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Latest & greatest articles for acetaminophen
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Intravenous vs Oral Acetaminophen as an Adjunct to Multimodal Analgesia After Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind Clinical Trial The efficacy of intravenous (IV) acetaminophen compared with its oral formulation for postoperative analgesia is unknown. We hypothesized that the addition of acetaminophen to a multimodal analgesia regimen would provide improved pain management in patients after total knee arthroplasty (TKA) and that the effect of acetaminophen would (...) be variable based on the route of delivery.The study was a single-center, randomized, double-blinded, placebo-controlled clinical trial on the efficacy of IV vs oral acetaminophen in patients undergoing unilateral TKA. One hundred seventy-four subjects were randomized to one of the 3 groups: IV acetaminophen group (IV group, n = 57) received 1 g IV acetaminophen and oral placebo before postanesthesia care unit (PACU) admission; oral acetaminophen group (PO group, n = 58) received 1 g oral acetaminophen
Paracetamol (acetaminophen) for chronic non-cancer pain in children and adolescents. Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. While in the past, pain was largely dismissed and was frequently left (...) the analgesic efficacy and adverse events of paracetamol (acetaminophen) used to treat chronic non-cancer pain in children and adolescents aged between birth and 17 years, in any setting.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) via the Cochrane Register of Studies Online, MEDLINE via Ovid, and Embase via Ovid from inception to 6 September 2016. We also searched the reference lists of retrieved studies and reviews, and searched online clinical trial registries.Randomised
-operative pain following orthopedic surgery? Key Message Five randomized controlled trials were identified regarding the clinical effectiveness of pre-operative administration of gabapentin, celecoxib, or acetaminophen for patients undergoing orthopedic surgical procedures. Tags acetaminophen, orthopedic procedures, orthopedics, premedication, preoperative care, preoperative period, musculoskeletal, surgery, gabapentin, Neurontin, celecoxib, celebrex, paracetamol, Tylenol, postoperative pain, post (...) Gabapentin, Celecoxib, and Acetaminophen for the Prevention of Post-Operative Pain: Clinical Effectiveness Gabapentin, Celecoxib, and Acetaminophen for the Prevention of Post-Operative Pain: Clinical Effectiveness | CADTH.ca Find the information you need Gabapentin, Celecoxib, and Acetaminophen for the Prevention of Post-Operative Pain: Clinical Effectiveness Gabapentin, Celecoxib, and Acetaminophen for the Prevention of Post-Operative Pain: Clinical Effectiveness Published on: July 31, 2017
Intravenous Acetaminophen in Multimodal Pain Management for Patients Undergoing Total Knee Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial Although multimodal pain management including periarticular multidrug injection can provide excellent pain relief in the early postoperative period after total knee arthroplasty (TKA), rebounding pain remains an important challenge. A randomized, double-blind, placebo-controlled trial was performed to investigate the efficacy of adding (...) intravenous acetaminophen to multimodal pain management for TKA.We enrolled 67 patients scheduled for unilateral TKA. Patients were randomly assigned to receive either 1000 mg of intravenous acetaminophen at 6-hour intervals or normal saline at the same intervals. All patients were treated with intraoperative periarticular multidrug injection and intravenous and oral nonsteroidal anti-inflammatory drugs. The primary outcome was the postoperative 100-mm visual analog pain scale at the time
-procedure by paracetamol (1000 mg), also known as acetaminophen, compared to combinations of paracetamol (1000 mg) plus one additional NSAID - either ibuprofen (600 mg), mefenamic acid (500 mg) or diclofenac K (50 mg) – compared to placebo. All five treatment groups, including placebo, showed significant reductions in post-operative pain scores compared to pre-operative pain scores on the numerical rating scale 11 (NRS-11) pain scale and the visual rating scale 4 (VRS-4) (p Evidence Search Endodontic (...) Combination Therapy of Acetaminophen and Ibuprofen Is the Most Effective Treatment for Patients with Post-Endodontic Pain UTCAT3197, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Combination Therapy of Acetaminophen and Ibuprofen Is the Most Effective Treatment for Patients with Post-Endodontic Pain Clinical Question In patients with post-operative endodontic pain, does the combination of non-steroidal anti
