Latest & greatest articles for antibiotics

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on antibiotics or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on antibiotics and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Antibiotics

Antibiotics also referred to as antibacterial are a type of medicine that prevents the growth of bacteria. As such they are used to treat infections caused by bacteria. They kill or prevents bacteria from spreading.

Antibiotics are vital in modern day medicine; they are among the most frequently prescribed drug. There are over a 100 types of antibiotics, the main types and most commonly prescribed are penicillin, cephalosporin, macrolides, fluoroquinolone and tetracycline. They tend to be classified by mechanism of action. So, those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Antibiotics such as macrolides, lincosamides and tetracyclines inhibit protein synthesis.

Antibiotics can all be defined by their specificity. “Narrow-spectrum” antibiotics target specific types of bacteria, for instance gram-negative (-ve) or gram-positive (+ve), whereas broad-spectrum antibiotics affect a wide range of bacteria.

Antibiotics are increasingly suffering from antibiotic resistance caused by bacterial mutations meaning the bacteria evolves to not be sensitive to the specific antibiotics being used.

Clinical trials are important to the development and understanding of antibiotics and their side effects. Although they are deemed safe, over use of the drug can kill good bacteria and lead to antibiotic resistance. This halts the ability of bacteria and microorganisms to resist the effects of the antibiotic. Clinical trials and research allow scientists and medical professionals to study the effects and develop new antibiotics.

Trip has extensive coverage of the evidence base on antibiotics allowing users to easily find trusted answers. Coverage include guidelines, systematic reviews, controlled trials and evidence-based synopses.

Top results for antibiotics

61. Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis. (Abstract)

Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis. Clinicians typically select the antibiotics used to treat pulmonary infections in people with cystic fibrosis based on the results of antimicrobial susceptibility testing performed on bacteria traditionally grown in a planktonic mode (grown in a liquid). However, there is considerable evidence to suggest that Pseudomonas aeruginosa actually grows in a biofilm (or slime layer (...) ) in the airways of people with cystic fibrosis with chronic pulmonary infections. Therefore, choosing antibiotics based on biofilm rather than conventional antimicrobial susceptibility testing could potentially improve response to treatment of Pseudomonas aeruginosa in people with cystic fibrosis. This is an update of a previously published Cochrane Review.To compare biofilm antimicrobial susceptibility testing-driven therapy to conventional antimicrobial susceptibility testing-driven therapy in the treatment

2020 Cochrane

62. Antibiotic treatment for nontuberculous mycobacteria lung infection in people with cystic fibrosis. (Abstract)

with cystic fibrosis leading to more a rapid decline in lung function and even death in certain circumstances. Although there are guidelines for the antimicrobial treatment of nontuberculous mycobacteria lung disease, these recommendations are not specific for people with cystic fibrosis and it is not clear which antibiotic regimen may be the most effective in the treatment of these individuals. This is an update of a previous review.The objective of our review was to compare antibiotic treatment (...) Antibiotic treatment for nontuberculous mycobacteria lung infection in people with cystic fibrosis. Nontuberculous mycobacteria are mycobacteria, other than those in the Mycobacterium tuberculosis complex, and are commonly found in the environment. Nontuberculous mycobacteria species (most commonly Mycobacterium avium complex and Mycobacterium abscessus) are isolated from the respiratory tract of approximately 5% to 40% of individuals with cystic fibrosis; they can cause lung disease in people

2020 Cochrane

63. Antimicrobial Poly (methyl methacrylate) with Silver Nanoparticles for Dentistry: A Systematic Review Full Text available with Trip Pro

Antimicrobial Poly (methyl methacrylate) with Silver Nanoparticles for Dentistry: A Systematic Review Applied Sciences | Free Full-Text | Antimicrobial Poly (methyl methacrylate) with Silver Nanoparticles for Dentistry: A Systematic Review Next Article in Journal Next Article in Special Issue Previous Article in Journal Information Initiatives Notice You can make submissions to other journals . You seem to have javascript disabled. Please note that many of the page functionalities won't work (...) section provides allows you to learn more about MDPI. JSmol Viewer Open Access Review Antimicrobial Poly (methyl methacrylate) with Silver Nanoparticles for Dentistry: A Systematic Review by , , and * Laboratorio de Investigación Interdisciplinaria (LII), Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México, Boulevard UNAM No. 2011, Predio El Saucillo y El Potrero, Guanajuato 36969, Mexico * Author to whom correspondence should be addressed. Appl. Sci. 2020 , 10

