Latest & greatest articles for acyclovir

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Top results for acyclovir

21. Does oral aciclovir improve clinical outcome in immunocompetent children with primary herpes simplex gingivotomatitis?

. The lesions have all appeared within the last 2 days. He has been crying inconsolably over the past 24 h and is refusing food and drink. Considering the current evidence we question whether the use of oral aciclovir is indicated for primary herpes gingivostomatitis in children. Search Strategy Cochrane Library: using "herpes AND gingivostomatitis AND aciclovir/acyclovir", "herpes AND gingivostomatitis", "herpes AND aciclovir", "aciclovir AND gingivostomatitis": one relevant result – "Acyclovir (...) children. Pediatr Emerg Care 2006;22:268–9. Ducoulombier H, Cousin J, Dewilde A, et al. Herpetic stomatitis-gingivitis in children: controlled trial of aciclovir versus placebo. Ann Pediatr (Paris) 1988;35:212–16. Aoki FY, Law BJ, Hammond GW, et al.. Acyclovir suspension for treatment of acute herpes simplex virus gingivostomatitis in children: a placebo controlled double blind trial. Abstract no. 1530. In: Program and abstracts of the 33rd Interscience Conference on Antimicrobial Agents

2009 BestBETS

22. Aciclovir effective in prevention and treatment of herpes simplex virus in patients being treated for cancer

Aciclovir effective in prevention and treatment of herpes simplex virus in patients being treated for cancer PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Aciclovir effective in prevention and treatment of herpes simplex virus in patients being treated for cancer Clinical question How effective are interventions for the prevention and/or treatment of herpes simplex virus (HSV) in patients (...) receiving treatment for cancer? Bottom line Aciclovir is efficacious in the prevention and treatment of HSV infections, in terms of preventing clinical/culture positive HSV infections, reduction in healing time, duration of viral shedding and relief of pain. There is no evidence valaciclovir is more efficacious than aciclovir, or a high dose of valaciclovir is better than a low dose of valaciclovir. There is evidence, for prevention, placebo is more efficacious than prostaglandin E. Caveat No trials

2009 Cochrane PEARLS

23. A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study

A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 Health Technology Assessment (HTA) Database.

24. Economic evaluation of early administration of prednisolone and/or aciclovir for the treatment of Bell's palsy

Economic evaluation of early administration of prednisolone and/or aciclovir for the treatment of Bell's palsy Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 NHS Economic Evaluation Database.

25. Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Full Text available with Trip Pro

Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Across many observational studies, herpes simplex virus type 2 (HSV-2) infection is associated with two-fold to three-fold increased risk for HIV-1 infection. We investigated whether HSV-2 suppression with aciclovir would reduce the risk of HIV-1 acquisition.We undertook a double-blind, randomised, placebo-controlled phase III (...) trial in HIV-negative, HSV-2 seropositive women in Africa and men who have sex with men (MSM) from sites in Peru and the USA. Participants were randomly assigned by block randomisation to twice daily aciclovir 400 mg (n=1637) or matching placebo (n=1640) for 12-18 months, and were seen monthly for dispensation of study drug, adherence counselling and measurement by pill count and self-reporting, and risk reduction counselling, and every 3 months for genital examination and HIV testing. The primary

2008 Lancet Controlled trial quality: predicted high

26. Some evidence that acyclovir is effective for treating primary herpetic gingivostomatitis

Some evidence that acyclovir is effective for treating primary herpetic gingivostomatitis PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Some evidence that acyclovir is effective for treating primary herpetic gingivostomatitis Clinical question How effective is acyclovir for treating primary herpetic gingivostomatitis (PHG)? Bottom line One trial (n=72) provided some limited evidence (...) to suggest for children under 6 years of age with PHG acyclovir is effective in reducing the number of oral lesions (NNT* 2), preventing the development of new extraoral lesions (NNT 3), decreasing the difficulty experienced in eating (NNT 3) and drinking (NNT 5) and reducing admissions to hospital (NNT 12). * NNT = number needed to treat to benefit 1 individual. Caveat Only 2 trials, one with 72 participants and the other with 20 participants, were included in this review. The second study failed

