Latest & greatest articles for acetaminophen

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acetaminophen or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on acetaminophen and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for acetaminophen

121. Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain

Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take advantage of endorsed (...) acetaminophen as an effective and safe reliever of acutepostoperative pain James Zahrowski DMD, MS, PharmD . Overview Systematic Review Conclusion A single standard dose of acetaminophen relieves moderate to severe postoperative pain in about one-half of adults for four hours with minimal adverse effects similar to those of placebo. Critical Summary Assessment An updated, high-quality of mostly high-quality evidence indicates that a standard dose of acetaminophen relieves postoperative pain safely for four

2010 ADA Center for Evidence-Based Dentistry

122. Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain

Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take advantage of endorsed (...) acetaminophen as an effective and safe reliever of acutepostoperative pain James Zahrowski DMD, MS, PharmD . Overview Systematic Review Conclusion A single standard dose of acetaminophen relieves moderate to severe postoperative pain in about one-half of adults for four hours with minimal adverse effects similar to those of placebo. Critical Summary Assessment An updated, high-quality of mostly high-quality evidence indicates that a standard dose of acetaminophen relieves postoperative pain safely for four

2010 ADA Center for Evidence-Based Dentistry

123. Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain

Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take advantage of endorsed (...) acetaminophen as an effective and safe reliever of acutepostoperative pain James Zahrowski DMD, MS, PharmD . Overview Systematic Review Conclusion A single standard dose of acetaminophen relieves moderate to severe postoperative pain in about one-half of adults for four hours with minimal adverse effects similar to those of placebo. Critical Summary Assessment An updated, high-quality of mostly high-quality evidence indicates that a standard dose of acetaminophen relieves postoperative pain safely for four

2010 ADA Center for Evidence-Based Dentistry

124. Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction.

Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take (...) Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. Carlos Flores-Mir DDS, DSc, FRCD(C); Analia Veitz-Keenan DDS . Overview Systematic Review Conclusion A single dose of acetaminophen plus codeine provides clinical useful levels of pain relief in patients with moderate to severe post –operative pain. Critical Summary Assessment This represents an update of a previously published Cochrane Review and it follows general accepted rules about how

2010 ADA Center for Evidence-Based Dentistry

125. Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction.

Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take (...) Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. Carlos Flores-Mir DDS, DSc, FRCD(C); Analia Veitz-Keenan DDS . Overview Systematic Review Conclusion A single dose of acetaminophen plus codeine provides clinical useful levels of pain relief in patients with moderate to severe post –operative pain. Critical Summary Assessment This represents an update of a previously published Cochrane Review and it follows general accepted rules about how

2010 ADA Center for Evidence-Based Dentistry

126. Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction.

Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. ADA Websites Access news, member benefits and ADA policy Attend ADA's premier event Access cutting-edge continuing education courses Find evidence to support your clinical decisions Access member-only practice content Investing in better oral health for all. Together. Take (...) Evidence supports the use of a single dose of acetaminophen with codeine for moderate to severe pain reduction. Carlos Flores-Mir DDS, DSc, FRCD(C); Analia Veitz-Keenan DDS . Overview Systematic Review Conclusion A single dose of acetaminophen plus codeine provides clinical useful levels of pain relief in patients with moderate to severe post –operative pain. Critical Summary Assessment This represents an update of a previously published Cochrane Review and it follows general accepted rules about how

2010 ADA Center for Evidence-Based Dentistry

127. Ofirmev (acetaminophen) Injection

Ofirmev (acetaminophen) Injection Drug Approval Package: Ofirmev (acetaminophen) NDA #022450 Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Ofirmev (acetaminophen) Injection, 10 mg/mL Company: Cadence Pharmaceuticals Application No.: 022450 Approval Date: 11/02/2010 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF

2010 FDA - Drug Approval Package

128. Intravenous paracetamol (Perfalgan ?): risk of accidental overdose

Intravenous paracetamol (Perfalgan ?): risk of accidental overdose Intravenous paracetamol (Perfalgan ▼): risk of accidental overdose - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Intravenous paracetamol (Perfalgan ▼): risk of accidental overdose Risk of accidental overdose, particularly in infants and neonates. Published 11 December 2014 From: Therapeutic area: , Contents Article date: July 2010 Cases of accidental overdose have been reported during treatment (...) with intravenous paracetamol 10 mg/mL solution for infusion (Perfalgan ▼). In most cases, this occurred in infants and neonates due to confusion between the prescription of Perfalgan being issued in mg and then administered in mL; in most of these cases, a 10-fold overdose was reported. Perfalgan is indicated for the short-term treatment of pain and fever, when there is a clinical need of paracetamol administration intravenously. It is available as a solution for infusion of 10 mg paracetamol per 1 mL solution

2010 MHRA Drug Safety Update

129. Randomised controlled trial: Ibuprofen provides similar pain relief but reduces adverse effects and improves function compared with acetaminophen plus codeine in children with uncomplicated fractures

Randomised controlled trial: Ibuprofen provides similar pain relief but reduces adverse effects and improves function compared with acetaminophen plus codeine in children with uncomplicated fractures Ibuprofen provides similar pain relief but reduces adverse effects and improves function compared with acetaminophen plus codeine in children with uncomplicated fractures | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage (...) similar pain relief but reduces adverse effects and improves function compared with acetaminophen plus codeine in children with uncomplicated fractures Article Text Therapeutics Randomised controlled trial Ibuprofen provides similar pain relief but reduces adverse effects and improves function compared with acetaminophen plus codeine in children with uncomplicated fractures Carie A Braun Carie A Braun College of Saint Benedict/Saint John’s University, 37 College Avenue South, Saint Joseph, MN 56374

2010 Evidence-Based Nursing

130. Systematic review: NSAIDs similarly effective to acetaminophen plus codeine for post-laparotomy pain and may reduce adverse effects

Systematic review: NSAIDs similarly effective to acetaminophen plus codeine for post-laparotomy pain and may reduce adverse effects NSAIDs similarly effective to acetaminophen plus codeine for post-laparotomy pain and may reduce adverse effects | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here NSAIDs similarly effective to acetaminophen plus codeine for post-laparotomy pain and may reduce adverse effects Article Text Therapeutics Systematic

2010 Evidence-Based Nursing

131. Intravenous paracetamol or morphine for the treatment of renal colic: a randomized, placebo-controlled trial (Abstract)

Intravenous paracetamol or morphine for the treatment of renal colic: a randomized, placebo-controlled trial This randomized, placebo-controlled trial evaluates the analgesic efficacy and safety of intravenous single-dose paracetamol and morphine for the treatment of renal colic.We conducted a randomized, double-blind, placebo-controlled clinical trial comparing single intravenous doses of paracetamol (1 g), morphine (0.1 mg/kg), and placebo (normal saline solution) for patients presenting (...) because of uncertain diagnoses, leaving 146 subjects available for analysis. The mean reduction in visual analogue scale pain intensity scores at 30 minutes was 43 mm for paracetamol (95% confidence interval [CI] 35 to 51 mm), 40 mm for morphine (95% CI 29 to 52 mm), and 27 mm for placebo (95% CI 19 to 34 mm). Statistically significant mean differences in pain intensity reductions compared with those for placebo were observed for paracetamol (16; 95% CI 5 to 27; P=.005) and morphine (14; 95% CI 0.4

2010 EvidenceUpdates Controlled trial quality: predicted high

132. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side-effects after major surgery: a systematic review

Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side-effects after major surgery: a systematic review Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side-effects after major surgery: a systematic review Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side (...) -effects after major surgery: a systematic review McDaid C, Maund E, Rice S, Wright K, Jenkins B, Woolacott N Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation McDaid C, Maund E, Rice S, Wright K, Jenkins B, Woolacott N. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related

2010 Health Technology Assessment (HTA) Database.

133. Randomised controlled trial: Prophylactic paracetamol at the time of infant vaccination reduces the risk of fever, but also reduces antibody response

Randomised controlled trial: Prophylactic paracetamol at the time of infant vaccination reduces the risk of fever, but also reduces antibody response Prophylactic paracetamol at the time of infant vaccination reduces the risk of fever, but also reduces antibody response | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please (...) see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Prophylactic paracetamol at the time of infant vaccination reduces the risk of fever, but also reduces antibody response

2010 Evidence-Based Nursing

134. Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review

Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 DARE.

