Latest & greatest articles for antibiotics

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This page lists the very latest high quality evidence on antibiotics and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Antibiotics

Antibiotics also referred to as antibacterial are a type of medicine that prevents the growth of bacteria. As such they are used to treat infections caused by bacteria. They kill or prevents bacteria from spreading.

Antibiotics are vital in modern day medicine; they are among the most frequently prescribed drug. There are over a 100 types of antibiotics, the main types and most commonly prescribed are penicillin, cephalosporin, macrolides, fluoroquinolone and tetracycline. They tend to be classified by mechanism of action. So, those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Antibiotics such as macrolides, lincosamides and tetracyclines inhibit protein synthesis.

Antibiotics can all be defined by their specificity. “Narrow-spectrum” antibiotics target specific types of bacteria, for instance gram-negative (-ve) or gram-positive (+ve), whereas broad-spectrum antibiotics affect a wide range of bacteria.

Antibiotics are increasingly suffering from antibiotic resistance caused by bacterial mutations meaning the bacteria evolves to not be sensitive to the specific antibiotics being used.

Clinical trials are important to the development and understanding of antibiotics and their side effects. Although they are deemed safe, over use of the drug can kill good bacteria and lead to antibiotic resistance. This halts the ability of bacteria and microorganisms to resist the effects of the antibiotic. Clinical trials and research allow scientists and medical professionals to study the effects and develop new antibiotics.

Trip has extensive coverage of the evidence base on antibiotics allowing users to easily find trusted answers. Coverage include guidelines, systematic reviews, controlled trials and evidence-based synopses.

Top results for antibiotics

81. Bacterial Causative Agents of Neonatal Sepsis and Their Antibiotic Susceptibility in Neonatal Intensive Care Units (NICUs) and Neonatal Wards in Iran: A Systematic Review Full Text available with Trip Pro

Infections in the Neonatal Intensive Care Unit and Determination of Their Antibiotic Resistance Pattern. Jundishapur J Microbiol . 2015; 8 (8). e19654. doi: . 21. Esmaeili R, Yousefi MR, Moshtaghi A, Alikhani M. Frequency of Antibiotic Resistance Patterns in Bacteria Isolated from Children. Med Lab J . 2014; 7 (5):57-64. 22. Ebrahim-Saraie HS, Motamedifar M, Mansury D, Halaji M, Hashemizadeh Z, Mohammadi YA. Bacterial Etiology and Antibacterial Susceptibility Patterns of Pediatric Bloodstream Infections (...) ; 5 (5):528-31. 33. Haj Ebrahim Tehrani F, Moradi M, Ghorbani N. Bacterial Etiology and Antibiotic Resistance Patterns in Neonatal Sepsis in Tehran during 2006-2014. Iran J Pathol . 2017; 12 (4):356-61. [PubMed: ]. [PubMed Central: ]. 34. Karlowsky JA, Jones ME, Draghi DC, Thornsberry C, Sahm DF, Volturo GA. Prevalence and antimicrobial susceptibilities of bacteria isolated from blood cultures of hospitalized patients in the United States in 2002. Ann Clin Microbiol Antimicrob . 2004; 3 :7. doi

2020 Archives of Pediatric Infectious Diseases

82. What is the best antibiotic protocol for preventing infection after orthognathic surgery? A protocol for systematic review and network meta-analysis Full Text available with Trip Pro

What is the best antibiotic protocol for preventing infection after orthognathic surgery? A protocol for systematic review and network meta-analysis Inplasy Protocol 256 - INPLASY.COM International Platform of Registered Systematic Review and Meta-analysis Protocols Main Menu Share this: Copyright © 2021 INPLASY.COM Powered by INPLASY.COM

2020 International Platform of Registered Systematic Review and Meta-analysis Protocols

83. Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT Full Text available with Trip Pro

Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from (...) the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} The antibiotic-impregnated ventriculoperitoneal shunt reduced infection whereas the silver did not; the antibiotic shunt is likely to be cost-saving. {{author}} {{($index , , , , , , , , , , , & . Conor L Mallucci 1, * , Michael D Jenkinson 2, 3 , Elizabeth J Conroy 4 , John C Hartley 5 , Michaela Brown 4 , Tracy Moitt 4 , Joanne

2020 NIHR HTA programme

84. C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT Full Text available with Trip Pro

C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: the PACE RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose (...) a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Point-of-care testing resulted in a 20% absolute reduction in patient-reported antibiotic consumption over 4 weeks, without impairing chronic obstructive pulmonary disease health status. {{author}} {{($index , , , , , , , , , , , , , , , , , , , , & . Nick A Francis 1, * , David Gillespie 2 , Patrick White 3

2020 NIHR HTA programme

85. COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital

that bacterial co-infection occurs in less than about 10% of patients with COVID-19. But patients in critical care have an increased likelihood of bacterial infection compared with patients in other hospital wards or settings. • Because COVID-19 pneumonia is caused by a virus, antibiotics are ineffective unless there is a bacterial co-infection. • Inappropriate antibiotic use may reduce their availability, and indiscriminate use may lead to Clostridioides difficile infection and antimicrobial resistance (...) or more after admission and that was not incubating at admission). 3.5 When choosing antibiotics, take account of: • local antimicrobial resistance data and • other factors such as their availability. 3.6 For patients who are already taking an antibiotic that was started in the community for suspected pneumonia: • review the antibiotic choice and • change the antibiotic in line with antibiotic prescribing table 1, if appropriate. 3.7 Give oral antibiotics if the patient can take oral medicines

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

86. What Is the Utility of Prophylactic Antibiotics for Patients After Cardiac Arrest? Full Text available with Trip Pro

on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke. Resuscitation . 2008 ; 79 : 350–379 | | | | | Consequently, prophylactic antibiotics may seem reasonable in this population. However, it is important to balance this against the need for antimicrobial stewardship. Although this study demonstrated (...) What Is the Utility of Prophylactic Antibiotics for Patients After Cardiac Arrest? What Is the Utility of Prophylactic Antibiotics for Patients After Cardiac Arrest? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 75, Issue 1, Pages 102–104 What Is the Utility of Prophylactic Antibiotics for Patients After Cardiac Arrest? x Michael Gottlieb , MD (EBEM Commentator) , x Trevor Landas , MD (EBEM

2020 Annals of Emergency Medicine Systematic Review Snapshots

87. Do Antibiotics Improve Outcomes in Patients With Acute Asthma Exacerbations? Full Text available with Trip Pro

Do Antibiotics Improve Outcomes in Patients With Acute Asthma Exacerbations? Do Antibiotics Improve Outcomes in Patients With Acute Asthma Exacerbations? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 74, Issue 5, Pages 711–712 Do Antibiotics Improve Outcomes in Patients With Acute Asthma Exacerbations? x Latha Ganti , MD, MBA (EBEM Commentator) , x Javier Rosario , MD (EBEM Commentator) Department (...) of Emergency Medicine, Envision Physician Services, University of Central Florida College of Medicine, Orlando, FL DOI: | Publication History Published online: April 11, 2019 Expand all Collapse all Article Outline Take-Home Message Moderate- to low-quality evidence suggests that antibiotics may reduce symptoms and improve pulmonary function but do not improve other outcomes in patients with acute asthma exacerbations. Methods Data Sources MEDLINE, EMBASE, the Cumulative Index of Nursing and Allied Health

2020 Annals of Emergency Medicine Systematic Review Snapshots

88. Do Antibiotics Improve Patient Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease? Full Text available with Trip Pro

