Latest & greatest articles for children

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on children or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on children and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for children

5741. Brief, intensive and concentrated cognitive behavioral treatments for anxiety disorders in children: A systematic review and meta-analysis. (Abstract)

Brief, intensive and concentrated cognitive behavioral treatments for anxiety disorders in children: A systematic review and meta-analysis. Anxiety disorders are among the most common disorders affecting youths in the general population, with up to 10% of children and 20% of adolescents meeting criteria for an anxiety disorder at any one point in time. Cognitive-behavior therapies (CBT), varying between 9 and 18 weeks of treatment, are considered evidence-based for the treatment of anxiety

2017 Behaviour research and therapy

5742. A Systematic Review of Speech Assessments for Children With Autism Spectrum Disorder: Recommendations for Best Practice. (Abstract)

A Systematic Review of Speech Assessments for Children With Autism Spectrum Disorder: Recommendations for Best Practice. The purpose of this systematic review was to provide a summary and evaluation of speech assessments used with children with autism spectrum disorders (ASD). A subsequent narrative review was completed to ascertain the core components of an evidence-based pediatric speech assessment, which, together with the results of the systematic review, provide clinical and research (...) guidelines for best practice.A systematic search of eight databases was used to find peer-reviewed research articles published between 1990 and 2014 assessing the speech of children with ASD. Eligible articles were categorized according to the assessment methods used and the speech characteristics described.The review identified 21 articles that met the inclusion criteria, search criteria, and confidence in ASD diagnosis. The speech of prelinguistic participants was assessed in seven articles. Speech

2017 American Journal of Speech-Language Pathology

5743. Paracetamol (acetaminophen) for chronic non-cancer pain in children and adolescents. (Full text)

Paracetamol (acetaminophen) for chronic non-cancer pain in children and adolescents. Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. While in the past, pain was largely dismissed and was frequently left (...) in the world today, chronic disease (and its associated pain) is a major health concern. Chronic pain (lasting three months or longer) can arise in the paediatric population in a variety of pathophysiological classifications: nociceptive, neuropathic, idiopathic, visceral, nerve damage pain, chronic musculoskeletal pain, and chronic abdominal pain, and other unknown reasons.Paracetamol (acetaminophen) is one of the most widely used analgesics in both adults and children. The recommended dosage in the UK

2017 Cochrane PubMed abstract

5744. Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. (Full text)

within paediatric pain management. Non-steroidal anti-inflammatory drugs are currently licensed for use in Western countries, however they are not approved for infants under three months old. The main adverse effects include renal impairment and gastrointestinal issues. Common side effects in children include diarrhoea, headache, nausea, constipation, rash, dizziness, and abdominal pain.To assess the analgesic efficacy and adverse events of NSAIDs used to treat chronic non-cancer pain in children (...) Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. While in the past pain was largely dismissed

2017 Cochrane PubMed abstract

5745. Heavy with child? Pregnancy status and stable isotope ratios as determined from biopsies of humpback whales (Full text)

Heavy with child? Pregnancy status and stable isotope ratios as determined from biopsies of humpback whales [This corrects the article DOI: 10.1093/conphys/cow050.].

2017 Conservation physiology PubMed abstract

5746. Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease. (Full text)

medication or placebo, in infants and children up to 18 years of age, who were undergoing surgery for congenital heart disease.Two review authors independently extracted data and assessed risk of bias according to a pre-defined protocol. We obtained additional information from all but one of the study authors of the included studies. We used the five GRADE considerations (study limitations, consistency of effect, imprecision, indirectness, and publication bias) to assess the quality of evidence from (...) Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease. Low cardiac output syndrome remains a serious complication, and accounts for substantial morbidity and mortality in the postoperative course of paediatric patients undergoing surgery for congenital heart disease. Standard prophylactic and therapeutic strategies for low cardiac output syndrome are based mainly on catecholamines, which

2017 Cochrane PubMed abstract

5747. HPV prevalence in the foreskins of asymptomatic healthy infants and children: Systematic review and meta-analysis. (Full text)

