Latest & greatest articles for antibiotics

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This page lists the very latest high quality evidence on antibiotics and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Antibiotics

Antibiotics also referred to as antibacterial are a type of medicine that prevents the growth of bacteria. As such they are used to treat infections caused by bacteria. They kill or prevents bacteria from spreading.

Antibiotics are vital in modern day medicine; they are among the most frequently prescribed drug. There are over a 100 types of antibiotics, the main types and most commonly prescribed are penicillin, cephalosporin, macrolides, fluoroquinolone and tetracycline. They tend to be classified by mechanism of action. So, those that target the bacterial cell wall (penicillins and cephalosporins) or the cell membrane (polymyxins), or interfere with essential bacterial enzymes (rifamycins, lipiarmycins, quinolones, and sulfonamides) have bactericidal activities. Antibiotics such as macrolides, lincosamides and tetracyclines inhibit protein synthesis.

Antibiotics can all be defined by their specificity. “Narrow-spectrum” antibiotics target specific types of bacteria, for instance gram-negative (-ve) or gram-positive (+ve), whereas broad-spectrum antibiotics affect a wide range of bacteria.

Antibiotics are increasingly suffering from antibiotic resistance caused by bacterial mutations meaning the bacteria evolves to not be sensitive to the specific antibiotics being used.

Clinical trials are important to the development and understanding of antibiotics and their side effects. Although they are deemed safe, over use of the drug can kill good bacteria and lead to antibiotic resistance. This halts the ability of bacteria and microorganisms to resist the effects of the antibiotic. Clinical trials and research allow scientists and medical professionals to study the effects and develop new antibiotics.

Trip has extensive coverage of the evidence base on antibiotics allowing users to easily find trusted answers. Coverage include guidelines, systematic reviews, controlled trials and evidence-based synopses.

Top results for antibiotics

101. Prevalence, antimicrobial susceptibility and genotypic characteristics of Staphylococcus aureus in Tanzania: a systematic review Full Text available with Trip Pro

be observed. Non-susceptibility to commonly prescribed antibiotics in community associated S aureus is of concern. Research strategies to better understand the S aureus epidemiology by including genotypic characterisations, as well as strengthening antimicrobial resistance surveillance and antimicrobial stewardship are recommended. Figures Figure 1 Figure 2 Figure 3 Background Materials And Methods Results And Discussion. Conclusion Abbreviations Declarations References Comments (0) Comments can take (...) Prevalence, antimicrobial susceptibility and genotypic characteristics of Staphylococcus aureus in Tanzania: a systematic review Prevalence, antimicrobial susceptibility and genotypic characteristics of Staphylococcus aureus in Tanzania: a systematic review | Research Square Browse Tools & Services Your Cart This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints

2020 Research Square

102. The effects of the primary health care providers’prescription behavior interventions to improve the rational use of antibiotics: a systematic review Full Text available with Trip Pro

The effects of the primary health care providers’prescription behavior interventions to improve the rational use of antibiotics: a systematic review The effects of the primary health care providers’prescription behavior interventions to improve the rational use of antibiotics: a systematic review | Research Square Browse Tools & Services Your Cart This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer (...) review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research article The effects of the primary health care providers’prescription behavior interventions to improve the rational use of antibiotics: a systematic review Lu Yao, Jia Yin, Qiang Sun, Ruiting Huo, Ding Yang, Liyan Shen, Shuqin Wen Lu Yao Shandong University ORCiD

2020 Research Square

103. A multifaceted intervention to reduce antimicrobial prescribing in care homes: a non-randomised feasibility study and process evaluation Full Text available with Trip Pro

A multifaceted intervention to reduce antimicrobial prescribing in care homes: a non-randomised feasibility study and process evaluation A multifaceted intervention to reduce antimicrobial prescribing in care homes: a non-randomised feasibility study and process evaluation Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation

2020 NIHR HTA programme

104. Impetigo: antimicrobial prescribing

T erms used in the guideline 11 Recommendation for research 13 1 Antiseptics compared with antibiotics for impetigo 13 Rationales 14 Advice to reduce the spread of impetigo 14 Initial treatment 14 Reassessment and further treatment 16 Referral and seeking specialist advice 17 Choice of antimicrobial 18 Context 21 Summary of the evidence 22 Antimicrobials 22 Choice of antibiotics 23 Course length 25 Route of administration 25 Other considerations 27 Medicines safety 27 Medicines adherence 27 (...) Resource implications 27 Impetigo: antimicrobial prescribing (NG153) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 28Overview Overview This guideline sets out an antimicrobial prescribing strategy for adults, young people and children aged 72 hours and over with impetigo. It aims to optimise antibiotic use and reduce antibiotic resistance. For managing other skin and soft tissue infections, see our web pages

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

105. Are Postoperative Intravenous Antibiotics Indicated After Laparoscopic Appendicectomy for Simple Appendicitis? A Prospective Double-blinded Randomized Controlled Trial

Are Postoperative Intravenous Antibiotics Indicated After Laparoscopic Appendicectomy for Simple Appendicitis? A Prospective Double-blinded Randomized Controlled Trial Are Postoperative Intravenous Antibiotics Indicated After Laparoscopic Appendicectomy for Simple Appendicitis? A Prospective Double-blinded Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy (...) to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Ann Surg Actions 2019 Dec 9 [Online ahead of print] Are Postoperative Intravenous Antibiotics Indicated After Laparoscopic Appendicectomy for Simple Appendicitis? A Prospective Double-blinded Randomized

2020 EvidenceUpdates

106. AB258. Systematic review of post-operative infection rates in minor orthopaedic procedures: are antibiotics the difference? Full Text available with Trip Pro

AB258. Systematic review of post-operative infection rates in minor orthopaedic procedures: are antibiotics the difference? AB258. Systematic review of post-operative infection rates in minor orthopaedic procedures: are antibiotics the difference? - O’Brien - Mesentery and Peritoneum Have a website account? or for exclusive website content. Title Full Text Author / / AB258. Systematic review of post-operative infection rates in minor orthopaedic procedures: are antibiotics the... AB258 (...) . Systematic review of post-operative infection rates in minor orthopaedic procedures: are antibiotics the difference? Orthopaedic Posters AB258. Systematic review of post-operative infection rates in minor orthopaedic procedures: are antibiotics the difference? Lukas Padraig O’Brien, Iain Feeley, Eoin Sheehan Download Citation Share About AME Publishing Company Copyright © 2009 - 2021 AME Publishing Company. All rights reserved. Published by AME Publishing Company Address: Rm C, 16/F, Kings Wing Plaza 1

2020 Mesentery and Peritoneum

107. The potential for developing new antimicrobial resistance from the use of medical devices containing chlorhexidine, minocycline, rifampicin and their combinations: a systematic review Full Text available with Trip Pro

The potential for developing new antimicrobial resistance from the use of medical devices containing chlorhexidine, minocycline, rifampicin and their combinations: a systematic review Validate User We are sorry, but we are experiencing unusual traffic at this time. Please help us confirm that you are not a robot and we will take you to your content. Could not validate captcha. Please try again. Take me to my Content

2020 JAC-Antimicrobial Resistance

108. Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. Full Text available with Trip Pro

Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. To assess the association between macrolide antibiotics prescribing during pregnancy and major malformations, cerebral palsy, epilepsy, attention deficit hyperactivity disorder, and autism spectrum disorder in children.Population based cohort study.The UK Clinical Practice Research Datalink.The study cohort included 104 605 children born from 1990 to 2016 (...) , 1.14 to 2.19, mainly hypospadias). Erythromycin in the first trimester was associated with an increased risk of any major malformation (27.39 v 17.65 per 1000, 1.50, 1.13 to 1.99). No statistically significant associations were found for other system specific malformations or for neurodevelopmental disorders. Findings were robust to sensitivity analyses.Prescribing macrolide antibiotics during the first trimester of pregnancy was associated with an increased risk of any major malformation

