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Prevalence, Mortality, and Indicators of Health Care Supplyâ€”Association Analysis of CardiovascularDiseases in Germany Introduction: There are regional differences in the morbidity of major cardiovasculardisease between the 16 federal states of Germany. An association between the morbidity and the health care supply has been described in international studies. The aim of the present analysis was to examine the relationship between the prevalence or mortality of major cardiovasculardisease (...) disease prevalence and mortality with these indicators and performed a weighted linear regression. Results: Regional variations between the federal states were found in general health and health care supply. The regression analysis yielded significant associations of the prevalence of major cardiovasculardisease with the number of internal medicine hospital beds (β = 10.042, p = 0.045), cardiologists (β = -0.689, p = 0.031), and the number of residents per chest pain unit (β = 42,730, p = 0.036
Population surveillance of cardiovasculardiseases in low-income to middle-income countries should leverage existing international collaborations 30294457 2018 11 14 2059-7908 3 5 2018 BMJ global health BMJ Glob Health Population surveillance of cardiovasculardiseases in low-income to middle-income countries should leverage existing international collaborations. e000866 10.1136/bmjgh-2018-000866 Echouffo-Tcheugui Justin B JB Brigham and Women's Hospital, Harvard Medical School, Boston (...) Wales, Sydney, Australia. Non-communicable Diseases Research Unit, South African Medical Research Council & University of Cape Town, Cape Town, South Africa. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. eng Journal Article 2018 10 01 England BMJ Glob Health 101685275 2059-7908 control strategies prevention strategies public health Competing interests: None declared. 2018 04 03 2018 08 15 2018 10 9 6 0 2018 10 9 6 0 2018 10 9 6 1
Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovasculardisease in primary care Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovasculardisease in primary care: 2018 update | CMAJ Main menu User menu Search Search for this keyword Search for this keyword Guideline Canadian Cardiovascular Harmonized National Guidelines Endeavour (C (...) -CHANGE) guideline for the prevention and management of cardiovasculardisease in primary care: 2018 update Sheldon W. Tobe , James A. Stone , Todd Anderson , Simon Bacon , Alice Y.Y. Cheng , Stella S. Daskalopoulou , Justin A. Ezekowitz , Jean C. Gregoire , Gord Gubitz , Rahul Jain , Karim Keshavjee , Patty Lindsay , Mary L’Abbe , David C.W. Lau , Lawrence A. Leiter , Eileen O’Meara , Glen J. Pearson , Doreen M. Rabi , Diana Sherifali , Peter Selby , Jack V. Tu , Sean Wharton , Kimberly M. Walker
Kadian-Dodov , Leo Lopez , Kristian H. Mortensen , Siddharth K. Prakash , Elizabeth V. Ratchford , Arwa Saidi , Iris van Hagen , Luciana T. Young , and Originally published 24 Sep 2018 Circulation: Genomic and Precision Medicine. 2018;11 Abstract Girls and women with Turner syndrome face a lifelong struggle with both congenital heart disease and acquired cardiovascularconditions. Bicuspid aortic valve is common, and many have left-sided heart obstructive disease of varying severity, from hypoplastic (...) left-sided heart syndrome to minimal aortic stenosis or coarctation of the aorta. Significant enlargement of the thoracic aorta may progress to catastrophic aortic dissection and rupture. It is becoming increasingly apparent that a variety of other cardiovascularconditions, including early-onset hypertension, ischemic heart disease, and stroke, are the major factors reducing the life span of those with Turner syndrome. The presentations and management of cardiovascularconditions in Turner
Tai Chi exercise is more effective than brisk walking in reducing cardiovasculardisease risk factors among adults with hypertension: A randomised controlled trial Physical inactivity is a major modifiable lifestyle risk factor associated with cardiovasculardisease. Tai Chi is a safe and popular form of physical activity among older adults, yet direct comparisons are lacking between Tai Chi and brisk walking in their ability to reduce cardiovasculardisease risk factors and improve (...) psychosocial well-being.246 adults (mean age = 64.4 ± 9.8 years, age range = 30-91 years, 45.5% men) with hypertension and at least two but not more than three modifiable cardiovasculardisease risk factors (diabetes, dyslipidaemia, overweight, physical inactivity and smoking) were randomly assigned to either Tai Chi (n = 82), brisk walking (n = 82) or control (n = 82) groups. The Tai Chi and brisk walking groups engaged in moderate-intensity physical activity 150 min/week for 3 months; daily home-based
The Metabolic Syndrome, Cardiovascular Fitness and Survival in Patients With Advanced Systolic Heart Failure The metabolic syndrome (MetS), which incorporates insulin resistance, visceral adiposity, and dyslipidemia, is an independent risk factor for incident heart failure (HF), but the impact on survival is uncertain. We sought to determine the relation between the metabolic syndrome and survival in ambulatory systolic HF patients and the impact of MetS on cardiopulmonary exercise test (CPET
Cardiovascular risk model performance in women with and without hypertensive disorders of pregnancy Compare the predictive performance of Framingham Risk Score (FRS), Pooled Cohort Equations (PCEs) and Systematic COronary Risk Evaluation (SCORE) model between women with and without a history of hypertensive disorders of pregnancy (hHDP) and determine the effects of recalibration and refitting on predictive performance.We included 29 751 women, 6302 with hHDP and 17 369 without. We assessed (...) whether models accurately predicted observed 10-year cardiovasculardisease (CVD) risk (calibration) and whether they accurately distinguished between women developing CVD during follow-up and not (discrimination), separately for women with and without hHDP. We also recalibrated (updating intercept and slope) and refitted (recalculating coefficients) the models.Original FRS and PCEs overpredicted 10-year CVD risks, with expected:observed (E:O) ratios ranging from 1.51 (for FRS in women with hHDP