Do Antibiotics Improve Patient Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease? Do Antibiotics Improve Patient Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease? - Annals of Emergency Medicine Email/Username: Password: Remember me Search Terms Search within Search Share this page Access provided by Volume 74, Issue 5, Pages e79–e81 Do Antibiotics Improve Patient Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease? x Brit Long (...) , MD (EBEM Commentator) , x Michael D. April , MD, DPhil (EBEM Commentator) Department of Emergency Medicine, San Antonio Uniformed Services Health Education Consortium, Fort Sam Houston, TX DOI: | Publication History Published online: February 14, 2019 Expand all Collapse all Article Outline Take-Home Message For patients with acute chronic obstructive pulmonary disease exacerbation, antibiotics reduce treatment failure for those with mild to moderate exacerbations. Antibiotics reduce mortality

2020 Annals of Emergency Medicine Systematic Review Snapshots

89. Antimicrobial and Immunomodulatory Therapy in Adult Patients with COVID-19

Antimicrobial and Immunomodulatory Therapy in Adult Patients with COVID-19 British Columbia COVID19 Therapeutics Committee (CTC) Clinical Practice Guidance for Antimicrobial and Immunomodulatory Therapy in Adult Patients with COVID-19 SEVERITY OF ILLNESS ANTIVIRAL THERAPY ANTIBACTERIAL THERAPY IMMUNOMODULATORY THERAPY Critically Ill Patients Hospitalized, ICU-based Patients requiring ventilatory and/or circulatory support; also includes patients requiring high-flow nasal cannula, or higher (...) for DVT prophylaxis Chloroquine or hydroxychloroquine (with or without azithromycin) is not recommended outside of approved clinical trials or where other indications would justify its use Lopinavir/ritonavir is not recommended outside of approved clinical trials Remdesivir* is not recommended outside of approved clinical trials Antibacterial therapy is not routinely recommended outside of approved clinical trials or where other indications would justify its use (eg. suspected bacterial co-infection

2020 Covid-19 Ad hoc guidelines

90. Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs Appendectomy for Uncomplicated Acute Appendicitis: A Secondary Analysis of a Randomized Clinical Trial

Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs Appendectomy for Uncomplicated Acute Appendicitis: A Secondary Analysis of a Randomized Clinical Trial Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs Appendectomy for Uncomplicated Acute Appendicitis: A Secondary Analysis of a Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features (...) in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation JAMA Surg Actions . 2020 Feb 19;e196028. doi: 10.1001/jamasurg.2019.6028. Online ahead of print. Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs Appendectomy for Uncomplicated Acute Appendicitis: A Secondary Analysis of a Randomized Clinical Trial , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Turku

2020 EvidenceUpdates

91. Antibacterial effect of sodium hypochlorite gel on Enterococcus faecalis in endodontics: A systematic review Full Text available with Trip Pro

Antibacterial effect of sodium hypochlorite gel on Enterococcus faecalis in endodontics: A systematic review Antibacterial effect of sodium hypochlorite gel on Enterococcus faecalis in endodontics: A systematic review | International Dental Research IDR Search / / / Original Article Nada George Bshara Damascus University, Faculty of Dentistry, Department of Pediatric Dentistry, Damascus, Syria Özkan Adıgüzel Dicle University, Faculty of Dentistry, Department of Endodontics, Diyarbakır, Turkey (...) DOI: Keywords: Sodium Hypochlorite Gel, Enterococcus Faecalis, root canal treatment Abstract Aim : The aim of this systematic review was to investigate the in vitro antibacterial effect of sodium hypochlorite gel on Enterococcus faecalis during root canal treatment. Methods : An electronic databases (PubMed, ScienceDirect, Google Scholar, CENTRAL, Health Advance) was performed (last updated was 1 st April 2019). The reference lists of the included studies were hand-searched. Randomized in vitro

2020 International Dental Research

92. Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernia repair. (Abstract)

Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernia repair. Inguinal or femoral hernia is a tissue protrusion in the groin region and has a cumulative incidence of 27% in adult men and of 3% in adult women. As most hernias become symptomatic over time, groin hernia repair is one of the most frequently performed surgical procedures worldwide. This type of surgery is considered 'clean' surgery with wound infection (...) rates expected to be lower than 5%. For clean surgical procedures, antibiotic prophylaxis is not generally recommended. However after the introduction of mesh-based hernia repair and the publication of studies that have high wound infection rates the debate as to whether antibiotic prophylaxis is required to prevent postoperative wound infections started again.To determine the effectiveness of antibiotic prophylaxis in reducing postoperative (superficial and deep) wound infections in elective open

