Latest & greatest articles for babies

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on babies or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on babies and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for babies

201. Cortical Pain Response of Newborn Infants to Venepuncture: A Randomized Controlled Trial Comparing Analgesic Effects of Sucrose Versus Breastfeeding (Abstract)

Cortical Pain Response of Newborn Infants to Venepuncture: A Randomized Controlled Trial Comparing Analgesic Effects of Sucrose Versus Breastfeeding Sucrose administration and breastfeeding decrease behavioral expressions of pain in neonates. However, recent studies indicated that there is a persistent cortical response with sucrose. This study compared the efficacy of sucrose administration versus breastfeeding to decrease cortical responses to pain during venepuncture.A randomized (...) , with 102 included for the primary outcome (breastfed group: 48; sucrose group: 54). Similar maximum increases in [HbT] were observed in both groups (mean±SD: sucrose group: 31.2±58.1 μmol/L; breastfed group: 38.9±61.4 μmol/L; P=0.70). Breastfed neonates presented more behavioral expressions that indicated pain compared with sucrose-administered neonates (46.8% vs. 26.8% of NFCS ≥1, P=0.04). The maximum increase in [HbT] was persistent, although newborn infants who did not express behavioral signs

2018 EvidenceUpdates

202. Variability of Very Low Birth Weight Infant Outcome and Practice in Swiss and US Neonatal Units Full Text available with Trip Pro

Variability of Very Low Birth Weight Infant Outcome and Practice in Swiss and US Neonatal Units Outcomes of very preterm infants vary considerably between health care facilities. Our objective was to compare outcome and practices between the Swiss Neonatal Network (SNN) and US members of the Vermont Oxford Network (US-VON).Retrospective observational study including all live-born infants with a birth weight between 501 and 1500 g as registered by SNN and US-VON between 2012 and 2014. We (...) performed multivariable and propensity score-matched analyses of neonatal outcome by adjusting for case-mix, race, prenatal care, and unit-level factors, and compared indirectly standardized practices.A total of 123 689 infants were born alive in 696 US-VON units and 2209 infants were born alive in 13 SNN units. Adjusted risk ratios (aRRs) for the composite "death or major morbidity" (aRR: 0.56, 95% confidence interval: 0.51-0.62) and all other outcomes were either comparable or lower in SNN except

2018 EvidenceUpdates

203. Adverse effects of small for gestational age differ by gestational week among very preterm infants Full Text available with Trip Pro

gestation without severe congenital anomalies. SGA was defined as a birth weight <10th percentile. The excess outcome risk independently associated with SGA birth among SGA babies was assessed using adjusted risk differences (aRDs).Of 6708 infants sampled from 717 US hospitals, 743 (11.1%) were SGA. SGA compared with non-SGA infants experienced higher unadjusted rates of each study outcome except grade 3-4 IVH among survivors. The excess risk independently associated with SGA birth varied by outcome (...) Adverse effects of small for gestational age differ by gestational week among very preterm infants To characterise the excess risk for death, grade 3-4 intraventricular haemorrhage (IVH), bronchopulmonary dysplasia (BPD) and stage 3-5 retinopathy of prematurity independently associated with birth small for gestational age (SGA) among very preterm infants, stratified by completed weeks of gestation.Retrospective cohort study using the Optum Neonatal Database. Study infants were born <32 weeks

2018 EvidenceUpdates

204. Effect of Higher vs Standard Dosage of Vitamin D3 Supplementation on Bone Strength and Infection in Healthy Infants: A Randomized Clinical Trial Full Text available with Trip Pro

