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Latest & greatest articles for children
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Epidemiology of Live Born Infants with Nonimmune Hydrops Fetalis-Insights from a Population-Based Dataset To evaluate the incidence, etiology, and 1-year mortality of nonimmune hydrops fetalis (NIHF) and to identify risk factors for mortality in a contemporary population-based dataset.The California Office of Statewide Health Planning and Development maintains a database linking maternal and infant hospital discharge, readmissions, and birth and death certificate date from 1 year before to 1 (...) year after birth. We searched the database (2005-2012) for infants with NIHF (identified by the International Classification of Diseases, 9th Revision, Clinical Modification code). Hazard models were used to identify risk factors for mortality in infants with NIHF; results are presented as hazard ratios (HRs, 95% CI).The incidence of NIHF was 2.5 out of 10 000 among live born infants. Neonatal mortality was 35.1% (364 out of 1037) and overall mortality was 43.2% (448 out of 1037) at 1 year of age
Supplemental Iodide for Preterm Infants and Developmental Outcomes at 2 Years: An RCT The recommendation for enteral iodide intake for preterm infants is 30 to 40 μg/kg per day and 1 μg/kg per day for parenteral intake. Preterm infants are vulnerable to iodide insufficiency and thyroid dysfunction. The hypothesis tested whether, compared with placebo, iodide supplementation of preterm infants improves neurodevelopment.A randomized controlled trial of iodide supplementation versus placebo (...) in infants <31 weeks' gestation. Trial solutions (sodium iodide or sodium chloride; dose 30 μg/kg per day) were given within 42 hours of birth to the equivalent of 34 weeks' gestation. The only exclusion criterion was maternal iodide exposure during pregnancy or delivery. Whole blood levels of thyroxine, thyrotropin, and thyroid-binding globulin were measured on 4 specific postnatal days. The primary outcome was neurodevelopmental status at 2 years of age, measured by using the Bayley Scales of Infant
Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy Purpose Childhood cancer survivors (CCSs) are at increased risk for subsequent malignant neoplasms (SMNs). We evaluated the long-term risk of SMNs in a well-characterized cohort of 5-year CCSs, with a particular focus on individual chemotherapeutic agents and solid cancer risk. Methods The Dutch Childhood Cancer Oncology Group-Long-Term Effects After (...) Childhood Cancer cohort includes 6,165 5-year CCSs diagnosed between 1963 and 2001 in the Netherlands. SMNs were identified by linkages with the Netherlands Cancer Registry, the Dutch Pathology Registry, and medical chart review. We calculated standardized incidence ratios, excess absolute risks, and cumulative incidences. Multivariable Cox proportional hazard regression analyses were used to evaluate treatment-associated risks for breast cancer, sarcoma, and all solid cancers. Results After a median
Update on invasive meningococcal vaccination for Canadian children and youth Invasive meningococcal disease (IMD) is serious, often resulting in fulminant sepsis or meningitis. IMD in Canada is primarily attributable to serogroups B and C. There are routine programs for serogroup C vaccine at 12 months of age, with some jurisdictions routinely providing additional earlier doses. Adolescents routinely receive a booster dose of serogroup C vaccine or of a quadrivalent (serogroups A, C, W and Y (...) ) vaccine. Serogroup B vaccines are not recommended for routine use pending further data on the efficacy and duration of protection from the available vaccine. However, children at increased risk for IMD should start immunization for serogroups B and C as soon as possible, assuming that they are at least 2 months of age. Keywords: IMD; Meningitis; Sepsis; Vaccine
Comparative Effectiveness of Clinical-Community Childhood Obesity Interventions: A Randomized Clinical Trial Novel approaches to care delivery that leverage clinical and community resources could improve body mass index (BMI) and family-centered outcomes.To examine the extent to which 2 clinical-community interventions improved child BMI z score and health-related quality of life, as well as parental resource empowerment in the Connect for Health Trial.This 2-arm, blinded, randomized clinical (...) trial was conducted from June 2014 through March 2016, with measures at baseline and 1 year after randomization. This intent-to-treat analysis included 721 children ages 2 to 12 years with BMI in the 85th or greater percentile from 6 primary care practices in Massachusetts.Children were randomized to 1 of 2 arms: (1) enhanced primary care (eg, flagging of children with BMI ≥ 85th percentile, clinical decision support tools for pediatric weight management, parent educational materials, a Neighborhood
Behavioral Problems and Socioemotional Competence at 18 to 22 Months of Extremely Premature Children Behavior and socioemotional development are crucial aspects of child development .A total of 2505 children born at <27 weeks' gestation was evaluated at 18 to 22 months' corrected age between January 1, 2008 and December 12, 2012 (86% follow-up). The Brief Infant and Toddler Social and Emotional Assessment was used to evaluate behavioral and socioemotional problems. Cognition and language were (...) evaluated by using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). Logistic regression analysis was used to evaluate for perinatal and demographic factors associated with behavioral problems (≥75th percentile) and delayed socioemotional competence (≤15th percentile). Structural equation modeling with bootstrapping was used to identify possible associated risk factors and Bayley-III scores as mediators.Thirty-five percent (873) of children had behavioral problems, and 26
