Latest & greatest articles for analgesia

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This page lists the very latest high quality evidence on analgesia and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Analgesia

Analgesic drugs are used to provide analgesia, the inability to feel pain. There are numerous groups of analgesics including simple analgesics, non-steroidal anti-inflammatory drugs (NSAIDs) and opioids. Analgesics types are prescribed differently depending on the severity of pain relief needed.

The most common type of analgesic generally known and used is non-steroidal anti-inflammatory drugs such as paracetamol, aspirin and ibuprofen. Opioid drugs include morphine, codeine, oxycodone, dihydromorphine and pethidine.

Research shows that analgesic drugs have an effect on the peripheral and central nervous system, relieving pain without the loss of consciousness. Opioids are highly effect pain relievers however case studies prove they can be highly addictive. Therefore use should be guided by the World Health Organization (WHO) pain ladder which specifies mild analgesics as its first step.

Clinical trials and studies carried out across all groups of analgesia have proven the drugs are highly effective painkillers, opioids in particular. However, years of research and clinical trials conclude that some groups have significant side effects such as addiction or cardiovascular side effects. Research evidence is broad including clinical guidelines, systematic reviews, randomised controlled trials, case studies etc. These can easily be found via a search of the Trip Database.

Top results for analgesia

1. The effect of manual therapy to the thoracic spine on pain-free grip and sympathetic activity in patients with lateral epicondylalgia humeri. A randomized, sample sized planned, placebo-controlled, patient-blinded monocentric trial Full Text available with Trip Pro

The effect of manual therapy to the thoracic spine on pain-free grip and sympathetic activity in patients with lateral epicondylalgia humeri. A randomized, sample sized planned, placebo-controlled, patient-blinded monocentric trial The Effect of Manual Therapy to the Thoracic Spine on Pain-Free Grip and Sympathetic Activity in Patients With Lateral Epicondylalgia Humeri. A Randomized, Sample Sized Planned, Placebo-Controlled, Patient-Blinded Monocentric Trial - PubMed This site needs JavaScript (...) ? Report format: Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation BMC Musculoskelet Disord Actions . 2020 Mar 24;21(1):186. doi: 10.1186/s12891-020-3175-y. The Effect of Manual Therapy to the Thoracic Spine on Pain-Free Grip and Sympathetic

2020 EvidenceUpdates

2. Comparing the analgesic effect of intravenous paracetamol with morphine on patients with renal colic pain: A meta-analysis of randomized controlled studies

Comparing the analgesic effect of intravenous paracetamol with morphine on patients with renal colic pain: A meta-analysis of randomized controlled studies Comparing the Analgesic Effect of Intravenous Paracetamol With Morphine on Patients With Renal Colic Pain: A Meta-Analysis of Randomized Controlled Studies - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Review Am J Emerg Med Actions . 2020 Apr 2;S0735-6757(20)30217-5. doi: 10.1016/j.ajem.2020.03.061. Online ahead of print. Comparing the Analgesic Effect of Intravenous Paracetamol With Morphine on Patients With Renal Colic Pain: A Meta-Analysis of Randomized Controlled Studies , , , Affiliations Expand Affiliations 1 Department

2020 EvidenceUpdates

3. Two Weeks of Wearing a Knee Brace Compared With Minimal Intervention on Kinesiophobia at 2 and 6 Weeks in People With Patellofemoral Pain: A Randomized Controlled Trial

for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Arch Phys Med Rehabil Actions . 2020 Apr;101(4):613-623. doi: 10.1016/j.apmr.2019.10.190. Epub 2019 Dec 10. Two Weeks of Wearing a Knee Brace Compared With Minimal Intervention on Kinesiophobia at 2 and 6 Weeks in People With Patellofemoral Pain: A Randomized Controlled Trial , , , , Affiliations Expand (...) Two Weeks of Wearing a Knee Brace Compared With Minimal Intervention on Kinesiophobia at 2 and 6 Weeks in People With Patellofemoral Pain: A Randomized Controlled Trial Two Weeks of Wearing a Knee Brace Compared With Minimal Intervention on Kinesiophobia at 2 and 6 Weeks in People With Patellofemoral Pain: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several

