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Latest & greatest articles for adverse events
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on adverse events or other clinical topics then use Trip today.
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High risk prescribing in primary care patients particularly vulnerable to adverse drug events: cross sectional population database analysis in Scottish general practice. To examine the prevalence and patterns of high risk prescribing, defined as potentially inappropriate prescribing of drugs to primary care patients particularly vulnerable to adverse drug events.Cross sectional population database analysis.General practices in Scotland.315 Scottish general practices with 1.76 million registered (...) patients, 139 404 (7.9%) of whom were defined as particularly vulnerable to adverse drug events because of age, comorbidity, or co-prescription.How reliably each of 15 indicators-four each for non-steroidal anti-inflammatory drugs, co-prescription with warfarin, and prescribing in heart failure, two for dose instructions for methotrexate, and one for antipsychotic prescribing in dementia-and a composite of all 15 could distinguish practices in terms of their rates of high risk prescribing
Paid malpractice claims for adverseevents in inpatient and outpatient settings. An analysis of paid malpractice claims may provide insight into the prevalence and seriousness of adverse medical events in the outpatient setting.To report and compare the number, magnitude, and type of paid malpractice claims for events in inpatient and outpatient settings.Retrospective analysis of malpractice claims paid on behalf of physicians in outpatient and inpatient settings using data from the National (...) Practitioner Data Bank from 2005 through 2009. We evaluated trends in claims paid by setting, characteristics of paid claims, and factors associated with payment amount.Number of paid claims, mean and median payment amounts, types of errors, and outcomes of errors.In 2009, there were 10,739 malpractice claims paid on behalf of physicians. Of these paid claims, 4910 (47.6%; 95% confidence interval [CI], 46.6%-48.5%) were for events in the inpatient setting, 4448 (43.1%; 95% CI, 42.1%-44.0%) were for events
Effects of adverseevents on the projected population benefits and cost-effectiveness of using live attenuated influenza vaccine in children aged 6 months to 4 years Effects of adverseevents on the projected population benefits and cost-effectiveness of using live attenuated influenza vaccine in children aged 6 months to 4 years Effects of adverseevents on the projected population benefits and cost-effectiveness of using live attenuated influenza vaccine in children aged 6 months to 4 years (...) or with inactivated influenza vaccine, for children younger than five years, considering the impact of adverseevents. The authors concluded that the live attenuated vaccine was similar in cost-effectiveness to the inactivated vaccine, under a wide range of assumptions on the incidence of adverseevents. The methods were valid and should ensure that the authors’ conclusions are robust. Type of economic evaluation Cost-effectiveness analysis, cost-utility analysis Study objective This study assessed the cost
Comparison of rates of adverseevents in adolescent and adult women undergoing medical abortion: population register based study. To determine the risks of short term adverseevents in adolescent and older women undergoing medical abortion.Population based retrospective cohort study.Finnish abortion register 2000-6.All women (n = 27,030) undergoing medical abortion during 2000-6, with only the first induced abortion analysed for each woman.Incidence of adverseevents (haemorrhage, infection (...) cohort (5.7% v 3.7%, P < 0.001). The incidence of adverseevents among adolescents was similar or lower than that among the adults. The risks of haemorrhage (adjusted odds ratio 0.87, 95% confidence interval 0.77 to 0.99), incomplete abortion (0.69, 0.59 to 0.82), and surgical evacuation (0.78, 0.67 to 0.90) were lower in the adolescent cohort. In subgroup analysis of primigravid women, the risks of incomplete abortion (0.68, 0.56 to 0.81) and surgical evacuation (0.75, 0.64 to 0.88) were lower
Literature review: do rapid response systems reduce the incidence of major adverseevents in the deteriorating ward patient? To conduct a literature review that explores the impact of rapid response systems on reducing major adverseevents experienced by deteriorating ward patients.Patients located on hospitals wards are frequently older, have multiple co-morbidities and are often at risk of life-threatening clinical deterioration. Rapid response systems have been developed and implemented (...) effectiveness of rapid response systems in reducing major adverseevents in deteriorating ward patients remains inconclusive. Six studies demonstrated that the introduction of a rapid response systems positively impacted on patient outcomes, but three studies demonstrated no positive impact on patient outcomes. Nursing staff appear reluctant to use rapid response systems; the rationale for this is unclear. However, the continued underuse and inactivation may be one reason why research findings evaluating
Comparison of adverse cardiovascular events and bleeding complications of loading dose of clopidogrel 300 mg versus 600 mg in stable patients undergoing elective percutaneous intervention (from the CADICE study) In large clinical trials enrolling patients with acute coronary syndromes, a high loading dose of clopidogrel (600 mg) has been found to be more effective compared to a low loading dose (300 mg). However, the applicability of these data to stable patients who undergo elective (...) percutaneous coronary intervention is still unclear. A total of 400 patients who underwent elective PCI were prospectively randomized to receive either 600 mg (n = 200) or 300 mg (n = 200) of clopidogrel, followed by a daily maintenance dose of 75 mg. The primary end point was the presence of major adverse cardiovascular events (combined death, myocardial infarction, acute neurologic event, stent thrombosis, and need for percutaneous or surgical revascularization of the target vessel) during
