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Placebo vs Amoxicillin for Nonsevere Fast-Breathing Pneumonia in Malawian Children Aged 2 to 59 Months: A Double-blind, Randomized Clinical Noninferiority Trial Pneumonia is the leading infectious killer of children. Rigorous evidence supporting antibiotic treatment of children with nonsevere fast-breathing pneumonia in low-resource African settings is lacking.To assess whether treatment with placebo for nonsevere fast-breathing pneumonia is substantively less effective than 3 days of treatment (...) with amoxicillin.This double-blind, 2-arm, randomized clinical noninferiority trial with follow-up of 14 days screened 1343 HIV-uninfected children aged 2 to 59 months with nonsevere fast-breathing pneumonia at outpatient departments of hospitals in Lilongwe, Malawi, Africa, between June 2016 and June 2017.Placebo or amoxicillin dispersible tablets administered twice daily for 3 days.The primary end point was the proportion of children failing treatment by day 4 with a relative noninferiority margin of 1.5 times
Amoxicillin-clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial. Although amoxicillin-clavulanate is the recommended first-line empirical oral antibiotic treatment for non-severe exacerbations in children with bronchiectasis, azithromycin is also often prescribed for its convenient once-daily dosing. No randomised controlled trials involving acute exacerbations (...) in children with bronchiectasis have been published to our knowledge. We hypothesised that azithromycin is non-inferior to amoxicillin-clavulanate for resolving exacerbations in children with bronchiectasis.We did this parallel-group, double-dummy, double-blind, non-inferiority randomised controlled trial in three Australian and one New Zealand hospital between April, 2012, and August, 2016. We enrolled children aged 1-19 years with radiographically proven bronchiectasis unrelated to cystic fibrosis
2018LancetControlled trial quality: predicted high
Amoxicillin Top results for amoxicillin - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for amoxicillin The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence
Safety and effectiveness of amoxicillin in the treatment of inflammatory acne Acne is a common skin disease that predominantly affects teenagers and young adults. Systemic antibiotic therapy, including tetracyclines, macrolides, and trimethoprim-sulfamethoxazole, is indicated in moderate-to-severe inflammatory disease. However, in certain cases, these antibiotics and other commonly prescribed treatments including oral contraceptives, spironolactone, and isotretinoin may be prohibited (...) , especially in cases of pregnancy and drug intolerance. In this retrospective study, we assessed the safety and efficacy of systemic amoxicillin, which has a favorable tolerability profile and compatibility with pregnancy in the treatment of inflammatory acne.
Effect of Postoperative Amoxicillin on Dental Implant Failure Rates Remains Unknown UTCAT3276, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Effect of Postoperative Amoxicillin on Dental Implant Failure Rates Remains Unknown Clinical Question For patients receiving dental implants, does the use of preoperative and postoperative amoxicillin reduce implant failure rates compared to the use of preoperative amoxicillin (...) alone? Clinical Bottom Line There is insufficient evidence to suggest that the use of postoperative amoxicillin reduces dental implant failure rates when used in conjunction with prophylactic amoxicillin. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Chrcanovic/2014 14 studies/14,872 implants Meta-Analysis Key results Antibiotic prophylaxis in healthy patients significantly reduced the risk of implant
Effect of Iron Oxide Nanoparticles and Amoxicillin on Bacterial Growth in the Presence of Dissolved Organic Carbon The impact of emerging contaminants in the presence of active pharmaceutical pollutants plays an important role in the persistence and activity of environmental bacteria. This manuscript focuses on the impact of amoxicillin functionalized iron oxide nanoparticles on bacterial growth, in the presence of dissolved organic carbon (humic acid). The impact of these emerging contaminants (...) individually and collectively on the growth profiles of model gram positive and negative bacteria was tracked for 24 h. Results indicate exposure to subinhibitory concentrations of amoxicillin bound iron oxide nanoparticles, in the presence of humic acid, increase bacterial growth in Pseudomonas aeruginosa and Staphylococcus aureus. Accelerated bacterial growth was associated with an increase in iron ions, which have been shown to influence upregulation of cellular metabolism. Though iron oxide
Amoxycillin and clavulanic acid induced Stevens-Johnson syndrome: A case report Stevens-Johnson syndrome (SJS) is an immune mediated hypersensitivity reaction. Significant involvement of oral, nasal, eye, vaginal, urethral, GI and lower respiratory tract mucous membrane may develop. It is usually a reaction due to a medication or due to an infection. In 95 % of case reports, drugs were found to be an important cause for the development of SJS. In this case report, a 32 year old female reported (...) chief complaint of itch skin eruptions all over the body along with erosive lesions on tongue, lips, buccal mucosa and genital mucosa. The reaction occurred after administration of augmentin (containing amoxycillin and clavulanic acid). She was treated with antimicrobials, antiallergics and conservative management. The patient improved and was discharged from the hospital. Causality assessment using Naranjo Adverse Drug Reaction Probability Scale revealed that amoxycillin and clavulanic acid
