Latest & greatest articles for asthma

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Top results for asthma

1201. Effect of a single oral dose of prednisolone in acute childhood asthma. (Abstract)

Effect of a single oral dose of prednisolone in acute childhood asthma. 140 children of 184 with acute asthma entered a randomised double-blind trial of oral prednisolone (n = 67) compared with placebo (n = 73) administered soon after admission. The dose of prednisolone was 30 mg in children under 5, otherwise 60 mg. All children also received salbutamol. All had moderate or severe dyspnoea. Initial evaluation was similar for both groups. On reassessment after a few hours 20 children (...) in the prednisolone group were fit for discharge compared with only 2 in the placebo group. There were no early reattendances. Children remaining in hospital had a shorter median duration of stay and were less likely to require further steroid therapy if they had initially received prednisolone. In acute asthma the prompt use of a single dose of oral prednisolone can reduce morbidity and the need for hospital care.

1987 Lancet Controlled trial quality: uncertain

1202. [Air purifiers in the treatment of asthma in adults]. (Abstract)

[Air purifiers in the treatment of asthma in adults]. 3698871 1986 06 02 2006 11 15 0012-7183 102 5 1986 Duodecim; laaketieteellinen aikakauskirja Duodecim [Air purifiers in the treatment of asthma in adults]. 313-9 Vilkka V V Haahtela T T Mönkäre S S Kuusisto P P Tukiainen P P fin Clinical Trial English Abstract Journal Article Randomized Controlled Trial Ilmanpuhdistimet aikuisten astman hoidossa. Finland Duodecim 0373207 0012-7183 IM Adolescent Adult Aged Air Pollution prevention & control (...) Asthma prevention & control Child Child, Preschool Electronics Female Filtration Humans Male Methods Middle Aged 1986 1 1 1986 1 1 0 1 1986 1 1 0 0 ppublish 3698871

1986 Duodecim; laaketieteellinen aikakauskirja Controlled trial quality: uncertain

1203. Controlled evaluation of the effects of patient education on asthma morbidity in general practice. (Abstract)

Controlled evaluation of the effects of patient education on asthma morbidity in general practice. Two different patient education programmes for asthma in general practice were evaluated in a controlled trial. Knowledge, self management, and morbidity due to asthma were assessed in 339 patients by means of a questionnaire. One group then received a maximum education programme, a second group received a limited education programme, and a third acted as a control group. 274 patients were (...) reassessed after one 1 year. In both the intervention groups, understanding of asthma was greater after the trial. Only in the maximum intervention group was a significant improvement in knowledge of asthma shown. Neither group showed any change in self-management ability or asthma morbidity that differed significantly from changes in the control group. These simple informational education programmes were ineffective when applied to a general practice population. Further studies of factors affecting

1986 Lancet

1204. A controlled trial of methylprednisolone in the emergency treatment of acute asthma. (Abstract)

A controlled trial of methylprednisolone in the emergency treatment of acute asthma. Ninety-seven acutely ill patients with bronchial asthma were enrolled in a double-blind, placebo-controlled, randomized trial of intravenous methylprednisolone (125 mg), given on presentation in the emergency room in addition to standard emergency treatments for asthma. Subjective and spirometric indexes of the severity of the asthma were similar on entry into the study in all patients, but only 9 of 48 (...) patients (19 percent) treated with methylprednisolone required hospital admission, as compared with 23 of 49 patients (47 percent) in the control group (P less than 0.003). Our results suggest that prompt use of glucocorticoids in the emergency treatment of severe asthma can prevent significant morbidity, reduce the number of hospitalizations, and effect substantial savings in health care costs.