2020 EvidenceUpdates

4. New procedure of high-frequency repetitive transcranial magnetic stimulation for central neuropathic pain: a placebo-controlled randomized crossover study

-frequency (20 Hz) rTMS was delivered over the primary motor cortex (M1) contralateral to the patient's pain using a neuronavigated robotic system. Patients and clinicians assessing outcomes were blinded to treatment allocation during the trial. The primary outcome measured the percentage of pain relief (%R) from baseline. Secondary outcomes were VAS score, Neuropathic Pain Symptom Inventory, analgesic drug consumption, and quality of life (EQ-5D). Thirty-six patients performed the entire study (...) New procedure of high-frequency repetitive transcranial magnetic stimulation for central neuropathic pain: a placebo-controlled randomized crossover study New Procedure of High-Frequency Repetitive Transcranial Magnetic Stimulation for Central Neuropathic Pain: A Placebo-Controlled Randomized Crossover Study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features

2020 EvidenceUpdates

5. Platelet-rich Plasma or Autologous Blood Do Not Reduce Pain or Improve Function in Patients with Lateral Epicondylitis: A Randomized Controlled Trial

Platelet-rich Plasma or Autologous Blood Do Not Reduce Pain or Improve Function in Patients with Lateral Epicondylitis: A Randomized Controlled Trial Platelet-rich Plasma or Autologous Blood Do Not Reduce Pain or Improve Function in Patients With Lateral Epicondylitis: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Clin Orthop Relat Res Actions . 2020 Feb 25. doi: 10.1097/CORR.0000000000001185. Online ahead of print. Platelet-rich Plasma or Autologous Blood Do Not Reduce Pain or Improve Function in Patients With Lateral Epicondylitis: A Randomized Controlled Trial , , , , Affiliations Expand Affiliation 1 L. Linnanmäki, K. Kanto, J. Lehtinen, Tays

2020 EvidenceUpdates

6. Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials

Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Pain Physician Actions . 2020 Mar;23(2):175-201. Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials , Affiliations Expand Affiliation 1 Laboratory and Clinical Research Institute for Pain, Dept of Anesthesiology, The University of Hong Kong. PMID

2020 EvidenceUpdates

7. Tramadol: an opioid analgesic to be used with caution

. Pain management must involve better use of non-pharmacological methods of pain relief and careful management of paracetamol and NSAID analgesics (ibuprofen, naproxen). ©Prescrire 1 June 2020 Source: "Tramadol: increased mortality?" Prescrire International 2020; 29 (216): 152-153. Subscribers only. Enjoy full access to Prescrire International, and support independent information Share See also: "Tramadol: fatal overdoses in children" Prescrire Int 2017; 26 (179): 44-45. "Tramadol: hypoglycaemia (...) as a weak opioid, tramadol poses risks that require the same vigilance as with morphine. Tramadol is an opioid marketed for the relief of moderate to severe pain. It exposes patients to the adverse effects of opioids (intestinal, neuropsychological, and respiratory disorders, dependence and addiction, etc.), and to specific adverse effects, including hypoglycaemia and cardiac arrhythmia, with a risk of overdose in combination with other medicines or in some patients. Tramadol became the best-selling

2020 Prescrire

8. Effect of Flurbiprofen and S-Flurbiprofen Patches on Multimodal Pain Management After Total Knee Arthroplasty: A Prospective Randomized Controlled Trial

investigated the efficacy of 2 patches after TKA. Methods: Seventy-nine knees that underwent unilateral TKA for osteoarthritis were included. Oral administration, local periarticular analgesic injection, and patches were adopted for pain management. The knees were randomly assigned to the flurbiprofen patch (FPP), S-flurbiprofen patch (SFPP), and control (no patch) groups. Patch treatment was continued for 14 days. Pain according to the visual analog scale, knee flexion angle, renal dysfunction (...) Effect of Flurbiprofen and S-Flurbiprofen Patches on Multimodal Pain Management After Total Knee Arthroplasty: A Prospective Randomized Controlled Trial Effect of Flurbiprofen and S-Flurbiprofen Patches on Multimodal Pain Management After Total Knee Arthroplasty: A Prospective Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features

