Latest & greatest articles for adverse events

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Top results for adverse events

1. Acute infusion-related adverse events to chemotherapy and monoclonal antibodies

Acute infusion-related adverse events to chemotherapy and monoclonal antibodies TITLE, ARIAL, SIZE 52-72 Program, project, initiative 2 lines, Garamond, size 14 Date, Garamond, size 14 Acute Infusion-Related Adverse Events to Chemotherapy and Monoclonal Antibodies Effective Date: September, 2020 Clinical Practice Guideline SUPP-019 – Version 1 www.ahs.ca/guru Guideline Resource Unit guru@ahs.ca 2 Guideline Resource Unit Last revision: September, 2020 Background Many chemotherapy drugs (...) and monoclonal antibodies are reported to cause acute infusion-related allergic and allergic-like reactions in cancer patients. These reactions range from mild cutaneous appearances (e.g. pruritus and hives) to life-threatening anaphylaxis with hypotension, oxygen desaturation and cardiovascular collapse, and death. 1 Acute infusion-related adverse events vary based on the type of drug used, as well as the duration, frequency of infusion and prior exposure to the drug. 2 Understanding the pathophysiology

2021 CPG Infobase

2. Carboplatin and Paclitaxel for Advanced Endometrial Cancer: Final Overall Survival and Adverse Event Analysis of a Phase III Trial (NRG Oncology/GOG0209)

Carboplatin and Paclitaxel for Advanced Endometrial Cancer: Final Overall Survival and Adverse Event Analysis of a Phase III Trial (NRG Oncology/GOG0209) Carboplatin and Paclitaxel for Advanced Endometrial Cancer: Final Overall Survival and Adverse Event Analysis of a Phase III Trial (NRG Oncology/GOG0209) - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) Nov 20;38(33):3841-3850. doi: 10.1200/JCO.20.01076. Epub 2020 Sep 29. Carboplatin and Paclitaxel for Advanced Endometrial Cancer: Final Overall Survival and Adverse Event Analysis of a Phase III Trial (NRG Oncology/GOG0209) , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 University of Texas Southwestern Medical Center, Dallas, TX. 2 NRG Oncology, Clinical Trial Development Division, Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY. 3

2021 EvidenceUpdates

3. Transforming the Medication Regimen Review Process Using Telemedicine to Prevent Adverse Events

Transforming the Medication Regimen Review Process Using Telemedicine to Prevent Adverse Events Transforming the Medication Regimen Review Process Using Telemedicine to Prevent Adverse Events - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public health information (...) Using Telemedicine to Prevent Adverse Events , , , , , , , , , , , Affiliations Expand Affiliations 1 School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 2 Department of Pharmacy, UPMC, Pittsburgh, Pennsylvania, USA. 3 Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 4 Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 5 Department of Biomedical Informatics, University

2020 EvidenceUpdates

4. Usefulness of the American Heart Association`s Ideal Cardiovascular Health Measure to Predict Long-term Major Adverse Cardiovascular Events (From the Heart SCORE Study)

Usefulness of the American Heart Association`s Ideal Cardiovascular Health Measure to Predict Long-term Major Adverse Cardiovascular Events (From the Heart SCORE Study) Usefulness of the American Heart Association's Ideal Cardiovascular Health Measure to Predict Long-term Major Adverse Cardiovascular Events (From the Heart SCORE Study) - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several (...) Cardiol Actions . 2020 Oct 13;S0002-9149(20)31091-2. doi: 10.1016/j.amjcard.2020.10.019. Online ahead of print. Usefulness of the American Heart Association's Ideal Cardiovascular Health Measure to Predict Long-term Major Adverse Cardiovascular Events (From the Heart SCORE Study) , , , , , , , , Affiliations Expand Affiliations 1 College of Public Health, University of South Florida, Tampa, Florida. 2 University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: saeeda2

