Latest & greatest articles for cancer

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on cancer or other clinical topics then use Trip today.

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Top results for cancer

11241. Computed tomography and magnetic resonance imaging in staging of uterine cervical carcinoma: a systematic review

be a problem in this review, as attempts to identify unpublished studies do not appear to have been made. However, it is unclear whether this is likely to have affected the results of the review. The authors' conclusions are supported by the results presented. Implications of the review for practice and research Practice: The authors stated that in clinically early-stage cancer, the prevalence of spread of disease outside the cervix is low and, therefore, the additional value of MRI is limited. In more (...) advanced disease, MRI can play an important role as clinical staging has significant limitations. Research: The authors stated that more MRI studies, satisfying all methodological criteria, are needed to fully evaluate MRI techniques and protocols and to obtain a uniform MRI strategy. Bibliographic details Bipat S, Glas A S, van der Velden J, Zwinderman A H, Bossuyt P M, Stoker J. Computed tomography and magnetic resonance imaging in staging of uterine cervical carcinoma: a systematic review

2003 DARE.

11242. Use of tamoxifen in the treatment of malignant melanoma: systematic review and metaanalysis of randomized controlled trials

Use of tamoxifen in the treatment of malignant melanoma: systematic review and metaanalysis of randomized controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2003 DARE.

11243. The effectiveness of community-based visual screening and utility of adjunctive diagnostic aids in the early detection of oral cancer

. Bibliographic details Patton L L. The effectiveness of community-based visual screening and utility of adjunctive diagnostic aids in the early detection of oral cancer. Oral Oncology 2003; 39(7): 708-723 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Community Health Services /methods; Humans; Mass Screening /methods; Mouth Neoplasms /diagnosis; Physical Examination /methods; Precancerous Conditions /diagnosis; Tolonium Chloride AccessionNumber 12003001975 Date bibliographic record published (...) The effectiveness of community-based visual screening and utility of adjunctive diagnostic aids in the early detection of oral cancer The effectiveness of community-based visual screening and utility of adjunctive diagnostic aids in the early detection of oral cancer The effectiveness of community-based visual screening and utility of adjunctive diagnostic aids in the early detection of oral cancer Patton L L CRD summary This review found that there is insufficient evidence to demonstrate

2003 DARE.

11244. Mistletoe in cancer: a systematic review on controlled clinical trials

preparations Iscador, Eurixor and Helixor. Most of the treatments involved intravenous administration of a substance extracted from fresh leafy mistletoe shoots and berries. Full details of the preparations used and the comparators were provided in tabular format. The doses were not reported. Participants included in the review To be eligible for inclusion, the studies had to focus on people with cancer of any type, including cervical intraepithelial neoplasia. The cancer sites in the studies included (...) survival. Two studies found that mistletoe had no effect on disease recurrence. Remission: one study found that mistletoe statistically significantly improved tumour remission, 2 studies found non-statistically significant remission benefits, and 3 studies found no effect on remission. Quality of life: 3 studies found that mistletoe statistically significantly improved quality of life. In addition, 3 studies found that mistletoe statistically significantly improved quality of life in relation

2003 DARE.

11245. The treatment of locally advanced pancreatic cancer: a practice guideline

. The treatment of locally advanced pancreatic cancer: a practice guideline. Canadian Journal of Gastroenterology 2003; 17(3): 161-167 PubMedID Other publications of related interest Earle CC, Agboola O, Maroun J, Zuraw L, Gastrointestinal Cancer Disease Site Group. The treatment of locally advanced pancreatic cancer. Ontario: Cancer Care Ontario Practice Guidelines Initiative; 2002. (accessed 09/11/2005). Available from: URL: Indexing Status Subject indexing assigned by NLM MeSH Adenocarcinoma /diagnosis (...) The treatment of locally advanced pancreatic cancer: a practice guideline The treatment of locally advanced pancreatic cancer: a practice guideline The treatment of locally advanced pancreatic cancer: a practice guideline Earle C C, Agboola O, Maroun J, Zuraw L CRD summary This review evaluated treatments for incurable, locally advanced, unresectable but non-metastatic disease. The authors concluded that combined chemotherapy (bolus or infusional 5-fluorouracil (5-FU)) and radiotherapy should

2003 DARE.

11246. Systematic review of adjuvant therapy for early stage (epithelial) ovarian cancer

for early stage (epithelial) ovarian cancer. International Journal of Gynecological Cancer 2003; 13(4): 395-404 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Adult; Aged; Antineoplastic Combined Chemotherapy Protocols /therapeutic use; Carcinoma /mortality /pathology /therapy; Chemotherapy, Adjuvant; Confidence Intervals; Disease-Free Survival; Female; Humans; Middle Aged; Neoplasm Staging; Ovarian Neoplasms /mortality /pathology /therapy; Ovariectomy /methods; Probability; Prognosis (...) studies comparing chemotherapy with radiotherapy and chemotherapy versus no treatment. Methods of synthesis How were the studies combined? Studies that reported surgical staging of the cancer were combined using a random-effects meta-analysis. The pooled HR and 95% confidence intervals (CIs) were calculated for adjuvant chemotherapy compared with radiotherapy and for adjuvant chemotherapy compared with observation (with treatment of progression of the disease). Adverse effects were tabulated by trial

2003 DARE.

11247. Survival after HLA-identical allogeneic peripheral blood stem cell and bone marrow transplantation for hematologic malignancies: meta-analysis of randomized controlled trials

Survival after HLA-identical allogeneic peripheral blood stem cell and bone marrow transplantation for hematologic malignancies: meta-analysis of randomized controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2003 DARE.