The effects of amoxicillin with or without clavulanic acid on the postoperative complaints after third molar surgery: a retrospective chart analysis The aim of this chart-based retrospective study was to evaluate the effects of orally administered amoxicillin alone or amoxicillin combined with clavulanic acid on the frequency of post-operative complications and patients' comfort after mandibular third molar surgery.The records of patients who had undergone lower third molar surgery between (...) October 2014 and December 2015 were examined. A total of 62 patients who had fully impacted teeth in mesioangular position and who had been prescribed same type and dose of anti-inflammatory drug were included in this study. Among them, 32 subjects were found to have been prescribed 500 mg amoxicillin trihydrate orally every 8 h for 5 days (Group A) and 30 patients 500 mg amoxicillin trihydrate plus 125 mg potassium clavulanate orally every 8 h for 5 days postoperatively (Group AC). Post-operative
The Adjunct Use of Azithromycin with Nonsurgical Periodontal Therapy Produces Probing Depth Reductions Similar to Metronidazole-Amoxicillin in Patients with Generalized Aggressive Periodontitis UTCAT3118, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title The Adjunct Use of Azithromycin with Nonsurgical Periodontal Therapy Produces Probing Depth Reductions Similar to Metronidazole-Amoxicillin in Patients with Generalized (...) Aggressive Periodontitis Clinical Question For patients with generalized aggressive periodontitis treated with nonsurgical periodontal therapy, will the use of adjunct systemic azithromycin compared to the use of metronidazole-amoxicillin in combination result in greater probing depth reduction? Clinical Bottom Line For patients with generalized aggressive periodontitis, nonsurgical periodontal therapy treatment in conjunction with systemic azithromycin produced similar probing depth reduction
Rescue Therapy for Helicobacter pylori Eradication: A Randomized Non-Inferiority Trial of Amoxicillin or Tetracycline in Bismuth Quadruple Therapy To compare the efficacy and safety of bismuth-containing quadruple therapy with tetracycline or amoxicillin for rescue treatment of Helicobacter pylori.The study was a non-inferiority trial of H. pylori eradication with at least two previous treatment failures. Subjects were randomized to receive 14-day therapy with b.i.d. lansoprazole 30 mg (...) and bismuth 220 mg, plus metronidazole 400 mg q.i.d and amoxicillin 1 g t.i.d (amoxicillin group) or tetracycline 500 mg q.i.d (tetracycline group). Antimicrobial susceptibility was assessed by the agar-dilution method. Primary outcome was H. pylori eradication at 6 weeks after treatment.In all, 312 subjects were randomized, 13 were lost to follow-up; 29 violated the protocol. The intention-to-treat, per-protocol, and modified intention-to-treat eradication rates were (amoxicillin) 88.5% (138/156, 95
Comparison of cefixime and amoxicillin plus metronidazole in the treatment of chronic periodontitis. Despite significant advances in current medicine and improvement of overall health education, chronic periodontitis is still a widespread disease. Losing teeth is the most serious complication of this particular illness. The aim of this study was to examine patients with chronic periodontitis in order to evaluate the efficacy of non-surgical therapy and combination of amoxicillin (...) and metronidazole compared with cefixime, which has not been so far used for the treatment of this disease.Adult patients with chronic periodontitis (n = 90) underwent non-surgical periodontal treatment (zero-day) and then randomly divided into three groups. The group I served as a control, the group II was additionally treated with the combination of amoxicillin and metronidazole (for 7 days), while the group III was treated with cefixime (also for 7 days). To assess the condition of periodontium before
Amoxicillin for Severe Acute Malnutrition in Children. 27410938 2016 07 15 2018 12 02 1533-4406 375 2 2016 07 14 The New England journal of medicine N. Engl. J. Med. Amoxicillin for Severe Acute Malnutrition in Children. 191-2 10.1056/NEJMc1605388 Isanaka Sheila S Adehossi Eric E Grais Rebecca F RF eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents 804826J2HU Amoxicillin AIM IM N Engl J Med. 2016 Feb 4;374(5):444-53 26840134 N Engl J Med. 2016 Jul 14;375(2 (...) ):190-1 27410939 N Engl J Med. 2016 Jul 14;375(2):191 27410940 Amoxicillin therapeutic use Anti-Bacterial Agents therapeutic use Female Humans Male Severe Acute Malnutrition drug therapy 2016 7 14 6 0 2016 7 14 6 0 2016 7 16 6 0 ppublish 27410938 10.1056/NEJMc1605388 10.1056/NEJMc1605388#SA3