1986 NEJM Controlled trial quality: uncertain

1205. Need for intravenous hydrocortisone in addition to oral prednisolone in patients admitted to hospital with severe asthma without ventilatory failure. (Abstract)

Need for intravenous hydrocortisone in addition to oral prednisolone in patients admitted to hospital with severe asthma without ventilatory failure. 52 severely ill asthmatic patients requiring acute admission to hospital entered a double-blind placebo-controlled trial to determine whether intravenous hydrocortisone given in addition to high-dose oral prednisolone and standard bronchodilator therapy accelerated recovery. Patients who had been given parenteral steroids before admission (...) in addition to oral prednisolone and bronchodilator therapy in patients admitted to hospital with severe asthma without ventilatory failure.

1986 Lancet Controlled trial quality: predicted high

1206. The link between exercise, respiratory heat exchange, and the mast cell in bronchial asthma. (Abstract)

The link between exercise, respiratory heat exchange, and the mast cell in bronchial asthma. There are two apparently conflicting theories on the pathogenesis of exercise-induced asthma. One view is that exercise-induced asthma is directly related to respiratory heat exchange and that mast cells are not involved. The other theory explains exercise-induced asthma on the basis of a temperature-independent release of mast-cell mediators. A theory is put forward here that airway cooling (...) in asthmatic subjects during exercise leads directly to mast-cell degranulation and that this explains the association between exercise, respiratory heat exchange, and mediator release.

1983 Lancet Controlled trial quality: uncertain

1207. Vasoactive intestinal peptide causes bronchodilatation and protects against histamine-induced bronchoconstriction in asthmatic subjects. (Abstract)

Vasoactive intestinal peptide causes bronchodilatation and protects against histamine-induced bronchoconstriction in asthmatic subjects. Vasoactive intestinal peptide (VIP) caused significant bronchodilatation in seven asthmatic volunteers when given intravenously at the rate of 6 pmol/kg/min for 15 min during a double-blind study. Tachycardia and cutaneous flushing were observed during the infusion. VIP also ameliorated histamine-induced bronchoconstriction in all subjects. VIP may (...) be an important natural bronchodilator in man and this has implications for the pharmacotherapy of asthma.

1983 Lancet Controlled trial quality: uncertain

1208. Single-dose slow-release aminophylline at night prevents nocturnal asthma. (Abstract)

Single-dose slow-release aminophylline at night prevents nocturnal asthma. Twelve asthmatic patients with nocturnal wheezing were given a single nocturnal oral dose of slow-release aminophylline or matched placebo in a double-blind crossover trial. A dose of slow-release aminophylline (mean 683 mg; 10.4 mg/kg) gave a therapeutic plasma-theophylline concentration 10 h later (mean 10.9 mg/l). This was not associated with any adverse effects. Mean peak expiratory flow on waking was significantly (...) was significantly less with aminophylline, and there was a subjective improvement in nocturnal symptoms in all patients. Slow-release aminophylline in adequate dosage appears to be the most effective treatment yet demonstrated for nocturnal asthma.

1982 Lancet Controlled trial quality: uncertain

1209. Routine antibiotics in hospital management of acute asthma. (Abstract)

Routine antibiotics in hospital management of acute asthma. The value of antibiotics was assessed in a randomised, double-blind study of amoxycillin and placebo in sixty adults admitted to hospital with acute exacerbations of asthma. 37 exacerbations were treated with amoxycillin and 34 were treated with placebo. Response to treatment was closely monitored but no significant difference in improvement was demonstrated between groups for length of hospital stay, time taken for 50% improvement (...) in symptoms, patient's self assessment and respiratory function, and symptoms and respiratory function at time of discharge from hospital. Antibiotics should not be given routinely to patients admitted to hospital with acute exacerbations of asthma.

1982 Lancet Controlled trial quality: uncertain

1210. The value of maintenance theophylline in steroid-dependent asthma. (Abstract)

The value of maintenance theophylline in steroid-dependent asthma. We examined the value of maintenance theophylline at serum concentrations of 10 to 20 micrograms per milliliter in a placebo-controlled, randomized, double-blind trial of 33 children with steroid-dependent chronic asthma. Patients were free of all symptoms 63 +/- 6 per cent of the days (mean +/- S.E.M.) when taking theophylline as compared with 42 +/- 6 per cent when taking placebo (P < 0.01). Inhaled metaproterenol was required (...) patients completing the exercise (P < 0.02). We conclude that maintenance bronchodilator therapy with theophylline can provide clinically important benefit for patients with chronic steroid-dependent asthma.

