Latest & greatest articles for baclofen

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Top results for baclofen

1. Baclofen (Baclocur) and alcohol dependence. At moderate doses, a modest aid in controlling alcohol consumption

Baclofen (Baclocur) and alcohol dependence. At moderate doses, a modest aid in controlling alcohol consumption Prescrire IN ENGLISH - Spotlight ''Baclofen (Baclocur°) and alcohol dependence. At moderate doses, a modest aid in controlling alcohol consumption'', 1 February 2020 {1} {1} {1} | | > > > Baclofen (Baclocur°) and alcohol dependence. At moderate doses, a modest aid in controlling alcohol consumption Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :   (...) |   |   |   |   |   |   |   |   |  Spotlight Baclofen (Baclocur°) and alcohol dependence. At moderate doses, a modest aid in controlling alcohol consumption FEATURED REVIEW The GABA analogue baclofen (Baclocur°, Ethypharm), used since the 1970s as a muscle relaxant, has now been granted marketing authorisation in France for the reduction of alcohol consumption in alcohol-dependent patients in whom the other drug treatments have

2020 Prescrire

2. Association of Baclofen With Encephalopathy in Patients With Chronic Kidney Disease. Full Text available with Trip Pro

Association of Baclofen With Encephalopathy in Patients With Chronic Kidney Disease. At least 30 case reports have linked the muscle relaxant baclofen to encephalopathy in patients with chronic kidney disease (CKD).To compare the 30-day risk of encephalopathy in patients with CKD and newly prescribed baclofen at greater than or equal to 20 mg per day vs less than 20 mg per day. The secondary objective was to compare the risk of encephalopathy in baclofen users vs nonusers.Retrospective (...) population-based cohort study in Ontario, Canada (2007-2018) using linked health care data. Participants comprised 15 942 older adults (aged 66 years or older) with CKD (defined as an estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m2 but not receiving dialysis). The primary cohort was restricted to patients who were newly prescribed baclofen; participants in the secondary cohort were new users and nonusers.Prescription for oral baclofen greater than or equal to 20 mg per day vs less than 20

2019 JAMA

3. The Effect of Intrathecal Baclofen in Dyskinetic Cerebral Palsy: The IDYS Trial Full Text available with Trip Pro

The Effect of Intrathecal Baclofen in Dyskinetic Cerebral Palsy: The IDYS Trial Intrathecal baclofen treatment is used for the treatment of dystonia in patients with severe dyskinetic cerebral palsy; however, the current level of evidence for the effect is low. The primary aim of this study was to provide evidence for the effect of intrathecal baclofen treatment on individual goals in patients with severe dyskinetic cerebral palsy.This multicenter, randomized, double-blind, placebo-controlled (...) trial was performed at 2 university medical centers in the Netherlands. Patients with severe dyskinetic cerebral palsy (Gross Motor Functioning Classification System level IV-V) aged 4 to 24 years who were eligible for intrathecal baclofen were included. Patients were assigned by block randomization (2:2) for treatment with intrathecal baclofen or placebo for 3 months via an implanted microinfusion pump. The primary outcome was goal attainment scaling of individual treatment goals (GAS T score

2019 EvidenceUpdates

4. Effect of Intrathecal Baclofen on Pain and Quality of Life in Poststroke Spasticity Full Text available with Trip Pro

Effect of Intrathecal Baclofen on Pain and Quality of Life in Poststroke Spasticity Background and Purpose- Intrathecal baclofen (ITB) is an effective treatment for managing patients with severe poststroke spasticity, who can experience continued pain and decline in their quality of life (QoL). SISTERS (Spasticity In Stroke-Randomized Study) was a randomized, controlled, open-label, multicenter, phase 4 study to evaluate ITB therapy versus conventional medical management (CMM) with oral

2019 EvidenceUpdates

5. Palliative cancer care - pain: What issues should I consider before prescribing baclofen?

Palliative cancer care - pain: What issues should I consider before prescribing baclofen? Baclofen | Prescribing information | Palliative cancer care - pain | CKS | NICE Search CKS… Menu Baclofen Palliative cancer care - pain: What issues should I consider before prescribing baclofen? Last revised in October 2016 What issues should I consider before prescribing baclofen? Sedation, drowsiness and nausea are commonly reported adverse effects. Do not stop baclofen abruptly; sudden withdrawal can (...) lead to serious psychiatric adverse effects such as agitation, confusion, hallucinations, psychosis, mania, paranoia, convulsions, tachycardia, and hyperthermia. Gradually reduce the dose over 1–2 weeks, or over a longer period if adverse effects occur during withdrawal. Consider using diazepam rather than baclofen in people with: Active (or history of) peptic ulceration, as baclofen stimulates gastric acid secretion. Psychiatric disorders, such as psychosis, schizophrenia, depression, or mania

2019 NICE Clinical Knowledge Summaries

6. Alcohol dependence: the risks of high-dose baclofen

Alcohol dependence: the risks of high-dose baclofen Prescrire IN ENGLISH - Spotlight ''Alcohol dependence: the risks of high-dose baclofen '', 1 November 2018 {1} {1} {1} | | > > > Alcohol dependence: the risks of high-dose baclofen Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Alcohol dependence: the risks of high-dose baclofen With high-dose (...) baclofen, there is an increased risk of epilepsy, infection, myocardial infarction or suicidal thoughts. Baclofen has been used as a muscle relaxant since the 1970s. In France, it has also been used orally since the 2000s, at higher doses, to reduce alcohol consumption or to help maintain abstinence among alcohol-dependent patients. At present, its use in alcohol dependence is governed by a temporary recommendation for use issued by the French Health Products Safety Agency (Agence française du

2018 Prescrire

7. Baclofen

Baclofen Top results for baclofen - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for baclofen The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted

2018 Trip Latest and Greatest

8. Intrathecal baclofen therapy versus conventional medical management for severe poststroke spasticity: results from a multicentre, randomised, controlled, open-label trial (SISTERS) Full Text available with Trip Pro

Intrathecal baclofen therapy versus conventional medical management for severe poststroke spasticity: results from a multicentre, randomised, controlled, open-label trial (SISTERS) Intrathecal baclofen (ITB) is a treatment option for patients with severe poststroke spasticity (PSS) who have not reached their therapy goal with other interventions.'Spasticity In Stroke-Randomised Study' (SISTERS) was a randomised, controlled, open-label, multicentre phase IV study to evaluate the efficacy

2018 EvidenceUpdates

9. Cerebral palsy: Baclofen

Cerebral palsy: Baclofen Baclofen | Prescribing information | Cerebral palsy | CKS | NICE Search CKS… Menu Baclofen Cerebral palsy: Baclofen June 2019 Baclofen Contraindications and cautions Do not prescribe baclofen to people with: Rare hereditary conditions of porphyria, galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption. Active peptic ulceration. Prescribe baclofen with caution to people: With cerebrovascular disease. With Parkinson's disease (...) . With respiratory, hepatic, or renal impairment. With a history of peptic ulceration. With bladder sphincter hypertonia. With epilepsy. With severe psychiatric disorders — may be exacerbated by baclofen. Taking certain . Pregnancy: the manufacturer advises use only if the potential benefit outweighs risk as studies in animals have shown reproductive toxicity. Driving and using machinery: baclofen may cause drowsiness and may affect performance of skilled tasks (such as driving). The effects of alcohol

2018 NICE Clinical Knowledge Summaries

10. Multiple sclerosis: Baclofen

Multiple sclerosis: Baclofen Baclofen | Prescribing information | Multiple sclerosis | CKS | NICE Search CKS… Menu Baclofen Multiple sclerosis: Baclofen Last revised in October 2019 Baclofen What doses of baclofen are indicated for spasticity? The dose of baclofen often needs adjustment to suit each person, but a typical regimen is: Initial dose: 5 mg three times a day. Titration: gradually increase the dose every three days. Typical maintenance dose is 60 mg daily in divided doses. Maximum (...) stopping treatment. [ ; ] What are the contraindications for baclofen? Do not prescribe baclofen to people with: Rare hereditary conditions of porphyria, galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption. Active peptic ulceration. [ ; ] What are the cautions when using baclofen? Prescribe baclofen with caution to people: With cerebrovascular disease. With Parkinson's disease. With respiratory, hepatic or renal impairment. With a history of peptic ulceration

2018 NICE Clinical Knowledge Summaries

11. Baclofen for alcohol withdrawal. Full Text available with Trip Pro

Baclofen for alcohol withdrawal. Baclofen shows potential for rapidly reducing symptoms of severe alcohol withdrawal syndrome (AWS) in people with alcoholism. Treatment with baclofen is easy to manage and rarely produces euphoria or other pleasant effects, or craving for the drug. This is an updated version of the original Cochrane Review published in 2015, Issue 4.To assess the efficacy and safety of baclofen for people with AWS.We updated our searches of the following databases to March 2017 (...) : the Cochrane Drugs and Alcohol Group Specialised Register, CENTRAL, PubMed, Embase, and CINAHL. We also searched registers of ongoing trials. We handsearched the references quoted in the identified trials, and sought information from researchers, pharmaceutical companies, and relevant trial authors about unpublished or uncompleted trials. We placed no restrictions on language.We included all randomised controlled clinical trials (RCTs) evaluating baclofen versus placebo or any other treatment for people

2017 Cochrane

12. Effect of baclofen on gastric acid pocket in subjects with gastroesophageal reflux disease symptoms. (Abstract)

Effect of baclofen on gastric acid pocket in subjects with gastroesophageal reflux disease symptoms. Postprandial gastroesophageal reflux (PGER) in the distal esophagus (DE) is associated with a gastric juice 'acid pocket' (AP). Baclofen reduces AP extension into the DE in healthy volunteers, in part through increased lower esophageal sphincter (LES) pressure. We aimed to verify whether baclofen also affects postprandial AP location and extent in gastroesophageal reflux disease (GERD) patients (...) . Thirteen treatment-naive heartburn-prevalent GERD patients underwent two AP studies, after pretreatment with baclofen 40 mg or placebo 30 minutes preprandially. We performed pH-probe stepwise pull-throughs (PT) (1 cm/min, LES -10 to +5 cm) before and every 30 minutes from 30 minutes before up to 150 minutes after a test meal. After the meal, both after placebo and baclofen, gastric pH significantly dropped at 30, 60, 90 minutes postprandially (P: nadir pHs of 3.9 ± 0.6, 2.3 ± 0.6, 2.1 ± 0.4; B: nadir

2017 Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus Controlled trial quality: uncertain

13. Intrathecal baclofen for treating spasticity in children with cerebral palsy. (Abstract)

Intrathecal baclofen for treating spasticity in children with cerebral palsy. Cerebral palsy is a disorder of movement and posture arising from a non-progressive lesion in the developing brain. Spasticity, a disorder of increased muscle tone, is the most common motor difficulty and is associated with activity limitation to varying degrees in mobility and self care.Oral baclofen, a gamma-aminobutyric acid (GABA) agonist, has been used in oral form to treat spasticity for some time, but it has (...) a variable effect on spasticity and the dose is limited by the unwanted effect of excessive sedation. Intrathecal baclofen produces higher local concentrations in cerebrospinal fluid at a fraction of the equivalent oral dose and avoids this excessive sedation.To determine whether intrathecal baclofen is an effective treatment for spasticity in children with cerebral palsy.We searched the CENTRAL, MEDLINE, EMBASE and CINAHL databases, handsearched recent conference proceedings, and communicated

2015 Cochrane

14. Baclofen for alcohol withdrawal. (Abstract)

Baclofen for alcohol withdrawal. The treatment baclofen shows potential for rapidly reducing symptoms of severe alcohol withdrawal syndrome (AWS) in people with alcoholism. Treatment with baclofen is easy to manage and rarely produces euphoria or other pleasant effects, or craving for the drug. This is an updated version of the original Cochrane review published in Issue 2, 2013.To assess the efficacy and safety of baclofen for people with AWS.We searched the Cochrane Drugs and Alcohol Group (...) companies, and relevant trial authors about unpublished or uncompleted trials. We placed no restrictions on language.We included all randomised controlled clinical trials (RCTs) evaluating baclofen versus placebo or any other treatment for people with AWS. We excluded uncontrolled, non-randomised, or quasi-randomised trials. We included both parallel group and cross-over studies.Two review authors independently assessed references retrieved for possible inclusion. Any disagreements were resolved

2015 Cochrane

15. Baclofen and severe alcohol dependence: an uncertain harm-benefit balance as of early 2013

Baclofen and severe alcohol dependence: an uncertain harm-benefit balance as of early 2013 Prescrire IN ENGLISH - Spotlight ''Baclofen and severe alcohol dependence: an uncertain harm-benefit balance as of early 2013 '', 1 September 2013 {1} {1} {1} | | > > > Baclofen and severe alcohol dependence: an uncertain harm-benefit balance as of early 2013 Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |    (...) |   |   |   |  Spotlight Baclofen and severe alcohol dependence: an uncertain harm-benefit balance as of early 2013 FEATURED REVIEW More data are needed on the efficacy and adverse effects of baclofen in alcohol dependence, compared with other options. Patients who have received thorough, well-balanced information, and decide to try baclofen as a last resort should be included in comparative clinical studies. Full review (4 pages) available for download by subscribers

2014 Prescrire

16. Continuous intrathecal baclofen (ITB) infusion for severe spasticity and dystonia

Continuous intrathecal baclofen (ITB) infusion for severe spasticity and dystonia Continuous intrathecal baclofen (ITB) infusion for severe spasticity and dystonia Continuous intrathecal baclofen (ITB) infusion for severe spasticity and dystonia Malaysian Health Technology Assessment (MaHTAS) Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database (...) . Citation Malaysian Health Technology Assessment (MaHTAS). Continuous intrathecal baclofen (ITB) infusion for severe spasticity and dystonia. Putrajaya: Malaysian Health Technology Assessment (MaHTAS). 2014 Authors' objectives To assess the safety, effectiveness, cost-effectiveness, organizational issues related to the use of continuous ITB infusion for treatment of patients with severe spasticity or severe dystonia or having both conditions compared with conventional treatment. Authors' conclusions

2014 Health Technology Assessment (HTA) Database.

17. Baclofen

Baclofen USE OF BACLOFEN IN PREGNANCY 0344 892 0909 USE OF BACLOFEN IN PREGNANCY (Date of issue: January 2019 , Version: 3 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary Baclofen is a gamma-aminobutyric acid (GABA) agonist licensed for oral (...) or intrathecal administration to alleviate spasticity of voluntary muscle in patients with multiple sclerosis, spinal cord lesions, cerebral palsy, cerebrovascular accidents, traumatic head injury and meningitis. Data on the use of baclofen in human pregnancy are derived from one small cohort study (presented in abstract only), case reports and two small case series (one presented only in abstract), and as such, are too limited to accurately assess risks to the infant or pregnancy. An increased risk

2014 UK Teratology Information Service

18. Baclofen for alcohol withdrawal. (Abstract)

Baclofen for alcohol withdrawal. The treatment baclofen can rapidly reduce symptoms of severe alcohol withdrawal syndrome (AWS) in alcoholic patients, with a significant reduction in the cost. Baclofen is easy to manage, and rare euphoria, craving and other pleasant effects are reported by patients treated with baclofen.To assess the efficacy and safety of baclofen for patients with AWS.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (October (...) randomized controlled clinical trials (RCTs) evaluating baclofen versus placebo or any other treatment for patients with AWS. Uncontrolled, non-randomized or quasi-randomized trials were excluded. Both parallel group and cross-over design were included.Two review authors independently assessed references retrieved for possible inclusion. All disagreements were resolved by an independent party. Study authors were contacted for additional information. Adverse effects information was collected from

2013 Cochrane

19. Baclofen for alcohol withdrawal. (Abstract)

Baclofen for alcohol withdrawal. The treatment of baclofen can rapidly reduce symptoms of severe alcohol withdrawal syndrome (AWS) in alcoholic patients, with a significant reduction in the cost. Baclofen is easily manageable, what's more, no patient treated with baclofen reported euphoria or other pleasant effects caused by the drug and no subject reported any degree of craving for the drug.To assess the efficacy and safety of baclofen for patients with alcohol withdrawal syndrome.We searched (...) . All searches included non-English language literature.All randomised controlled clinical trials (RCTs) evaluating baclofen versus placebo or any other treatment for patients with AWS. Uncontrolled, non-randomised or quasi-randomised trials were excluded. Both parallel group and cross-over design were included.Two reviewers independently assessed references retrieved for possible inclusion. All disagreements were resolved by an independent party. Study authors were contacted for additional

2011 Cochrane

20. Gablofen (baclofen) Injection

Gablofen (baclofen) Injection Drug Approval Package: Brand Name (Generic Name) NDA # Drug Approval Package U.S. Food & Drug Administration Search FDA Drug Approval Package - Gablofen (baclofen) Injection Company: CNS Therapeutics, Inc. Application No.: 022462 Approval Date: 11/19/2010 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date created: March 7

2010 FDA - Drug Approval Package