11248. Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review

, Chew P W, Lau J, Carr D. Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review. Journal of Pain 2003; 4(5): 231-256 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Analgesics, Opioid /adverse effects; Chronic Disease; Constipation /chemically induced; Delirium /chemically induced; Humans; Myoclonus /chemically induced; Nausea /chemically induced; Neoplasms /complications; Pain /complications /etiology; Pruritus /chemically induced (...) Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review McNicol E, Horowicz-Mehler N, Fisk R A, Bennett K, Gialeli-Goudas M, Chew P W, Lau J, Carr D CRD summary The authors concluded that they found limited evidence to support diverse interventions

2003 DARE.

11249. Assessment of clinical utility of F-18-FDG PET in patients with head and neck cancer: a probability analysis

and detect recurrence of head and neck cancer. It concluded that PET is most useful to rule out disease in patients whose probability of having the disease is low. The results need careful interpretation because of uncertainty about the quality of the studies and the types of patients in the studies reviewed. Authors' objectives To determine the diagnostic accuracy of positron emission tomography (PET) in the primary assessment and detection of recurrence of head and neck cancer. Searching MEDLINE (...) excluded. Reference standard test against which the new test was compared Studies that used histopathological verification or suitable follow-up were selected for inclusion. Histological verification was the reference standard used in the review. Participants included in the review Studies of patients with known primary head and neck cancer (squamous cell cancer or adenocarcinoma) were eligible for inclusion. There was no information on the characteristics of the patients in the included studies

2003 DARE.

11250. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival

Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2003 DARE.

11251. Communication, information and support for adults with malignant cerebral glioma: a systematic literature review

of support such as counselling. Studies that investigate the impact of cognitive differences in the comprehension of information would be useful to inform practice. Bibliographic details Davies E, Higginson I J. Communication, information and support for adults with malignant cerebral glioma: a systematic literature review. Supportive Care in Cancer 2003; 11(1): 21-29 PubMedID DOI Indexing Status Subject indexing assigned by NLM MeSH Adult; Aged; Awareness; Brain Neoplasms /psychology /therapy (...) by which cancer patients are cared for should be applied to patients with cerebral glioma. This conclusion may not be reliable because all included studies were observational and no evidence of effective interventions was found. Authors' objectives To establish the evidence for information, communication and support for adults with malignant cerebral glioma. Searching MEDLINE (1966 to May 2000), EMBASE (1988 to May 2000), CINAHL (1982 to March 2000), British Nursing Index (March 2000), Cancerlit

2003 DARE.

11252. Meta-analysis of the performance of 18F-FDG PET in primary tumor detection in unknown primary tumors

Meta-analysis of the performance of 18F-FDG PET in primary tumor detection in unknown primary tumors Meta-analysis of the performance of 18F-FDG PET in primary tumor detection in unknown primary tumors Meta-analysis of the performance of 18F-FDG PET in primary tumor detection in unknown primary tumors Delgado-Bolton R C, Fernandez-Perez C, Gonzalez-Mate A, Carreras J L CRD summary This review aimed to determine the usefulness of 18-fluorine fluorodeoxyglucose positron emission tomography (18F (...) -FDG PET) in detecting primary tumours whose location is unknown. It concluded that 18F-FDG PET may be useful for this purpose and would miss few tumours that subsequently prove locatable by other available tests. However, further research is required to determine the effect of this imaging technique on patient management. Authors' objectives To assess the accuracy of 18-fluorine fluorodeoxyglucose positron emission tomography (18F-FDG PET) for the detection of primary tumours in patients

2003 DARE.

11253. Invasive staging of non-small cell lung cancer: a review of the current evidence

-positive and true-negative results summed across the studies. Studies in which all participants had mediastinol disease were excluded from these calculations. The data were analysed in three ways: for patients undergoing invasive techniques (regardless of the indication), where a definitive diagnosis of any malignancy was considered positive and a definitive benign diagnosis was considered negative; for patients suspected of having lung cancer (either non-SCLC or SCLC), where a definitive diagnosis (...) for practice or further research. Funding American College of Chest Physicians. Bibliographic details Toloza EM, Harpole L, Detterbeck F, McCrory DC. Invasive staging of non-small cell lung cancer: a review of the current evidence. Chest 2003; 123(1 Supplement): 157S-166S PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Biopsy, Needle; Carcinoma, Non-Small-Cell Lung /diagnosis /pathology /secondary; Endosonography; Evidence-Based Medicine; Humans; Lung Neoplasms