2020 Applied Sciences

64. Efficacy and safety of rapid tests to guide antibiotic prescriptions for sore throat. (Abstract)

Efficacy and safety of rapid tests to guide antibiotic prescriptions for sore throat. Sore throat is a common condition caused by viruses or bacteria, and is a leading cause of antibiotic prescription in primary care. The most common bacterial species is group A streptococcus ('strep throat'). Between 50% to 70% of pharyngitis cases are treated with antibiotics, despite the majority of cases being viral in origin. One strategy to reduce antibiotics is to use rapid tests for group (...) A streptococcus to guide antibiotic prescriptions. Rapid tests can be used alone or in combination with a clinical scoring system.To assess the efficacy and safety of strategies based on rapid tests to guide antibiotic prescriptions for sore throat in primary care settings.We searched CENTRAL, MEDLINE, Embase, CINAHL, Web of Science, and LILACS, as well as the trial registries ClinicalTrials.gov and the WHO ICTRP on 5 June 2019.We included randomised controlled trials (RCTs) comparing rapid tests

2020 Cochrane

65. Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7-Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients With Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7-Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients With Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial. Antibiotic overuse drives antibiotic resistance. Gram-negative bacteremia is a common infection that results in substantial antibiotic use.To compare the clinical effectiveness of C-reactive protein (CRP)-guided, 7-day, and 14-day antibiotic durations 30, 60, and 90 days after (...) treatment initiation.Multicenter, noninferiority, point-of-care randomized clinical trial including adults hospitalized with gram-negative bacteremia conducted in 3 Swiss tertiary care hospitals between April 2017 and May 2019, with follow-up until August 2019. Patients and physicians were blinded between randomization and antibiotic discontinuation. Adults (aged ≥18 years) were eligible for randomization on day 5 (±1 d) of microbiologically efficacious therapy for fermenting, gram-negative bacteria

2020 JAMA

66. Dental antimicrobial stewardship: toolkit

Dental antimicrobial stewardship: toolkit Dental antimicrobial stewardship: toolkit - GOV.UK GOV.UK uses cookies to make the site simpler. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Dental antimicrobial stewardship: toolkit Resources to help primary care practitioners promote the appropriate use of antibiotics in dental care. Published 9 November 2016 Last updated 16 July 2019 — From: Contents The dental antimicrobial stewardship ( ( ( Guidance (...) ( Education and training tools Audit tool and action planning An audit tool developed as a collaboration between Why the toolkit was developed The inappropriate use of antibiotics is related to bacterial resistance. Responsible use of antimicrobials should help control it. The toolkit aims to influence prescribers and patients attitudes to enable optimal antibiotic prescribing. An independent review of antimicrobial resistance, the commissioned by the UK Government in 2014 and chaired by Lord Jim O’Neill

2020 Public Health England

67. Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics Full Text available with Trip Pro

demonstrated that dual antibiotics were associated with improved infection prevention and higher intra-articular antibiotic concentrations. Conclusion: In addition to broader pathogen coverage, several studies document synergy of elution and increased antibacterial activity when dual antibiotics are added to cement. Limited clinical evidence suggests that dual antibiotic cement may be associated with reduced infection rates. Keywords: antibiotic cement; antibiotic elution; antibiotic synergy; dual (...) Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics Antibiotic Choice: The Synergistic Effect of Single vs Dual Antibiotics - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology Information Show account info Close Account

2020 EvidenceUpdates

68. Cefiderocol (Fetcroja) - antibiotic

Cefiderocol (Fetcroja) - antibiotic Official address Domenico Scarlattilaan 6 ? 1083 HS Amsterdam ? The Netherlands An agency of the European Union Address for visits and deliveries Refer to www.ema.europa.eu/how-to-find-us Send us a question Go to www.ema.europa.eu/contact Telephone +31 (0)88 781 6000 © European Medicines Agency, 2020. Reproduction is authorised provided the source is acknowledged. EMA/115665/2020 EMEA/H/C/004829 Fetcroja (cefiderocol) An overview of Fetcroja and why (...) it is authorised in the EU What is Fetcroja and what is it used for? Fetcroja is an antibiotic used in adults to treat infections caused by bacteria classed as aerobic Gram- negative bacteria. It is for use when other treatments might not work. Fetcroja contains the active substance cefiderocol. How is Fetcroja used? Fetcroja can only be obtained with a prescription. It should only be used after taking advice from a doctor with appropriate experience of managing patients with infectious diseases. Fetcroja