2020 EvidenceUpdates

9. Complementary Saphenous Nerve Block to Intra-Articular Analgesia Reduces Pain After Total Knee Arthroplasty: A Prospective Randomized Controlled Trial Full Text available with Trip Pro

nerve block (SNB) vs intra-articular infiltration alone. Methods: We performed a controlled, double-blinded, and randomized trial to evaluate postoperative pain in TKA. One group was treated with intra-articular analgesia associated with SNB, whereas a second group received the same intra-articular cocktail, associated with placebo. Efficacy was evaluated according to average pain, pain-free time, and morphine rescue indices. Safety was assessed by intervention complications and surgery. Results (...) Complementary Saphenous Nerve Block to Intra-Articular Analgesia Reduces Pain After Total Knee Arthroplasty: A Prospective Randomized Controlled Trial Complementary Saphenous Nerve Block to Intra-Articular Analgesia Reduces Pain After Total Knee Arthroplasty: A Prospective Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features

2020 EvidenceUpdates

10. Sensation of Pain Using Buffered Lidocaine for Infiltration Before Vulvar Biopsy: A Randomized Controlled Trial

Sensation of Pain Using Buffered Lidocaine for Infiltration Before Vulvar Biopsy: A Randomized Controlled Trial Sensation of Pain Using Buffered Lidocaine for Infiltration Before Vulvar Biopsy: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine (...) Obstet Gynecol Actions . 2020 Mar;135(3):609-614. doi: 10.1097/AOG.0000000000003710. Sensation of Pain Using Buffered Lidocaine for Infiltration Before Vulvar Biopsy: A Randomized Controlled Trial , , , , , , Affiliations Expand Affiliation 1 Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan; and the Department of Obstetrics and Gynecology, the Program in Women's Oncology, Division of Research, Department of Obstetrics and Gynecology, and the Program in Women's

2020 EvidenceUpdates

11. The effectiveness of an aerobic exercise training on patients with neck pain during a short- and long-term follow-up: a prospective double-blind randomized controlled trial

Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation Clin Rehabil Actions . 2020 May;34(5):617-629. doi: 10.1177/0269215520912000. Epub 2020 Mar 17. The Effectiveness of an Aerobic Exercise Training on Patients With Neck Pain During a Short- And Long-Term Follow-Up: A Prospective Double-Blind Randomized Controlled Trial , , , , Affiliations Expand Affiliations 1 Department of Physical Therapy, Faculty of Social Welfare & Health (...) , Netanya, Israel. PMID: 32183555 DOI: Item in Clipboard Full-text links Cite Abstract Objective: To examine the effect of adding aerobic exercise (AE) to neck-specific exercise treatment for patients with neck pain (NP) to reduce pain and disability. Design: A prospective multicentre randomized controlled trial. Setting: Physiotherapy outpatient clinics. Subjects: Patients with nonspecific NP. Intervention: Patients with NP were randomly assigned to six weeks of neck-specific exercise with and without

2020 EvidenceUpdates

12. Consensus Practice Guidelines on Interventions for Lumbar Facet Joint Pain from a Multispecialty, International Working Group Full Text available with Trip Pro

Consensus Practice Guidelines on Interventions for Lumbar Facet Joint Pain from a Multispecialty, International Working Group Consensus practice guidelines on interventions for lumbar facet joint pain from a multispecialty, international working group | Regional Anesthesia & Pain Medicine Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search (...) for this keyword Main menu Log in via your Society Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Consensus practice guidelines on interventions for lumbar facet joint pain from a multispecialty, international working group Article Text Special article Consensus practice guidelines on interventions for lumbar facet joint pain from a multispecialty, international working group Steven P Cohen

2020 American Society of Regional Anesthesia and Pain Medicine

13. Reduction of Postoperative Hip Arthroscopy Pain With an Ultrasound-Guided Fascia Iliaca Block: A Prospective Randomized Controlled Trial

