Latest & greatest articles for children

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Top results for children

5761. Eggs in Early Complementary Feeding and Child Growth: A Randomized Controlled Trial (Full text)

Eggs in Early Complementary Feeding and Child Growth: A Randomized Controlled Trial Eggs are a good source of nutrients for growth and development. We hypothesized that introducing eggs early during complementary feeding would improve child nutrition.A randomized controlled trial was conducted in Cotopaxi Province, Ecuador, from March to December 2015. Children ages 6 to 9 months were randomly assigned to treatment (1 egg per day for 6 months [n = 83]) and control (no intervention [n = 80 (...) ; 95% CI, 0.51-0.97) compared with control.The findings supported our hypothesis that early introduction of eggs significantly improved growth in young children. Generally accessible to vulnerable groups, eggs have the potential to contribute to global targets to reduce stunting.Copyright © 2017 by the American Academy of Pediatrics.

2017 EvidenceUpdates PubMed abstract

5762. Epidemiology of Live Born Infants with Nonimmune Hydrops Fetalis-Insights from a Population-Based Dataset (Abstract)

Epidemiology of Live Born Infants with Nonimmune Hydrops Fetalis-Insights from a Population-Based Dataset To evaluate the incidence, etiology, and 1-year mortality of nonimmune hydrops fetalis (NIHF) and to identify risk factors for mortality in a contemporary population-based dataset.The California Office of Statewide Health Planning and Development maintains a database linking maternal and infant hospital discharge, readmissions, and birth and death certificate date from 1 year before to 1 (...) year after birth. We searched the database (2005-2012) for infants with NIHF (identified by the International Classification of Diseases, 9th Revision, Clinical Modification code). Hazard models were used to identify risk factors for mortality in infants with NIHF; results are presented as hazard ratios (HRs, 95% CI).The incidence of NIHF was 2.5 out of 10 000 among live born infants. Neonatal mortality was 35.1% (364 out of 1037) and overall mortality was 43.2% (448 out of 1037) at 1 year of age

2017 EvidenceUpdates

5763. Supplemental Iodide for Preterm Infants and Developmental Outcomes at 2 Years: An RCT (Full text)

Supplemental Iodide for Preterm Infants and Developmental Outcomes at 2 Years: An RCT The recommendation for enteral iodide intake for preterm infants is 30 to 40 μg/kg per day and 1 μg/kg per day for parenteral intake. Preterm infants are vulnerable to iodide insufficiency and thyroid dysfunction. The hypothesis tested whether, compared with placebo, iodide supplementation of preterm infants improves neurodevelopment.A randomized controlled trial of iodide supplementation versus placebo (...) in infants <31 weeks' gestation. Trial solutions (sodium iodide or sodium chloride; dose 30 μg/kg per day) were given within 42 hours of birth to the equivalent of 34 weeks' gestation. The only exclusion criterion was maternal iodide exposure during pregnancy or delivery. Whole blood levels of thyroxine, thyrotropin, and thyroid-binding globulin were measured on 4 specific postnatal days. The primary outcome was neurodevelopmental status at 2 years of age, measured by using the Bayley Scales of Infant

2017 EvidenceUpdates PubMed abstract

5764. Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy (Full text)

Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy Purpose Childhood cancer survivors (CCSs) are at increased risk for subsequent malignant neoplasms (SMNs). We evaluated the long-term risk of SMNs in a well-characterized cohort of 5-year CCSs, with a particular focus on individual chemotherapeutic agents and solid cancer risk. Methods The Dutch Childhood Cancer Oncology Group-Long-Term Effects After (...) Childhood Cancer cohort includes 6,165 5-year CCSs diagnosed between 1963 and 2001 in the Netherlands. SMNs were identified by linkages with the Netherlands Cancer Registry, the Dutch Pathology Registry, and medical chart review. We calculated standardized incidence ratios, excess absolute risks, and cumulative incidences. Multivariable Cox proportional hazard regression analyses were used to evaluate treatment-associated risks for breast cancer, sarcoma, and all solid cancers. Results After a median