2020 Cochrane

93. The impact of intraperitoneal antibiotic administration in patients with peritoneal dialysis-related peritonitis: systematic review and meta-analysis Full Text available with Trip Pro

The impact of intraperitoneal antibiotic administration in patients with peritoneal dialysis-related peritonitis: systematic review and meta-analysis The impact of intraperitoneal antibiotic administration in patients with peritoneal dialysis-related peritonitis: systematic review and meta-analysis | Renal Replacement Therapy | Full Text Search Search all BMC articles Search The impact of intraperitoneal antibiotic administration in patients with peritoneal dialysis-related peritonitis (...) : systematic review and meta-analysis , , , , , , , , , , , , , , , , , & , volume 6 , Article number: 19 ( 2020 ) 1652 Accesses Abstract Background Peritonitis is a common and clinically important complication in patients receiving peritoneal dialysis (PD). Antibiotic administration is essential for PD-related peritonitis, but routes of administration have not been established enough. Here, we performed a systematic review to assess the efficacy and safety of intraperitoneal (IP) antibiotic administration

2020 Renal Replacement Therapy

94. Antibiotic stewardship in premature infants: a systematic review Full Text available with Trip Pro

Antibiotic stewardship in premature infants: a systematic review Antibiotic stewardship in premature infants: a systematic review | medRxiv Search for this keyword Antibiotic stewardship in premature infants: a systematic review Polona Rajar , Ola D. Saugstad , Dag Berild , Anirban Dutta , Gorm Greisen , Ulrik Lausten-Thomsen , Sharmila S. Mande , Sushma Nangia , Fernanda C. Petersen , Ulf R. Dahle , Kirsti Haaland doi: https://doi.org/10.1101/2020.04.10.20060988 Polona Rajar 1 Department (...) Rigshospitalet , Copenhagen, Denmark Ulrik Lausten-Thomsen 7 Copenhagen University Hospital Rigshospitalet , Copenhagen, Denmark Sharmila S. Mande 6 TCS Research, Tata Consultancy Services Ltd., Pune , Maharashtra, India Sushma Nangia 8 Lady Hardinge Medical College and Kalawati Saran Hospital , New Delhi, Delhi, India Fernanda C. Petersen 2 Institute of Oral Biology, University of Oslo , Oslo, Norway Ulf R. Dahle 9 Centre for Antimicrobial Resistance, Norwegian Institute of Public Health , Oslo, Norway

2020 Cold Spring Harbor Laboratory

95. Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation. (Abstract)

Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation. Chronic pulmonary infection is a hallmark of lung disease in cystic fibrosis. Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least 18 closely-related species of gram-negative bacteria, are particularly difficult to treat. These infections may be associated with a fulminant necrotising pneumonia. Burkholderia cepacia complex bacteria (...) are resistant to many common antibiotics and able to acquire resistance against many more. Following patient segregation in cystic fibrosis medical care, the more virulent epidemic strains are not as frequent, and new infections are more likely to be with less virulent environmentally-acquired strains. Although evidence-based guidelines exist for treating respiratory exacerbations involving Pseudomonas aeruginosa, these cannot be extended to Burkholderia cepacia complex infections. This review, which

2020 Cochrane

96. Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis Full Text available with Trip Pro

Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set (...) : Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation Diabetes Care Actions . 2020 Mar 4;dc191162. doi: 10.2337/dc19-1162. Online ahead of print. Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis

2020 EvidenceUpdates

97. Evaluation of a clinical decision rule to guide antibiotic prescription in children with suspected lower respiratory tract infection in The Netherlands: A stepped-wedge cluster randomised trial Full Text available with Trip Pro