2008 Cochrane PEARLS

27. Early treatment with prednisolone, but not acyclovir, was effective in Bell’s palsy

Early treatment with prednisolone, but not acyclovir, was effective in Bell’s palsy Early treatment with prednisolone, but not acyclovir, was effective in Bell’s palsy | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional (...) accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Early treatment with prednisolone, but not acyclovir, was effective in Bell’s palsy Article Text Therapeutics Early treatment with prednisolone, but not acyclovir, was effective in Bell’s palsy Statistics from Altmetric.com

2008 Evidence-Based Medicine

28. Early treatment with prednisolone or acyclovir in Bell's palsy. Full Text available with Trip Pro

Early treatment with prednisolone or acyclovir in Bell's palsy. Corticosteroids and antiviral agents are widely used to treat the early stages of idiopathic facial paralysis (i.e., Bell's palsy), but their effectiveness is uncertain.We conducted a double-blind, placebo-controlled, randomized, factorial trial involving patients with Bell's palsy who were recruited within 72 hours after the onset of symptoms. Patients were randomly assigned to receive 10 days of treatment with prednisolone (...) , acyclovir, both agents, or placebo. The primary outcome was recovery of facial function, as rated on the House-Brackmann scale. Secondary outcomes included quality of life, appearance, and pain.Final outcomes were assessed for 496 of 551 patients who underwent randomization. At 3 months, the proportions of patients who had recovered facial function were 83.0% in the prednisolone group as compared with 63.6% among patients who did not receive prednisolone (P<0.001) and 71.2% in the acyclovir group

2007 NEJM Controlled trial quality: predicted high

29. Acyclovir for treating varicella in otherwise healthy children and adolescents. Full Text available with Trip Pro

Acyclovir for treating varicella in otherwise healthy children and adolescents. Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox.1) To examine the evidence evaluating the efficacy of acyclovir in alleviating symptoms of chickenpox and shortening the duration of illness. 2) To examine complications of chickenpox and adverse effects associated with acyclovir as reported in the relevant trials.We searched (...) the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 2, 2005), MEDLINE (January 1966 to June 2005), and EMBASE (1988 to June 2005). The reference lists of all relevant articles were reviewed. The primary author of relevant studies and the pharmaceutical company that manufactures acyclovir were contacted.Randomized controlled trials that evaluated otherwise healthy children zero to 18 years of age, with chickenpox.Two authors independently reviewed the studies

2005 Cochrane

30. Should acyclovir be prescribed for immunocompetent children presenting with chickenpox?

. You wonder whether the prescribing of oral acyclovir would reduce the disease severity and duration compared to the advising of symptomatic control only. Search Strategy Medline 1966 – 07 / 04 using the Ovid interface. The Cochrane Library Issue 2, 2004 [(aciclovir OR acyclovir).mp. AND (chickenpox OR chicken pox).mp.] LIMIT to human AND English language AND all child AND randomised controlled trial. Cochrane "aciclovir and chicken pox" Search Outcome The Medline search found 14 papers of which 3 (...) patient numbers. Clinical Bottom Line Oral acyclovir shortens time to fever reduction and time to no new lesions by one day but has no effect on complication rates secondary to infection. These reductions were only seen if treatment was initiated with 24 hours of rash onset. Use of acyclovir should not currently be recommended in immunocompetent children with chickenpox infection. References Balfour HH Jr, Kelly JM, Suarez CS et al. Aciclovir treatment of varicella in otherwise healthy children

2005 BestBETS

31. Acyclovir prophylaxis for pregnant women with a known history of herpes simplex virus: a cost-effectiveness analysis

Acyclovir prophylaxis for pregnant women with a known history of herpes simplex virus: a cost-effectiveness analysis Acyclovir prophylaxis for pregnant women with a known history of herpes simplex virus: a cost-effectiveness analysis Acyclovir prophylaxis for pregnant women with a known history of herpes simplex virus: a cost-effectiveness analysis Little S E, Caughey A B Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each (...) abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The study examined prophylactic antiviral (acyclovir) therapy for women with a history of herpes simplex virus (HSV) but without recurrence during pregnancy. Type of intervention Secondary prevention. Economic study type Cost-utility analysis. Study population The study population comprised a hypothetical