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovasculardisease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial. Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death (...) , myocardial infarction, or stroke.We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovasculardisease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30-50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web
2018LancetControlled trial quality: predicted high
PON-1 Q192R (rs662) Gene Polymorphism and the Risk of Major Adverse Cardiovascular Events in Clopidogrel-Treated Patients with Coronary Heart Disease: A Systematic Review and Meta-Analysis PON 1 Q192R rs662 Gene Polymorphism and The Risk of Major Adverse Cardiovascular Events in Clopidogrel Treated Patients with Coronary Heart Disease | Ocimum Scientific Publishers Go! Journal of Cardiology and Catheterization Share Article Quick Links Original Research PON-1 Q192R (rs662) Gene Polymorphism (...) and the Risk of Major Adverse Cardiovascular Events in Clopidogrel-Treated Patients with Coronary Heart Disease: A Systematic Review and Meta-Analysis Ling-Yun Zhou 1 , Long Shen 2 , Xiao-Cong Zuo 1 and Zhi-Chun Gu 3,4* 1 Clinical Pharmacy and Pharmacology Research Institute, Third Xiangya Hospital, Central South University, China 2 Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China 3 Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai
Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovasculardisease (ARRIVE): a randomised, double-blind, placebo-controlled trial. The use of aspirin in the primary prevention of cardiovascular events remains controversial. We aimed to assess the efficacy and safety of aspirin versus placebo in patients with a moderate estimated risk of a first cardiovascular event.ARRIVE is a randomised, double-blind, placebo-controlled, multicentre study done (...) in seven countries. Eligible patients were aged 55 years (men) or 60 years (women) and older and had an average cardiovascular risk, deemed to be moderate on the basis of the number of specific risk factors. We excluded patients at high risk of gastrointestinal bleeding or other bleeding, or diabetes. Patients were randomly assigned (1:1) with a computer-generated randomisation code to receive enteric-coated aspirin tablets (100 mg) or placebo tablets, once daily. Patients, investigators, and others
Editorial: Extracellular Vesicle-Mediated Processes in CardiovascularDiseases 30283791 2019 02 02 2297-055X 5 2018 Frontiers in cardiovascular medicine Front Cardiovasc Med Editorial: Extracellular Vesicle-Mediated Processes in CardiovascularDiseases. 133 10.3389/fcvm.2018.00133 Koenen Rory R RR Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands. Aikawa Elena E Cardiovascular Division, Department of Medicine, Center
Association of dairy intake with cardiovasculardisease and mortality in 21 countries from five continents (PURE): a prospective cohort study. Dietary guidelines recommend minimising consumption of whole-fat dairy products, as they are a source of saturated fats and presumed to adversely affect blood lipids and increase cardiovasculardisease and mortality. Evidence for this contention is sparse and few data for the effects of dairy consumption on health are available from low-income and middle (...) events (deaths [n=6796] or major cardiovascular events [n=5855]) during the 9·1 years of follow-up. Higher intake of total dairy (>2 servings per day compared with no intake) was associated with a lower risk of the composite outcome (HR 0·84, 95% CI 0·75-0·94; ptrend=0·0004), total mortality (0·83, 0·72-0·96; ptrend=0·0052), non-cardiovascular mortality (0·86, 0·72-1·02; ptrend=0·046), cardiovascular mortality (0·77, 0·58-1·01; ptrend=0·029), major cardiovasculardisease (0·78, 0·67-0·90; ptrend=0
, maternal heart disease is the major cause of maternal death during pregnancy. , Hypertensive disorders are the most frequent cardiovasculardisorders during pregnancy, occurring in 5–10% of all pregnancies (see section 10). Among the other diseaseconditions, congenital heart disease is the most frequent CVD present during pregnancy in the western world (75–82%). , Rheumatic valvular disease dominates in non-western countries, comprising 56–89% of all CVDs in pregnancy. , Peripartum intensive care unit (...) for recommending a healthy lifestyle, including smoking cessation. 3.3.1 Risk of maternal cardiovascular complications The risk of complications in pregnancy depends on the underlying cardiac diagnosis, ventricular and valvular function, functional class, presence of cyanosis, pulmonary artery pressures, and other factors. Comorbidities, including for example rheumatoid and musculoskeletal diseases as well as mental disorders, should also be taken into account. Therefore, risk estimation should
Extracellular Vesicles as Biomarkers in CardiovascularDisease; Chances and Risks The field of extracellular vesicles (EV) is rapidly expanding, also within cardiovasculardiseases. Besides their exciting roles in cell-to-cell communication, EV have the potential to serve as excellent biomarkers, since their counts, content, and origin might provide useful information about the pathophysiology of cardiovasculardisorders. Various studies have already indicated associations of EV counts (...) and content with cardiovasculardiseases. However, EV research is complicated by several factors, most notably the small size of EV. In this review, the advantages and drawbacks of EV-related methods and applications as biomarkers are highlighted.
