Latest & greatest articles for acetaminophen

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Top results for acetaminophen

61. Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update Full Text available with Trip Pro

Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional overdose of acetaminophen (APAP) has affected patients for decades, and involves the cornerstone metabolic pathways which take place in the microsomes within hepatocytes. APAP hepatotoxicity remains a global issue; in the United States, in particular, it accounts for more than 50% of overdose-related acute liver failure and approximately 20

2016 Journal of clinical and translational hepatology

62. Comparison of Intravenous Morphine vs Paracetamol in Sciatica: A Randomized Placebo Controlled Trial (Abstract)

Comparison of Intravenous Morphine vs Paracetamol in Sciatica: A Randomized Placebo Controlled Trial The objective was to compare intravenous morphine and intravenous acetaminophen (paracetamol) for pain treatment in patients presenting to the emergency department with sciatica.Patients, between the ages of 21 and 65 years, suffering from pain in the sciatic nerve distribution and a positive straight leg-raise test composed the study population. Study patients were assigned to one of three (...) intravenous interventions: morphine (0.1 mg/kg), acetaminophen (1 g), or placebo. Physicians, nurses, and patients were blinded to the study drug. Changes in pain intensity were measured at 15 and 30 minutes using a visual analog scale. Rescue drug (fentanyl) use and adverse effects were also recorded.Three-hundred patients were randomized. The median change in pain intensity between treatment arms at 30 minutes were as follows: morphine versus acetaminophen 25 mm (95% confidence interval [CI] = 20 to 29

2016 EvidenceUpdates Controlled trial quality: predicted high

63. 400 mg Ibuprofen/1000 mg Acetaminophen (Paracetamol) Is Suggested Effective Dosage for Ibuprofen/Acetaminophen Combination Therapy in Postoperative Pain Reduction

400 mg Ibuprofen/1000 mg Acetaminophen (Paracetamol) Is Suggested Effective Dosage for Ibuprofen/Acetaminophen Combination Therapy in Postoperative Pain Reduction UTCAT2994, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title 400 mg Ibuprofen/1000 mg Acetaminophen (Paracetamol) Is Suggested Effective Dosage for Ibuprofen/Acetaminophen Combination Therapy in Postoperative Pain Reduction Clinical Question In patients (...) receiving acetaminophen (paracetamol) and ibuprofen combination therapy, what is the effective dosage to relieve postoperative pain? Clinical Bottom Line For patients with postoperative pain, 400 mg ibuprofen/1000 mg acetaminophen (paracetamol) is the suggested effective dosage for short-term pain management. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Mehlisch/2010 234 patients post extraction

2016 UTHSCSA Dental School CAT Library

64. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. (Abstract)

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. 27028921 2016 03 31 2018 12 02 1533-4406 374 13 2016 03 31 The New England journal of medicine N. Engl. J. Med. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. 1292-3 10.1056/NEJMc1601361 Young Paul P Saxena Manoj M Beasley Richard R eng Letter Comment United States N Engl J Med 0255562 0028-4793 362O9ITL9D Acetaminophen AIM IM N Engl J Med. 2015 Dec 3;373(23):2215-24 26436473 N Engl J Med (...) . 2016 Mar 31;374(13):1291 27028922 N Engl J Med. 2016 Mar 31;374(13):1291-2 27028923 N Engl J Med. 2016 Mar 31;374(13):1292 27028924 Acetaminophen therapeutic use Female Fever drug therapy Humans Infection drug therapy Male 2016 3 31 6 0 2016 3 31 6 0 2016 4 1 6 0 ppublish 27028921 10.1056/NEJMc1601361 10.1056/NEJMc1601361#SA4

2016 NEJM

65. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. Full Text available with Trip Pro

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. 27028922 2016 03 31 2018 12 02 1533-4406 374 13 2016 03 31 The New England journal of medicine N. Engl. J. Med. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. 1291 10.1056/NEJMc1601361 Patel Jayshil J Medical College of Wisconsin, Milwaukee, WI jpatel2@mcw.edu. eng Letter Comment United States N Engl J Med 0255562 0028-4793 362O9ITL9D Acetaminophen AIM IM N Engl J Med. 2015 Dec 3;373(23 (...) ):2215-24 26436473 N Engl J Med. 2016 Mar 31;374(13):1292-3 27028921 Acetaminophen therapeutic use Female Fever drug therapy Humans Infection drug therapy Male 2016 3 31 6 0 2016 3 31 6 0 2016 4 1 6 0 ppublish 27028922 10.1056/NEJMc1601361 10.1056/NEJMc1601361#SA1