2005 NHS Economic Evaluation Database.

32. Acyclovir for treating varicella in otherwise healthy children and adolescents. (Abstract)

Acyclovir for treating varicella in otherwise healthy children and adolescents. Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox.1) To examine the evidence evaluating the efficacy of acyclovir in alleviating symptoms of chickenpox and shortening the duration of illness. 2) To examine complications of chickenpox and adverse effects associated with acyclovir as reported in the relevant trials.We searched (...) The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 1, 2003), MEDLINE (January 1966 to May 2003), and EMBASE (1988 to April 2003). The reference lists of all relevant articles were reviewed. The primary author of relevant studies and the pharmaceutical company that manufactures acyclovir were contacted.Randomized controlled trials that evaluated otherwise healthy children zero to 18 years of age, with chickenpox.Two reviewers independently reviewed the studies

2004 Cochrane

33. Aciclovir or valaciclovir for Bell's palsy (idiopathic facial paralysis). (Abstract)

Aciclovir or valaciclovir for Bell's palsy (idiopathic facial paralysis). The most common disorder of the facial nerve is acute idiopathic facial paralysis or Bell's palsy and there may be significant morbidity or incomplete recovery associated with severe cases.To assess the efficacy of aciclovir or similar agents for treating Bell's palsy.We searched the Cochrane Neuromuscular Disease Group register (searched April 2003), MEDLINE (from January 1966 to April 2003), EMBASE (from January 1980 (...) to April 2003) and LILACS (from January 1982 to April 2003). We also contacted authors of identified trials.Randomised or quasi-randomised trials of aciclovir or valaciclovir therapy, alone or in combination with any other drug, in patients with Bell's palsy.We identified six randomised trials.Three studies met our inclusion criteria, including 246 patients. One study evaluated aciclovir with corticosteroid versus corticosteroid alone, another study evaluated aciclovir alone versus corticosteroid

2004 Cochrane

34. Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review

Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review Sheffield J S, Hollier L M, Hill J B, Stuart G S, Wendel G D CRD summary This review assessed prophylactic acyclovir for pregnant women with genital herpes simplex virus (HSV) near term. The authors (...) concluded that acyclovir at 36 weeks' gestation reduces clinical HSV recurrence at delivery, Caesarean section for recurrent genital herpes and shedding of HSV at delivery. This was a well-conducted and clearly presented review. The authors' conclusions are likely to be reliable. Authors' objectives To assess the effects of prophylactic acyclovir administered to pregnant women with genital herpes simplex virus (HSV) near term on HSV recurrence at delivery. Searching MEDLINE (from 1966 to March 2003

2003 DARE.

35. Aciclovir for Bell's palsy (idiopathic facial paralysis). (Abstract)

Aciclovir for Bell's palsy (idiopathic facial paralysis). The most common disorder of the facial nerve is acute idiopathic facial paralysis or Bell's palsy and there may be significant morbidity or incomplete recovery associated with severe cases. Although the cause remains unknown, recent evidence suggests a possible association with Herpes simplex virus (HSV) infection. To test this hypothesis clinically four clinical trials have used aciclovir, an antiviral agent, either alone (...) or in combination with corticosteroids to treat Bell's palsy.To assess the efficacy of aciclovir for treating Bell's palsy and to evaluate any adverse effects of the drug treatment.Search of the Cochrane Neuromuscular Disease Group register, MEDLINE, EMBASE and LILACS databases for randomised trials. We also contacted authors of identified trials.Randomised or quasi-randomised trials of aciclovir therapy, alone or in combination with any other drug, in patients with Bell's palsy.We identified four randomised