2020 BMJ

109. Antimicrobial resistance and conflict in the Middle East: A systematic review Full Text available with Trip Pro

-conflict affected countries. Conclusions: There is a lack of standardization in the methodological approach to AMR research in the Middle East. The proportion of antibiotic resistances among specific GLASS pathogens is high, particularly among Acinetobacter spp. Keywords Antibiotic resistance, Antimicrobial resistance, Middle East, conflict Figures Figure 1 Figure 2 Background Methods Results Discussion Conclusions List Of Abbreviations Declarations References Tables Due to technical limitations, all (...) Antimicrobial resistance and conflict in the Middle East: A systematic review Antimicrobial resistance and conflict in the Middle East: A systematic review | Research Square Browse Tools & Services Your Cart See the published version of this article at . This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should

2020 Research Square

110. How effective are strategies to control the dissemination of antibiotic resistance in the environment? A systematic review Full Text available with Trip Pro

How effective are strategies to control the dissemination of antibiotic resistance in the environment? A systematic review How effective are strategies to control the dissemination of antibiotic resistance in the environment? A systematic review | Environmental Evidence | Full Text Search Search all BMC articles Search How effective are strategies to control the dissemination of antibiotic resistance in the environment? A systematic review , , , , , , , , , , , , , , , , , , , , , & , volume 9 (...) , Article number: 4 ( 2020 ) 3492 Accesses 3 Citations 33 Altmetric The to this article has been published in Environmental Evidence 2018 7 :3 Abstract Background Antibiotic resistance is a major concern for public and environmental health. The role played by the environment in disseminating resistance is increasingly considered, as well as its capacity for mitigation. We reviewed the literature on strategies to control dissemination of antibiotic-resistant bacteria (ARB), antibiotic resistance genes

2020 Environmental evidence

111. The antimicrobial properties of Moringa oleifera Lam. for water treatment: a systematic review Full Text available with Trip Pro

concentration lead to completely different results. These findings suggest that factors other than the extraction method and extract concentration are relevant for the antibacterial effectiveness of MO. To overcome this complexity, the amount of bioactive compounds for the antimicrobial activity should be quantified in the MO extract. Actually, it is important to remark that all the plants currently studied to determine their antimicrobial activity contain bioactive compounds responsible for antimicrobial (...) comparing antimicrobial efficacy of ‘essential oil of Ocimum sanctum ’ with triple antibiotic paste as an intracanal medicament in primary molars. J Indian Soc Pedod Prev Dent. 8. Moyo M, Aremu AO, Van Staden J (2015) Medicinal plants. An invaluable, dwindling resource in sub-Saharan Africa. J Ethnopharmacol, 9. Vázquez-Sánchez D, Galvão JA, Mazine MR, Gloria EM, Oetterer M (2018) Control of Staphylococcus aureus biofilms by the application of single and combined treatments based in plant essential oils

2020 SN Applied Sciences

112. Prophylaxis of Wound Infections-antibiotics in Renal Donation (POWAR): A UK Multicentre Double blind Placebo Controlled Randomised Trial (Abstract)

Prophylaxis of Wound Infections-antibiotics in Renal Donation (POWAR): A UK Multicentre Double blind Placebo Controlled Randomised Trial Postoperative infection after hand-assisted laparoscopic donor nephrectomy (HALDN) confers significant morbidity to a healthy patient group. Current UK guidelines cite a lack of evidence for routine antibiotic prophylaxis. This trial assessed if a single preoperative antibiotic dose could reduce post HALDN infections.Eligible donors were randomly and blindly (...) allocated to preoperative single-dose intravenous co-amoxiclav or saline. The primary composite endpoint was clinical evidence of any postoperative infection at 30 days, including surgical site infection (SSI), urinary tract infection (UTI), and lower respiratory tract infection (LRTI).In all, 293 participants underwent HALDN (148 antibiotic arm and 145 placebo arm). Among them, 99% (291/293) completed follow-up. The total infection rate was 40.7% (59/145) in the placebo group and 23% (34 of 148

2020 EvidenceUpdates

113. Antibiotic Use for the Urgent Management of Dental Pain and Intra-oral Swelling Clinical Practice Guideline Full Text available with Trip Pro

