin (...) of an echocardiographically diagnosed PDA in preterm or low birth weight infants. SEARCH METHODS: We used the standard search strategy 2018 2. 400 mg Ibuprofen/1000 mg Acetaminophen ( Paracetamol ) Is Suggested Effective Dosage for Ibuprofen/ Acetaminophen Combination Therapy in Postoperative Pain Reduction UTCAT2994, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title 400 mg Ibuprofen/1000 mg Acetaminophen ( Paracetamol ) Is Suggested Effective

2018 Trip Latest and Greatest

27. Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial (Abstract)

Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial Nonsteroidal antiinflammatory drug use has been shown to increase blood pressure in nonpregnant adults. Because of this, the American College of Obstetricians and Gynecologists suggests avoiding their use in women with postpartum hypertension; however, evidence to support this recommendation is lacking.Our goal was to test the hypothesis (...) that nonsteroidal antiinflammatory drugs, such as ibuprofen, adversely affect postpartum blood pressure control in women with preeclampsia with severe features.At delivery, we randomized women with preeclampsia with severe features to receive around-the-clock oral dosing with either 600 mg of ibuprofen or 650 mg of acetaminophen every 6 hours. Dosing began within 6 hours after delivery and continued until discharge, with opioid analgesics available as needed for breakthrough pain. Study drugs were encapsulated

2018 EvidenceUpdates

28. Intravenous acetaminophen for postoperative supratentorial craniotomy pain: a prospective, randomized, double-blinded, placebo-controlled trial Full Text available with Trip Pro

Intravenous acetaminophen for postoperative supratentorial craniotomy pain: a prospective, randomized, double-blinded, placebo-controlled trial Acute pain control after cranial surgery is challenging. Prior research has shown that patients experience inadequate pain control post-craniotomy. The use of oral medications is sometimes delayed because of postoperative nausea, and the use of narcotics can impair the evaluation of brain function and thus are used judiciously. Few nonnarcotic (...) intravenous (IV) analgesics exist. The authors present the results of the first prospective study evaluating the use of IV acetaminophen in patients after elective craniotomy.The authors conducted a randomized, double-blinded, placebo-controlled investigation. Adults undergoing elective, supratentorial craniotomies between September 2013 and June 2015 were randomized into two groups. The experimental group received 1000 mg/100 ml IV acetaminophen every 8 hours for 48 hours. The placebo group received 100

2018 EvidenceUpdates

29. Efficacy of Intravenous Acetaminophen in Periimplantation Pain of Cardiac Electronic Devices: A Randomized Double-Blinded Study. (Abstract)

Efficacy of Intravenous Acetaminophen in Periimplantation Pain of Cardiac Electronic Devices: A Randomized Double-Blinded Study. Although intravenous acetaminophen has been administered to reduce postoperative pain, it has not been used during cardiac implantable electronic devices (CIEDs) implantation.This was a randomized double-blinded interventional study.Thirty-two patients who were referred for new CIED implantation during July 2012 until April 2013 randomly received placebo or 1 g (...) of intravenous acetaminophen. All patients were treated with local anesthesia. Pain score during incision, pocket creation, and in the recovery room, and the patients' need for analgesics during the 6 hours after the procedure were recorded in both groups.Seventeen and 15 patients received acetaminophen and placebo, respectively. Pain scores in patients treated with acetaminophen were significantly lower (4.4 vs 2.9, P = .004), and they received less analgesics (17% vs 60%, P = .014).Intravenous

2018 Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses Controlled trial quality: uncertain

30. Preoperative cesarean delivery intravenous acetaminophen treatment for postoperative pain control: a randomized double-blinded placebo control trial (Abstract)

Preoperative cesarean delivery intravenous acetaminophen treatment for postoperative pain control: a randomized double-blinded placebo control trial The United States currently has an opioid use disorder epidemic and research evaluating ways to minimize the use of opioids postsurgery are needed. One of these options is intravenous acetaminophen. If the use of preoperative intravenous acetaminophen was found to be effective for cesarean delivery, this would be beneficial for both the mother (...) and breast-feeding neonate.The primary study objective was to see if maternal opioid use was significantly less in the postoperative period for the study group that received 1 g of intravenous acetaminophen preoperatively compared with a control group that received placebo. The secondary objectives were to evaluate maternal length of stay and pain scores postoperatively, and assess the acetaminophen level in cord blood at delivery.This study was a prospective double-blinded randomized placebo-controlled