2001 Cochrane

36. Practice parameter: steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology

Practice parameter: steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology Practice parameter: steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology Practice parameter: steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review). Report of the Quality Standards (...) Subcommittee of the American Academy of Neurology Grogan P M, Gronseth G S Authors' objectives To determine the effectiveness of steroids, acyclovir, and surgical facial nerve decompression in Bell's palsy. Searching MEDLINE was searched from 1966 to June 2000. The search terms included 'facial paralysis', 'Bell's palsy', 'prednisone', 'prednisolone', 'hydrocortisone', 'acyclovir' and 'surgery'. The references of the retrieved studies were examined for additional studies. Study selection Study designs

2001 DARE.

37. Acyclovir for the prevention of recurrent herpes simplex virus eye disease. Herpetic Eye Disease Study Group. Full Text available with Trip Pro

Acyclovir for the prevention of recurrent herpes simplex virus eye disease. Herpetic Eye Disease Study Group. Long-term treatment with antiviral agents has been shown to prevent recurrences of genital and orofacial herpes simplex virus (HSV) disease, but it is uncertain whether prophylactic treatment can prevent recurrences of ocular HSV disease.We randomly assigned 703 immunocompetent patients who had had ocular HSV disease within the preceding year to receive 400 mg of acyclovir or placebo (...) orally twice daily. The study outcomes were the rates of development of ocular or nonocular HSV disease during a 12-month treatment period and a 6-month observation period.The cumulative probability of a recurrence of any type of ocular HSV disease during the 12-month treatment period was 19 percent in the acyclovir group and 32 percent in the placebo group (P<0.001). Among the 337 patients with a history of stromal keratitis, the most common serious form of ocular HSV disease, the cumulative

1998 NEJM Controlled trial quality: uncertain

38. Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data

Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data Ioannidis J P, Collier A C, Cooper D (...) A, Corey L, Fiddian A P, Gazzard B G, Griffiths P D, Contopoulos-Ioannidis D G, Lau J, Pavia A T, Saag M S, Spruance S L, Youle M S Authors' objectives To determine the efficacy of high-dose acyclovir in patients with the human immunodeficiency virus (HIV). Searching The trials were identified by searching MEDLINE, abstracts from meetings and trial directories, and through correspondence with experts, investigators of the identified trials and industry personnel. Study selection Study designs

1998 DARE.

39. Cost-effectiveness of acyclovir suppression to prevent recurrent genital herpes in term pregnancy Full Text available with Trip Pro

Cost-effectiveness of acyclovir suppression to prevent recurrent genital herpes in term pregnancy Cost-effectiveness of acyclovir suppression to prevent recurrent genital herpes in term pregnancy Cost-effectiveness of acyclovir suppression to prevent recurrent genital herpes in term pregnancy Scott L L, Alexander J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods (...) , the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Acyclovir suppression to prevent recurrent genital herpes (HSV) in term pregnancy. Type of intervention Secondary prevention. Economic study type Cost-effectiveness analysis. Study population Pregnant women with a history of HSV or with their first episode diagnosed during pregnancy. Setting Community and secondary care. The economic study was conducted

1998 NHS Economic Evaluation Database.

40. Cost effectiveness of early treatment with oral aciclovir in adult chickenpox

. Source of funding None stated. Bibliographic details Smith K J, Roberts M S. Cost effectiveness of early treatment with oral aciclovir in adult chickenpox. PharmacoEconomics 1998; 13(5 Part 2): 645-651 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Acyclovir /economics /therapeutic use; Administration, Oral; Adult; Antiviral Agents /therapeutic use; Chickenpox /drug therapy; Cost-Benefit Analysis; Humans; Quality of Life; Quality-Adjusted Life Years AccessionNumber 21998008154 Date (...) Cost effectiveness of early treatment with oral aciclovir in adult chickenpox Cost effectiveness of early treatment with oral aciclovir in adult chickenpox Cost effectiveness of early treatment with oral aciclovir in adult chickenpox Smith K J, Roberts M S Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical

1998 NHS Economic Evaluation Database.