2020 EvidenceUpdates

5. Withdrawal, dependence and adverse events of antidepressants: lessons from patients and data

Withdrawal, dependence and adverse events of antidepressants: lessons from patients and data Withdrawal, dependence and adverse events of antidepressants: lessons from patients and data | Evidence-Based Mental Health Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? You are here Withdrawal, dependence and adverse events of antidepressants: lessons from patients and data Article Text Editorial Withdrawal, dependence and adverse events of antidepressants: lessons from patients and data Anneka Tomlinson , Katharine Boaden , Andrea Cipriani Statistics from Altmetric.com Tolerability, withdrawal effects and dependence on prescription medication is an important topic of current scientific and clinical

2020 Evidence-Based Mental Health

6. Gastrointestinal adverse events with insulin glargine/lixisenatide fixed-ratio combination versus glucagon-like peptide-1 receptor agonists in people with type 2 diabetes mellitus: A network meta-analysis Full Text available with Trip Pro

Gastrointestinal adverse events with insulin glargine/lixisenatide fixed-ratio combination versus glucagon-like peptide-1 receptor agonists in people with type 2 diabetes mellitus: A network meta-analysis Gastrointestinal adverse events with insulin glargine/lixisenatide fixed-ratio combination versus glucagon-like peptide-1 receptor agonists in people with type 2 diabetes mellitus: A network meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage (...) Display options Format Share Permalink Copy Page navigation Diabetes Obes Metab Actions . 2020 Sep 29. doi: 10.1111/dom.14202. Online ahead of print. Gastrointestinal adverse events with insulin glargine/lixisenatide fixed-ratio combination versus glucagon-like peptide-1 receptor agonists in people with type 2 diabetes mellitus: A network meta-analysis , , , , , , , Affiliations Expand Affiliations 1 Centre of Research Excellence in Translating Nutritional Science to Good Health, University

2020 EvidenceUpdates

7. Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events

Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events Journal Club Eastern Virginia Medical School Therapy Article Presenter: Allison Wood Date: 8/31/20 Citation: Conway, J., et al, Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events. Critical Care Medicine, 47, p.498. I. WHAT IS BEING STUDIED? 1. Study Objective To study “whether (...) the administration of ketamine for tracheal intubation in critically ill children with or without shock was associated with fewer adverse hemodynamic events compared with other induction agents.” “We also investigated if there was a dose dependence for any association between ketamine use and adverse hemodynamic events.” 2. Study Design Retrospective analysis of prospectively collected observational data from the NEAR4KIDS and PALISI databases that included 40 PICU’s in US & Canada 3. Inclusion Criteria All

2020 Emergency Medicine Journal Club

8. Sodium glucose cotransporter 2 inhibitors and risk of major adverse cardiovascular events: multi-database retrospective cohort study. Full Text available with Trip Pro

Sodium glucose cotransporter 2 inhibitors and risk of major adverse cardiovascular events: multi-database retrospective cohort study. To compare the risk of cardiovascular events between sodium glucose cotransporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors among people with type 2 diabetes in a real world context of clinical practice.Multi-database retrospective cohort study using a prevalent new user design with subsequent meta-analysis.Canadian Network (...) for Observational Drug Effect Studies (CNODES), with administrative healthcare databases from seven Canadian provinces and the United Kingdom, 2013-18.209 867 new users of a SGLT2 inhibitor matched to 209 867 users of a DPP-4 inhibitor on time conditional propensity score and followed for a mean of 0.9 years.The primary outcome was major adverse cardiovascular events (MACE, a composite of myocardial infarction, ischaemic stroke, or cardiovascular death). Secondary outcomes were the individual components of MACE

2020 BMJ

9. Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial Full Text available with Trip Pro

Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial - PubMed This site needs JavaScript to work properly. Please enable (...) options Display options Format Share Permalink Copy Page navigation Eur Heart J Actions . 2020 Aug 21;ehaa498. doi: 10.1093/eurheartj/ehaa498. Online ahead of print. Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Division of Cardiology, Fundación Jiménez Díaz, Autónoma

2020 EvidenceUpdates

10. Identifying low-risk chest pain in the emergency department: Obstructive coronary artery disease and major adverse cardiac events