Reduction of Postoperative Hip Arthroscopy Pain With an Ultrasound-Guided Fascia Iliaca Block: A Prospective Randomized Controlled Trial Reduction of Postoperative Hip Arthroscopy Pain With an Ultrasound-Guided Fascia Iliaca Block: A Prospective Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National (...) Actions Cite Share Permalink Copy Page navigation Am J Sports Med Actions . 2020 Mar;48(3):682-688. doi: 10.1177/0363546519898205. Epub 2020 Jan 30. Reduction of Postoperative Hip Arthroscopy Pain With an Ultrasound-Guided Fascia Iliaca Block: A Prospective Randomized Controlled Trial , , , , , , Affiliations Expand Affiliations 1 Steadman Hawkins Clinic of the Carolinas, Prisma Health-Upstate, Greenville, South Carolina, USA. 2 Prisma Health-Upstate, Greenville, South Carolina, USA. 3 Mayo Clinic

2020 EvidenceUpdates

14. Efficacy and safety of multiple doses of tapentadol oral solution in the treatment of moderate to severe acute pain in children aged 2 to <18 years - a randomized, double-blind, placebo-controlled trial Full Text available with Trip Pro

-controlled analgesia. Figure 2 5 Patient flow chart. Notes: “Recovery... Figure 2 13 Patient flow chart. Notes: “Recovery” denotes that opioid analgesic medication is no longer... Figure 2 Patient flow chart. Notes: “Recovery” denotes that opioid analgesic medication is no longer required. “Physician decision” denotes the switch to exclusively oral opioid analgesic medication indicated according to local standard of care. a All patients treated with study medication were included in the full analysis set (...) Efficacy and safety of multiple doses of tapentadol oral solution in the treatment of moderate to severe acute pain in children aged 2 to <18 years - a randomized, double-blind, placebo-controlled trial Efficacy and Safety of Multiple Doses of Tapentadol Oral Solution in the Treatment of Moderate to Severe Acute Pain in Children Aged 2 to - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History

2020 EvidenceUpdates

15. The effect of expressed breast milk, swaddling and facilitated tucking methods in reducing the pain caused by orogastric tube insertion in preterm infants: A randomized controlled trial

in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation Int J Nurs Stud Actions . 2020 Apr;104:103532. doi: 10.1016/j.ijnurstu.2020.103532. Epub 2020 Jan 24. The Effect of Expressed Breast Milk, Swaddling and Facilitated Tucking Methods in Reducing the Pain Caused by Orogastric Tube Insertion in Preterm Infants: A Randomized Controlled Trial , Affiliations Expand Affiliations 1 Child Health Nursing Department (...) the facilitated tucking group had 6.301, the facilitated tucking+expressed breast milk group had 3.107, the control group had 13.015, and the swaddling group had 7.892 times more pain. Conclusion: The swaddling+expressed breast milk method is clinically better pain relief nonpharmalogical option and is the recommended method to nurses for the orogastric tube insertion procedures, preterm infants. Keywords: Newborn nurse; Orogastric tube; Pain; Premature; Preterm. Copyright © 2020. Published by Elsevier Ltd

2020 EvidenceUpdates

16. A Double-Blind, Randomized Controlled Trial of Pre-incision Wound Infiltration Using Diclofenac Versus Bupivacaine for Post-operative Pain Relief in Open Thyroid and Parathyroid Surgery

in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation World J Surg Actions . 2020 Mar 19. doi: 10.1007/s00268-020-05458-6. Online ahead of print. A Double-Blind, Randomized Controlled Trial of Pre-incision Wound Infiltration Using Diclofenac Versus Bupivacaine for Post-operative Pain Relief in Open Thyroid and Parathyroid Surgery , , , Affiliations Expand Affiliations 1 Department of Surgery, University (...) A Double-Blind, Randomized Controlled Trial of Pre-incision Wound Infiltration Using Diclofenac Versus Bupivacaine for Post-operative Pain Relief in Open Thyroid and Parathyroid Surgery A Double-Blind, Randomized Controlled Trial of Pre-incision Wound Infiltration Using Diclofenac Versus Bupivacaine for Post-operative Pain Relief in Open Thyroid and Parathyroid Surgery - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features

