Latest & greatest articles for adverse events

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Top results for adverse events

1. Sodium glucose cotransporter 2 inhibitors and risk of major adverse cardiovascular events: multi-database retrospective cohort study. Full Text available with Trip Pro

Sodium glucose cotransporter 2 inhibitors and risk of major adverse cardiovascular events: multi-database retrospective cohort study. To compare the risk of cardiovascular events between sodium glucose cotransporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors among people with type 2 diabetes in a real world context of clinical practice.Multi-database retrospective cohort study using a prevalent new user design with subsequent meta-analysis.Canadian Network (...) for Observational Drug Effect Studies (CNODES), with administrative healthcare databases from seven Canadian provinces and the United Kingdom, 2013-18.209 867 new users of a SGLT2 inhibitor matched to 209 867 users of a DPP-4 inhibitor on time conditional propensity score and followed for a mean of 0.9 years.The primary outcome was major adverse cardiovascular events (MACE, a composite of myocardial infarction, ischaemic stroke, or cardiovascular death). Secondary outcomes were the individual components of MACE

2020 BMJ

2. Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial Full Text available with Trip Pro

Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial - PubMed This site needs JavaScript to work properly. Please enable (...) options Display options Format Share Permalink Copy Page navigation Eur Heart J Actions . 2020 Aug 21;ehaa498. doi: 10.1093/eurheartj/ehaa498. Online ahead of print. Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Division of Cardiology, Fundación Jiménez Díaz, Autónoma

2020 EvidenceUpdates

3. Identifying low-risk chest pain in the emergency department: Obstructive coronary artery disease and major adverse cardiac events

Identifying low-risk chest pain in the emergency department: Obstructive coronary artery disease and major adverse cardiac events Identifying low-risk chest pain in the emergency department: Obstructive coronary artery disease and major adverse cardiac events - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging (...) . Identifying low-risk chest pain in the emergency department: Obstructive coronary artery disease and major adverse cardiac events , , , , , , Affiliations Expand Affiliations 1 Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 2 Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: ans1023@gmail.com. PMID: 32738469 DOI: Item in Clipboard

2020 EvidenceUpdates

4. Effects of Blended (Yellow) vs Forced Coagulation (Blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial Full Text available with Trip Pro

Effects of Blended (Yellow) vs Forced Coagulation (Blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial Effects of Blended (Yellow) vs Forced Coagulation (Blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History (...) Gastroenterology Actions . 2020 Jul;159(1):119-128.e2. doi: 10.1053/j.gastro.2020.03.014. Epub 2020 Mar 12. Effects of Blended (Yellow) vs Forced Coagulation (Blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial , , , , , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Dartmouth Geisel School of Medicine, Hanover, New Hampshire; Section of Gastroenterology and Hepatology, Veterans Affairs Medical Center White River Junction

2020 EvidenceUpdates

5. Association Between Oral Corticosteroid Bursts and Severe Adverse Events : A Nationwide Population-Based Cohort Study. (Abstract)

Association Between Oral Corticosteroid Bursts and Severe Adverse Events : A Nationwide Population-Based Cohort Study. Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (≤14 days) is largely unknown.To examine the associations between steroid bursts and severe adverse events, specifically gastrointestinal (GI) bleeding, sepsis, and heart failure.Self-controlled case series.Entire National Health Insurance Research Database of medical (...) claims records in Taiwan.Adults aged 20 to 64 years with continuous enrollment in the National Health Insurance program from 1 January 2013 to 31 December 2015.Incidence rates of severe adverse events in steroid burst users and non-steroid users, as well as incidence rate ratios (IRRs) for severe adverse events within 5 to 30 and 31 to 90 days after initiation of steroid therapy.Of 15 859 129 adult participants, 2 623 327 who received a single steroid burst were included. The most common indications