HPV prevalence in the foreskins of asymptomatic healthy infants and children: Systematic review and meta-analysis. The true HPV prevalence in the foreskins of infants and children has been little documented, but reporting on this prevalence is of great importance given its impact on the rationale for treating asymptomatic boys. We searched multiple databases from 1960 to 2016 for observational or prospective studies that reported on HPV prevalence in foreskins. We conducted a meta-analysis (...) using a random-effects model to pool for HPV prevalence in the foreskins of infants and children. Eight studies, with a total of 556 infants and children with phimosis, were eligible for the meta-analysis. The pooled overall prevalence of general HPV, high-risk HPV, low-risk HPV, HPV 16/18, HPV 16, and HPV 18 were 17.3 (95%CI: 0.8-46.3), 12.1 (95% CI: 0.9-31.5), 2.4 (95% CI: 0.0-11.2), 4.8 (95% CI: 0.0-16.8), 1.7 (95% CI: 0.0-5.1), and 0 (95% CI: 0-0.5), respectively. The estimated HPV prevalence

2017 Scientific reports PubMed abstract

5748. Short-term association between ambient air pollution and pneumonia in children: A systematic review and meta-analysis of time-series and case-crossover studies. (Abstract)

Short-term association between ambient air pollution and pneumonia in children: A systematic review and meta-analysis of time-series and case-crossover studies. Ambient air pollution has been associated with respiratory diseases in children. However, its effects on pediatric pneumonia have not been meta-analyzed. We conducted a systematic review and meta-analysis of the short-term association between ambient air pollution and hospitalization of children due to pneumonia. We searched the Web (...) of Science and PubMed for indexed publications up to January 2017. Pollutant-specific excess risk percentage (ER%) and confidence intervals (CI) were estimated using random effect models for particulate matter (PM) with diameter ≤ 10 (PM10) and ≤2.5 μm (PM2.5), sulfur dioxide (SO2), ozone (O3), nitrogen dioxide (NO2), and carbon monoxide (CO). Results were further stratified by subgroups (children under five, emergency visits versus hospital admissions, income level of study location, and exposure period

2017 Environmental pollution (Barking, Essex : 1987)

5749. Systematic Review and Meta-Analysis of the Utilization of Ethanol Locks in Pediatric Patients With Intestinal Failure. (Full text)

Systematic Review and Meta-Analysis of the Utilization of Ethanol Locks in Pediatric Patients With Intestinal Failure. Intestinal failure is a chronic condition related to loss of bowel length and/or function, resulting in dependence on central venous catheters for fluids and nutrition. Catheter use can be associated with significant complications, including catheter-related bloodstream infections (CRBSIs), which can lead to loss of vascular access, advancing intestinal failure associated-liver (...) disease and death. Our objective was to evaluate the effectiveness and safety of ethanol locks as compared with standard heparin locks in pediatric intestinal failure.Databases, including MEDLINE and EMBASE, were searched until March 2017. Titles and abstracts were reviewed independently and relevant articles reassessed by full-text review. The main outcome was the rate of CRBSIs, while secondary outcomes were catheter replacement and repair.Nine observational studies were included. The mean

2017 JPEN. Journal of parenteral and enteral nutrition PubMed abstract

5750. Probiotics and Child Care Absence Due to Infections: A Randomized Controlled Trial (Full text)

Probiotics and Child Care Absence Due to Infections: A Randomized Controlled Trial The risk of infections is higher in children attending child care compared with children cared for at home. This study examined the effect of a combination of probiotics on absence from child care because of respiratory and gastrointestinal infections in healthy infants aged 8 to 14 months at the time of enrollment in child care.The ProbiComp study was a randomized, double-blind, placebo-controlled study. A total (...) months did not reduce the number of days absent from child care in healthy infants at the time of enrollment in child care.Copyright © 2017 by the American Academy of Pediatrics.

2017 EvidenceUpdates PubMed abstract

5751. Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood (Full text)

Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, a specific description of subtypes of atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lacking.To identify different phenotypes of atopic dermatitis using a definition based on symptoms before age 6 years and to determine whether (...) class analysis was used to identify subtypes of atopic dermatitis in childhood based on the course of symptoms. Multivariable logistic regressions were used to analyze the association between atopic dermatitis phenotypes and other allergic diseases.We included 1038 children; of these, 506 were girls. The latent class analysis model with the best fit to PASTURE data separated 4 phenotypes of atopic dermatitis in childhood: 2 early phenotypes with onset before age 2 years (early transient [n = 96; 9.2