Effect of Topical Application of Nigella Sativa Oil and Oral Acetaminophen on Pain in Elderly with Knee Osteoarthritis: A Crossover Clinical Trial. Limited evidence supports Nigella sativa's role as an effective complementary and alternative medicine and the anti-inflammatory effects of Nigella sativa on patients with allergic rhinitis.The aim of this study was to investigate the effect of topical application of Nigella sativa oil and oral acetaminophen on pain in the elderly with knee (...) osteoarthritis residing in a parents' home in Sabzevar.This study is done as a crossover clinical trial. After obtaining written consent of elderly patients with osteoarthritis of the knee, they were randomly divided into two groups. In step 1, in group 1, 1 cc of Nigella sativa oil was applied on the knee joint every 8 hours for 3 weeks; for the second group, every 8 hours for 3 weeks, patients were given 1 tablet of 325 mg acetaminophen. After a period of 1 month without medication to wash out each group
: 951–958 | | | There are 3 other large retrospective cohort studies that have been published in the last few years (2013–2014) that examined the potential association between maternal acetaminophen use and ADHD in their offspring; all reported a weak association. x 6 Brandlistuen, R.E., Ystrom, E., Nulman, I., Koren, G., and Nordeng, H. Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled cohort study. Int J Epidemiol . 2013 ; 42 : 1702–1713 | | | , x 7 Liew, Z., Ritz, B (...) /hyperactivity disorder in children. Ann Pharmacother . 2015 ; 49 : 1357–1361 | | | , x 11 Andrade, C. Use of acetaminophen (paracetamol) during pregnancy and the risk of attention-deficit/hyperactivity disorder in the offspring. J Clin Psychiatr . 2016 ; 77 : e312–e314 | | | While correlating exposures during pregnancy with childhood outcomes is problematic, it is especially difficult with regard to neurobehavioral disorders. The definition and diagnosis of these illnesses, especially ADHD, continues
Limited Knowledge of Acetaminophen in Patients with Liver Disease Background and Aims: Unintentional acetaminophen overdose remains the leading cause of acute liver failure in the United States. Patients with underlying liver disease are at higher risk of poor outcomes from acetaminophen overdose. Limited knowledge of acetaminophen may be a preventable contributor to elevated rates of overdose and thus acute liver failure. The purpose of this study is to assess knowledge of acetaminophen dosing (...) and presence of acetaminophen in common combination products in patients with liver disease. Methods: We performed a cross-sectional study of patients with liver disease at the Pfleger Liver Institute at the University of California, Los Angeles between June 2015 and August 2016. Patients completed a demographic questionnaire and an acetaminophen knowledge survey. Additional information was obtained from the medical record. Results: Of 401 patients with liver disease, 30 (15.7%) were able to correctly
Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults. Paracetamol, either alone or in combination with codeine or dihydrocodeine, is commonly used to treat chronic neuropathic pain. This review sought evidence for efficacy and harm from randomised double-blind studies.To assess the analgesic efficacy and adverse events of paracetamol with or without codeine or dihydrocodeine for chronic neuropathic pain in adults.We searched the Cochrane Central (...) Register of Controlled Trials (CENTRAL), MEDLINE, and Embase from inception to July 2016, together with reference lists of retrieved papers and reviews, and two online study registries.We included randomised, double-blind studies of two weeks' duration or longer, comparing paracetamol, alone or in combination with codeine or dihydrocodeine, with placebo or another active treatment in chronic neuropathic pain.Two review authors independently searched for studies, extracted efficacy and adverse event
Ibuprofen plus paracetamol versus ibuprofen in acute low back pain: a randomized open label multicenter clinical study. to estimate whether combination of ibuprofen and paracetamol is more effective than ibuprofen in monotherapy, in the treatment of acute low back pain.80 adult patients with acute low back pain were randomized into two subgroups. In the first subgroup, 40 patients were treated with ibuprofen 400mg three times a day (TID), whilst patients in the second subgroup (n=40) were (...) treated with a fixed-dose combination tablet of ibuprofen 200mg plus paracetamol 325mg TID, for three consecutive days. Patients were followed for another 7 days. Efficacy and tolerability of both treatment options was assessed.A statistically significant decrease in pain intensity, assessed using a visual analogue scale (p<0.001), as well as the 5-point Likert scale, was noticed in both subgroups of patients. However, intensity of pain on Day 4 was significantly lower in patients treated