2017 EvidenceUpdates PubMed abstract

5765. Update on invasive meningococcal vaccination for Canadian children and youth

Update on invasive meningococcal vaccination for Canadian children and youth Invasive meningococcal disease (IMD) is serious, often resulting in fulminant sepsis or meningitis. IMD in Canada is primarily attributable to serogroups B and C. There are routine programs for serogroup C vaccine at 12 months of age, with some jurisdictions routinely providing additional earlier doses. Adolescents routinely receive a booster dose of serogroup C vaccine or of a quadrivalent (serogroups A, C, W and Y (...) ) vaccine. Serogroup B vaccines are not recommended for routine use pending further data on the efficacy and duration of protection from the available vaccine. However, children at increased risk for IMD should start immunization for serogroups B and C as soon as possible, assuming that they are at least 2 months of age. Keywords: IMD; Meningitis; Sepsis; Vaccine

2017 Canadian Paediatric Society

5766. Comparative Effectiveness of Clinical-Community Childhood Obesity Interventions: A Randomized Clinical Trial (Full text)

Comparative Effectiveness of Clinical-Community Childhood Obesity Interventions: A Randomized Clinical Trial Novel approaches to care delivery that leverage clinical and community resources could improve body mass index (BMI) and family-centered outcomes.To examine the extent to which 2 clinical-community interventions improved child BMI z score and health-related quality of life, as well as parental resource empowerment in the Connect for Health Trial.This 2-arm, blinded, randomized clinical (...) trial was conducted from June 2014 through March 2016, with measures at baseline and 1 year after randomization. This intent-to-treat analysis included 721 children ages 2 to 12 years with BMI in the 85th or greater percentile from 6 primary care practices in Massachusetts.Children were randomized to 1 of 2 arms: (1) enhanced primary care (eg, flagging of children with BMI ≥ 85th percentile, clinical decision support tools for pediatric weight management, parent educational materials, a Neighborhood

2017 EvidenceUpdates PubMed abstract

5767. Behavioral Problems and Socioemotional Competence at 18 to 22 Months of Extremely Premature Children (Full text)

Behavioral Problems and Socioemotional Competence at 18 to 22 Months of Extremely Premature Children Behavior and socioemotional development are crucial aspects of child development .A total of 2505 children born at <27 weeks' gestation was evaluated at 18 to 22 months' corrected age between January 1, 2008 and December 12, 2012 (86% follow-up). The Brief Infant and Toddler Social and Emotional Assessment was used to evaluate behavioral and socioemotional problems. Cognition and language were (...) evaluated by using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). Logistic regression analysis was used to evaluate for perinatal and demographic factors associated with behavioral problems (≥75th percentile) and delayed socioemotional competence (≤15th percentile). Structural equation modeling with bootstrapping was used to identify possible associated risk factors and Bayley-III scores as mediators.Thirty-five percent (873) of children had behavioral problems, and 26

2017 EvidenceUpdates PubMed abstract

5768. Pneumococcal and Hib vaccines for children - Harms may outweigh benefits: not recommended

of age in the Philippines: a randomized, double-blind, placebo- controlled trial. Pediatr Infect Dis J. 2009 Jun;28(6):455-62. 18) Eskola J, et al. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. New Engl J Med 2001; 344(6):403–9. 19) Kilpi T, et al. Protective efficacy of a second pneumococcal conjugate vaccine against pneumococcal acute otitis media in infants and children: randomized, controlled trial of a 7-valent pneumococcal polysaccharide- meningococcal outer membrane (...) pneumonia (Table 1). Total 4 children and 2 children died from pneumonia due to streptococcus pneumoniae over 14 years between 1996 and 2009, and over 6 years between 2010 and 2015 respectively. Launching of PC vaccine did not have any impact. Strong association between sudden death and vaccination According to the Japanese vital statistics [10], the number of deaths among infants aged 2 months to 4 years old was 1,790 in 2015. Of these, when deaths from sudden infant death syndrome (SIDS) and deaths

2017 Med Check - The Informed Prescriber

5769. Asfotase alfa for treating paediatric-onset hypophosphatasia

outside these recommendations may continue without change to the funding arrangements in place for them before this guidance was published, until they and their NHS clinician consider it appropriate to stop. For children and young people, this decision should be made jointly by the clinician and the child or young person or the child or young person's parents or carers. Asfotase alfa for treating paediatric-onset hypophosphatasia (HST6) © NICE 2019. All rights reserved. Subject to Notice of rights (...) highlighted that the parents of 1 infant understood that, without asfotase alfa, their child was unlikely to survive to 9 months. Clinical evidence 4.3 The company did a systematic literature review to identify studies evaluating the clinical effectiveness of asfotase alfa for treating paediatric-onset hypophosphatasia. It found 4 open-label phase II studies of asfotase alfa (2 of which had associated extension studies): ENB-002-08, a non-randomised 24-week single-arm study in 11 people of 36 months