Identifying low-risk chest pain in the emergency department: Obstructive coronary artery disease and major adverse cardiac events Identifying low-risk chest pain in the emergency department: Obstructive coronary artery disease and major adverse cardiac events - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging (...) . Identifying low-risk chest pain in the emergency department: Obstructive coronary artery disease and major adverse cardiac events , , , , , , Affiliations Expand Affiliations 1 Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 2 Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: ans1023@gmail.com. PMID: 32738469 DOI: Item in Clipboard

2020 EvidenceUpdates

11. Effects of Blended (Yellow) vs Forced Coagulation (Blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial Full Text available with Trip Pro

Effects of Blended (Yellow) vs Forced Coagulation (Blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial Effects of Blended (Yellow) vs Forced Coagulation (Blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History (...) Gastroenterology Actions . 2020 Jul;159(1):119-128.e2. doi: 10.1053/j.gastro.2020.03.014. Epub 2020 Mar 12. Effects of Blended (Yellow) vs Forced Coagulation (Blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial , , , , , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Dartmouth Geisel School of Medicine, Hanover, New Hampshire; Section of Gastroenterology and Hepatology, Veterans Affairs Medical Center White River Junction

2020 EvidenceUpdates

12. Association Between Oral Corticosteroid Bursts and Severe Adverse Events : A Nationwide Population-Based Cohort Study. (Abstract)

Association Between Oral Corticosteroid Bursts and Severe Adverse Events : A Nationwide Population-Based Cohort Study. Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (≤14 days) is largely unknown.To examine the associations between steroid bursts and severe adverse events, specifically gastrointestinal (GI) bleeding, sepsis, and heart failure.Self-controlled case series.Entire National Health Insurance Research Database of medical (...) claims records in Taiwan.Adults aged 20 to 64 years with continuous enrollment in the National Health Insurance program from 1 January 2013 to 31 December 2015.Incidence rates of severe adverse events in steroid burst users and non-steroid users, as well as incidence rate ratios (IRRs) for severe adverse events within 5 to 30 and 31 to 90 days after initiation of steroid therapy.Of 15 859 129 adult participants, 2 623 327 who received a single steroid burst were included. The most common indications

2020 Annals of Internal Medicine

13. Prospective validation of classification of intraoperative adverse events (ClassIntra): international, multicentre cohort study. Full Text available with Trip Pro

Prospective validation of classification of intraoperative adverse events (ClassIntra): international, multicentre cohort study. To prospectively assess the construct and criterion validity of ClassIntra version 1.0, a newly developed classification for assessing intraoperative adverse events.International, multicentre cohort study.18 secondary and tertiary centres from 12 countries in Europe, Oceania, and North America.The cohort study included a representative sample of 2520 patients (...) adjusted association between the most severe intraoperative and postoperative complications, measured in a multivariable hierarchical proportional odds model. For criterion validity, inter-rater reliability was evaluated in a survey of 10 fictitious case scenarios describing intraoperative complications.Of 2520 patients enrolled, 610 (24%) experienced at least one intraoperative adverse event and 838 (33%) at least one postoperative complication. Multivariable analysis showed a gradual increase in risk

2020 BMJ

14. Some glucose-lowering drugs reduce risk for major adverse cardiac events. (Abstract)

Some glucose-lowering drugs reduce risk for major adverse cardiac events. Zhu J, Yu X, Zheng Y, et al. Association of glucose-lowering medications with cardiovascular outcomes: an umbrella review and evidence map. Lancet Diabetes Endocrinol. 2020;8:192-205. 32006518.