2020 European Medicines Agency - EPARs

69. A Multifaceted Antimicrobial Stewardship Program for the Treatment of Uncomplicated Cystitis in Nursing Home Residents

-intensity, multifaceted intervention was associated with improved antibiotic prescribing for uncomplicated cystitis in a cohort of nursing homes without an adverse association with other safety outcomes. Although promising, further study is needed to determine whether the intervention could be widely implemented to assist facilities in meeting new federal nursing home requirements for antimicrobial stewardship and quality assurance performance improvement programs. Conflict of interest statement (...) A Multifaceted Antimicrobial Stewardship Program for the Treatment of Uncomplicated Cystitis in Nursing Home Residents A Multifaceted Antimicrobial Stewardship Program for the Treatment of Uncomplicated Cystitis in Nursing Home Residents - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library

2020 EvidenceUpdates

70. Practical advice on maintaining antimicrobial stewardship during the COVID-19 pandemic

Practical advice on maintaining antimicrobial stewardship during the COVID-19 pandemic SAPG response to COVID-19 Latest updates / / / 13 May 2020 SAPG response to COVID-19 To prioritise and support the capacity of health and social care services, Healthcare Improvement Scotland and the Scottish Antimicrobial Prescribing Group (SAPG) have taken the decision to adapt our normal ways of working. This action is supported by Scottish Government. This is an unprecedented situation requiring unusual (...) measures, and that it is important that SAPG supports NHSScotland in maintaining essential services. All meetings of the SAPG committee and project groups have been suspended until further notice. The duration of these measures is unknown and we will provide further updates in due course. In the interim, if you have any queries, please contact: We have developed some interim pragmatic practical advice for clinical teams to ensure we maintain antimicrobial stewardship during the COVID-19 pandemic

2020 Covid-19 Ad hoc papers

71. Antibiotics Treatment and Immune-checkpoint Inhibitors Efficacy: A Systematic Review and Meta-analysis Full Text available with Trip Pro

Antibiotics Treatment and Immune-checkpoint Inhibitors Efficacy: A Systematic Review and Meta-analysis Antibiotics Treatment and Immune-checkpoint Inhibitors Efficacy: A Systematic Review and Meta-analysis | Research Square Browse Tools & Services Your Cart This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should (...) not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research Antibiotics Treatment and Immune-checkpoint Inhibitors Efficacy: A Systematic Review and Meta-analysis Jie Hao, Yang Zhao, Jiangyi He, Yunlong Wang, Yan Dong Jie Hao Third Military Medical University Southwest Hospital Yang Zhao Third Military Medical University Southwest Hospital Jiangyi He Third Military Medical University Southwest Hospital Yunlong Wang

2020 Research Square

72. Authors’ reply re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset Group B streptococcal disease: a systematic review and meta‐analysis Full Text available with Trip Pro

Authors’ reply re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset Group B streptococcal disease: a systematic review and meta‐analysis Authors’ reply re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset Group B streptococcal disease: a systematic review and meta‐analysis - Hasperhoven - 2020 - BJOG: An International Journal of Obstetrics & Gynaecology (...) - Wiley Online Library Working off-campus? Learn about our By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term Search term BJOG Exchange Authors’ reply re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset Group B streptococcal disease: a systematic review and meta‐analysis Corresponding Author Faculty of Health, Medicine and Life Sciences, Maastricht University

2020 BJOG: An International Journal of Obstetrics & Gynaecology

73. Re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis Full Text available with Trip Pro

Re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis Re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis - Lamont - 2020 - BJOG: An International Journal of Obstetrics & Gynaecology - Wiley Online Library Working off (...) -campus? Learn about our By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term Search term BJOG Exchange Re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis Research Unit of Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics, Odense University Hospital, Institute of Clinical

2020 BJOG: An International Journal of Obstetrics & Gynaecology

74. In utero exposure to systemic antibiotics vs reference penicillins was not linked to congenital malformations. (Abstract)

In utero exposure to systemic antibiotics vs reference penicillins was not linked to congenital malformations. Damkier P, Brønniche LM, Korch-Frandsen JF, Broe A. In utero exposure to antibiotics and risk of congenital malformations: a population-based study. Am J Obstet Gynecol. 2019;221:648.e1-648.e15. 31260651.