2003 DARE.

11254. Noninvasive staging of non-small cell lung cancer: a review of the current evidence Full Text available with Trip Pro

was to evaluate the accuracy of clinical evaluation for predicting metastatic disease in suspected lung cancer patients. Searching MEDLINE (from January 1991 to July 2001), HealthSTAR and the Cochrane Library. The keywords used were reported. In addition, the authors searched the reference lists from a number of sources. Only English language articles were included. Study selection Study designs of evaluations included in the review Inclusion and exclusion were not reported in terms of the study design (...) . The studies had to include at least 20 patients, while studies of CT scanning had to include at least 50 patients. Specific interventions included in the review Question 1: studies that examined CT scanning, MRI, EUS and PET scanning for detecting malignant mediastinal lymph node involvement were eligible. Question 2: studies that examined the accuracy of clinical evaluation for predicting metastatic disease were eligible. Reference standard test against which the new test was compared Question 1

2003 DARE.

11255. Prevention of lung cancer: summary of published evidence

. The primary prevention studies included smokers and non-smokers; the tertiary prevention studies included patients with head and neck and/or lung cancer. Outcomes assessed in the review The outcome eligible for inclusion was lung cancer incidence. In the tertiary prevention studies this was defined as a second primary tumour. How were decisions on the relevance of primary studies made? The authors did not state how the papers were selected for the review, or how many reviewers performed the selection (...) Prevention of lung cancer: summary of published evidence Prevention of lung cancer: summary of published evidence Prevention of lung cancer: summary of published evidence Kelley MJ, McCrory DC CRD summary This review assessed the effect of chemoprevention on the incidence of lung cancer. The authors concluded that no agent has been shown to be effective in preventing lung cancer. The conclusions are in line with the evidence presented but may not be reliable because validity of included studies

2003 DARE.

11256. The efficacy of behavioral interventions for cancer treatment-related side effects

chemotherapy, surgery, or radiotherapy. Most of the included studies contained people with many different types of cancer, and they were of children and adults. Details about the gender and disease of the participants from each study were tabulated in the review. Outcomes assessed in the review Studies were eligible if they included data about any cancer treatment-related adverse effect, such as pain, nausea and vomiting, and anxiety and distress. How were decisions on the relevance of primary studies made (...) The efficacy of behavioral interventions for cancer treatment-related side effects The efficacy of behavioral interventions for cancer treatment-related side effects The efficacy of behavioral interventions for cancer treatment-related side effects Mundy E A, DuHamel K N, Montgomery G H CRD summary This review found that behavioural interventions could reduce anticipatory nausea and vomiting in people undergoing chemotherapy and decrease anxiety related to cancer diagnosis and treatment

2003 DARE.

11257. Docetaxel in advanced gastric cancer: review of the main clinical trials

Docetaxel in advanced gastric cancer: review of the main clinical trials Docetaxel in advanced gastric cancer: review of the main clinical trials Docetaxel in advanced gastric cancer: review of the main clinical trials Di Cosimo S, Ferretti G, Fazio N, Silvestris N, Carlini P, Alimonti A, Gelibter A, Felici A, Papaldo P, Cognetti F CRD summary This review assessed the effectiveness of docetaxel, either as a single agent or in combination with other widely used cancer drugs, in the treatment (...) of advanced gastric cancer. The authors concluded that firm conclusions about the effectiveness of docetaxel cannot be drawn until the results of further phase III studies are available. On the basis of the limited evidence reviewed and a number of potential biases in the review process, this statement appears reliable. Authors' objectives To assess the effectiveness of docetaxel, either as a single agent or in combination with widely used other cancer drugs, in the treatment of advanced gastric cancer

2003 DARE.

11258. Meta-analysis of the effect of psychoeducational interventions on pain in adults with cancer

Meta-analysis of the effect of psychoeducational interventions on pain in adults with cancer Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2003 DARE.

11259. Systematic review of role of bisphosphonates on skeletal morbidity in metastatic cancer

Systematic review of role of bisphosphonates on skeletal morbidity in metastatic cancer Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2003 DARE.

11260. Test characteristics of alpha-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C

to define whether a screening strategy can provide clinically important benefits. Funding PRIME Residency Program, University of California. Bibliographic details Gupta S, Bent S, Kohlwes J. Test characteristics of alpha-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C. Annals of Internal Medicine 2003; 139(1): 46-50 PubMedID Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Biomarkers, Tumor /blood; Carcinoma, Hepatocellular /complications (...) Test characteristics of alpha-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C Test characteristics of alpha-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C Test characteristics of alpha-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C Gupta S, Bent S, Kohlwes J CRD summary This review evaluated the accuracy of alpha-foetoprotein (AFP) for the diagnosis of hepatocellular carcinoma (HCC) in patients

2003 DARE.