2020 EvidenceUpdates

17. A Comparison of Intrathecal and Intravenous Morphine for Analgesia After Hepatectomy: A Randomized Controlled Trial Full Text available with Trip Pro

aimed to evaluate the effects of the addition of preoperative intrathecal morphine to multimodal intravenous analgesia in patients undergoing liver resection. Methods: In this single-blind randomized controlled trial, patients undergoing liver resection were randomly assigned to the patient-controlled analgesia with (ITM-IV) or without (IV) preoperative intrathecal morphine groups. All patients received acetaminophen and dexketoprofen. The primary outcome was pain severity at rest over three (...) A Comparison of Intrathecal and Intravenous Morphine for Analgesia After Hepatectomy: A Randomized Controlled Trial A Comparison of Intrathecal and Intravenous Morphine for Analgesia After Hepatectomy: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library

2020 EvidenceUpdates

18. Erector spinae plane versus paravertebral nerve blocks for postoperative analgesia after breast surgery: a randomized clinical trial

Share Permalink Copy Page navigation Reg Anesth Pain Med Actions . 2020 Apr;45(4):260-266. doi: 10.1136/rapm-2019-101013. Epub 2020 Jan 21. Erector Spinae Plane Versus Paravertebral Nerve Blocks for Postoperative Analgesia After Breast Surgery: A Randomized Clinical Trial , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Anesthesiology, University of California San Diego, San Diego, California, USA mwswisher@ucsd.edu. 2 Surgery, University of California San Diego, San Diego, California (...) , USA. 3 Anesthesiology, University of California San Diego, San Diego, California, USA. 4 Biomedical Informatics, University of California San Diego, San Diego, California, United States. 5 Neurology, University of Southern California, Los Angeles, California, USA. PMID: 31969443 DOI: Item in Clipboard Erector Spinae Plane Versus Paravertebral Nerve Blocks for Postoperative Analgesia After Breast Surgery: A Randomized Clinical Trial Matthew W Swisher et al. Reg Anesth Pain Med . 2020 Apr . Show

2020 EvidenceUpdates

19. Does adding case management to standard rehabilitation affect functional ability, pain, or the rate of return to work after lumbar spinal fusion? A randomized controlled trial with two-year follow-up

Does adding case management to standard rehabilitation affect functional ability, pain, or the rate of return to work after lumbar spinal fusion? A randomized controlled trial with two-year follow-up Does Adding Case Management to Standard Rehabilitation Affect Functional Ability, Pain, or the Rate of Return to Work After Lumbar Spinal Fusion? A Randomized Controlled Trial With Two-Year Follow-Up - PubMed This site needs JavaScript to work properly. Please enable it to take advantage (...) ? Report format: Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation Clin Rehabil Actions . 2020 Mar;34(3):357-368. doi: 10.1177/0269215519897106. Epub 2020 Jan 22. Does Adding Case Management to Standard Rehabilitation Affect Functional Ability, Pain, or the Rate of Return to Work After Lumbar Spinal Fusion? A Randomized Controlled Trial

2020 EvidenceUpdates

20. Consensus Practice Guidelines on Interventions for Lumbar Facet Joint Pain

facetogenic pain; ? Lack of information on important outcome measures. More information may allow estimation of effects on treatment outcomes. grading of evidence guidelines, with the level of certainty rated as high, medium or low (tables 1–3). 29 This system, which has been modified for use in interventional pain management guide- lines drafted by the American Society of Regional Anesthesia & Pain Medicine, American Academy of Pain Medicine, American Society of Anesthesiologists, American Society (...) Pain Med: first published as 10.1136/rapm-2019-101243 on 3 April 2020. Downloaded from 4 Cohen SP , et al. Reg Anesth Pain Med 2020;0:1–44. doi:10.1136/rapm-2019-101243 Special article Table 4 Studies evaluating physical examination findings and facet block results Study design/criteria for positive block Interventions findings Fairbank et al 37 Prospective n=25 Subjective pain relief IA (double blocks, one injection at symptomatic level, another at a random level) Responders: pain in the back

2020 American Academy of Pain Medicine