2018 EvidenceUpdates

31. CRACKCast Episode 148 – Acetaminophen

CRACKCast Episode 148 – Acetaminophen CRACKCast Episode 148 - Acetaminophen - CanadiEM CRACKCast Episode 148 – Acetaminophen In , by Adam Thomas January 29, 2018 This 148th episode of CRACKCast covers Rosen’s 9th edition, Chapter 143, acetaminophen. Also known as paracetamol and Tylenol, you need to know this overdose cold! Shownotes – Rosen’s In Perspective YOU NEED TO KNOW THIS OVERDOSE COLD!!! Acetaminophen (aka paracetamol aka APAP) is ubiquitous. It’s hard to find a house these days (...) > 24hrs Chronic ingestion (ie over 8 hrs) Co-ingestions w/ drugs that affect gut motility (eg anticholinergics) Note: Use of extended release tablets = EXT Not a contraindication … just changes the way we use it… do 4 and 8 hour levels and watch for nomogram crossing. [2] Define a massive acetaminophen overdose and [2a] how does this affect the NAC protocol As seen on : Massive paracetamol Overdoses and when to give extra NAC: Massive paracetamol overdose is considered to be >500mg/kg or >30g total

2018 CandiEM

32. Emergency care: Combination of ibuprofen and acetaminophen is no different than low-dose opioid analgesic preparations in relieving short-term acute extremity pain Full Text available with Trip Pro

Emergency care: Combination of ibuprofen and acetaminophen is no different than low-dose opioid analgesic preparations in relieving short-term acute extremity pain Combination of ibuprofen and acetaminophen is no different than low-dose opioid analgesic preparations in relieving short-term acute extremity pain | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time (...) . To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Combination of ibuprofen and acetaminophen is no different than low-dose opioid

2018 Evidence-Based Medicine

33. Intravenous Acetaminophen for the Management of Short-Term Post-Operative Pain: A Review of Clinical Effectiveness and Cost-Effectiveness

Intravenous Acetaminophen for the Management of Short-Term Post-Operative Pain: A Review of Clinical Effectiveness and Cost-Effectiveness Intravenous Acetaminophen for the Management of Short-Term Post-Operative Pain: A Review of Clinical Effectiveness and Cost-Effectiveness | CADTH.ca Find the information you need Intravenous Acetaminophen for the Management of Short-Term Post-Operative Pain: A Review of Clinical Effectiveness and Cost-Effectiveness Intravenous Acetaminophen for the Management (...) of Short-Term Post-Operative Pain: A Review of Clinical Effectiveness and Cost-Effectiveness Last updated: October 12, 2018 Project Number: RC1023-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of intravenous acetaminophen for patients with post-operative pain? What is the cost-effectiveness of intravenous acetaminophen for patients with post-operative pain? Key Message Evidence identified from seven

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

34. Effect of Preemptive Acetaminophen Administered Within 1 Hour of General Anesthesia on Gastric Residual Volume and pH in Children. (Abstract)

Effect of Preemptive Acetaminophen Administered Within 1 Hour of General Anesthesia on Gastric Residual Volume and pH in Children. Determine whether preoperative oral acetaminophen increases gastric residual volume and lowers gastric pH.Prospective, randomized.Healthy children, 1 to 14 years, having elective magnetic resonance imaging (MRI) were randomized to oral acetaminophen within 1 hour of induction versus fasting. Gastric volume and pH were measured immediately after intubation. Adverse (...) events were documented from induction through 72 hours post MRI.Thirty-seven children completed the study (16 treatment, 21 control). Gastric residual volume between groups was not significantly different. The acetaminophen group had significantly higher pH than control group (1.86 ± 0.42 vs 1.56 ± 0.34; P ≤ .044). Three children in the control and 6 in the treatment group experienced minor adverse events.Findings suggest administering oral acetaminophen prior to induction of anesthesia