Naproxen, paracetamol and pamabrom versus paracetamol, pyrilamine and pamabrom in primary dysmenorrhea: a randomized, double-blind clinical trial. Dysmenorrhea is caused by the discharge of prostaglandins into the uterine tissue; therefore, non-steroidal anti-inflammatory drugs (NSAIDs) are the established initial therapy for dysmenorrhea. Dysmenorrhea therapy may include the administration of drug monotherapy or combination therapy. However, clinical scientific evidence on the efficacy (...) of medications with two or three drugs combined is scarce or nonexistent.To evaluate and compare the efficacy and safety of two oral fixed-dose combinations for the relief of the symptoms of primary dysmenorrhea among Mexican women. One of the combinations is widely used in Mexico (paracetamol, pyrilamine and pamabrom) and the selected comparison was a medication with naproxen sodium, paracetamol and pamabrom based on the pathophysiology of primary dysmenorrhea.This was a single-centre, double blind
and safety of different individual doses of acetaminophen for patients with pain or fever? What is the clinical effectiveness and safety of doses in excess of the recommended daily maximum dose (4 g) for patients with pain or fever? What is the safety of chronic use of acetaminophen? Key Message Thirty-three systematic reviews and meta-analyses were identified regarding the effectiveness and safety of acetaminophen. Tags acetaminophen, Tylenol, paracetamol Files Rapid Response Reference List Published (...) Acetaminophen for Pain or Fever: Clinical Effectiveness and Safety Acetaminophen for Pain or Fever: Clinical Effectiveness and Safety | CADTH.ca Find the information you need Acetaminophen for Pain or Fever: Clinical Effectiveness and Safety Acetaminophen for Pain or Fever: Clinical Effectiveness and Safety Published on: September 9, 2016 Project Number: RA0864-000 Product Line: Research Type: Drug Report Type: Reference List Result type: Report Question What is the clinical effectiveness
Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking.In a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 children (age range (...) , 12 to 59 months) with mild persistent asthma and assigned them to receive either acetaminophen or ibuprofen when needed for the alleviation of fever or pain over the course of 48 weeks. The primary outcome was the number of asthma exacerbations that led to treatment with systemic glucocorticoids. Children in both groups received standardized asthma-controller therapies that were used in a simultaneous, factorially linked trial.Participants received a median of 5.5 doses (interquartile range, 1.0
Acetaminophen and Asthma - A Small Sigh of Relief? 27532835 2016 08 24 2018 12 02 1533-4406 375 7 2016 Aug 18 The New England journal of medicine N. Engl. J. Med. Acetaminophen and Asthma--A Small Sigh of Relief? 684-5 10.1056/NEJMe1607629 Litonjua Augusto A AA From the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School - both in Boston. eng Editorial Comment United States N Engl J Med 0255562 0028-4793 362O9ITL9D (...) Acetaminophen AIM IM N Engl J Med. 2016 Aug 18;375(7):619-30 27532828 Acetaminophen Asthma drug therapy Humans 2016 8 18 6 0 2016 8 18 6 0 2016 8 25 6 0 ppublish 27532835 10.1056/NEJMe1607629
Paracetamol: widely used and largely ineffective Paracetamol: widely used and largely ineffective - Evidently Cochrane Search and hit Go By August 12, 2016 // In this guest blog, Andrew Moore, who has authored over 200 systematic reviews, many on pain, lifts the lid on paracetamol. Effective and safe? We are challenged to think again… People with pain have some very simple demands. They want the pain gone, and they want it gone now. A successful result is one where the pain is reduced by half (...) or more, or where they have no or only mild pain. That result delivers not just on pain, but also improves sleep, depression, quality of life, work, and the ability to get on with life. Paracetamol – the ‘go-to’ painkiller but largely ineffective For many years paracetamol has been the ‘go-to’ medicine for all sorts of acute and chronic pain conditions. NICE recommends it for back pain and osteoarthritis, and paracetamol or paracetamol/opioid combinations are among the most common medicines