1981 NEJM Controlled trial quality: uncertain

1211. Controlled trial of an electrostatic precipitator in childhood asthma. (Abstract)

Controlled trial of an electrostatic precipitator in childhood asthma. A cross-over trial was conducted on 10 children with moderate to severe asthma, who had positive skin tests to Dermatophagoides pteronyssinus and nocturnal wheeze. An electrostatic precipitator was used during the night to remove airborne particles from the bedroom. During use of the precipitator peak expiratory flow rates were no better than in a control period.

1980 Lancet Controlled trial quality: uncertain

1212. [Therapeutic differences between atenolol and pindolol in asthmatic patients]. (Abstract)

[Therapeutic differences between atenolol and pindolol in asthmatic patients]. 374041 1979 07 25 2013 11 21 0012-7183 95 6 1979 Duodecim; laaketieteellinen aikakauskirja Duodecim [Therapeutic differences between atenolol and pindolol in asthmatic patients]. 287-91 Hellström P E PE Salonen T T fin Clinical Trial Comparative Study English Abstract Journal Article Randomized Controlled Trial Atenololin ja pindololin soveltuvuus astmaatikolle. Finland Duodecim 0373207 0012-7183 0 Placebos 0 (...) Propanolamines 50VV3VW0TI Atenolol BJ4HF6IU1D Pindolol IM Asthma complications Atenolol therapeutic use Clinical Trials as Topic Double-Blind Method Drug Evaluation Hemodynamics drug effects Humans Hypertension complications drug therapy Pindolol therapeutic use Placebos Propanolamines therapeutic use Respiration drug effects Respiratory Function Tests 1979 1 1 1979 1 1 0 1 1979 1 1 0 0 ppublish 374041

1979 Duodecim; laaketieteellinen aikakauskirja Controlled trial quality: uncertain

1213. Emergency treatment of asthma. A comparison of two treatment regimens. (Abstract)

Emergency treatment of asthma. A comparison of two treatment regimens. The effectiveness of epinephrine was compared to that of a combination of epinephrine and aminophylline in the initial treatment of acute asthma. Forty-four patients with 51 episodes of acute asthma were evaluated. Peak flow spirometry served as an objective measure of airway resistance, and theophylline levels were determined at fixed intervals throughout the study. Epinephrine and aminophylline were not found (...) to be superior to epinephrine alone. There was no correlation between mean serum theophylline levels and the magnitude of improvement. Rapidity of emergency department discharge and frequency of admission was independent of treatment method. The failure of epinephrine-aminophylline to effect more rapid or profound improvement in pulmonary function might suggest that epinephrine alone, or an equivalent sympathomimetic is a rational choice in the initial treatment of acute asthma.

1979 JAMA Controlled trial quality: uncertain

1214. Education for self-treatment by adult asthmatics. (Abstract)

Education for self-treatment by adult asthmatics. A prospective experimental design evaluated the ability of a series of educational and motivational interventions to enhance self-treatment by adult asthmatics and to reduce use of emergency department services for asthma attacks. After treatment for an asthma attack, subjects were randomly assigned to the following sequential interventions: (1) reinforcement by interpersonal similarity at the time of the emergency visit, (2) recepit of positive (...) written appeals, and (3) follow-up telephone reinforcement. The asthmatic nurse educator was generally more effective in achieving short-term reduction of emergency department visits. Although the usefulness of the positive written appeal increased when employed by the asthmatic nurse, there were no substantive independent effects of the written message on emergency department use.