2020 Annals of Internal Medicine

6. Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events

Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events Journal Club Eastern Virginia Medical School Therapy Article Presenter: Allison Wood Date: 8/31/20 Citation: Conway, J., et al, Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events. Critical Care Medicine, 47, p.498. I. WHAT IS BEING STUDIED? 1. Study Objective To study “whether (...) the administration of ketamine for tracheal intubation in critically ill children with or without shock was associated with fewer adverse hemodynamic events compared with other induction agents.” “We also investigated if there was a dose dependence for any association between ketamine use and adverse hemodynamic events.” 2. Study Design Retrospective analysis of prospectively collected observational data from the NEAR4KIDS and PALISI databases that included 40 PICU’s in US & Canada 3. Inclusion Criteria All

2020 Emergency Medicine Journal Club

7. Prospective validation of classification of intraoperative adverse events (ClassIntra): international, multicentre cohort study. Full Text available with Trip Pro

Prospective validation of classification of intraoperative adverse events (ClassIntra): international, multicentre cohort study. To prospectively assess the construct and criterion validity of ClassIntra version 1.0, a newly developed classification for assessing intraoperative adverse events.International, multicentre cohort study.18 secondary and tertiary centres from 12 countries in Europe, Oceania, and North America.The cohort study included a representative sample of 2520 patients (...) adjusted association between the most severe intraoperative and postoperative complications, measured in a multivariable hierarchical proportional odds model. For criterion validity, inter-rater reliability was evaluated in a survey of 10 fictitious case scenarios describing intraoperative complications.Of 2520 patients enrolled, 610 (24%) experienced at least one intraoperative adverse event and 838 (33%) at least one postoperative complication. Multivariable analysis showed a gradual increase in risk

2020 BMJ

8. Some glucose-lowering drugs reduce risk for major adverse cardiac events. (Abstract)

Some glucose-lowering drugs reduce risk for major adverse cardiac events. Zhu J, Yu X, Zheng Y, et al. Association of glucose-lowering medications with cardiovascular outcomes: an umbrella review and evidence map. Lancet Diabetes Endocrinol. 2020;8:192-205. 32006518.

2020 Annals of Internal Medicine

9. Pulmonary adverse events of small molecule JAK inhibitors in autoimmune disease: systematic review and meta-analysis

Pulmonary adverse events of small molecule JAK inhibitors in autoimmune disease: systematic review and meta-analysis Pulmonary adverse events of small molecule JAK inhibitors in autoimmune disease: systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library (...) displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Rheumatology (Oxford) Actions . 2020 May 14;keaa117. doi: 10.1093/rheumatology/keaa117. Online ahead of print. Pulmonary adverse events of small molecule JAK inhibitors in autoimmune disease: systematic review and meta-analysis , , , , Affiliations Expand Affiliations 1 Department of Respiratory Medicine, Alfred Hospital. 2 Central Clinical School, Monash University, Melbourne. 3 Cabrini Medical Centre

2020 EvidenceUpdates

10. Predicting Adverse Events beyond Stroke and Bleeding with the ABC-Stroke and ABC-Bleeding Scores in Patients with Atrial Fibrillation: The Murcia AF Project

Predicting Adverse Events beyond Stroke and Bleeding with the ABC-Stroke and ABC-Bleeding Scores in Patients with Atrial Fibrillation: The Murcia AF Project Predicting Adverse Events beyond Stroke and Bleeding with the ABC-Stroke and ABC-Bleeding Scores in Patients with Atrial Fibrillation: The Murcia AF Project - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Thromb Haemost Actions . 2020 Jun 7. doi: 10.1055/s-0040-1712914. Online ahead of print. Predicting Adverse Events beyond Stroke and Bleeding with the ABC-Stroke and ABC-Bleeding Scores in Patients with Atrial Fibrillation: The Murcia AF Project # , # , , , , Affiliations Expand Affiliations 1 Department of Cardiology, Hospital Clínico

2020 EvidenceUpdates

11. 60-day major adverse cardiac events in emergency department patients with non-low modified HEART scores

