Latest & greatest articles for autism

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on autism or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on autism and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Autism

Autism is a neurodevelopmental disorder (a type of mental disorder) characterised by difficult social interaction, impaired communication (both verbal and non-verbal), and restricted and repetitive behaviours. It forms part of the broader autism spectrum disorder (ASD), a range of similar conditions, including Asperger syndrome.

Autism is a condition that begins from early childhood and is often suspected and diagnosed by ages 1-3. It is a lifelong disability that affects how people interact with others.

Autism causes and treatment

There have been many misconceptions as to what causes autism in the past such as the MMR vaccine and diet. Extensive research and clinical trials have concluded that none of these factors cause autism or ASD. However, the real cause is little understood but research is starting to unpick potential factors such as genetics, pollution and other environmental factors. A current favoured idea is that genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors.

The exact cause of autism spectrum disorder is unknown, however research into the disorder suggest that it is caused by several genetic and environmental factors. Genes inherited from a child’s parents can make them more vulnerable to developing autism, some researchers suggest that the disorder will only develop when triggered by environmental factors. Read more in clinical papers on autism.

Autism can be managed with a combination of prescribed medicines and behavioural treatment, depending on the severity of the disorder. Read about clinical trials and medical advancements for the treatment of autism on Trip.

Hot topics in Trip

Users of Trip frequently look at topics around adolescents, therapies, behaviour and screening. They also explore such topics as omega-3 fatty acids, SSRIs and aripiprazole. All these topics, and more, can be easily searched for within Trip.

Top results for autism

1. Melatonin (Slenyto) - Treatment of insomnia in children and adolescents aged 2 to 18 years with autism spectrum disorder and / or Smith-Magenis syndrome

Melatonin (Slenyto) - Treatment of insomnia in children and adolescents aged 2 to 18 years with autism spectrum disorder and / or Smith-Magenis syndrome 1 Published 18 January 2021 1 SMC2306 melatonin 1mg and 5mg prolonged-release tablets (Slenyto®) Flynn Pharma Ltd 4 December 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHS Scotland. The advice is summarised (...) as follows: ADVICE: following a resubmission melatonin prolonged-release (Slenyto ® ) is not recommended for use within NHSScotland. Indication under review: Treatment of insomnia in children and adolescents aged 2 to 18 years with autism spectrum disorder and / or Smith-Magenis syndrome, where sleep hygiene measures have been insufficient. Melatonin prolonged-release (Slenyto ® ), compared with placebo, increased total sleep time and sleep onset latency in children aged 2 to 17.5 years with sleep

2021 Scottish Medicines Consortium

2. Family navigation to increase evaluation for autism spectrum disorder in toddlers: Screening and Linkage to Services for Autism pragmatic randomized trial

Family navigation to increase evaluation for autism spectrum disorder in toddlers: Screening and Linkage to Services for Autism pragmatic randomized trial Family navigation to increase evaluation for autism spectrum disorder in toddlers: Screening and Linkage to Services for Autism pragmatic randomized trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) updates of new search results? Saved Search Alert Radio Buttons Yes No Email: ( ) Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Autism Actions . 2020 Nov

2021 EvidenceUpdates

3. Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase-2 Superiority Trial Full Text available with Trip Pro

Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase-2 Superiority Trial Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase-2 Superiority Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several (...) navigation J Am Acad Child Adolesc Psychiatry Actions . 2020 Jul 27;S0890-8567(20)31290-9. doi: 10.1016/j.jaac.2020.07.888. Online ahead of print. Bumetanide for Core Symptoms of Autism Spectrum Disorder (BAMBI): A Single Center, Double-Blinded, Participant-Randomized, Placebo-Controlled, Phase-2 Superiority Trial , , , , , , , , Affiliations Expand Affiliations 1 UMC Utrecht Brain Centre, University Medical Centre Utrecht, the Netherlands. 2 Julius Centre for Health Sciences and Primary Care, University

2021 EvidenceUpdates

4. Management of patients with a learning disability, autism or both: easy read (Covid-19)

Management of patients with a learning disability, autism or both: easy read (Covid-19) 1 Important advice to staff supporting people with a learning disability or autistic people Clinical guide for staff supporting patients with a learning disability, autism or both during the coronavirus pandemic COVID-19 is a new illness. Lots of people call it coronavirus. It can affect your lungs and your breathing. There are some people who are very ill with coronavirus They are being looked after (...) people with a learning disability or autistic people. 3 Clinical guide for staff supporting patients with a learning disability, autism or both during the coronavirus pandemic 1. Staff should make sure they know the difference between your illness and your learning disability or autism. This is to make sure you get the right treatment for your illness. 2. Staff must follow the information on your hospital passport (if you have one). 3. Staff should listen to you and your family and any carers who