2016 NEJM

66. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. Full Text available with Trip Pro

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. 27028923 2016 03 31 2018 12 02 1533-4406 374 13 2016 03 31 The New England journal of medicine N. Engl. J. Med. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. 1291-2 10.1056/NEJMc1601361 Leiner Steven S Mission Neighborhood Health Center, San Francisco, CA steven.leiner@gmail.com. eng Letter Comment United States N Engl J Med 0255562 0028-4793 362O9ITL9D Acetaminophen AIM IM N Engl J Med (...) . 2015 Dec 3;373(23):2215-24 26436473 N Engl J Med. 2016 Mar 31;374(13):1292-3 27028921 Acetaminophen therapeutic use Female Fever drug therapy Humans Infection drug therapy Male 2016 3 31 6 0 2016 3 31 6 0 2016 4 1 6 0 ppublish 27028923 10.1056/NEJMc1601361 10.1056/NEJMc1601361#SA2

2016 NEJM

67. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. Full Text available with Trip Pro

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. 27028924 2016 03 31 2018 12 02 1533-4406 374 13 2016 03 31 The New England journal of medicine N. Engl. J. Med. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. 1292 10.1056/NEJMc1601361 Arik Gunes G Gazi University, Ankara, Turkey guneseken@yahoo.com. Şengül Ayçiçek Gözde G Gazi University, Ankara, Turkey guneseken@yahoo.com. Ulger Zekeriya Z Gazi University, Ankara, Turkey guneseken (...) @yahoo.com. eng Letter Comment United States N Engl J Med 0255562 0028-4793 362O9ITL9D Acetaminophen AIM IM N Engl J Med. 2015 Dec 3;373(23):2215-24 26436473 N Engl J Med. 2016 Mar 31;374(13):1292-3 27028921 Acetaminophen therapeutic use Female Fever drug therapy Humans Infection drug therapy Male 2016 3 31 6 0 2016 3 31 6 0 2016 4 1 6 0 ppublish 27028924 10.1056/NEJMc1601361 10.1056/NEJMc1601361#SA3

2016 NEJM

68. AcetaMINophen for Back Osteoarthritis Pain: Is the effect in the name?

AcetaMINophen for Back Osteoarthritis Pain: Is the effect in the name? Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,400 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research (...) . www.acfp.ca September 26, 2016 AcetaMINophen for Back and Osteoarthritis Pain: Is the effect in the name? Clinical Question: Is acetaminophen effective for the management of back pain or osteoarthritis? Bottom Line: Acetaminophen is not efficacious for back pain, and provides no clinically meaningful impact on osteoarthritis. There are many other better interventions for these conditions like: short-term oral NSAIDs for back pain; topical NSAIDs or intra-articular steroids for osteoarthritis; and exercise

2016 Tools for Practice

69. Randomised controlled trial: NSAIDs or paracetamol for short-term treatment of mild to moderate knee pain in early osteoarthritis: are they equivalent?

Randomised controlled trial: NSAIDs or paracetamol for short-term treatment of mild to moderate knee pain in early osteoarthritis: are they equivalent? NSAIDs or paracetamol for short-term treatment of mild to moderate knee pain in early osteoarthritis: are they equivalent? | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies (...) , please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here NSAIDs or paracetamol for short-term treatment of mild to moderate knee pain in early osteoarthritis

2016 Evidence-Based Medicine

70. Systematic review: No difference in pain, swelling or function with NSAIDs compared with paracetamol for soft tissue injury

Systematic review: No difference in pain, swelling or function with NSAIDs compared with paracetamol for soft tissue injury No difference in pain, swelling or function with NSAIDs compared with paracetamol for soft tissue injury | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here No difference in pain, swelling or function with NSAIDs compared with paracetamol for soft tissue injury Article Text Pain management Systematic review No difference

