Latest & greatest articles for anticoagulation

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Top results for anticoagulation

461. A controlled comparison of aspirin and oral anticoagulants in prevention of death after myocardial infarction. (Abstract)

A controlled comparison of aspirin and oral anticoagulants in prevention of death after myocardial infarction. Although neither aspirin nor oral anticoagulants have been conclusively shown to reduce mortality in patients surviving myocardial infarction, both have been widely used for that purpose. In the present clinical trial we compared the effects of aspirin (0.5 g given three times a day) and oral-anticoagulant therapy. Of 6908 patients considered for entry, 1303 were randomized (...) to anticoagulant (652) or aspirin (651) an average of 11.4 days after the onset of myocardial infarction and were followed for 6 to 59 months (mean, 29 months). There were 65 deaths in the anticoagulant group and 72 in the aspirin group. The number of patients with reinfarctions was higher in the aspirin group (33 vs. 20). None of these differences were statistically significant. Almost twice as many patients were withdrawn from therapy in the aspirin group. There were 54 per cent more patients

1982 NEJM Controlled trial quality: uncertain

462. Different intensities of oral anticoagulant therapy in the treatment of proximal-vein thrombosis. (Abstract)

Different intensities of oral anticoagulant therapy in the treatment of proximal-vein thrombosis. We have previously reported that long-term therapy with warfarin is effective for preventing recurrent venous thromboembolism in patients with proximal-vein thrombosis but that there is an appreciable risk of hemorrhage. To determine whether that risk could be reduced without a loss of effectiveness, we randomly allocated 96 patients with proximal-vein thrombosis to a group receiving less intense (...) anticoagulant therapy, with a mean prothrombin time of 26.9 seconds using the Manchester comparative reagent (corresponding Simplastin time, 15 seconds), or a group given more intense therapy, with a mean Simplastin time of 19.4 seconds (corresponding prothrombin time 41 seconds with the Manchester comparative reagent) (P less than 0.001). Two of 47 patients (4 per cent) in the less intensely treated group had hemorrhagic complications, as compared with 11 of 49 patients (22 per cent) in the more intensely

1982 NEJM Controlled trial quality: uncertain

463. A double-blind trial to assess long-term oral anticoagulant therapy in elderly patients after myocardial infarction. Report of the Sixty Plus Reinfarction Study Research Group. (Abstract)

A double-blind trial to assess long-term oral anticoagulant therapy in elderly patients after myocardial infarction. Report of the Sixty Plus Reinfarction Study Research Group. In a randomised double-blind multicentre clinical trial the effect of continued oral anticoagulant therapy after a myocardial infarction was assessed in a group of patients over 60 years of age. Half of the 878 patients who had been on anticoagulants ever since their primary myocardial infarction received placebos (...) instead of the anticoagulant; the others continued anticoagulant therapy. All were followed for 2 years. The levels of hypocoagulability reached in the group on anticoagulants were such that, of the registered prothrombin times ('Thrombotest'), 72% were between 107 and 180 s. 2-year total mortality was 13.4% in the placebo group and 7.6% in the group treated with anticoagulants (p = 0.017. 2-year incidence of recurrent myocardial infarction was 15.9% in the placebo group and 5.7% in the anticoagulant

1980 Lancet Controlled trial quality: predicted high

464. Failure of antiplatelet and anticoagulant therapy to improve patency of grafts after coronary-artery bypass: a controlled, randomized study. (Abstract)

Failure of antiplatelet and anticoagulant therapy to improve patency of grafts after coronary-artery bypass: a controlled, randomized study. Fifty patients who underwent aortocoronary saphenous-vein bypass-graft surgery were randomly assigned to one of three groups to determine the effects of antiplatelet or anticoagulant therapy on graft patency. Twenty-four patients served as controls; 13 patients received aspirin (325 mg three times a day) and dipyridamole (75 mg three times a day); and 13

1979 NEJM Controlled trial quality: uncertain

465. Evidence favoring the use of anticoagulants in the hospital phase of acute myocardial infarction. (Abstract)

Evidence favoring the use of anticoagulants in the hospital phase of acute myocardial infarction. Since the last comprehensive review of anticoagulation in acute myocardial infarction four additional randomized control trials have been reported. The overwhelming majority of all trials favored anticoagulation. Rates of thromboembolism were higher in the control, and hemorrhagic complications in the anticoagulated group. Pooling of all randomized control trials gives mean case fatality rates (...) of 19.6% for the control and 15.4% for the anticoagulated group, a relative reduction of 21% (P less than 0.05 or less than 0.001, depending on the analytic method). Five of six randomized control trials reported "no effect" because the difference favoring anticoagulation was not statistically significant. However, sample sizes in these "negative" papers were too small to protect against missing a 21% reduction in true case fatality rate due to anticoagulation (beta greater than 0.10). All patients

1977 NEJM Controlled trial quality: uncertain

466. Anticoagulants in acute myocardial infarction. Results of a cooperative clinical trial. (Abstract)

Anticoagulants in acute myocardial infarction. Results of a cooperative clinical trial. 4578167 1973 09 21 2016 10 17 0098-7484 225 7 1973 Aug 13 JAMA JAMA Anticoagulants in acute myocardial infarction. Results of a cooperative clinical trial. 724-9 eng Clinical Trial Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Anticoagulants 0 Placebos 5Q7ZVV76EI Warfarin 9005-49-6 Heparin 9NEZ333N27 Sodium AIM IM Acute Disease Adult Aged Anticoagulants adverse effects

1973 JAMA Controlled trial quality: uncertain

467. Anticoagulant therapy after acute myocardial infarction. Relation of therapeutic benefit to patient's age, sex, and severity of infarction. (Abstract)

Anticoagulant therapy after acute myocardial infarction. Relation of therapeutic benefit to patient's age, sex, and severity of infarction. 4117261 1973 01 05 2016 10 17 0098-7484 222 5 1972 Oct 30 JAMA JAMA Anticoagulant therapy after acute myocardial infarction. Relation of therapeutic benefit to patient's age, sex, and severity of infarction. 541-8 Drapkin A A Merskey C C eng Clinical Trial Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Anticoagulants 0 (...) Placebos 5M7Y6274ZE Phenindione 5Q7ZVV76EI Warfarin 7QID3E7BG7 Dicumarol 9005-49-6 Heparin AIM IM Age Factors Aged Anticoagulants adverse effects therapeutic use Cerebrovascular Disorders mortality Clinical Trials as Topic Diabetes Complications Dicumarol therapeutic use Electrocardiography Female Heart Failure complications Hemorrhage chemically induced Heparin therapeutic use Humans Hypertension complications Male Middle Aged Myocardial Infarction complications drug therapy mortality Phenindione

1973 JAMA Controlled trial quality: uncertain

468. Long-term anticoagulant therapy after myocardial infarction. Final report of the Veterans Administration cooperative study. (Abstract)

Long-term anticoagulant therapy after myocardial infarction. Final report of the Veterans Administration cooperative study. 4885975 1969 04 16 2016 10 17 0098-7484 207 12 1969 Mar 24 JAMA JAMA Long-term anticoagulant therapy after myocardial infarction. Final report of the Veterans Administration cooperative study. 2263-7 Ebert R V RV eng Clinical Trial Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Anticoagulants 97C5T2UQ7J Cholesterol AIM IM Anticoagulants

1969 JAMA Controlled trial quality: uncertain