Excess mortality and cardiovasculardisease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study. People with type 1 diabetes are at elevated risk of mortality and cardiovasculardisease, yet current guidelines do not consider age of onset as an important risk stratifier. We aimed to examine how age at diagnosis of type 1 diabetes relates to excess mortality and cardiovascular risk.We did a nationwide, register-based cohort study (...) of individuals with type 1 diabetes in the Swedish National Diabetes Register and matched controls from the general population. We included patients with at least one registration between Jan 1, 1998, and Dec 31, 2012. Using Cox regression, and with adjustment for diabetes duration, we estimated the excess risk of all-cause mortality, cardiovascular mortality, non-cardiovascular mortality, acute myocardial infarction, stroke, cardiovasculardisease (a composite of acute myocardial infarction and stroke
Urinary sodium excretion, blood pressure, cardiovasculardisease, and mortality: a community-level prospective epidemiological cohort study. WHO recommends that populations consume less than 2 g/day sodium as a preventive measure against cardiovasculardisease, but this target has not been achieved in any country. This recommendation is primarily based on individual-level data from short-term trials of blood pressure (BP) without data relating low sodium intake to reduced cardiovascular events (...) from randomised trials or observational studies. We investigated the associations between community-level mean sodium and potassium intake, cardiovasculardisease, and mortality.The Prospective Urban Rural Epidemiology study is ongoing in 21 countries. Here we report an analysis done in 18 countries with data on clinical outcomes. Eligible participants were adults aged 35-70 years without cardiovasculardisease, sampled from the general population. We used morning fasting urine to estimate 24 h
Development and validation of a cardiovasculardisease risk-prediction model using population health surveys: the CardiovascularDisease Population Risk Tool (CVDPoRT) Routinely collected data from large population health surveys linked to chronic disease outcomes create an opportunity to develop more complex risk-prediction algorithms. We developed a predictive algorithm to estimate 5-year risk of incident cardiovasculardisease in the community setting.We derived the CardiovascularDisease (...) ; women: 0.86, 95% CI 0.85-0.87) and was well-calibrated in the overall population (5-year observed cumulative incidence function v. predicted risk, men: 0.28%; women: 0.38%) and in nearly all predefined policy-relevant subgroups (206 of 208 groups).The CVDPoRT algorithm can accurately discriminate cardiovasculardisease risk for a wide range of health profiles without the aid of clinical measures. Such algorithms hold potential to support precision medicine for individual or population uses. Study
Performance of CardiovascularDisease Risk Scores in People Diagnosed With Type 2 Diabetes: External Validation Using Data From the National Scottish Diabetes Register To evaluate the performance of five cardiovasculardisease (CVD) risk scores developed in diabetes populations and compare their performance to QRISK2.A cohort of people diagnosed with type 2 diabetes between 2004 and 2016 was identified from the Scottish national diabetes register. CVD events were identified using linked (...) hospital and death records. Five-year risk of CVD was estimated using each of QRISK2, ADVANCE (Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation), Cardiovascular Health Study (CHS), New Zealand Diabetes Cohort Study (NZ DCS), Fremantle Diabetes Study, and Swedish National Diabetes Register (NDR) risk scores. Discrimination and calibration were assessed using the Harrell C statistic and calibration plots, respectively.The external validation cohort consisted