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Latest & greatest articles for azithromycin
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Effects of azithromycin on malariometric indices in The Gambia. Azithromycin (a macrolide-like antibiotic) has antimalarial effects in vitro and in animal models. In the course of a randomised trial of trachoma control we examined the effects of azithromycin on parasite and spleen rates in the population aged 5-14 years from eight villages in the Farafenni study area in The Gambia, West Africa. The entire population of four treatment villages received three doses of azithromycin 20 mg/kg weekly (...) (days 1, 8, and 15) and four control villages received daily tetracycline eye ointment topically (days 1-42). Among 226 children studied before treatment and at day 28, azithromycin reduced the proportions with Plasmodium falciparum parasites (rate ratio 0.56, 95% confidence interval 0.44-0.71; p < 0.0001), with palpable spleens (RR 0.50, 95% CI 0.36-0.70; p < 0.0001), with febrile parasitaemia (RR 0.45, 95% CI 0.27-0.75; p < 0.01), and with P malariae infection (p < 0.001). This effect was related
Azithromycin for empirical treatment of the nongonococcal urethritis syndrome in men. A randomized double-blind study. To evaluate the use of single-dose azithromycin for empirical treatment of nongonococcal urethritis.Randomized, double-blind, multicenter trial comparing azithromycin vs doxycycline therapy, with a 2:1 randomization ratio. Patients were evaluated clinically and microbiologically for Chlamydia trachomatis and Ureaplasma urealyticum infection before therapy and at 2 and 5 weeks (...) after study entry.Eleven sexually transmitted disease clinics throughout the United States.A total of 452 men aged 18 years or older with symptomatic nongonococcal urethritis of less than 14 days' duration.Patients were treated with either 1.0 g of azithromycin as a single oral dose or 100 mg of doxycycline taken orally twice daily for 7 days.Clinical resolution of symptoms and signs of nongonococcal urethritis, microbiological cure of C trachomatis and U urealyticum, and occurrence of adverse
Azithromycin compared with clarithromycin in the treatment of patients with acute purulent tracheobronchitis: a cost of illness study Azithromycin compared with clarithromycin in the treatment of patients with acute purulent tracheobronchitis: a cost of illness study Azithromycin compared with clarithromycin in the treatment of patients with acute purulent tracheobronchitis: a cost of illness study Sternon J, Leclerq P, Knepper C, Blot K Record Status This is a critical abstract of an economic (...) evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Azithromycin or clarithromycin in the treatment of acute purulent tracheobronchitis in adult patients. Clarithromycin (250mg twice daily) was given for 7 to 10 days. Azithromycin was given for 3 days (500mg once daily) or5 days (500mg once daily
The cost effectiveness of azithromycin for Chlamydia trachomatis infections in women The cost effectiveness of azithromycin for Chlamydia trachomatis infections in women The cost effectiveness of azithromycin for Chlamydia trachomatis infections in women Haddix A C, Hillis S D, Kassler W J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Azithromycin and doxycycline in the treatment of cervical chlamydia infections. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population A hypothetical cohort of 10,000 women with clinically suspected genital Chlamydia trachomatis and a cohort of 10,000 women with laboratory confirmed Chlamydia trachomatis. Pregnant women were excluded since
Randomised controlled trial of single-dose azithromycin in treatment of trachoma. Blindness due to trachoma is a serious public health issue world wide. The currently recommended treatment of active trachoma with repeated doses of tetracycline eye ointment has many disadvantages. The new azalide antibiotic azithromycin is effective as a single oral dose in the chemotherapy of genital Chlamydia trachomatis infections, and we have assessed its efficacy for trachoma treatment. We carried out (...) a randomised single-blind comparison of azithromycin (a single oral dose of 20 mg/kg) with conventional treatment (6 weeks of topical tetracycline plus erythromycin for severe cases) in two villages with endemic trachoma in The Gambia. The patients were followed up for 26 weeks from the start of treatment by an observer unaware of treatment allocation. By 6 months' follow-up, trachoma had resolved in 76 (78%) of 97 subjects who received azithromycin compared with 70 (72%) of 97 who were treated
A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. The Azithromycin for Chlamydial Infections Study Group. Currently, there is no single-dose therapy that is effective in the treatment of urethral or endocervical infections with Chlamydia trachomatis. Azithromycin is a new azalide antibiotic that has substantial activity against C. trachomatis, is concentrated intracellularly, and has a long half-life in serum and tissue.We conducted (...) a trial in which 299 female patients and 158 male patients with uncomplicated genital infection and a positive C. trachomatis antigen test were randomly assigned to receive either azithromycin (1 g once orally) or doxycycline (100 mg orally twice daily for seven days). Only patients subsequently determined to have a culture positive for C. trachomatis at base line were included in the evaluation of efficacy.Among the patients who could be evaluated, 5 of the 141 patients (4 percent) treated