2016 Evidence-Based Nursing

71. Systematic review with meta analysis: In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery

fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery Article Text Therapeutics/Prevention Systematic review with meta analysis In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery Christoph Bührer Statistics from Altmetric.com Commentary on: Ohlsson A , Shah PS . Paracetamol (acetaminophen) for prevention or treatment of pain in newborns (...) Systematic review with meta analysis: In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie

2016 Evidence-Based Medicine

72. Comparative Analgesic Efficacy of Oxycodone/Acetaminophen Versus Hydrocodone/Acetaminophen for Short-term Pain Management in Adults Following ED Discharge Full Text available with Trip Pro

Comparative Analgesic Efficacy of Oxycodone/Acetaminophen Versus Hydrocodone/Acetaminophen for Short-term Pain Management in Adults Following ED Discharge The objective was to test the hypothesis that oxycodone/acetaminophen provides superior analgesia to hydrocodone/acetaminophen for the treatment of acute extremity pain following emergency department (ED) discharge.This was a prospective, randomized, double-blind clinical trial of nonelderly adult ED patients with acute musculoskeletal (...) extremity pain, randomly allocated at discharge to receive oxycodone/acetaminophen (5 mg/325 mg) or hydrocodone/acetaminophen (5 mg/325 mg). The primary outcome was the between-group difference in improvement in numerical rating scale (NRS) pain scores over a 2-hour period following the most recent ingestion of study drug, obtained during telephone contact 24 hours after ED discharge. Secondary outcomes included proportionate decrease in pain, comparative side-effect profiles, and patient satisfaction.A

2015 EvidenceUpdates Controlled trial quality: predicted high

73. Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness

: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of tramadol plus acetaminophen for the management of pain in adult patients? Key Message Two randomized controlled trials and four non-randomized studies were identified regarding the clinical effectiveness of tramadol plus acetaminophen for the management of pain in adult patients. Tags acetaminophen, anesthesia, paracetamol, tramadol, Tramacet Files Rapid Response Summary of Abstracts (...) Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness | CADTH.ca Find the information you need Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Tramadol Plus Acetaminophen for the Management of Pain in Adult Patients: Clinical Effectiveness Published on: November 3, 2015 Project Number: RB0927-000 Product Line

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

74. Comparing the Therapeutic Effectiveness of N-acetylcysteine with the Combination of N-acetyl Cysteine and Cimetidine in Acute Acetaminophen Toxicity: A Double-Blinded Clinical Trial. Full Text available with Trip Pro

Comparing the Therapeutic Effectiveness of N-acetylcysteine with the Combination of N-acetyl Cysteine and Cimetidine in Acute Acetaminophen Toxicity: A Double-Blinded Clinical Trial. N-acetylcysteine (NAC) has been used as a classic treatment for hepatotoxicity induced by N-acetyl-p-benzoquinone imine (NAPQI) as a metabolite of acetaminophen. However, cimetidine theoretically can reduce the production of toxic metabolites through the inhibition of cytochrome p450, and it recently was proposed (...) as a complementary treatment for acetaminophen toxicity.The aim of this study was to compare the effects of treating acute acetaminophen toxicity with NAC alone and with a combination of NAC and cimetidine.From October 2013 to March 2014, 105 patients suspected of acetaminophen toxicity who had paraclinical confirmation of toxicity requiring medical treatment (based on the risk assessment nomogram of acetaminophen serum level) were enrolled in this double-blind, randomized, controlled trial at Imam Reza Hospital

2015 Electronic physician Controlled trial quality: predicted high

75. Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. Full Text available with Trip Pro

Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. Low back pain (LBP) is responsible for more than 2.5 million visits to US emergency departments (EDs) annually. These patients are usually treated with nonsteroidal anti-inflammatory drugs, acetaminophen, opioids, or skeletal muscle relaxants, often in combination.To compare functional outcomes and pain at 1 week and 3 months after an ED visit for acute LBP among (...) commonly used to measure LBP and related functional impairment on which 0 indicates no functional impairment and 24 indicates maximum impairment. Beginning in April 2012, a total of 2588 patients were approached for enrollment. Of the 323 deemed eligible for participation, 107 were randomized to receive placebo and 108 each to cyclobenzaprine and to oxycodone/acetaminophen. Follow-up was completed in December 2014.All participants were given 20 tablets of naproxen, 500 mg, to be taken twice a day