1979 JAMA Controlled trial quality: uncertain

1215. Combined therapy with salbutamol and beclomethasone inhalers in chronic asthma. (Abstract)

Combined therapy with salbutamol and beclomethasone inhalers in chronic asthma. A double-blind cross-over trial was carried out to compare the effect of identical placebo with that of salbutamol inhalers used 30 min before inhalation of 100 microgram of beclomethasone dipropionate (B.D.P.) in 18 chronic asthmatics over two consecutive 4-week periods. The salbutamol and B.D.P. combination resulted in a significant improvement in the peak expiratory flow-rate and F.E.V.1, significantly less use

1978 Lancet

1216. Bronchodilator effects of terbutaline and aminophylline alone and in combination in asthmatic patients. (Abstract)

Bronchodilator effects of terbutaline and aminophylline alone and in combination in asthmatic patients. In 17 patients with moderate to severe asthma, we compared acute bronchodilator effects of the following drugs or drug combinations using a double-blind crossover design: terbutaline, 5; aminophyline 400; terbutaline, 5, plus aminophyline, 400; terbutaline, 2.5; aminophylline, 200; terbutaline, 2.5, plus aminophyline, 200 mg; and placebo. The higher doses of terbutaline and aminophylline (...) (terbutaline) in asthma not well controlled on high doses of either drug alone and in combining these drugs in lower doses in patients experiencing intolerable side effects from a high dose of either drug.

1978 NEJM Controlled trial quality: uncertain

1217. Controlled trial of hyposensitisation to Dermatophagoides pteronyssinus in children with asthma. (Abstract)

Controlled trial of hyposensitisation to Dermatophagoides pteronyssinus in children with asthma. Hyposensitisation with Dermatophagoides pteronyssinus tyrosine absorbate in asthmatic children with bronchial sensitivity to D. pteronyssinus was effective in a 12-month double-blind controlled clinical trial. Compared with controls, treated children used a smaller quantity of drugs while maintaining clinical and lung function improvements. In most children who improved there was no change

1978 Lancet

1218. Comparison of cromoglycate (cromolyn) and theophylline in controlling symptoms of chronic asthma. A collaborative study. (Abstract)

Comparison of cromoglycate (cromolyn) and theophylline in controlling symptoms of chronic asthma. A collaborative study. 28 children with chronic asthma (15 in Denver and 13 in London) completed a 12 wk double-blind trial of treatment with sodium cromoglycate (cromolyn sodium), theophylline, and a combination of both. The three regimens were administered, each for 4 wk, in random sequence as part of a collaborative investigation of the relative efficacy of the two antiasthmatic agents (...) while on cromoglycate and 71% of days symptom-free when on both the theophylline and the combination regimens (P less than 0.025). None of the 13 patients whose asthmatic symptoms were previously controlled with cromoglycate was unable to complete the 4 wk trial with theophylline alone; 1 patient whose symptoms had been previously controlled with theophylline twice developed severe asthmatic symptoms while receiving cromoglycate, and he had to be withdrawn from that study period. No significant

1977 Lancet

1219. Cromolyn therapy in patients with bronchial asthma. Effect on inhalation challenge with allergen, histamine, and methacholine. (Abstract)

Cromolyn therapy in patients with bronchial asthma. Effect on inhalation challenge with allergen, histamine, and methacholine. The action mechanism of cromolyn sodium and its effect on bronchial sensitivity to allergen, methacholine chloride, and histamine inhalations were studied in 17 asthmatic subjects. Cromolyn capsules or placebo was administered by an inhaler (Spinhaler) randomly on alternate days 30 minutes before aerosol challenge. Cromolyn and placebo did not differ in their effect

1976 JAMA Controlled trial quality: uncertain

1220. Anti-mite measurements in mite-sensitive adult asthma. A controlled trial. (Abstract)

Anti-mite measurements in mite-sensitive adult asthma. A controlled trial. A cross-over controlled trial has been conducted among 32 adult patients with mite-sensitive asthma. The bedclothes and pillows of each subject were laundered and vacuum-cleaned and a plastic cover applied to the mattress for six weeks in an attempt to reduce exposure to mites. No improvement in daily peak-flow reading or drug usage was found in comparison with a control period.

1976 Lancet