2017 EvidenceUpdates PubMed abstract

5752. Preventing Severe Asthma Exacerbations in Children. A Randomized Trial of Mite-Impermeable Bedcovers (Full text)

Preventing Severe Asthma Exacerbations in Children. A Randomized Trial of Mite-Impermeable Bedcovers Allergen exposure in sensitized individuals with asthma interacts with viruses to increase the risk of asthma exacerbation.To evaluate the use of house dust mite-impermeable bedding and its impact on severe asthma exacerbations in children.We randomized mite-sensitized children with asthma (ages 3-17 yr) after an emergency hospital attendance with an asthma exacerbation to receive mite (...) -impermeable (active group) or control (placebo group) bed encasings.Over a 12-month intervention period, the occurrence of severe asthma exacerbations was investigated. Of 434 children with asthma who consented, 286 (mean age, 7.7 yr; male sex, 65.8%) were mite sensitized, and 284 were randomized (146 to the active group and 138 to the placebo group). At 12 months, significantly fewer children in the active group than in the placebo group had attended the hospital with an exacerbation (36 [29.3%] of 123

2017 EvidenceUpdates PubMed abstract

5753. Timing of Etonogestrel-Releasing Implants and Growth of Breastfed Infants: A Randomized Controlled Trial (Abstract)

Timing of Etonogestrel-Releasing Implants and Growth of Breastfed Infants: A Randomized Controlled Trial To evaluate the growth of breastfed infants whose mothers had inserted an etonogestrel-releasing implant in the immediate postpartum period.An open, randomized controlled, and parallel trial of postpartum women who were block-randomized to early (up to 48 hours postpartum before discharge) or conventional (at 6 weeks postpartum) insertion of an etonogestrel implant. The primary outcome (...) was average infant weight at 12 months (360 days) and a difference of equal to or greater than 10% between groups was considered clinically significant. The secondary outcomes were infant's height and head and arm circumferences. These variables were measured at baseline and at 14, 40, 90, 180, 270, and 360 days postpartum. The mixed-effects linear regression model was used to evaluate the outcomes with a power of 80% and a significance level of 1% for the primary outcome and 0.3% for secondary outcomes

2017 EvidenceUpdates

5754. It is possible to replace chest X-rays with pulmonary ultrasound in the diagnose of pneumonia in children?

manos de personal con menor experiencia. Palabras clave: ; ; Cómo citar este artículo Albi Rodríguez MS, Martínez Rubio MV. ¿Puede la ecografía pulmonar sustituir a la radiografía para diagnosticar la neumonía en niños? Evid Pediatr. 2017;13:26. AVC | Artículos Valorados Críticamente Boursiani C, Tsolia M, Koumanidou C, Malagari A, Vakaki M, Karapostolakis G, et al . Lung ultrasound as first-line examination for the diagnosis of community-acquired pneumonia in children. Revisores: Albi Rodríguez M.S (...) It is possible to replace chest X-rays with pulmonary ultrasound in the diagnose of pneumonia in children? ¿Puede la ecografía pulmonar sustituir a la radiografía, para diagnosticar la neumonía en niños? - Evidencias en pediatría Buscando, por favor espere. Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su biblioteca. | Buscar Toma de decisiones clínicas basadas en pruebas científicas Toma de decisiones clínicas basadas en pruebas científicas Mostrar menú Gestión de

2017 Evidencias en Pediatría

5755. Absorbable sutures containing triclosan decrease wound infection rates in children

Absorbable sutures containing triclosan decrease wound infection rates in children Las suturas absorbibles que contienen triclosán disminuyen las tasas de infección de la herida quirúrgica en los niños - Evidencias en pediatría Buscando, por favor espere. Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su biblioteca. | Buscar Toma de decisiones clínicas basadas en pruebas científicas Toma de decisiones clínicas basadas en pruebas científicas Mostrar menú Gestión de (...) | Artículos Valorados Críticamente Renko M, Paalanne N, Tapiainen T, Hinkkainen M, Pokka T, Kinnula S, et al . Triclosan-containing sutures versus ordinary sutures for reducing surgical site infections in children: a double-blind, randomized controlled trial. Revisores: Ruiz-Canela Cáceres J 1 , García Vera C 2 . 1 CS Virgen de África. Sevilla. España. 2 CS José Ramón Muñoz Fernández. Zaragoza. España. Correspondencia: Juan Ruiz-Canela Cáceres. Correo electrónico: Fecha de recepción: 11/05/2017 Fecha de