60-day major adverse cardiac events in emergency department patients with non-low modified HEART scores 60-day major adverse cardiac events in emergency department patients with non-low modified HEART scores - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center (...) Copy Actions Cite Share Permalink Copy Page navigation Case Reports Am J Emerg Med Actions . 2020 May 28;S0735-6757(20)30442-3. doi: 10.1016/j.ajem.2020.05.081. Online ahead of print. 60-day major adverse cardiac events in emergency department patients with non-low modified HEART scores , , , , , , Affiliations Expand Affiliations 1 Department of Emergency Medicine, Kaiser Permanente, 3600 Broadway, Oakland, CA 94611, USA; Department of Critical Care Medicine, Kaiser Permanente, 3600 Broadway

2020 EvidenceUpdates

12. Statins and Major Adverse Limb Events in Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis

Statins and Major Adverse Limb Events in Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis Statins and Major Adverse Limb Events in Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National (...) of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Thromb Haemost Actions . 2020 May;120(5):866-875. doi: 10.1055/s-0040-1709711. Epub 2020 May 5. Statins and Major Adverse Limb Events in Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis , , , , , , Affiliations Expand Affiliations 1 Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Italy. 2 Department

2020 EvidenceUpdates

13. EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors Full Text available with Trip Pro

EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors EULAR Points to Consider for the Diagnosis and Management of Rheumatic Immune-Related Adverse Events Due to Cancer Immunotherapy With Checkpoint Inhibitors - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Ann Rheum Dis Actions . 2020 Apr 23;annrheumdis-2020-217139. doi: 10.1136/annrheumdis-2020-217139. Online ahead of print. EULAR Points to Consider for the Diagnosis and Management of Rheumatic Immune-Related Adverse Events Due to Cancer Immunotherapy With Checkpoint Inhibitors , , , , , , , , , , , , , , , , , , , , , , Affiliations

2020 EvidenceUpdates

14. Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes: A Randomized Clinical Trial. Bromodomain and extraterminal proteins are epigenetic regulators of gene transcription. Apabetalone is a selective bromodomain and extraterminal protein inhibitor targeting bromodomain 2 and is hypothesized to have potentially favorable effects on pathways related to atherothrombosis. Pooled phase 2 data suggest (...) favorable effects on clinical outcomes.To test whether apabetalone significantly reduces major adverse cardiovascular events.A randomized, double-blind, placebo-controlled trial, conducted at 190 sites in 13 countries. Patients with an acute coronary syndrome in the preceding 7 to 90 days, type 2 diabetes, and low high-density lipoprotein cholesterol levels were eligible for enrollment, which started November 11, 2015, and ended July 4, 2018, with end of follow-up on July 3, 2019.Patients were

2020 JAMA

15. Impact of Timing of Preprocedural Opioids on Adverse Events in Procedural Sedation (Abstract)

Impact of Timing of Preprocedural Opioids on Adverse Events in Procedural Sedation The risk of respiratory depression is increased when opioids are added to sedative agents. In our recent multicenter emergency department (ED) procedural sedation cohort, we reported a strong association between preprocedural opioids and sedation-related adverse events. We sought to examine the association between timing of opioids and the incidence of adverse sedation outcomes.We conducted a secondary analysis

2020 EvidenceUpdates

16. ASGE review of adverse events in colonoscopy

ASGE review of adverse events in colonoscopy ASGE STANDARDS OF PRACTICE COMMITTEE REVIEW ASGE review of adverse events in colonoscopy Shivangi T. Kothari, MD, FASGE, 1, * Robert J. Huang, MD, 2, * Aasma Shaukat, MD, MPH, FASGE, 3 Deepak Agrawal, MD, FASGE, 4 James L. Buxbaum, MD, FASGE, 5 Syed M. Abbas Fehmi, MD, MSc, FASGE, 6 Douglas S. Fishman, MD, FASGE, 7 Suryakanth R. Gurudu, MD, FASGE, 8 Mouen A. Khashab, MD, 9 Laith H. Jamil, MD, FASGE, 10 Terry L. Jue, MD, FASGE, 11 Joanna K. Law, MD (...) - cedure. However, adverse events (AEs) related to this routinely performed procedure for screening, diagnostic, ortherapeuticpurposesareanimportantclinicalconsideration.ThepurposeofthisdocumentfromtheAmerican Society for Gastrointestinal Endoscopy’s Standards of Practice Committee is to provide an update on estimates of AEs related to colonoscopy in an evidence-based fashion. A systematic review and meta-analysis of population- based studies was conducted for the 3 most common and important serious