Amoxicillin for Severe Acute Malnutrition in Children. 27410939 2016 07 15 2018 12 02 1533-4406 375 2 2016 07 14 The New England journal of medicine N. Engl. J. Med. Amoxicillin for Severe Acute Malnutrition in Children. 190-1 10.1056/NEJMc1605388 Rawson Timothy M TM Imperial College London, London, United Kingdom firstname.lastname@example.org. Moore Luke S LS Imperial College London, London, United Kingdom email@example.com. Holmes Alison H AH Imperial College London, London, United Kingdom firstname.lastname@example.org. eng (...) II-LA-0214-20008 Department of Health United Kingdom Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents 804826J2HU Amoxicillin AIM IM N Engl J Med. 2016 Feb 4;374(5):444-53 26840134 N Engl J Med. 2016 Jul 14;375(2):191-2 27410938 Amoxicillin therapeutic use Anti-Bacterial Agents therapeutic use Female Humans Male Severe Acute Malnutrition drug therapy 2016 7 14 6 0 2016 7 14 6 0 2016 7 16 6 0 ppublish 27410939 10.1056/NEJMc1605388 10.1056/NEJMc1605388#SA1
Amoxicillin for Severe Acute Malnutrition in Children. 27410940 2016 07 15 2018 12 02 1533-4406 375 2 2016 07 14 The New England journal of medicine N. Engl. J. Med. Amoxicillin for Severe Acute Malnutrition in Children. 191 10.1056/NEJMc1605388 Trehan Indi I Washington University in St. Louis, St. Louis, MO email@example.com. Schechtman Kenneth B KB Washington University in St. Louis, St. Louis, MO firstname.lastname@example.org. Manary Mark J MJ Washington University in St. Louis, St. Louis, MO (...) email@example.com. eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Bacterial Agents 804826J2HU Amoxicillin AIM IM N Engl J Med. 2016 Feb 4;374(5):444-53 26840134 N Engl J Med. 2016 Jul 14;375(2):191-2 27410938 Amoxicillin therapeutic use Anti-Bacterial Agents therapeutic use Female Humans Male Severe Acute Malnutrition drug therapy 2016 7 14 6 0 2016 7 14 6 0 2016 7 16 6 0 ppublish 27410940 10.1056/NEJMc1605388 10.1056/NEJMc1605388#SA2
Bismuth, lansoprazole, amoxicillin and metronidazole or clarithromycin as first-line Helicobacter pylori therapy To evaluate the efficacy and tolerability of replacing tetracycline with amoxicillin in bismuth quadruple therapy.Subjects who were infected with Helicobacter pylori and naïve to treatment were randomly (1:1) assigned to receive a 14-day modified bismuth quadruple therapy: lansoprazole 30 mg, amoxicillin 1 g, bismuth potassium citrate 220 mg (elemental bismuth), twice a day (...) % CI 90.5% to 99.3%) by per-protocol and 88.9% (95% CI 83.0% to 94.8%) and 88.8% (95% CI 82.8% to 94.8%) by intention-to-treat, respectively. Amoxicillin, metronidazole and clarithromycin resistance rates were 1.5%, 45.5% and 26.5%, respectively. Only clarithromycin resistance reduced treatment success (e.g., susceptible 98.6%, resistant 76.9%, p=0.001). Adverse events were more common in the metronidazole group.These results suggest that amoxicillin can substitute for tetracycline in modified 14
Oral amoxicillin compared with injectable procaine benzylpenicillin plus gentamicin for treatment of neonates and young infants with fast breathing when referral is not possible: a randomised, open-label, equivalence trial. WHO recommends referral to hospital for possible serious bacterial infection in young infants aged 0-59 days. We aimed to assess whether oral amoxicillin treatment for fast breathing, in the absence of other signs, is as efficacious as the combination of injectable procaine (...) amoxicillin treatment twice per day for 7 days. A person who was off-site generated randomisation lists using computer software. Trained health professionals gave injections, but outcome assessors were masked to group allocations. The primary outcome was treatment failure by day 8 after enrolment, defined as clinical deterioration, development of a serious adverse event including death, persistence of fast breathing on day 4, or recurrence up to day 8. The primary analysis was per protocol and we used
2015LancetControlled trial quality: predicted high
Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication When prescribing antibiotics for common indications, clinicians need information about both harms and benefits, information that is currently available only from observational studies. We quantified the common harms of the most frequently prescribed antibiotic, amoxicillin, from randomized placebo-controlled trials.For this systematic review, we searched MEDLINE (...) , Embase and the Cochrane Central Register of Controlled Trials, without language restriction, for any randomized, participant-blinded, placebo-controlled trials of amoxicillin or amoxicillin-clavulanic acid for any indication, in any setting. Our main outcome was any reported adverse event.Of 730 studies identified, we included 45 trials: 27 involving amoxicillin, 17 involving amoxicillin-clavulanic acid and 1 involving both. The indications for antibiotic therapy were variable. The risk of bias
Amoxicillin USE OF AMOXICILLIN IN PREGNANCY 0344 892 0909 USE OF AMOXICILLIN IN PREGNANCY (Date of issue: September 2014 , Version: 2.1 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Amoxicillin is a broad spectrum β-lactam antibiotic used (...) in the treatment of susceptible bacterial infections, principally respiratory, middle ear and urinary tract infections. There are over 25,000 published cases of amoxicillin use during pregnancy, subsets of which have been analysed for various outcomes. No increased risks of spontaneous abortion, overall congenital malformation, intrauterine death, or neonatal complications were identified in these analyses. Two studies found a significant increase in cleft lip/palate, however this was not replicated