of age in the Philippines: a randomized, double-blind, placebo- controlled trial. Pediatr Infect Dis J. 2009 Jun;28(6):455-62. 18) Eskola J, et al. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. New Engl J Med 2001; 344(6):403–9. 19) Kilpi T, et al. Protective efficacy of a second pneumococcal conjugate vaccine against pneumococcal acute otitis media in infants and children: randomized, controlled trial of a 7-valent pneumococcal polysaccharide- meningococcal outer membrane (...) pneumonia (Table 1). Total 4 children and 2 children died from pneumonia due to streptococcus pneumoniae over 14 years between 1996 and 2009, and over 6 years between 2010 and 2015 respectively. Launching of PC vaccine did not have any impact. Strong association between sudden death and vaccination According to the Japanese vital statistics , the number of deaths among infants aged 2 months to 4 years old was 1,790 in 2015. Of these, when deaths from sudden infant death syndrome (SIDS) and deaths
. There are justified doubts about a comparable prognosis between adults versus children and adolescents. These are due to the partly advanced age in the adult population, but also based on the data on overall survival and progression of the disease under vandetanib presented by the company and available from the earlier dossier assessment in adults. In addition, the origin of the disease differed between the populations (mainly sporadic in adults, only hereditary in the paediatric population). Even under (...) progression or pain in children and adolescents and of their treatment, particularly in comparison with adults. ? The company presented the results of the paediatric study 98 and drew conclusions only for individual outcomes whether it considered the results under vandetanib to agree with the results from the adult study 58. Irrespective of this, the data presented by the company and available from the earlier dossier assessment on vandetanib only partly supported the postulate of a comparable course
. Guex P, Halfon O. [Hegemonic model of autism: epistemological crossroads between medicine, family and politics]. Rev Med Suisse. 2011 Sep 21;7(309):1813-6. PMID: 22016936.X-1 659. Guiraud JA, Kushnerenko E, Tomalski P, et al. Differential habituation to repeated sounds in infants at high risk for autism. Neuroreport. 2011 Nov 16;22(16):845-9. doi: 10.1097/WNR.0b013e32834c0bec. PMID: 21934535.X-1 660. Hall HR, Graff JC. The relationships among adaptive behaviors of children with autism, family (...) . 2011 May 1;81(9):1078-86. doi: 10.1016/j.bcp.2011.02.005. PMID: 21333634.X-1 665. Handen BL, Johnson CR, McAuliffe-Bellin S, et al. Safety and efficacy of donepezil in children and adolescents with autism: neuropsychological D-57 measures. J Child Adolesc Psychopharmacol. 2011 Feb;21(1):43-50. doi: 10.1089/cap.2010.0024. PMID: 21309696. 666. Hayakawa K, Kobayashi K. Physical and motor skill training for children with intellectual disabilities. Percept Mot Skills. 2011 Apr;112(2):573-80. doi
Peritoneal Dialysis vs Furosemide for Prevention of Fluid Overload in Infants After Cardiac Surgery: A Randomized Clinical Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
bone marrow aspirates of 45 pediatric AML patients and 7 healthy sibling controls. Of the measured cytokines, only IL-6 levels were associated with event-free survival. Importantly, the effect of elevated IL-6 was most striking among children classified as having a low risk of relapse. In these patients, 5-year event-free survival was 82.5% ± 11% for patients with low IL-6 levels at diagnosis (n = 14) compared with 17.3% ± 11% for patients with elevated IL-6 (n = 13, log-rank P = .0003). In vitro (...) , exogenous IL-6 reduced mitoxantrone-induced apoptosis in cell lines and primary pediatric AML samples. These results suggest that IL-6 levels at diagnosis could be used to help identify children at high risk of relapse, particularly those who are otherwise classified as low risk by current algorithms. Moreover, the IL-6 pathway could represent a target for overcoming environment-mediated chemotherapy resistance.
Infants With Congenital Adrenal Hyperplasia Are at Risk for Hypercalcemia, Hypercalciuria, and Nephrocalcinosis Hypercalcemia is reported as a rare finding in adrenal insufficiency, but is not well described in congenital adrenal hyperplasia (CAH).A retrospective chart review was conducted of patients with CAH diagnosed before the age of 2 years who had at least one recorded serum calcium measurement. Data from birth to 6 years of age were reviewed.Of the 40 patients who met inclusion criteria
The prevalence of zinc deficiency in 6-month to 12-year old children in Bandar Abbas in 2013 Zinc deficiency is an important problem in children, especially in developing countries. Zinc supplements have beneficial effects on multiple factors, including treatment of growth retardation and hypogonadism, and they can be used as therapeutic and prophylactic agents against infection in children.To determine the prevalence of zinc deficiency in 6-month to 12-year-old children in Bandar Abbas.This (...) study was done in Bandar Abbas in 2013. In this cross-sectional study, 583 children were evaluated after obtaining a written informed consent from their parents. Zinc levels < 6 μg/dl were defined as zinc deficiency, zinc levels of 80-66 μg/dl were defined as insufficient, and zinc levels of 80-115 μg/dl were defined as sufficient levels. SPSS software, version 20, descriptive statistics, the chi-squared test, and the t-test were used to analyze the data.Five hundred and eighty-three children
Re: â€œCombination of Extracorporeal Shockwave Lithotripsy and Ureteroscopy for Large Staghorn Calculi in a Pediatric Patient: Case Reportâ€ by Schults et al.: (J Endourol Case Rep 2017;3:64â€“66) 29082323 2018 11 13 2379-9889 3 1 2017 Journal of endourology case reports J Endourol Case Rep Re: "Combination of Extracorporeal Shockwave Lithotripsy and Ureteroscopy for Large Staghorn Calculi in a Pediatric Patient: Case Report" by Schults et al.: ( J Endourol Case Rep 2017;3:64-66). 101 10.1089