Risk of Serious Adverse Cardiovascular (CV) Events with Varenicline (Champix) Comment on Systematic Review and Meta?analysis RxFiles Trial Summary Q&A www.RxFiles.ca - July 2011 Could the NNH really be 28? Risk of Serious Adverse Cardiovascular (CV) Events with Varenicline (Champix) Comment on Systematic Review and Meta-analysis 1 Findings at a glance In 14 randomized placebo controlled trials with 8216 participants, varenicline was associated with an increase in serious adverse CV events. o (...) . ? In 14 trials that analysed 8216 patients on varenicline vs placebo, the NNH was 417. In 0 trials analysing 0 patients, but all of whom were at much higher risk, this extrapolated NNH would be 28, assuming that the proposed odds ratio holds true. Note that the absolute risk of continuing smoking would also be a major factor to consider in weighing the risk/benefit of therapy. Extras: RxFiles Meta Q&A – July 2011: Risk of Serious Adverse Cardiovascular (CV) Events with Varenicline (Champix, Chantix
Adverseevents of intravenous glucocorticoid pulse therapy in inflammatory diseases: a meta-analysis Adverseevents of intravenous glucocorticoid pulse therapy in inflammatory diseases: a meta-analysis Adverseevents of intravenous glucocorticoid pulse therapy in inflammatory diseases: a meta-analysis Smits NA, Duru N, Bijlsma JW, Jacobs JW CRD summary The review concluded that intravenous glucocorticoid pulse therapy resulted in a high adverseevent rate; cardiovascular adverseevents were (...) the most commonly reported. The review had methodological and data limitations that limit the reliability of the authors’ conclusions. Authors' objectives To determine the adverseevents associated with intravenous pulse glucocorticoids for inflammatory diseases. Searching PubMed, EMBASE and The Cochrane Library were searched to October 2009 for articles published in English. Full search strategies were reported. Reference lists of retrieved studies were searched. Study selection Full text randomised
Tirofiban use with clopidogrel and aspirin decreases adverse cardiovascular events after percutaneous coronary intervention for ST-elevation myocardial infarction: a meta-analysis of randomized trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Aspirin effect on the incidence of major adverse cardiovascular events in patients with diabetes mellitus: a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Impact of treatment completion, intolerance and adverseevents on health system costs in a randomised trial of 4 months rifampin or 9 months isoniazid for latent TB Treatment for latent tuberculosis infection with isoniazid for 9 months (9INH) has poor completion and serious adverseevents, while treatment for 4 months with daily rifampin (4RIF) has significantly higher completion and fewer adverse events.To compare the health system costs of 4RIF and 9INH.In a randomised trial conducted (...) with $970 for 9INH (p<0.0001). The average cost per patient for the 328 of 420 (78%) who completed 4RIF therapy was $1094 compared with $1625 for the 254 of 427 (60%) completing 9INH (p<0.0001). Costs were modestly increased in patients with minor intolerance and substantially increased if the treating physician stopped treatment because of possible adverseevents. Total costs related to management of adverseevents with 9INH were $48 142 compared with $25 684 for 4RIF (p=0.008). Using these data
Adverseevents and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study To evaluate toxicity profiles in patients with rheumatoid arthritis (RA) treated either according to an intensive or a conventional treatment strategy approach with methotrexate (MTX) and to study factors associated with MTX-related toxicity.Data were used from the Computer-Assisted Management in Early Rheumatoid Arthritis (CAMERA (...) ) study, in which clinical efficacy of an intensive treatment strategy with MTX was more beneficial than a conventional treatment strategy approach. In this study, data on adverseevents (AEs) were compared between the two strategy groups. Logistic regression analyses were used to identify possible associations between factors assessed at baseline and withdrawal due to MTX-related AEs or liver toxicity at follow-up.Although significantly more patients in the intensive strategy group experienced MTX
A randomised trial of target-vessel versus multi-vessel revascularisation in ST-elevation myocardial infarction: major adverse cardiac events during long-term follow-up Few reports described outcomes of complete compared with infarct-related artery (IRA)-only revascularisation in patients with ST-elevation myocardial infarction (STEMI) and multivessel coronary artery disease (CAD). Moreover, no studies have compared the simultaneous treatment of non-IRA with the IRA treatment followed (...) at least one major adverse cardiac event (MACE), 13 (20.0%) in the SR group and 15 (23.1%) in the CR group, p<0.001. Inhospital death, repeat revascularisation and re-hospitalisation occurred more frequently in the COR group (all p<0.05), whereas there was no significant difference in re-infarction among the three groups. Survival free of MACE was significantly reduced in the COR group but was similar in the CR and SR groups.Culprit vessel-only angioplasty was associated with the highest rate of long
Use of manometry for laryngeal mask airway reduces postoperative pharyngolaryngeal adverseevents: a prospective, randomized trial Adverseevents such as pharyngolaryngeal complications are indicators of quality patient care. Use of manometry to limit the laryngeal mask airway (LMA) intracuff pressure is not currently a routine practice. This double-blind randomized trial compared pharyngolaryngeal complications in patients managed with manometers to limit the LMA intracuff pressure (<44 mmHg
Associations between renal duplex parameters and adverse cardiovascular events in the elderly: a prospective cohort study Atherosclerotic renovascular disease is associated with an increased risk of cardiovascular disease (CVD) events. This study examines associations between Doppler-derived parameters from the renal artery and renal parenchyma and all-cause mortality and fatal and nonfatal CVD events in a cohort of elderly Americans.Cohort study.A subset of participants from the Cardiovascular (...) renal artery peak systolic velocity.Proportional hazard regression analysis was used to determine associations between renal duplex sonography-derived Doppler signals and CVD events and all-cause mortality adjusted for accepted cardiovascular risk factors. Index CVD outcomes were defined as coronary events (angina, myocardial infarction, and coronary artery bypass grafting/percutaneous coronary intervention), cerebrovascular events (stroke or transient ischemic attack), and any CVD event (angina