Latest & greatest articles for acne

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acne or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on acne and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Acne treatment and clinical papers

Acne is a common skin condition characterised by whiteheads (or blackheads), pimples and oily skin. It can lead to possible scarring. It is typically caused when hair follicles become inflamed and the sebaceous glands in the skin are overactive. The over production of sebum and a combination of dead skin cells and dirt can clog follicles and pores causing a break out. Acne can affect any age group but it’s more common in adolescents.

There are many ways to treat acne depending on the severity of the case. Treatments include a range of medications such as topical retinoids, antibiotics and in severe cases isotretinoin is prescribed. Research is ongoing to determine the side effects and harms caused by these drugs. Clinical trials and studies are vital to assess treatment.

The Trip Database has an extensive collection of articles on acne ranging from clinical trials, systematic reviews, clinical guidelines and case reports. These can be found via searching the site.

Top results for acne

61. Treatment of acne vulgaris with a pulsed dye laser: a randomized controlled trial. Full Text available with Trip Pro

Treatment of acne vulgaris with a pulsed dye laser: a randomized controlled trial. The high prevalence of acne vulgaris and its significant morbidity underscore the need for convenient, low-risk, and efficacious therapy. Treatment with various lasers has been reported to improve acne.To evaluate the clinical efficacy of pulsed dye laser therapy in the treatment of acne.Randomized, single-blind, controlled, split-face clinical trial of a volunteer sample of 40 patients aged 13 years or older (...) with facial acne conducted at an academic referral center from August 2002 to September 2003.One or 2 nonpurpuric pulsed dye laser treatments to half of the face (fluence of 3 J/cm2), serial blinded clinical assessments (lesion counts), and grading of acne severity using standardized bilateral serial photographs.Comparison of the changes in lesion counts from baseline to 12 weeks between treated and untreated sides of the face and changes in photographic evidence of acne severity as graded by a panel

2004 JAMA Controlled trial quality: uncertain

62. Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial

Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2004 NHS Economic Evaluation Database.

63. Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. (Abstract)

Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. Low-fluence (low irradiation energy density) pulsed-dye lasers (PDLs) have been used for atrophic acne scarring, and anecdotal experience suggests that long-term improvements in inflammatory acne can be seen after one PDL treatment. Our aim was to compare the efficacy and tolerability of such PDL treatment with sham treatment in patients with facial inflammatory acne in a double-blind, randomised controlled (...) trial.We recruited 41 adults with mild-to-moderate facial inflammatory acne. We randomly assigned patients to PDL (n=31) or sham treatment (n=10). Treatment was given at baseline and patients were seen after 2, 4, 8, and 12 weeks. Assessors and participants were unaware of treatment allocations. Primary outcome measures were acne severity after 12 weeks and adverse events at any time. Secondary measures were change in lesion counts after 12 weeks and change in acne severity with time. Analysis

2003 Lancet Controlled trial quality: predicted high

64. High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study. (Abstract)

High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study. Administration of 13-cis retinoic acid (isotretinoin) for acne is occasionally accompanied by hyperlipidemia. It is not known why some persons develop this side effect.To determine whether isotretinoin triggers a familial susceptibility to hyperlipidemia and the metabolic syndrome.Cross-sectional comparison.University hospital (...) in Lausanne, Switzerland.102 persons in whom triglyceride levels increased at least 1.0 mmol/L (> or =89 mg/dL) (hyperresponders) and 100 persons in whom triglyceride levels changed 0.1 mmol/L (< or =9 mg/dL) or less (nonresponders) during isotretinoin therapy for acne. Parents of 71 hyperresponders and 60 nonresponders were also evaluated.Waist-to-hip ratio; fasting glucose, insulin, and lipid levels; and apoE genotype.Hyperresponders and nonresponders had similar pretreatment body weight and plasma

2002 Annals of Internal Medicine

65. Laser resurfacing for facial acne scars. (Abstract)

Laser resurfacing for facial acne scars. Most people have acne at some stage during their life, with about one per cent being left with permanent acne scars. Recent laser techniques are thought to be more effective than chemical peels and dermabrasion.To assess the effects of laser resurfacing for treating facial acne scars.We searched MEDLINE (1966 to April 1999), EMBASE (1980 to April 1999), Science Citation Index (1981 to April 1999), the Cochrane Controlled Trials Register (April 1999 (...) ), DARE (April 1999), INAHTA (April 1999), NHS HTA Internet site (April 1999). Dermatological Surgery (1995 to March 1999) and the British Journal of Dermatology (1995 to September 1999) were handsearched. We searched the reference lists of relevant articles and contacted experts and commercial laser manufacturers.Randomised controlled trials which compare different laser resurfacing techniques for treating patients with facial acne scars, or compare laser resurfacing with other resurfacing techniques