Effect of Higher vs Standard Dosage of Vitamin D3 Supplementation on Bone Strength and Infection in Healthy Infants: A Randomized Clinical Trial Although guidelines for vitamin D supplementation in infants have been widely implemented, they are mostly based on studies focusing on prevention of rickets. The optimal dose for bone strength and infection prevention in healthy infants remains unclear.To determine whether daily supplementation with 1200 IU of vitamin D3 increases bone strength (...) or decreases incidence of infections in the first 2 years of life compared with a dosage of 400 IU/d.A randomized clinical trial involving a random sample of 975 healthy term infants at a maternity hospital in Helsinki, Finland. Study recruitment occurred between January 14, 2013, and June 9, 2014, and the last follow-up was May 30, 2016. Data analysis was by the intention-to-treat principle.Randomization of 489 infants to daily oral vitamin D3 supplementation of 400 IU and 486 infants to 1200 IU from age

2018 EvidenceUpdates

205. Minimally invasive perventricular versus open surgical ventricular septal defect closure in infants and children: a randomised clinical trial (Abstract)

Minimally invasive perventricular versus open surgical ventricular septal defect closure in infants and children: a randomised clinical trial Robust evidence is lacking regarding the clinical efficacy, safety and cardiopulmonary performance of perventricular closure. This study investigated the perioperative efficacy, safety and cardiorespiratory performance of perventricular closure of perimembranous ventricular septal defects (pmVSDs).Operation-naïve infants and young children aged 5-60 (...) )), but was shown in the PP (0.010 (95% CI -0.043 to 0.062)) and AT populations (0.048 (95% CI -0.009 to 0.106)). Perventricular closure reduced the rate of compromising cardiac haemodynamics, electrophysiological responses, cardiomyocyte viability, respiratory mechanics, ventilatory and gas exchange function and oxygenation and tissue perfusion compared with surgical closure (all between-group P<0.05).For infants and young children with pmVSD, perventricular closure reduced the rate of postoperative

2018 EvidenceUpdates

206. HIV and infant feeding in emergencies: operational guidance

children, including issues around infant and young child feeding 27 4.2 Mothers living with HIV and feeding of their infants and young children 27 4.3 Operational gaps 27 5. Roles and responsibilities 28 5.1 Government 28 5.2 United Nations agencies 28 5.3 International and local nongovernmental organizations 29 5.4 Donors 29iv HIV AND INFANT FEEDING IN EMERGENCIES: OPERATIONAL GUIDANCE Annex 1: Meeting description 30 Annex 2: Country experiences 31 Annex 3: Extracts from Infant and young child feeding (...) in emergencies. Operational guidance for emergency relief staff and programme managers , version 3, 2017 33 Annex 4: World Health Organization recommendations relevant to HIV and infant feeding in emergencies 36 Resources 40 References 41v Acknowledgements ACKNOWLEDGEMENTS The Department of Nutrition for Health and Development and the Department of Maternal, Newborn, Child and Adolescent Health of the World Health Organization (WHO) gratefully acknowledge the contributions that many individuals

2018 World Health Organisation Guidelines

207. Fever in the returning child traveller: Highlights for health care providers

Fever in the returning child traveller: Highlights for health care providers Recreation, globalization, migration and families visiting friends and relatives (VFRs) overseas have increased the frequency of international travel and potential exposures to tropical diseases. Young infected patients can present a diagnostic challenge to clinicians when they return to Canada, with significant consequences if untreated. High quality guidelines for screening and diagnosis exist, but care providers (...) need to know where to access them. This practice point highlights key points in the management of fever in the returning child traveller and provides links to detailed resources on this topic. Keywords: Children; Fever; Travel health; Tropical disease

2018 Canadian Paediatric Society

208. New study suggests risk of birth defects in babies born to women on HIV medicine dolutegravir

New study suggests risk of birth defects in babies born to women on HIV medicine dolutegravir New study suggests risk of birth defects in babies born to women on HIV medicine dolutegravir | European Medicines Agency Search Search Menu New study suggests risk of birth defects in babies born to women on HIV medicine dolutegravir Press release 18/05/2018 While EMA review is ongoing, dolutegravir should not be used in women seeking to become pregnant The European Medicines Agency (EMA (...) ) is evaluating preliminary results from a study which found 4 cases of birth defects such as spina bifida (malformed spinal cord) in babies born to mothers who became pregnant while taking dolutegravir. While EMA is assessing the new evidence it has issued the following precautionary advice: Dolutegravir HIV medicines should not be prescribed to women seeking to become pregnant. Women who can become pregnant should use effective contraception while taking dolutegravir medicines. The study, which looked

2018 European Medicines Agency - EPARs

209. Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants. Full Text available with Trip Pro

Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants. Duration of use may be a modifiable risk factor for central venous catheter-associated bloodstream infection in newborn infants. Early planned removal of peripherally inserted central catheters (PICCs) is recommended as a strategy to reduce the incidence of infection and its associated morbidity and mortality.To determine the effectiveness of early planned (...) removal of PICCs (up to two weeks after insertion) compared to an expectant approach or a longer fixed duration in preventing bloodstream infection and other complications in newborn infants.We searched of the Cochrane Central Register of Controlled Trials (CENTRAL; 2018, Issue 4), Ovid MEDLINE, Embase, Maternity & Infant Care Database, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) (until April 2018), and conference proceedings and previous reviews.Randomised and quasi

2018 Cochrane

210. Translation, cultural adaptation and preliminary psychometric evaluation of the “Family Management Measure” among Iranian families with a child with a chronic disease Full Text available with Trip Pro

Translation, cultural adaptation and preliminary psychometric evaluation of the “Family Management Measure” among Iranian families with a child with a chronic disease The basis of any research is the use of valid and reliable tools for collecting information. One of the valid and reliable tools used to identify the family management in chronic childhood diseases is "FaMM" which has never been translated and validated in previous research in Iran.The present study aimed to translate (...) , incorporate cultural adaptation, and determine psychometric features of FaMM among Iranian families with a child with a chronic disease.This study was conducted using the methodological research approach in Tehran, during 2016-2017. The translation of FaMM was done using "World Health Organization Translation and Cultural Adaptation Guidelines". The preliminary psychometric evaluation of the above tool was performed by determining the validity (face and content validity) and reliability (internal

2018 Electronic physician

211. Fat supplementation of human milk for promoting growth in preterm infants. Full Text available with Trip Pro

Fat supplementation of human milk for promoting growth in preterm infants. As preterm infants do not experience the nutrient accretion and rapid growth phase of the third trimester of pregnancy, they are vulnerable to postnatal nutritional deficits, including of fat. Consequently, they require higher fat intakes compared to their full term counterparts to achieve adequate growth and development. Human milk fat provides the major energy needs of the preterm infant and also contributes to several (...) metabolic and physiological functions. Although human milk has many benefits for this population, its fat content is highly variable and may be inadequate for their optimum growth and development. This is a 2018 update of a Cochrane Review last published in 2000.To determine whether supplementation of human milk with fat compared with unsupplemented human milk fed to preterm infants improves growth, body composition, cardio-metabolic, and neurodevelopmental outcomes without significant adverse

2018 Cochrane

212. The best of intentions: Prenatal breastfeeding intentions and infant health Full Text available with Trip Pro

The best of intentions: Prenatal breastfeeding intentions and infant health Health organizations recommend that mothers exclusively breastfeed infants for the first six months of life. The current study contributes to a growing body of research that examines whether the purported benefits of breastfeeding are causal. We systematically evaluated the role of an expectant mother's prenatal breastfeeding intentions, which reflect not only demographic characteristics, but also knowledge, attitudes (...) , and social norms about infant feeding, and therefore serve as a proxy for positive maternal selection into breastfeeding. We used the Infant Feeding Practices Study (IFPS) II (n = 1008) to examine a heretofore overlooked group of mothers-those who intended to breastfeed but did not actually breastfeed. Results suggest that mothers who intended to breastfeed had infants with fewer ear infections and respiratory syncytial viruses, and used fewer antibiotics in the first year of life compared to infants

2018 SSM - population health

213. Spontaneous reversion of a lineage switch following an initial blinatumomab-induced ALL-to-AML switch in MLL-rearranged infant ALL Full Text available with Trip Pro

Spontaneous reversion of a lineage switch following an initial blinatumomab-induced ALL-to-AML switch in MLL-rearranged infant ALL 29898879 2019 03 15 2473-9537 2 12 2018 06 26 Blood advances Blood Adv Spontaneous reversion of a lineage switch following an initial blinatumomab-induced ALL-to-AML switch in MLL -rearranged infant ALL. 1382-1385 10.1182/bloodadvances.2018018093 Wölfl Matthias M Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, University

2018 Blood advances

214. Early Caffeine and Weaning from Mechanical Ventilation in Preterm Infants: A Randomized, Placebo-Controlled Trial (Abstract)

Early Caffeine and Weaning from Mechanical Ventilation in Preterm Infants: A Randomized, Placebo-Controlled Trial To evaluate in a randomized, double-blind, placebo-controlled trial the effect of early caffeine on the age of first successful extubation in preterm infants.Preterm infants born at 23-30 weeks of gestation requiring mechanical ventilation in the first 5 postnatal days were randomized to receive a 20 mg/kg loading dose followed by 5 mg/kg/day of caffeine or placebo until considered (...) the trial. Unblinded analysis revealed mortality did not differ significantly between the early caffeine (9 [22%]) and control groups (5 [12%]; P = .22).Early initiation of caffeine in this group of premature infants did not reduce the age of first successful extubation. A nonsignificant trend toward higher mortality in the early caffeine group led to a cautious decision to stop the trial. These findings suggest caution with early use of caffeine in mechanically ventilated preterm infants until more

2018 EvidenceUpdates

215. Cost-Effectiveness Analysis of Nasal Continuous Positive Airway Pressure Versus Nasal High Flow Therapy as Primary Support for Infants Born Preterm (Abstract)

Cost-Effectiveness Analysis of Nasal Continuous Positive Airway Pressure Versus Nasal High Flow Therapy as Primary Support for Infants Born Preterm To compare the cost-effectiveness of 2 common "noninvasive" modes of respiratory support for infants born preterm.An economic evaluation was conducted as a component of a multicenter, randomized control trial from 2013 to 2015 enrolling infants born preterm at ≥28 weeks of gestation with respiratory distress, <24 hours old, who had not previously (...) intubation and mechanical ventilation during admission.Hospital inpatient cost records for 435 infants enrolled in all Australian centers were obtained. With "rescue" CPAP backup, an incremental cost-effectiveness ratio was estimated of A$179 000 (US$123 000) per ventilation avoided if CPAP was used compared with high flow. Without rescue CPAP backup, cost per ventilation avoided was A$7000 (US$4800) if CPAP was used compared with high flow.As sole primary support, CPAP is highly likely to be cost

2018 EvidenceUpdates

216. Usefulness of an Online Risk Estimator for Bronchopulmonary Dysplasia in Predicting Corticosteroid Treatment in Infants Born Preterm (Abstract)

Usefulness of an Online Risk Estimator for Bronchopulmonary Dysplasia in Predicting Corticosteroid Treatment in Infants Born Preterm To assess the usefulness of a bronchopulmonary dysplasia (BPD) outcome estimator developed by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in identifying high-risk preterm infants treated with steroids.This was a single-center retrospective study of infants born ≤30 weeks of gestational age. The NICHD BPD outcome (...) estimator was used to retrospectively calculate BPD risk at various postnatal ages. The best combination of risk estimates for identifying steroid treatment was identified using stepwise model selection. A cut-off value with the best combination of sensitivity and specificity was identified using receiver operating characteristic analysis.A total of 165 infants born preterm (mean gestational age 26 ± 1.6 weeks, mean birth weight 837 ± 171 g) were included. Of these, 61 were treated with steroids for BPD

2018 EvidenceUpdates

217. Evaluation of a Booster Dose of Pentavalent Rotavirus Vaccine Co-Administered with Measles, Yellow Fever and Meningitis A Vaccines in 9-month-old Malian Infants Full Text available with Trip Pro

Evaluation of a Booster Dose of Pentavalent Rotavirus Vaccine Co-Administered with Measles, Yellow Fever and Meningitis A Vaccines in 9-month-old Malian Infants Rotavirus vaccines given to infants are safe and efficacious. A booster dose of rotavirus vaccine could extend protection into the second year of life in low-resource countries.We conducted an open-label, individual-randomized trial in Bamako, Mali. We assigned 600 infants aged 9-11 months to receive measles vaccine (MV), yellow fever (...) vaccine (YFV), and meningococcal A conjugate vaccine (MenAV) with or without pentavalent rotavirus vaccine (PRV). We assessed the noninferiority (defined as a difference of ≤10%) of seroconversion and seroresponse rates to MV, YFV, and MenAV. We compared the seroresponse to PRV.Seroconversion to MV occurred in 255 of 261 PRV recipients (97.7%) and 246 of 252 control infants (97.6%; difference, 0.1% [95% confidence interval {CI}, -4.0%-4.2%]). Seroresponse to YFV occurred in 48.1% of PRV recipients

2018 EvidenceUpdates

218. Repetitive versus standard tactile stimulation of preterm infants at birth - A randomized controlled trial Full Text available with Trip Pro

Repetitive versus standard tactile stimulation of preterm infants at birth - A randomized controlled trial To evaluate the direct effect of repetitive tactile stimulation on breathing effort of preterm infants at birth.This randomized controlled trial compared the effect of repetitive stimulation on respiratory effort during the first 4 min after birth with standard stimulation based on clinical indication in preterm infants with a gestational age of 27-32 weeks. All details of the stimulation

2018 EvidenceUpdates

219. Preprocedural Ultrasound for Infant Lumbar Puncture: A Randomized Clinical Trial Full Text available with Trip Pro

Preprocedural Ultrasound for Infant Lumbar Puncture: A Randomized Clinical Trial Our purpose was to determine the potential effect of preprocedural ultrasound (US) to increase lumbar puncture (LP) success compared with standard palpation method. Further, we assessed feasibility of and clinician satisfaction with a standardized US protocol.This prospective, two-arm, parallel-group randomized trial was conducted in a single-center pediatric emergency department. We compared preprocedural US (...) versus palpation method on success with infant LPs. Infants less than 3 months of age requiring LP were enrolled. Sixteen pediatric emergency medicine physicians with varied US experience were trained to conduct the USs to mark interspace locations. Primary outcome was successful LP, defined as obtaining a cerebrospinal fluid (CSF) sample on first attempt with < 1,000 red blood cells per high-powered field (clear CSF). Secondary outcomes included clear CSF on any attempt, any CSF on the first attempt

2018 EvidenceUpdates

220. Effect of non-nutritive sucking and sucrose alone and in combination for repeated procedural pain in preterm infants: A randomized controlled trial (Abstract)

Effect of non-nutritive sucking and sucrose alone and in combination for repeated procedural pain in preterm infants: A randomized controlled trial Sucrose combined with non-nutritive sucking provided better pain relief than sucrose or non-nutritive sucking alone in a single painful procedure. However, whether the combination of non-nutritive sucking with sucrose could obtain a significant difference in analgesic effect of the repeated procedural pain than any single intervention has not been (...) established.To compare the effect of non-nutritive sucking and sucrose alone and in combination of repeated procedural pain in preterm infants.Randomized controlled trial.A level III neonatal intensive care unit of a university hospital in China.Preterm infants born before 37 weeks of gestation were randomly assigned to four groups: routine care group (routine comfort through gentle touch when infants cried; n = 21), non-nutritive sucking group (n = 22), sucrose group (0.2 ml/kg of 20%; n = 21), sucrose

2018 EvidenceUpdates