Centers for Disease Control and Prevention. Telebriefing on today's drug-resistant health threats. ( Available at: ) . , x 16 Centers for Disease Control and Prevention. Joint Statement on Importance of Outpatient Antibiotics Stewardship From 12 National Health Organizations. ( Available at: ) . , x 17 Centers for Disease Control and Prevention. Antibiotic/antimicrobial resistance (AR/AMR): the AMR challenge. ( Available at: ) . , x 18 White House Office of the Press Secretary. Fact sheet: over 150 (...) Antibiotic Use for the Urgent Management of Dental Pain and Intra-oral Swelling Clinical Practice Guideline Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling - The Journal of the American Dental Association Email/Username: Password: Remember me Search Terms Search within Search Access provided by Volume 150, Issue 11, Pages 906–921.e12 Evidence-based clinical practice guideline

2020 American Dental Association Guidelines

114. Leg ulcer infection: antimicrobial prescribing

26 Medicines safety 26 Medicines adherence 27 Resource implications 27 Leg ulcer infection: antimicrobial prescribing (NG152) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 28Overview Overview This guideline sets out an antimicrobial prescribing strategy for adults with leg ulcer infection. It aims to optimise antibiotic use and reduce antibiotic resistance. See a 2-page visual summary (...) antibiotic use. 1.1.4 Give oral antibiotics if the person can take oral medicines, and the severity of their condition does not require intravenous antibiotics. 1.1.5 If intravenous antibiotics are given, review by 48 hours and consider switching to oral antibiotics if possible. T o find out why the committee made the recommendations on treatment for adults with an infected leg ulcer, see the rationales. Leg ulcer infection: antimicrobial prescribing (NG152) © NICE 2020. All rights reserved. Subject

2020 National Institute for Health and Clinical Excellence - Clinical Guidelines

115. Theoretical approaches in the development and evaluation of behaviour change interventions that improve clinicians’ antimicrobial prescribing: a systematic review Full Text available with Trip Pro

Theoretical approaches in the development and evaluation of behaviour change interventions that improve clinicians’ antimicrobial prescribing: a systematic review Theoretical approaches in the development and evaluation of behaviour change interventions that improve clinicians’ antimicrobial prescribing: a systematic review | Microbiology Society 1887 search Toggle navigation Tools Toggle navigation Share Meeting Report Open Access Theoretical approaches in the development and evaluation (...) of behaviour change interventions that improve clinicians’ antimicrobial prescribing: a systematic review 1 , 1 , 1 , 2 , 2 , 1 , View Affiliations Hide Affiliations Affiliations: 1 2 * Correspondence: Hisham Ziglam, First Published: 28 February 2020 Tools /recommendto/form?webId=%2Fcontent%2Fjournal%2Facmi&title=Access+Microbiology&eissn=2516-8290 Access Microbiology — Recommend this title to your library Share Abstract Many countries have developed antimicrobial stewardship programmes with strategies

2020 Access Microbiology

116. Update in Antibiotics Prophylaxis in Oral Surgery: A Systematic Review Full Text available with Trip Pro

as the adverse reactions are too high. In the other hand, amoxicillin is a safe option in antimicrobial prophylaxis in oral surgery. However, Gastrointestinal disturbances accounted for a significant proportion of the adverse reactions recorded for all antibiotics examined, special consideration is needed in the administration of antibiotic prophylaxis in patients with gastrointestinal problems. Conclusions: The usage of prophylactic antibiotic therapy in oral surgery is not effective and doesn´t improve (...) the ideal antimicrobial in the treatment of acute dentoalveolar abscesses, it is not used in odontogenic abscesses because it causes pseudomembranous colitis [7]. The extraction of the third molar, despite being the most common intervention in oral surgery, no studies have been found that providestandardized protocols for the clinician in the use of antibiotic prophylaxis. The purpose of this study is thus, to evaluate the efficacy of antibiotic prophylaxis in preventing postoperative complications