2018 Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses Controlled trial quality: uncertain

35. Paracetamol overdose

. The definition of hepatotoxicity after paracetamol overdose is a serum AST concentration at least 1000 IU/L. Paracetamol is known as acetaminophen in some countries. History and exam attempted self-harm repeated non-prescription analgesic use for pain relief asymptomatic presentation nausea, vomiting, or abdominal pain right upper quadrant pain and tenderness jaundice confusion, decreased consciousness level, and/or asterixis history of self-harm history of frequent or repeated use of medications for pain (...) Paracetamol overdose Paracetamol overdose - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Paracetamol overdose Last reviewed: February 2019 Last updated: September 2018 Summary Overdose may occur after an acute single ingestion of a large amount of paracetamol or paracetamol-containing medication, or repeated ingestion of an amount exceeding recommended dosage. Patients are often asymptomatic or have only mild

2018 BMJ Best Practice

38. Acetaminophen or Nonsteroidal Anti-Inflammatory Drugs in Acute Musculoskeletal Trauma: A Multicenter, Double-Blind, Randomized, Clinical Trial (Abstract)

Acetaminophen or Nonsteroidal Anti-Inflammatory Drugs in Acute Musculoskeletal Trauma: A Multicenter, Double-Blind, Randomized, Clinical Trial We determine whether pain treatment with acetaminophen was not inferior to nonsteroidal anti-inflammatory drugs or the combination of both in minor musculoskeletal trauma.The Paracetamol or NSAIDs in Acute Musculoskeletal Trauma Study was a double-blind, randomized, clinical trial conducted in 2 general practices and 2 emergency departments (...) in the Netherlands. A total of 547 adults, aged 18 years and older, with acute blunt minor musculoskeletal extremity trauma were randomly assigned in a 1:1:1 ratio to acetaminophen 4,000 mg/day, diclofenac 150 mg/day, or acetaminophen 4,000 mg/day+diclofenac 150 mg/day during 3 consecutive days. Patients, health care staff, and outcome assessors were blinded for treatment allocation. Follow-up for each patient was 30 days. Primary outcome measures were between-group differences in mean numeric rating scale (NRS

2017 EvidenceUpdates

39. Modified-release paracetamol-containing products to be suspended from EU market

Modified-release paracetamol-containing products to be suspended from EU market Modified-release paracetamol-containing products to be suspended from EU market | European Medicines Agency Search Search Menu Modified-release paracetamol-containing products to be suspended from EU market Press release 15/12/2017 Recommendation endorsed due to the difficulty in managing overdose The has endorsed by majority a European Medicines Agency recommendation to suspend marketing of modified- or prolonged (...) -release products containing paracetamol (designed to release paracetamol slowly over a longer period than the usual immediate-release products). The recommendation was made by the Agency's experts in medicines safety, the ( ). agreed with the Agency's advice that the advantages of a longer-acting product did not outweigh the complications of managing an overdose of the medicine, since the treatment procedures for immediate-release products are not appropriate for modified-release paracetamol. In many

2017 European Medicines Agency - EPARs

40. Prophylactic administration of acetaminophen in childhood vaccination is still not recommended

Prophylactic administration of acetaminophen in childhood vaccination is still not recommended Prophylactic administration of acetaminophen in childhood vaccination is still not recommended - Evidencias en pediatría Searching, please wait Show menu Library Management You did not add any article to your library yet. | Search Evidence-Based decision making Evidence-Based decision making Show menu Library Management You did not add any article to your library yet. × User Password Log in × Reset (...) password If you need to reset your password please enter your email and click the Send button. You will receive an email to complete the process. Email Send × Library Management × September 2017. Volume 13. Number 3 Prophylactic administration of acetaminophen in childhood vaccination is still not recommended Rating: 0 (0 Votes) Reviewers: , . | Newsletter Free Subscription Regularly recieve most recent articles by e-mail Subscribe × Newsletter subscription: Email Confirm email I accept the journal’s

2017 Evidencias en Pediatría