135. Do routine paracetamol levels need to be taken in all patients presenting with overdose ?

with suicidal intent. You wonder whether her management should include 4 hour paracetamol levels. Search Strategy Medline 1950 to April Week 3 2009 via OVID interphase: ({[overdose.mp or exp overdose or deliberate self harm.mp. or exp self-injurious behaviour] AND [paracetamol.mp or acetaminophen.mp or exp acetaminophen] limit to "diagnosis(sensitivity)"} OR {[overdose.mp or exp overdose or deliberate self harm.mp. or exp self-injurious behaviour] AND [paracetamol.mp or acetaminophen.mp or exp acetaminophen (...) Do routine paracetamol levels need to be taken in all patients presenting with overdose ? BestBets: Do routine paracetamol levels need to be taken in all patients presenting with overdose ? Do routine paracetamol levels need to be taken in all patients presenting with overdose ? Report By: T Leckie - Consultant in Emergency Medicine Search checked by Kerstin Hogg - Clinical Lecturer Emergency Medicine, Salford Royal Hospital, Salford, UK Institution: Royal Oldham Hospital, Oldham, UK, Date

2009 BestBETS

136. Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. (Abstract)

Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. Although fever is part of the normal inflammatory process after immunisation, prophylactic antipyretic drugs are sometimes recommended to allay concerns of high fever and febrile convulsion. We assessed the effect of prophylactic administration of paracetamol at vaccination on infant febrile reaction rates and vaccine (...) responses.In two consecutive (primary and booster) randomised, controlled, open-label vaccination studies, 459 healthy infants were enrolled from ten centres in the Czech Republic. Infants were randomly assigned with a computer-generated randomisation list to receive three prophylactic paracetamol doses every 6-8 h in the first 24 h (n=226) or no prophylactic paracetamol (n=233) after each vaccination with a ten-valent pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV

2009 Lancet Controlled trial quality: uncertain

137. Paracetamol plus ibuprofen increased time without fever compared with paracetamol but did not differ from ibuprofen in children

Paracetamol plus ibuprofen increased time without fever compared with paracetamol but did not differ from ibuprofen in children Paracetamol plus ibuprofen increased time without fever compared with paracetamol but did not differ from ibuprofen in childrenCommentary | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our (...) . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Paracetamol plus ibuprofen increased time without fever compared with paracetamol but did not differ from ibuprofen

2009 Evidence-Based Nursing

138. Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever

Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

139. Codeine-acetaminophen versus nonsteroidal anti-inflammatory drugs in the treatment of post-abdominal surgery pain: a systematic review of randomized trials

Codeine-acetaminophen versus nonsteroidal anti-inflammatory drugs in the treatment of post-abdominal surgery pain: a systematic review of randomized trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

140. Paracetamol plus ibuprofen reduced fever in young children faster than paracetamol alone but not ibuprofen alone

. Patients: 156 children 6 months to 6 years of age (mean age 2 y, 56% boys) who had an axillary temperature of 37.8°C to 41°C and could be managed at home. Exclusion criteria included dehydration and chronic neurological disease. Interventions: paracetamol (PCM) (acetaminophen), 15 mg/kg (every 4–6 h, maximum 4 doses/d), plus ibuprofen (IBF), 10 mg/kg (every 6–8 h, maximum 3 doses/d) (n = 52); PCM alone (n = 52); or IBF alone (n = 52) for ⩽48 hours. … Request Permissions If you wish to reuse any or all (...) Paracetamol plus ibuprofen reduced fever in young children faster than paracetamol alone but not ibuprofen alone Paracetamol plus ibuprofen reduced fever in young children faster than paracetamol alone but not ibuprofen alone | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username

2009 Evidence-Based Medicine