2020 American Society for Gastrointestinal Endoscopy

17. Safety and Adverse Events after Targeted Lung Denervation for Symptomatic Moderate to Severe Chronic Obstructive Pulmonary Disease (AIRFLOW). A Multicenter Randomized Controlled Clinical Trial Full Text available with Trip Pro

Safety and Adverse Events after Targeted Lung Denervation for Symptomatic Moderate to Severe Chronic Obstructive Pulmonary Disease (AIRFLOW). A Multicenter Randomized Controlled Clinical Trial Safety and Adverse Events After Targeted Lung Denervation for Symptomatic Moderate to Severe Chronic Obstructive Pulmonary Disease (AIRFLOW). A Multicenter Randomized Controlled Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set (...) to Collections Create a new collection Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Am J Respir Crit Care Med Actions , 200 (12), 1477-1486 2019 Dec 15 Safety and Adverse Events After Targeted Lung Denervation for Symptomatic Moderate

2020 EvidenceUpdates

18. ERCP-related adverse events

ERCP-related adverse events ERCP-relatedadverseevents:EuropeanSocietyofGastrointestinal Endoscopy (ESGE) Guideline Authors Jean-MarcDumonceau 1 ,ChristineKapral 2 ,Lars Aabakken 3 ,IoannisS.Papanikolaou 4 ,Andrea Tringali 5,6 ,Geoffroy Vanbiervliet 7 ,Torsten Beyna 8 ,MarioDinis-Ribeiro 9,10 ,IstvanHritz 11 ,AlbertoMariani 12 ,Gregorios Paspatis 13 ,Franco Radaelli 14 , SundeepLakhtakia 15 ,AndrewM.Veitch 16 ,JeaninE.vanHooft 17 Institutions ?1 Gastroenterology Service, Hôpital Civil Marie (...) viewableat: https://doi.org/10.1055/a-1075-4080 Dumonceau Jean-Marc et al. ERCP-related adverse events: ESGEClinical Guideline… Endoscopy1Introduction The range and incidence of adverse events (AEs) related to endoscopic retrograde cholangiopancreatography (ERCP) dif- fer substantially from those related to other endoscopic proce- dures. Familiarity with these AEs is critical for providing patient information during the consent phaseas well as for prophylaxis and management. Adverse events related

2020 European Society of Gastrointestinal Endoscopy

19. During Conscious Sedation the Risk of Adverse Events Is Likely Increased in Obese Children Compared to Those of Healthy Weight

During Conscious Sedation the Risk of Adverse Events Is Likely Increased in Obese Children Compared to Those of Healthy Weight UTCAT3394, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title During Conscious Sedation the Risk of Adverse Events Is Likely Increased in Obese Children Compared to Those of Healthy Weight Clinical Question Are obese children undergoing conscious sedation at increased risk for adverse events (...) compared to children who are at healthy weight? Clinical Bottom Line For children with childhood obesity, conscious sedation may lead to more adverse events including oxyhemoglobin desaturation, nausea and true apnea. However, additional evidence is needed to know if there is any clinical and statistical difference between obese children and healthy weight children during conscious sedation. This is supported by both a cross-sectional retrospective study and a review of literature on the relationship

2019 UTHSCSA Dental School CAT Library

20. Performance of cardiac troponins within the HEART score in predicting major adverse cardiac events at the emergency department (Abstract)

Performance of cardiac troponins within the HEART score in predicting major adverse cardiac events at the emergency department This study compared the performance of a single blood draw of high-sensitivity troponin T (hsTnT), high-sensitivity troponin I (hsTnI) and conventional troponin I (cTnI) within a modified HEART score for predicting 30-day MACE at Emergency Department (ED) presentation, and established local reference norms for all three assays by determining the cut-off point which

2019 EvidenceUpdates