2001 Cochrane

66. Management of acne

in these different areas. Research is needed to define the optimal sequence of acne therapy, and to define the relative roles of specialists and generalists in the care of acne. Project page URL URL for DARE abstract Indexing Status Subject indexing assigned by CRD MeSH Acne Vulgaris /drug therapy; Acneiform Eruptions /drug therapy; Adolescent Language Published English Country of organisation United States Address for correspondence Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither (...) Management of acne Management of acne Management of acne Agency for Healthcare Research and Quality Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Agency for Healthcare Research and Quality. Management of acne. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Report/Technology Assessment No. 17. 2001 Authors

2001 Health Technology Assessment (HTA) Database.

67. Management of acne

and Quality. Evidence Report/Technology Assessment; 17. 2001 Original Paper URL Indexing Status Subject indexing assigned by CRD MeSH Acne Vulgaris; Anti-Bacterial Agents /therapeutic use; Benzoyl Peroxide /therapeutic use; Dermatologic Agents /therapeutic use; Isotretinoin /therapeutic use; Retinoids /therapeutic use AccessionNumber 12002008303 Date bibliographic record published 31/10/2003 Date abstract record published 31/10/2003 Record Status This is a critical abstract of a systematic review (...) Management of acne Management of acne Management of acne Lehmann H P, Andrews J S, Robinson K A, Holloway V L, Goodman S N Authors' objectives To provide a comprehensive review on the management of acne. Searching The search utilised several electronic databases from inception to 1999, including the CENTRAL Register in the Cochrane Library, MEDLINE, OLDMEDLINE (from 1960 to 1965), EMBASE, CINAHL and PsycINFO amongst others. Details of the searches were given in the report. In addition

2001 DARE.

68. Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data

compared with those not exposed is required] Funding John Wyeth and Brother Ltd., UK. Bibliographic details Lawrenson R A, Seaman H E, Sundstrom A, Williams T J, Farmer R D. Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data. Drug Safety 2000; 23(4): 333-349 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Acne Vulgaris /complications /drug therapy; Adolescent; Anti-Bacterial Agents /adverse effects /therapeutic (...) Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Liver damage associated with minocycline use in acne: a systematic review of the published literature and pharmacovigilance data Lawrenson R A, Seaman H E, Sundstrom A, Williams T J, Farmer R D Authors' objectives To identify

2000 DARE.

69. The cost-effectiveness of isotretinoin in the treatment of acne. Part 3: A cost-minimisation pharmaco-economic model

with each treatment strategy. Outcomes assessed in the review The following outcomes were assessed: relapse rate; treatment effectiveness levels corresponding to excellent, fair, and poor responses; success rate; and average treatment period. Study designs and other criteria for inclusion in the review The review included published trials since 1981 fulfilling the following inclusion criteria: (1) studies stating a clear diagnosis of acne vulgaris with success rate or treatment period; (2) randomised (...) Subject indexing assigned by NLM MeSH Acne Vulgaris /drug therapy /economics; Administration, Oral; Androgen Antagonists /economics /therapeutic use; Anti-Bacterial Agents /economics /therapeutic use; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Humans; Isotretinoin /economics /therapeutic use; Keratolytic Agents /economics /therapeutic use; Male; Models, Economic; Recurrence; Treatment Outcome AccessionNumber 21999001498 Date bibliographic record published 31/12/2000 Date abstract record

1999 NHS Economic Evaluation Database.

70. Laser resurfacing of the skin for the improvement of facial acne scarring

are required to compare the impact of treatments on patient quality of life. Project page URL Final publication URL URL for DARE abstract Indexing Status Subject indexing assigned by CRD MeSH Acne Vulgaris; Cicatrix /surgery; Laser Therapy; Lasers; Skin /surgery Language Published English Country of organisation England Address for correspondence Elaena Donald-Lopez, West Midlands Health Technology Assessment Coalition, Department of Public Health and Epidemiology, University of Birmingham, Edgbaston (...) Laser resurfacing of the skin for the improvement of facial acne scarring Laser resurfacing of the skin for the improvement of facial acne scarring Laser resurfacing of the skin for the improvement of facial acne scarring Jordan R, Cummins C, Burls A Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Jordan R, Cummins C, Burls A. Laser resurfacing of the skin

1998 Health Technology Assessment (HTA) Database.

71. Topical agents alone in acne. A blind assessment study. (Abstract)

Topical agents alone in acne. A blind assessment study. The comparative effectiveness of three comprehensive therapeutic programs was studied in 118 patients with mild to moderate acne vulgaris. A topical program of tretinoin, benzoyl peroxide, and water avoidance was found to be as effective as the more commonly employed program of systemic tetracycline therapy with topically applied tretinoin and better than a program using systemic tetracycline therapy with abradant cleansers. At 16 weeks (...) of therapy for all groups, the degree of skin dryness correlated with lack of improvement. Skin dryness is established as an aggravating factor in both the pathogenesis and treatment of acne. The topical program was nonirritating, well accepted by patients, and less expensive than the other two regimens.

1980 JAMA Controlled trial quality: uncertain