2021 NHS England

5. Management of patients with a learning disability, autism or both (Covid-19)

Management of patients with a learning disability, autism or both (Covid-19) Publications approval reference: 001559 NHS England and NHS Improvement Speciality guides for patient management during the coronavirus pandemic Clinical guide for front line staff to support the management of patients with a learning disability, autism or both during the coronavirus pandemic – relevant to all clinical specialities November 2020 “…and there are no more surgeons, urologists, orthopaedists, we are only (...) in hospitals. We may also need to work outside our specific areas of training and expertise and the General Medical Council (GMC) has already indicated its support for this in the exceptional circumstances we may face. As a clinician working in other fields you may have had limited clinical contact with people with a learning disability or people with autism, however in 2018/19 at least 41% of people with a learning disability who died, died as a result of a respiratory condition. There is, therefore

2021 NHS England

6. Effectiveness of Music Therapy for Autism Spectrum Disorder, Dementia, Depression, Insomnia and Schizophrenia

Effectiveness of Music Therapy for Autism Spectrum Disorder, Dementia, Depression, Insomnia and Schizophrenia Effectiveness of Music Therapy for Autism Spectrum Disorder, Dementia, Depression, Insomnia and Schizophrenia - Repository of AIHTA GmbH English | Browse - - - Effectiveness of Music Therapy for Autism Spectrum Disorder, Dementia, Depression, Insomnia and Schizophrenia Gassner, L. and Mayer-Ferbas, J. (2020): Effectiveness of Music Therapy for Autism Spectrum Disorder, Dementia (...) , Depression, Insomnia and Schizophrenia. HTA-Projektbericht 133. Preview - Sie müssen einen PDF-Viewer auf Ihrem PC installiert haben wie z. B. , oder 1MB Abstract Introduction: Music therapy is an expression promoting, scientific-artistic-creative and independent form of treatment and aims at maintaining, restoring, and furthering physical, emotional, and mental health. This systematic review aims at assessing the effectiveness of music therapy for the treatment of autism spectrum disorder, dementia

2020 Austrian Institute of Health Technology Assessment

7. Evaluating specialist autism teams' provision of care and support for autistic adults without learning disabilities: the SHAPE mixed-methods study Full Text available with Trip Pro

Evaluating specialist autism teams' provision of care and support for autistic adults without learning disabilities: the SHAPE mixed-methods study Evaluating specialist autism teams' provision of care and support for autistic adults without learning disabilities: the SHAPE mixed-methods study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from (...) the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} This study identified how different Specialist Autism Teams are operating in alternative organisational settings, found some evidence of benefit from Specialist Autism Teams and made recommendations for further evaluation. {{author}} {{($index , , , , , , & . Bryony Beresford 1, * , Suzanne Mukherjee 1 , Emese Mayhew 1 , Emily

2020 NIHR HTA programme

8. Maternal Influenza A(H1N1) Immunization During Pregnancy and Risk for Autism Spectrum Disorder in Offspring : A Cohort Study. (Abstract)

Maternal Influenza A(H1N1) Immunization During Pregnancy and Risk for Autism Spectrum Disorder in Offspring : A Cohort Study. There are concerns that influenza vaccine exposure during pregnancy may be associated with increased risk for autism spectrum disorder (ASD).To examine the risk for ASD in offspring of mothers who were vaccinated against influenza A(H1N1)pdm09 ("swine flu") during pregnancy.Population-based cohort study using nationwide registers.Seven health care regions in Sweden.Live (...) births between October 2009 and September 2010, with follow-up through December 2016. In total, 39 726 infants were prenatally exposed to H1N1 vaccine (13 845 during the first trimester) and 29 293 infants were unexposed.Cox regression was used to estimate hazard ratios (HRs) for the primary outcome, ASD, before and after adjustment for potential confounders. The secondary outcome was autistic disorder (AD).Mean follow-up was 6.7 years in both unexposed and exposed children. During follow-up, 394

2020 Annals of Internal Medicine

9. Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder

Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder A Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other (...) citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation J Pediatr Actions . 2020 Jul;222:164-173.e5. doi: 10.1016/j.jpeds.2020.03.011. Epub 2020 May 19. A Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder

2020 EvidenceUpdates

10. Implementation of Advanced Methods for Reproductive Pharmacovigilance in Autism: A Meta-Analysis of the Effects of Prenatal Antidepressant Exposure

, Rickert ME, Öberg AS, Quinn PD, Hernández-Díaz S, Almqvist C, Lichtenstein P, Larsson H, D'Onofrio BM. Sujan AC, et al. JAMA. 2017 Apr 18;317(15):1553-1562. doi: 10.1001/jama.2017.3413. JAMA. 2017. PMID: 28418479 Free PMC article. Show more similar articles Publication types Meta-Analysis Actions MeSH terms Antidepressive Agents / therapeutic use* Actions Autism Spectrum Disorder / epidemiology Actions Autistic Disorder / epidemiology* Actions Control Groups* Actions Depressive Disorder / drug therapy (...) Implementation of Advanced Methods for Reproductive Pharmacovigilance in Autism: A Meta-Analysis of the Effects of Prenatal Antidepressant Exposure Implementation of Advanced Methods for Reproductive Pharmacovigilance in Autism: A Meta-Analysis of the Effects of Prenatal Antidepressant Exposure - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily

2020 EvidenceUpdates

11. Interventions based on early intensive applied behaviour analysis for autistic children: a systematic review and cost-effectiveness analysis Full Text available with Trip Pro

Interventions based on early intensive applied behaviour analysis for autistic children: a systematic review and cost-effectiveness analysis Interventions based on early intensive applied behaviour analysis for autistic children: a systematic review and cost-effectiveness analysis Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from (...) the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} This review found limited evidence that early intensive applied behaviour analysis-based interventions improve cognitive ability and adaptive behaviour in autistic children, but the long-term impact of the interventions remains unknown. {{author}} {{($index , , , , , , , , & . Mark Rodgers 1 , David Marshall 1 , Mark Simmonds 1

2020 NIHR HTA programme

12. Measles-mumps-rubella vaccine (MMR): no link with autism

FEATURED REVIEW Studies based on a very significant number of children, taken together, do not show any link between MMR vaccination and the occurrence of autistic disorders. The authors of the two studies claiming the opposite used incorrect data or applied inappropriate analytical methods. Full review (3 pages) available for download by subscribers. Abstract Studies proposing a link between the measles-mumps-rubella vaccine (MMR) and autism were published in 1998 and 2014, and then retracted because (...) Measles-mumps-rubella vaccine (MMR): no link with autism Prescrire IN ENGLISH - Spotlight ''Measles-mumps-rubella vaccine (MMR): no link with autism'', 1 May 2020 {1} {1} {1} | | > > > Measles-mumps-rubella vaccine (MMR): no link with autism Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Measles-mumps-rubella vaccine (MMR): no link with autism

2020 Prescrire

13. Interventions for anxiety in mainstream school-aged children with autism spectrum disorder (ASD) Full Text available with Trip Pro

, diagnosed with ASD (inclusive of autism, ASD, Autistic Disorder, Asperger's Disorder, Asperger Syndrome, atypical autism, PDD‐NOS) by a professional eligible to diagnose these conditions, and also experiencing anxiety symptoms or a diagnosis of an anxiety disorder provided by a professional eligible to diagnose such conditions. The majority of included studies (21 of 24) used a screening instrument to confirm the existence of clinically significant levels of anxiety at intake, while the remaining (...) excluded at abstract screening stage Author and Publication Date Title Reason for exclusion Schohl et al. ( ) A replication and extension of the PEERS intervention: Examining effects on social skills and social anxiety in adolescents with autism spectrum disorders. Different intervention focus, no anxiety diagnosis or measurement at intake Ooi et al. ( ) Effects of cognitive‐behavioral therapy on anxiety for children with high‐functioning autistic spectrum disorders. Observational study (pre‐post

2020 Campbell Collaboration

14. Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial

Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily unavailable (...) your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation JAMA Psychiatry Actions 2019 Nov 22 [Online ahead of print] Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial , , , , , , , Affiliations Expand Affiliations 1 Department of Education, University of California, Los Angeles, Los Angeles. 2 Department

2020 EvidenceUpdates

15. Provision for people with a known or suspected learning disability, autism or both

Provision for people with a known or suspected learning disability, autism or both NHS England » Provision for people with a known or suspected learning disability, autism or both Search Search Menu Provision for people with a known or suspected learning disability, autism or both Document first published: 22 January 2020 Page updated: 22 January 2020 Topic: Publication type: Document PDF 432 KB 22 pages

2020 NHS England

16. Treatment for Insomnia and Disrupted Sleep Behavior in Children and Adolescents with Autism Spectrum Disorder

Treatment for Insomnia and Disrupted Sleep Behavior in Children and Adolescents with Autism Spectrum Disorder 1 1 Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and 2 adolescents with autism spectrum disorder 3 4 Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the 5 American Academy of Neurology 6 7 Ashura Williams Buckley, MD, 1 Deborah Hirtz, MD, 2 Maryam Oskoui, MD, 3 Melissa J. 8 Armstrong, MD, MSc, 4 Anshu Batra (...) . Division of Developmental Medicine, Boston Children’s Hospital, Boston, MA 24 2 7. Departments of Pediatrics and Psychiatry, The Ohio State University College of 1 Medicine, Columbus 2 8. Duke Center for Autism and Brain Development, Duke Institute for Brain Sciences, and 3 Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, 4 Durham, NC 5 9. Northern Michigan Neurology, Traverse City 6 10. Department of Child and Behavioral Sciences, Johns Hopkins University

2020 American Academy of Neurology

17. Association of Comorbid Mood and Anxiety Disorders With Autism Spectrum Disorder (Abstract)

Association of Comorbid Mood and Anxiety Disorders With Autism Spectrum Disorder It is critical to evaluate the risk of comorbid psychiatric diagnoses to meet the needs of individuals with autism spectrum disorder (ASD).To examine whether individuals with ASD are at greater risk for comorbid diagnoses of depression, anxiety, or bipolar disorder.This cohort study used data from a population-based birth cohort of 31 220 individuals born in Olmsted County, Minnesota, from January 1, 1976

2020 EvidenceUpdates

18. Effect of a Computer-Based Decision Support Intervention on Autism Spectrum Disorder Screening in Pediatric Primary Care Clinics: A Cluster Randomized Clinical Trial Full Text available with Trip Pro

Effect of a Computer-Based Decision Support Intervention on Autism Spectrum Disorder Screening in Pediatric Primary Care Clinics: A Cluster Randomized Clinical Trial Effect of a Computer-Based Decision Support Intervention on Autism Spectrum Disorder Screening in Pediatric Primary Care Clinics: A Cluster Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed (...) collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation JAMA Netw Open Actions , 2 (12), e1917676 2019 Dec 2 Effect of a Computer-Based Decision Support Intervention on Autism Spectrum Disorder Screening in Pediatric Primary Care Clinics: A Cluster Randomized Clinical

2020 EvidenceUpdates

19. Linking risk factors and outcomes in autism spectrum disorder: is there evidence for resilience? Full Text available with Trip Pro

Linking risk factors and outcomes in autism spectrum disorder: is there evidence for resilience? Autism spectrum disorder (referred to here as autism) is one of several overlapping neurodevelopmental conditions that have variable impacts on different individuals. This variability results from dynamic interactions between biological and non-biological risk factors, which result in increasing differentiation between individuals over time. Although this differentiation continues well (...) into adulthood, the infancy period is when the brain and behavior develop rapidly, and when the first signs and symptoms of autism emerge. This review discusses advances in our understanding of the causal pathways leading to autism and overlapping neurodevelopmental conditions. Research is also mapping trajectories of brain and behavioral development for some risk groups, namely later born siblings of children with autism and/or infants referred because of developmental concerns. This knowledge has been

2020 BMJ

20. Guided self-help for depression in autistic adults: the ADEPT feasibility RCT Full Text available with Trip Pro

Guided self-help for depression in autistic adults: the ADEPT feasibility RCT Guided self-help for depression in autistic adults: the ADEPT feasibility RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1 (...) )"> {{metadata.Title}} {{metadata.Headline}} This low-intensity psychological intervention was feasible and well-received, and a full trial is warranted. {{author}} {{($index , , , , , , , , , , & . Ailsa Russell 1, * , Daisy Gaunt 2 , Kate Cooper 1 , Jeremy Horwood 2 , Stephen Barton 3 , Ian Ensum 4 , Barry Ingham 5 , Jeremy Parr 6 , Chris Metcalfe 2 , Dheeraj Rai 7 , David Kessler 7 , Nicola Wiles 8 1 Centre for Applied Autism Research, Department of Psychology, Faculty of Humanities and Social Sciences

2020 NIHR HTA programme