2017 National Institute for Health and Clinical Excellence - Highly specialised technology

5770. Vandetanib (medullary thyroid carcinoma in children and adolescents from the age of 5) ? Benefit assessment according to § 35a Social Code Book V

. There are justified doubts about a comparable prognosis between adults versus children and adolescents. These are due to the partly advanced age in the adult population, but also based on the data on overall survival and progression of the disease under vandetanib presented by the company and available from the earlier dossier assessment in adults. In addition, the origin of the disease differed between the populations (mainly sporadic in adults, only hereditary in the paediatric population). Even under (...) progression or pain in children and adolescents and of their treatment, particularly in comparison with adults. ? The company presented the results of the paediatric study 98 and drew conclusions only for individual outcomes whether it considered the results under vandetanib to agree with the results from the adult study 58. Irrespective of this, the data presented by the company and available from the earlier dossier assessment on vandetanib only partly supported the postulate of a comparable course

2017 Institute for Quality and Efficiency in Healthcare (IQWiG)

5771. Interventions Targeting Sensory Challenges in Children with Autism Spectrum Disorder - An Update

. Guex P, Halfon O. [Hegemonic model of autism: epistemological crossroads between medicine, family and politics]. Rev Med Suisse. 2011 Sep 21;7(309):1813-6. PMID: 22016936.X-1 659. Guiraud JA, Kushnerenko E, Tomalski P, et al. Differential habituation to repeated sounds in infants at high risk for autism. Neuroreport. 2011 Nov 16;22(16):845-9. doi: 10.1097/WNR.0b013e32834c0bec. PMID: 21934535.X-1 660. Hall HR, Graff JC. The relationships among adaptive behaviors of children with autism, family (...) . 2011 May 1;81(9):1078-86. doi: 10.1016/j.bcp.2011.02.005. PMID: 21333634.X-1 665. Handen BL, Johnson CR, McAuliffe-Bellin S, et al. Safety and efficacy of donepezil in children and adolescents with autism: neuropsychological D-57 measures. J Child Adolesc Psychopharmacol. 2011 Feb;21(1):43-50. doi: 10.1089/cap.2010.0024. PMID: 21309696. 666. Hayakawa K, Kobayashi K. Physical and motor skill training for children with intellectual disabilities. Percept Mot Skills. 2011 Apr;112(2):573-80. doi

2017 Effective Health Care Program (AHRQ)

5772. Developmental follow-up of children and young people born preterm

that their child's developmental (corrected) age, which is calculated from their original due date (and not the date they were born), will be used for the first 2 years when assessing their functional and developmental skills (such as walking and talking). 1.1.14 Advise parents or carers to talk to their health visitor or GP if they have any concerns about their child's development at any stage of childhood or adolescence. Car Care, support and follow-up after discharge e, support and follow-up after discharge (...) function problems at preschool and school ages, and that prevalence increases with decreasing gestational age. Speech, language and communication Speech, language and communication 1.2.10 Be aware that children born preterm are at increased risk of speech, language and communication problems and disorders, and that the following are Developmental follow-up of children and young people born preterm (NG72) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms

2017 National Institute for Health and Clinical Excellence - Clinical Guidelines

5773. Physical restraint of acting-out children

Physical restraint of acting-out children Physical restraint of acting-out children We use cookies on this website. By using this site, you agree that we may store and access cookies on your device. Swedish Agency for Health Technology Assessment and Assessment of Social Services Physical restraint of acting-out children Share: Reading time approx. 1 minute Staff in kindergartens, schools and residential treatments sometimes intervene physically when a child is acting out, by physically (...) restraining the child. This is an immediate and temporary measure that is used when verbal intervention doesn´t work and the child is in danger of hurting himself or others. Physical restraint means that the staff sits down and restrain the child in the lap, stand up and restrain the child in arms and legs or lay down the child on the floor and restrain him or her there. To use physical restraint routinely is controversial. Physical restraint can be perceived as offensive and can also harm the child