2017 Evidencias en Pediatría

5756. Neonatal abstinence syndrome worsens school performance in childhood

Neonatal abstinence syndrome worsens school performance in childhood El síndrome de abstinencia neonatal se asocia a peor rendimiento escolar en la infancia - Evidencias en pediatría Ortega Páez E, Molina Arias M. El síndrome de abstinencia neonatal se asocia a bajo rendimiento escolar en la infancia. Evid Pediatr.2017;13:24. " /> Buscando, por favor espere. Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su biblioteca. | Buscar Toma de decisiones clínicas basadas en (...) abstinencia neonatal sobre el fracaso escolar. Esto justificaría que a estos niños en su etapa escolar se les prestara una especial atención para cribado de bajo rendimiento escolar, para su inclusión en un programa de apoyo, cuyo coste/beneficio debería ser evaluado en estudios prospectivos. Palabras clave: ; Cómo citar este artículo Ortega Páez E, Molina Arias M. El síndrome de abstinencia neonatal se asocia a bajo rendimiento escolar en la infancia. Evid Pediatr.2017;13:24. AVC | Artículos Valorados

2017 Evidencias en Pediatría

5757. Vitamin D supplements during gestation and wheezing in childhood: we need more evidence

Vitamin D supplements during gestation and wheezing in childhood: we need more evidence Suplementos de vitamina D en la gestación y sibilancias en la infancia: necesitamos más pruebas - Evidencias en pediatría Ochoa Sangrador C, Andrés de Llano JM. Suplementos de vitamina D en la gestación y sibilancias en la infancia: necesitamos más pruebas. Evid Pediatr. 2017;13:23. " /> Buscando, por favor espere. Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su biblioteca. | Buscar (...) suplementación a dosis altas de vitamina D en la gestación, ya que la evidencia disponible es imprecisa y hay dudas sobre su aplicabilidad en la práctica clínica. Palabras clave: ; ; ; Cómo citar este artículo Ochoa Sangrador C, Andrés de Llano JM. Suplementos de vitamina D en la gestación y sibilancias en la infancia: necesitamos más pruebas. Evid Pediatr. 2017;13:23. AVC | Artículos Valorados Críticamente Christensen N, Søndergaard J, Fisker N, Christesen HT. Infant respiratory tract infections or wheeze

2017 Evidencias en Pediatría

5758. Can we predict which children with pneumonia will have a severe prognosis?

predecir qué niños con neumonía van a tener un pronóstico grave? Evid Pediatr. 2017;13:18. AVC | Artículos Valorados Críticamente Williams DJ, Zhu Y, Grijalva CG, Self WH, Harrell FE Jr, Reed C, et al . Predicting Severe Pneumonia Outcomes in Children. Revisores: Orejón de Luna G 1 , Cuestas Montañés E 2 . 1 CS General Ricardos. Madrid. España. 2 Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina (...) Can we predict which children with pneumonia will have a severe prognosis? ¿Podemos predecir qué niños con neumonía van a tener un pronóstico grave? - Evidencias en pediatría Buscando, por favor espere. Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su biblioteca. | Buscar Toma de decisiones clínicas basadas en pruebas científicas Toma de decisiones clínicas basadas en pruebas científicas Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su

2017 Evidencias en Pediatría

5759. Effect of Attendance of the Child on Body Weight, Energy Intake, and Physical Activity in Childhood Obesity Treatment: A Randomized Clinical Trial (Full text)

Effect of Attendance of the Child on Body Weight, Energy Intake, and Physical Activity in Childhood Obesity Treatment: A Randomized Clinical Trial Family-based weight loss treatment (FBT) is considered the gold-standard treatment for childhood obesity and is provided to the parent and child. However, parent-based treatment (PBT), which is provided to the parent without the child, could be similarly effective and easier to disseminate.To determine whether PBT is similarly effective as FBT (...) on child weight loss over 24 months. Secondary aims evaluated the effect of these 2 treatments on parent weight loss, child and parent dietary intake, child and parent physical activity, parenting style, and parent feeding behaviors.Randomized 2-arm noninferiority trial conducted at an academic medical center, University of California, San Diego, between July 2011 and July 2015. Participants included 150 overweight and obese 8- to 12-year-old children and their parents.Both PBT and FBT were delivered

2017 EvidenceUpdates PubMed abstract

5760. Impact of Initial CSF Findings on Outcome Among Patients With National Cancer Institute Standard- and High-Risk B-Cell Acute Lymphoblastic Leukemia: A Report From the Children`s Oncology Group (Full text)

Impact of Initial CSF Findings on Outcome Among Patients With National Cancer Institute Standard- and High-Risk B-Cell Acute Lymphoblastic Leukemia: A Report From the Children`s Oncology Group Purpose To determine the prognostic significance of blasts, and of white and red blood cells, in CSF samples at diagnosis of acute lymphoblastic leukemia (ALL), a uniform CSF and risk group classification schema was incorporated into Children's Oncology Group B-cell ALL (B-ALL) clinical trials. Methods

2017 EvidenceUpdates PubMed abstract