2020 Annals of Internal Medicine

75. Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas aeruginosa in cystic fibrosis. (Abstract)

Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas aeruginosa in cystic fibrosis. Antibiotic therapy for acute pulmonary exacerbations in people with cystic fibrosis is usually chosen based on the results of antimicrobial susceptibility testing of individual drugs. Combination antimicrobial susceptibility testing assesses the efficacy of drug combinations including two or three antibiotics in vitro and can often demonstrate antimicrobial (...) efficacy against bacterial isolates even when individual antibiotics have little or no effect. Therefore, choosing antibiotics based on combination antimicrobial susceptibility testing could potentially improve response to treatment in people with cystic fibrosis with acute exacerbations. This is an updated version of a previously published review.To compare antibiotic therapy based on conventional antimicrobial susceptibility testing to antibiotic therapy based on combination antimicrobial

2020 Cochrane

76. A comparison of different antibiotic regimens for the treatment of infective endocarditis. (Abstract)

A comparison of different antibiotic regimens for the treatment of infective endocarditis. Infective endocarditis is a microbial infection of the endocardial surface of the heart. Antibiotics are the cornerstone of treatment, but due to the differences in presentation, populations affected, and the wide variety of micro-organisms that can be responsible, their use is not standardised. This is an update of a review previously published in 2016.To assess the existing evidence about the clinical (...) benefits and harms of different antibiotics regimens used to treat people with infective endocarditis.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase Classic and Embase, LILACS, CINAHL, and the Conference Proceedings Citation Index - Science on 6 January 2020. We also searched three trials registers and handsearched the reference lists of included papers. We applied no language restrictions.We included randomised controlled trials (RCTs) assessing the effects

2020 Cochrane

77. Probiotics, Prebiotics, Antibiotic, Chinese Herbal Medicine, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: Protocol for a Systematic Review and Network Meta-analysis Full Text available with Trip Pro

Probiotics, Prebiotics, Antibiotic, Chinese Herbal Medicine, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: Protocol for a Systematic Review and Network Meta-analysis Inplasy Protocol 280 - INPLASY.COM International Platform of Registered Systematic Review and Meta-analysis Protocols Main Menu Share this: Copyright © 2021 INPLASY.COM Powered by INPLASY.COM

2020 INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols

78. Re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis Full Text available with Trip Pro

Re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis Re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis - Seedat - 2020 - BJOG: An International Journal of Obstetrics & Gynaecology - Wiley Online Library Working off (...) -campus? Learn about our By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term Search term BJOG Exchange Re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis Corresponding Author UK National Screening Committee Evidence Team, London, UK UK National Screening Committee Evidence Team, London, UK

2020 BJOG: An International Journal of Obstetrics & Gynaecology

79. Authors' reply re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis Full Text available with Trip Pro

Authors' reply re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis Authors' reply re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis - Walker - 2020 - BJOG: An International Journal of Obstetrics & Gynaecology - Wiley (...) Online Library Working off-campus? Learn about our By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term Search term BJOG Exchange Authors' reply re: Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis Corresponding Author Division of Child Health, Obstetrics and Gynaecology, School of Medicine

2020 BJOG: An International Journal of Obstetrics & Gynaecology

80. Authors’ reply re: Universal screening versus risk-based protocols for antibiotic prophylaxis during childbirth to prevent early-onset Group B streptococcal disease: A systematic review and meta-analysis. (Response to BJOG-20-0671) Full Text available with Trip Pro

Authors’ reply re: Universal screening versus risk-based protocols for antibiotic prophylaxis during childbirth to prevent early-onset Group B streptococcal disease: A systematic review and meta-analysis. (Response to BJOG-20-0671) Authors’ reply re: Universal screening versus risk-based protocols for antibiotic prophylaxis during childbirth to prevent early-onset Group B streptococcal disease: A systematic review and meta-analysis. (Response to BJOG-20-0671) - Authorea (...) "); } "); } "); } "); } "); } "); } "); } AUTHOREA loading page this is for holding javascript data Authors’ reply re: Universal screening versus risk-based protocols for antibiotic prophylaxis during childbirth to prevent early-onset Group B streptococcal disease: A systematic review and meta-analysis. (Response to BJOG-20-0671) +2 Geke Hasperhoven , Salwan Al-Nasiry , Vincent Bekker , Eduardo Villamor , Boris Kramer Geke Hasperhoven Maastricht University Medical Centre+ Salwan Al-Nasiry Maastricht UMC Vincent Bekker Leiden University Medical

2020 Authorea, Inc.