2020 International Journal of Pharma Research and Health Sciences

117. Antimicrobial stewardship in residential aged care facilities: A Systematic Review Full Text available with Trip Pro

/bmrat.v7i1.582 Copyrights: Ali Akhtar, Amer Hayat Khan, Samreen Fatima, Mohamad Azmi Hassali, 2020. License: This work is licensed under a . Abstract Background : Antimicrobial Stewardship (AMS) programs are increasingly implemented in healthcare facilities to reduce inappropriate use of antibiotics. Inappropriate use of antimicrobials is one of the leading causes of increasing antimicrobial resistance (AMR). As such, decreasing inappropriate use of antimicrobials can reduce AMR. The main objective (...) of this systematic review was to identify the effectiveness of AMS interventions in reducing inappropriate antimicrobial use in residential aged care facilities (RACFs). Methods : Multiple databases were searched to identify studies evaluating the effectiveness of AMS interventions in RACFs. Descriptive studies and those, which did not report an outcome measure related to antibiotic usage, were excluded. Results : Overall, 6505 studies were identified and 17 were included. Most of the studies were randomized

2020 Biomedical Research and Therapy

118. Probiotics for the prevention of antibiotic-associated adverse events in children – a systematic review to inform development of a core outcome set Full Text available with Trip Pro

Probiotics for the prevention of antibiotic-associated adverse events in children – a systematic review to inform development of a core outcome set Probiotics for the prevention of antibiotic-associated adverse events in children – a systematic review to inform development of a core outcome set | bioRxiv Search for this keyword New Results Probiotics for the prevention of antibiotic-associated adverse events in children – a systematic review to inform development of a core outcome set Jan (...) University, Department of Community Health and Epidemiology , Halifax, Canada Abstract Introduction Routine use of probiotics during antibiotic therapy in children remains a subject of discussion. To facilitate synthesis of individual study results and guideline formulation, it is important to assess predefined, similar, and clinically important outcomes. Core outcome sets are a proposed solution for this issue. Aim of this review was to document choice, design, and heterogeneity of outcomes in studies

2020 Cold Spring Harbor Laboratory

119. Symptomatic treatment (using NSAIDS) versus antibiotics in uncomplicated lower urinary tract infection: a meta-analysis and systematic review of randomized controlled trials Full Text available with Trip Pro

Symptomatic treatment (using NSAIDS) versus antibiotics in uncomplicated lower urinary tract infection: a meta-analysis and systematic review of randomized controlled trials Symptomatic treatment (using NSAIDS) versus antibiotics in uncomplicated lower urinary tract infection: a meta-analysis and systematic review of randomized controlled trials | Research Square Browse Tools & Services Your Cart This preprint is under consideration at BMC Infectious Diseases . A preprint is a preliminary (...) version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research article Symptomatic treatment (using NSAIDS) versus antibiotics in uncomplicated lower urinary tract infection: a meta-analysis and systematic review

2020 Research Square

120. F1000Prime recommendation of Prevalence of antibiotic resistance in helicobacter pylori: a systematic review and meta-analysis in world health organization regions. Full Text available with Trip Pro

F1000Prime recommendation of Prevalence of antibiotic resistance in helicobacter pylori: a systematic review and meta-analysis in world health organization regions. Prevalence of antibiotic resistance in helicobacter... | Faculty Opinions On April 12th, 2020, F1000Prime became Faculty Opinions. See our to learn more. Welcome Guest 1 Recommendations info_outline Systematic Review / Meta-analysis New Finding close Classified As New Finding 1 Article Type Systematic Review / Meta-analysis More (...) more_vert close Download article Export article Sciwheel Download citation BibTeX RIS Share Email Prevalence of antibiotic resistance in helicobacter pylori: a systematic review and meta-analysis in world health organization regions. ARTICLE PUBLISHED: 2018 11 CITE AS: Gastroenterology. 2018 11 ; 155 ( 5 ): 1372-1382.e17 Recommendations Abstract Comments You have reached your article limit. Register for 30-day free trial Registration is free and only takes a moment, or subscribe for unlimited access

2020 Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature