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larotrectinib (N = 72) ? with NTRK gene fusion (n = 10) ? without NTRK gene fusion (n = 62) Subpopulations of patients with NTRK gene fusion analysed by the company: ? ePAS2 d (n = 8) ? salivary gland cancer (n = 3) ? gastrointestinal stromal cancer (n = 2) ? lung cancer - NSCLC (n = 1) ? soft tissue sarcoma (n = 1) ? thyroid cancer (n = 1) ? SAS3 e (n = 0) Data cut-off 19 February 2019: ? ESMO 2019 f (n = 12) ? separated by tumour histology: ND ? SAS3 e (n = 0) Screening: 4 weeks Treatment: until disease (...) Larotrectinib (solid tumours) - Benefit assessment according to §35a Social Code Book V 1 Translation of Sections 2.1 to 2.6 of the dossier assessment Larotrectinib (solide Tumore mit einer neurotrophen Tyrosin-Rezeptor-Kinase [NTRK]-Genfusion) – Nutzenbewertung gemäß § 35a SGB V (Version 1.0; Status: 13 January 2020). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally
. In men, genetic factors and hormonal changes are the main factors responsible for the development of breast cancer [12-16]. Breast cancer precursors Breast cancer precursors are cell changes associated with an elevated risk of breast cancer. In addition to lesions of unclear biological potential, these precursors include ductal carcinoma in situ (DCIS), which develops within the milk ducts and has not yet grown into surrounding tissue. Due to the higher risk of it developing into malignant invasive (...) carcinoma when compared to other breast cancer precursors, surgical removal is always recommended for DCIS [13, 14, 17]. Tumour classification To describe the clinical and pathological spread of a carcinoma, it is classified on the basis of its size (T), lymph node involvement (N), and presence of distant metastases (M) (TNM classification) [14, 17, 18]. Other factors taken into account when classifying the tissue and assessing the chances for recovery include cancer tissue differentiation (grading
. Nat Rev Endocrinol. 2016;12(6):313-314. 12. Rubino C, de Vathaire F, Dottorini ME, et al. Second primary malignan- cies in thyroid cancer patients. Br J Cancer. 2003;89(9):1638-1644. 13. Yu CY, Saeed O, Goldberg AS, et al. A systematic review and me- ta-analysis of subsequent malignantneoplasm risk after radioactive iodine treatment of thyroid cancer. Thyroid. 2018;28(12):1662-1673. 14. Hill AB. The environment and disease: association or causation? 1965. J R Soc Med. 2015;108(1):32-37. 15 (...) cancer patients (mean iodine-131 activity varied from 3700 to 5500 MBq). 13 A small risk of leukaemia was observed at these doses but there was no significant increase in the occurrence of breast cancer or other solid malignancies. 13 A causative role for radioiodine in the study by Kitahara et al thus seems unlikely given that excess risk was only observed for solid malignancies in their study, and the mean administered radioiodine activity (375 MBq for Graves' disease and 488 MBq for toxic nodules
Oxodotreotide (Netspot) - adjunct to other diagnostic tests for localization of somatostatin receptor-positive neuroendocrine tumors (NETs) Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product
C et al. Long-term efficacy, tolerability and overall survival in patients with platinum-sensitive, recurrent high-grade serous ovarian cancer treated with maintenance olaparib capsules following response to chemotherapy. Br J Cancer 2018; 119: 1075–1085. Colombo N, Sessa C, du Bois A et al. ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease. Ann Oncol 2019; 30: 672–705. Oza AM (...) eUpdate – Relapsed Epithelial Ovarian Carcinoma Treatment Recommendations Relapsed Epithelial Ovarian Carcinoma Treatment Recommendations Search eUpdate – Ovarian Cancer Treatment Recommendations eUpdate – Relapsed Epithelial Ovarian Carcinoma Treatment Recommendations Published: 01 April 2020 . Authors: ESMO Guidelines Committee Clinical Practice Guidelines This update refers to . Ledermann JA, Raja FA, Fotopoulou C et al. Ann Oncol 2013; 24 (Suppl 6): vi24–vi32. Section Chemotherapy
that specific exercise programming adaptations may be required for people with cancer based on disease and treatment-related adverse effects, anticipated disease trajectory and their health status • Effective exercise prescriptions can be delivered across a variety of settings including hospital, cancer treatment centre, community and home-based (i.e. self-managed). • Accredited exercise physiologists or physiotherapists with experience in cancer care are the most appropriate health professionals (...) and functional ability), attenuating cancer- related fatigue, alleviating psychological distress and improving quality of life across multiple general health and cancer-specific domains [3-17]. Emerging evidence highlights that regular exercise before, during and/or following cancer treatment decreases the severity of other adverse side effects and is associated with reduced risk of developing new cancers and comorbid conditions such as cardiovascular disease, diabetes and osteoporosis [3, 4]. Furthermore
. For negative margins (i.e. ink not touching invasive cancer or DCIS), thedistanceofinvasivecancerand/orDCIS from the margin(s) should be reported. No tumour at the inked margin is required and>2mm for in situ disease is preferred [63–66]. Marking the tumour bed with clips in a standardised way facili- tates accurate planning of the radiation boost if indicated. Currently achievable low local recurrence rates [ 2mm for in situ disease is preferred [I, A]. Mastectomy: Besides simple mastectomy and skin (...) - rences and improved cosmetic outcomes [II, B]. Axillary node evaluation with SLNB is not required withinsitu malignancy but may be reasonable in large and/or high-grade tumours, especially when mastectomy is required (in case an inci- dental invasive cancer is subsequently identi?ed in the surgical specimen). The risk of a positive SLN with pure DCIS is small (7%–9%) and most of the metastases found are micrometastases or isolated tumour cells, detected by IHC [82, 83]. The decision to carry out
or IB1 cervical cancer and a histological subtype of squamous-cell carcinoma, adenocarcinoma or adenosquamous carcinoma were randomly assigned to undergo minimally invasive surgery (laparoscopy or robot-assisted surgery) or conventional open surgery. Minimally invasive surgery was associated with a lower rate of disease-free survival (DFS) than open surgery [3-year rate, 91.2% versus 97.1%; hazard ratio (HR) for disease recurrence or death from cervical cancer 3.74; 95% confidence interval (CI) 1.63 (...) eUpdate – Cervical Cancer Treatment Recommendations eUpdate – Cervical Cancer Treatment Recommendations Search eUpdate – Cervical Cancer Treatment Recommendations eUpdate - Cervical Cancer Treatment Recommendations Published: 01 April 2020 . Authors: ESMO Guidelines Committee Clinical Practice Guidelines This update refers to . Section Management of local/locoregional disease; primary treatment Text update In the ESMO Clinical Practice Guidelines on cervical cancer, radical hysterectomy
EarlyCDT-Lung (Oncimmune) is a blood test that measures a group of 7 autoantibodies (p53, NYESO-1, CAGE, GBU4-5, HuD, MAGE A4 and SOX2) to tumour-associated antigens related to lung cancer. It helps early detection of lung cancer in people with high risk and allows differentiation of benign or malignant nodules. In the early stages of lung cancer, autoantibodies and tumour-associated antigens are produced as the body's immune system's response to cancer antigens. Blood levels of autoantibodies (...) . NICE's guideline on the diagnosis and management of lung cancer recommends sputum cytology for investigation in people with suspected lung cancer who have centrally placed nodules and are unable to tolerate bronchoscopy or invasive tests. A contrast-enhanced chest CT scan is recommended for further diagnosis and to stage the disease. The guideline recommends PET-CT as a first test after CT with a low probability of nodal malignancy (lymph nodes below 10 mm). MRI, endobronchial ultrasound-guided
University Shanghai Cancer Centre, Shanghai, China. 7 Department of Thoracic Surgery, Henan Cancer Hospital, Zhengzhou, China. PMID: 32108326 DOI: Item in Clipboard Three-field Versus Two-Field Lymphadenectomy in Transthoracic Oesophagectomy for Oesophageal Squamous Cell Carcinoma: Short-Term Outcomes of a Randomized Clinical Trial B Li et al. Br J Surg . 2020 . Show details Br J Surg Actions . 2020 Feb 28. doi: 10.1002/bjs.11497. Online ahead of print. Authors (...) of Oncology, Fudan University Shanghai Cancer Centre, Shanghai, China. 7 Department of Thoracic Surgery, Henan Cancer Hospital, Zhengzhou, China. PMID: 32108326 DOI: Item in Clipboard Full-text links Cite Abstract in , Background: The benefit and harm of three-field lymphadenectomy for oesophageal cancer are still unknown. The aim of this study was to compare overall survival and morbidity and mortality between three- and two-field lymphadenectomy in patients with oesophageal squamous cell carcinoma
trial conducted at the US Department of Veterans Affairs and National Cancer Institute sites. The participants were men (n=731) ≤75yr of age with localized prostate cancer, prostate-specific antigen (PSA) <50ng/ml, life expectancy ≥10yr, and medically fit for surgery. Intervention: Radical prostatectomy versus observation. Outcome measurements and statistical analysis: All-cause mortality was assessed in the entire cohort and patient and tumor subgroups. Intention-to-treat analysis was conducted (...) with intermediate-risk disease although not in men with high-risk disease. Patient summary: In this randomized study, we evaluated death from any cause in men with early prostate cancer treated with either surgery or observation. Overall, surgery may provide small very long-term reductions in death from any cause and increases in years of life gained. Absolute effects were much smaller in men with low-risk disease, but were greater in men with intermediate-risk disease although not in men with high-risk disease
Endometrial Cancer: A Randomised Controlled Trial , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Department of Gynaecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China. 2 Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China. 3 Department of Clinical Epidemiology, Obstetrics and Gynaecology Hospital, Fudan University, Shanghai, China. 4 Department of Cervical Diseases, Obstetrics and Gynaecology Hospital, Fudan University (...) for endometrial cancer and atypical complex endometrial hyperplasia: a systematic review and metaanalysis. Am J Obstet Gynecol 2012;207:266.e1-12. Ushijima K, Yahata H, Yoshikawa H, Konishi I, Yasugi T, Saito T, et al. Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. J Clin Oncol 2007;25:2798-803. Lee TY, Martinez-Outschoorn UE, Schilder RJ, Kim CH, Richard SD, Rosenblum NG, et al. Metformin
subclasificación del sistema BCLC. MÉTODOS: Los pacientes con carcinoma hepatocelular (hepatocellular cancer, HCC) BCLC-0, A y B que se sometieron a una hepatectomía con intención curativa entre 2000 y 2017 fueron identificados utilizando una base de datos multi-institucional. Se calculó la puntuación de carga tumoral (tumour burden score, TBS) y se examinó la supervivencia global (overall survival, OS) en relación con la TBS y los estadios BCLC. Resultados: En la serie de 1.053 pacientes, 63 (6%) tenían HCC (...) , School of Medicine, Sydney, New South Wales, Australia. 11 Yokohama City University School of Medicine, Yokohama, Japan. 12 Department of Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio. PMID: 32057105 DOI: Item in Clipboard Hepatocellular CarcinomaTumour Burden Score to Stratify Prognosis After Resection D I Tsilimigras et al. Br J Surg . 2020 . Show details Br J Surg Actions . 2020 Feb 14. doi: 10.1002/bjs.11464. Online ahead of print. Authors