2017 Swedish Council on Technology Assessement

5774. Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis

Resuscitation With Balanced Fluids Is Associated With Improved Survival in Pediatric Severe Sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

5775. Peritoneal Dialysis vs Furosemide for Prevention of Fluid Overload in Infants After Cardiac Surgery: A Randomized Clinical Trial

Peritoneal Dialysis vs Furosemide for Prevention of Fluid Overload in Infants After Cardiac Surgery: A Randomized Clinical Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

5776. Patterns of Postoperative Delirium in Children

Patterns of Postoperative Delirium in Children PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

5777. Interleukin-6 levels predict event-free survival in pediatric AML and suggest a mechanism of chemotherapy resistance (Full text)

bone marrow aspirates of 45 pediatric AML patients and 7 healthy sibling controls. Of the measured cytokines, only IL-6 levels were associated with event-free survival. Importantly, the effect of elevated IL-6 was most striking among children classified as having a low risk of relapse. In these patients, 5-year event-free survival was 82.5% ± 11% for patients with low IL-6 levels at diagnosis (n = 14) compared with 17.3% ± 11% for patients with elevated IL-6 (n = 13, log-rank P = .0003). In vitro (...) , exogenous IL-6 reduced mitoxantrone-induced apoptosis in cell lines and primary pediatric AML samples. These results suggest that IL-6 levels at diagnosis could be used to help identify children at high risk of relapse, particularly those who are otherwise classified as low risk by current algorithms. Moreover, the IL-6 pathway could represent a target for overcoming environment-mediated chemotherapy resistance.

2017 Blood advances PubMed abstract

5778. Infants With Congenital Adrenal Hyperplasia Are at Risk for Hypercalcemia, Hypercalciuria, and Nephrocalcinosis (Full text)

Infants With Congenital Adrenal Hyperplasia Are at Risk for Hypercalcemia, Hypercalciuria, and Nephrocalcinosis Hypercalcemia is reported as a rare finding in adrenal insufficiency, but is not well described in congenital adrenal hyperplasia (CAH).A retrospective chart review was conducted of patients with CAH diagnosed before the age of 2 years who had at least one recorded serum calcium measurement. Data from birth to 6 years of age were reviewed.Of the 40 patients who met inclusion criteria

2017 Journal of the Endocrine Society PubMed abstract

5779. The prevalence of zinc deficiency in 6-month to 12-year old children in Bandar Abbas in 2013 (Full text)

The prevalence of zinc deficiency in 6-month to 12-year old children in Bandar Abbas in 2013 Zinc deficiency is an important problem in children, especially in developing countries. Zinc supplements have beneficial effects on multiple factors, including treatment of growth retardation and hypogonadism, and they can be used as therapeutic and prophylactic agents against infection in children.To determine the prevalence of zinc deficiency in 6-month to 12-year-old children in Bandar Abbas.This (...) study was done in Bandar Abbas in 2013. In this cross-sectional study, 583 children were evaluated after obtaining a written informed consent from their parents. Zinc levels < 6 μg/dl were defined as zinc deficiency, zinc levels of 80-66 μg/dl were defined as insufficient, and zinc levels of 80-115 μg/dl were defined as sufficient levels. SPSS software, version 20, descriptive statistics, the chi-squared test, and the t-test were used to analyze the data.Five hundred and eighty-three children

2017 Electronic physician PubMed abstract

5780. Re: “Combination of Extracorporeal Shockwave Lithotripsy and Ureteroscopy for Large Staghorn Calculi in a Pediatric Patient: Case Report” by Schults et al.: (J Endourol Case Rep 2017;3:64–66) (Full text)

Re: “Combination of Extracorporeal Shockwave Lithotripsy and Ureteroscopy for Large Staghorn Calculi in a Pediatric Patient: Case Report” by Schults et al.: (J Endourol Case Rep 2017;3:64–66) 29082323 2018 11 13 2379-9889 3 1 2017 Journal of endourology case reports J Endourol Case Rep Re: "Combination of Extracorporeal Shockwave Lithotripsy and Ureteroscopy for Large Staghorn Calculi in a Pediatric Patient: Case Report" by Schults et al.: ( J Endourol Case Rep 2017;3:64-66). 101 10.1089

2017 Journal of endourology case reports PubMed abstract