2015 JAMA Controlled trial quality: predicted high

76. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. Full Text available with Trip Pro

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection. Acetaminophen is a common therapy for fever in patients in the intensive care unit (ICU) who have probable infection, but its effects are unknown.We randomly assigned 700 ICU patients with fever (body temperature, ≥38°C) and known or suspected infection to receive either 1 g of intravenous acetaminophen or placebo every 6 hours until ICU discharge, resolution of fever, cessation of antimicrobial therapy, or death (...) . The primary outcome was ICU-free days (days alive and free from the need for intensive care) from randomization to day 28.The number of ICU-free days to day 28 did not differ significantly between the acetaminophen group and the placebo group: 23 days (interquartile range, 13 to 25) among patients assigned to acetaminophen and 22 days (interquartile range, 12 to 25) among patients assigned to placebo (Hodges-Lehmann estimate of absolute difference, 0 days; 96.2% confidence interval [CI], 0 to 1; P=0.07

2015 NEJM Controlled trial quality: predicted high

77. N-Acetylcysteine for Acute Acetaminophen Overdose in the Pre-Hospital Setting

of Paracetamol Poisoning, pages 14, 110-112 PREPARED BY: Canadian Agency for Drugs and Technologies in Health Tel: 1-866-898-8439 www.cadth.ca N-Acetylcysteine for Acute Acetaminophen Overdose in the Pre-Hospital Setting 4 APPENDIX – FURTHER INFORMATION: Clinical Practice Guidelines – Pre-Hospital Setting Not Specified 2. Nambiar NJ. Management of paracetamol poisoning: the old and the new. Journal of Clinical and Diagnostic Research [Internet]. 2015 [cited 2015 Jun 16];6(6):1101-04. Available from: http (...) N-Acetylcysteine for Acute Acetaminophen Overdose in the Pre-Hospital Setting Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

78. Systematic review with meta-analysis: Paracetamol is ineffective for spinal pain and knee and hip osteoarthritis

Systematic review with meta-analysis: Paracetamol is ineffective for spinal pain and knee and hip osteoarthritis Paracetamol is ineffective for spinal pain and knee and hip osteoarthritis | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Paracetamol is ineffective for spinal pain and knee and hip osteoarthritis Article Text Therapeutics/Prevention Systematic review with meta-analysis Paracetamol is ineffective for spinal pain and knee

2015 Evidence-Based Medicine

79. Systematic review with meta analysis: In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective

Systematic review with meta analysis: In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content (...) are here In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective Article Text Therapeutics/Prevention Systematic review with meta analysis In knee osteoarthritis, pharmacological interventions, with the exception of acetaminophen, significantly improve pain; with intra-articular administration being more effective Bryan M Saltzman , Kirk A Campbell Statistics from Altmetric.com

2015 Evidence-Based Medicine

80. Summary statement: new guidelines for the management of paracetamol poisoning in Australia and New Zealand

Summary statement: new guidelines for the management of paracetamol poisoning in Australia and New Zealand Summary statement: new guidelines for the management of paracetamol poisoning in Australia and New Zealand | The Medical Journal of Australia mja-search search Use the for more specific terms. Title contains Body contains Date range from Date range to Article type Author's surname Volume First page doi: 10.5694/mja__.______ Search Reset  close Individual Login Purchase options Connect (...) person_outline Login keyboard_arrow_down Individual Login Purchase options menu search Advertisement close Summary statement: new guidelines for the management of paracetamol poisoning in Australia and New Zealand Angela L Chiew, John S Fountain, Andis Graudins, Geoffrey K Isbister, David Reith and Nicholas A Buckley Med J Aust 2015; 203 (5): 215-218. || doi: 10.5694/mja15.00614 Published online: 7 September 2015 Topics Related Articles A large proportion of accidental paediatric exposures and deliberate

2015 MJA Clinical Guidelines