Evaluation of a clinical decision rule to guide antibiotic prescription in children with suspected lower respiratory tract infection in The Netherlands: A stepped-wedge cluster randomised trial Evaluation of a Clinical Decision Rule to Guide Antibiotic Prescription in Children With Suspected Lower Respiratory Tract Infection in The Netherlands: A Stepped-Wedge Cluster Randomised Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set (...) : Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation PLoS Med Actions . 2020 Jan 31;17(1):e1003034. doi: 10.1371/journal.pmed.1003034. eCollection 2020 Jan. Evaluation of a Clinical Decision Rule to Guide Antibiotic Prescription in Children With Suspected Lower Respiratory Tract Infection in The Netherlands: A Stepped-Wedge Cluster

2020 EvidenceUpdates

98. Survival of Patients Treated with Antibiotics and Immunotherapy for Cancer: A Systematic Review and Meta-Analysis Full Text available with Trip Pro

Survival of Patients Treated with Antibiotics and Immunotherapy for Cancer: A Systematic Review and Meta-Analysis Survival of Patients Treated with Antibiotics and Immunotherapy for Cancer: A Systematic Review and Meta-Analysis[v1] | Preprints Share this article with Create alert Email: Submit > > > doi: 10.20944/preprints202003.0425.v1 Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed Survival of Patients Treated with Antibiotics and Immunotherapy for Cancer (...) : A Systematic Review and Meta-Analysis * , , , , , , , , , Version 1 : Received: 27 March 2020 / Approved: 29 March 2020 / Online: 29 March 2020 (06:43:23 CEST) How to cite: Petrelli, F.; Iaculli, A.; Signorelli, D.; Ghidini, A.; Dottorini, L.; Perego, G.; Ghidini, M.; Zaniboni, A.; Gori, S.; Inno, A. Survival of Patients Treated with Antibiotics and Immunotherapy for Cancer: A Systematic Review and Meta-Analysis. Preprints 2020 , 2020030425 (doi: 10.20944/preprints202003.0425.v1). Petrelli, F.; Iaculli

2020 MDPI AG

99. Antibiotic prophylaxis for operative vaginal delivery. Full Text available with Trip Pro

Antibiotic prophylaxis for operative vaginal delivery. Vacuum and forceps assisted vaginal deliveries are reported to increase the incidence of postpartum infections and maternal readmission to hospital compared to spontaneous vaginal delivery. Prophylactic antibiotics may be prescribed to prevent these infections. However, the benefit of antibiotic prophylaxis for operative vaginal deliveries is still unclear. This is an update of a review last published in 2017.To assess the effectiveness (...) and safety of antibiotic prophylaxis in reducing infectious puerperal morbidities in women undergoing operative vaginal deliveries including vacuum or forceps delivery, or both.For this update, we searched Cochrane Pregnancy and Childbirth's Trials Register, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP) (5 July 2019), and reference lists of retrieved studies.All randomised controlled trials comparing any prophylactic antibiotic regimens with placebo or no treatment

2020 Cochrane

100. Antibiotic treatment for Stenotrophomonas maltophilia in people with cystic fibrosis. (Abstract)

Antibiotic treatment for Stenotrophomonas maltophilia in people with cystic fibrosis. Stenotrophomonas maltophilia is one of the most common emerging multi-drug resistant organisms found in the lungs of people with cystic fibrosis and its prevalence is increasing. Chronic infection with Stenotrophomonas maltophilia has recently been shown to be an independent predictor of pulmonary exacerbation requiring hospitalization and antibiotics. However, the role of antibiotic treatment (...) of Stenotrophomonas maltophilia infection in people with cystic fibrosis is still unclear. This is an update of a previously published review.The objective of our review is to assess the effectiveness of antibiotic treatment for Stenotrophomonas maltophilia in people with cystic fibrosis. The primary objective is to assess this in relation to lung function and pulmonary exacerbations in the setting of acute pulmonary exacerbations. The secondary objective is to assess this in relation to the eradication

2020 Cochrane