2020 Annals of Internal Medicine

15. Pulmonary adverse events of small molecule JAK inhibitors in autoimmune disease: systematic review and meta-analysis

Pulmonary adverse events of small molecule JAK inhibitors in autoimmune disease: systematic review and meta-analysis Pulmonary adverse events of small molecule JAK inhibitors in autoimmune disease: systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library (...) displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Rheumatology (Oxford) Actions . 2020 May 14;keaa117. doi: 10.1093/rheumatology/keaa117. Online ahead of print. Pulmonary adverse events of small molecule JAK inhibitors in autoimmune disease: systematic review and meta-analysis , , , , Affiliations Expand Affiliations 1 Department of Respiratory Medicine, Alfred Hospital. 2 Central Clinical School, Monash University, Melbourne. 3 Cabrini Medical Centre

2020 EvidenceUpdates

16. Predicting Adverse Events beyond Stroke and Bleeding with the ABC-Stroke and ABC-Bleeding Scores in Patients with Atrial Fibrillation: The Murcia AF Project

Predicting Adverse Events beyond Stroke and Bleeding with the ABC-Stroke and ABC-Bleeding Scores in Patients with Atrial Fibrillation: The Murcia AF Project Predicting Adverse Events beyond Stroke and Bleeding with the ABC-Stroke and ABC-Bleeding Scores in Patients with Atrial Fibrillation: The Murcia AF Project - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Thromb Haemost Actions . 2020 Jun 7. doi: 10.1055/s-0040-1712914. Online ahead of print. Predicting Adverse Events beyond Stroke and Bleeding with the ABC-Stroke and ABC-Bleeding Scores in Patients with Atrial Fibrillation: The Murcia AF Project # , # , , , , Affiliations Expand Affiliations 1 Department of Cardiology, Hospital Clínico

2020 EvidenceUpdates

17. 60-day major adverse cardiac events in emergency department patients with non-low modified HEART scores

60-day major adverse cardiac events in emergency department patients with non-low modified HEART scores 60-day major adverse cardiac events in emergency department patients with non-low modified HEART scores - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center (...) Copy Actions Cite Share Permalink Copy Page navigation Case Reports Am J Emerg Med Actions . 2020 May 28;S0735-6757(20)30442-3. doi: 10.1016/j.ajem.2020.05.081. Online ahead of print. 60-day major adverse cardiac events in emergency department patients with non-low modified HEART scores , , , , , , Affiliations Expand Affiliations 1 Department of Emergency Medicine, Kaiser Permanente, 3600 Broadway, Oakland, CA 94611, USA; Department of Critical Care Medicine, Kaiser Permanente, 3600 Broadway

2020 EvidenceUpdates

18. Statins and Major Adverse Limb Events in Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis

Statins and Major Adverse Limb Events in Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis Statins and Major Adverse Limb Events in Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National (...) of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Thromb Haemost Actions . 2020 May;120(5):866-875. doi: 10.1055/s-0040-1709711. Epub 2020 May 5. Statins and Major Adverse Limb Events in Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis , , , , , , Affiliations Expand Affiliations 1 Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Italy. 2 Department

2020 EvidenceUpdates

19. EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors Full Text available with Trip Pro

EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors EULAR Points to Consider for the Diagnosis and Management of Rheumatic Immune-Related Adverse Events Due to Cancer Immunotherapy With Checkpoint Inhibitors - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Ann Rheum Dis Actions . 2020 Apr 23;annrheumdis-2020-217139. doi: 10.1136/annrheumdis-2020-217139. Online ahead of print. EULAR Points to Consider for the Diagnosis and Management of Rheumatic Immune-Related Adverse Events Due to Cancer Immunotherapy With Checkpoint Inhibitors , , , , , , , , , , , , , , , , , , , , , , Affiliations

2020 EvidenceUpdates

20. Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes: A Randomized Clinical Trial. Bromodomain and extraterminal proteins are epigenetic regulators of gene transcription. Apabetalone is a selective bromodomain and extraterminal protein inhibitor targeting bromodomain 2 and is hypothesized to have potentially favorable effects on pathways related to atherothrombosis. Pooled phase 2 data suggest (...) favorable effects on clinical outcomes.To test whether apabetalone significantly reduces major adverse cardiovascular events.A randomized, double-blind, placebo-controlled trial, conducted at 190 sites in 13 countries. Patients with an acute coronary syndrome in the preceding 7 to 90 days, type 2 diabetes, and low high-density lipoprotein cholesterol levels were eligible for enrollment, which started November 11, 2015, and ended July 4, 2018, with end of follow-up on July 3, 2019.Patients were

2020 JAMA