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The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on children or other clinical topics then use Trip today.
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Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. To assess the association between macrolide antibiotics prescribing during pregnancy and major malformations, cerebral palsy, epilepsy, attention deficit hyperactivity disorder, and autism spectrum disorder in children.Population based cohort study.The UK Clinical Practice Research Datalink.The study cohort included 104 605 children born from 1990 to 2016 (...) whose mothers were prescribed one macrolide monotherapy (erythromycin, clarithromycin, or azithromycin) or one penicillin monotherapy from the fourth gestational week to delivery. Two negative control cohorts consisted of 82 314 children whose mothers were prescribed macrolides or penicillins before conception, and 53 735 children who were siblings of the children in the study cohort.Risks of any major malformations and system specific major malformations (nervous, cardiovascular, gastrointestinal
Trial , , , , Affiliations Expand Affiliations 1 Division of Children's Health Services Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis. 2 Regenstrief Institute Inc, Indianapolis, Indiana. 3 Axon Health Associates LLC, Indianapolis, Indiana. 4 Department of Biostatistics, Indiana University School of Medicine, Indianapolis. 5 Division of Pediatric and Adolescent Comparative Effectiveness Research, Department of Pediatrics, Indiana University School of Medicine (...) , Indianapolis. PMID: 31851348 PMCID: DOI: Item in Clipboard Effect of a Computer-Based Decision Support Intervention on Autism Spectrum Disorder Screening in Pediatric Primary Care Clinics: A Cluster Randomized Clinical Trial Stephen M Downs et al. JAMA Netw Open . 2019 Show details JAMA Netw Open Actions , 2 (12), e1917676 Authors , , , , Affiliations 1 Division of Children's Health Services Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis. 2 Regenstrief Institute Inc
are present (see Table 3B). • For pediatric patients meeting severe or fulminant clinical criteria (Table 3B), or having risk factors associated with severe CDI disease (Table 3B), testing should be performed as described above (Figure 2), and empiric therapy should be strongly considered while awaiting results. The majority of CDI in infants and children is of mild to moderate disease severity criteria. 21,22,63 Applying the same criteria for adult severe disease to pediatric populations tends (...) in Adults and Children 12/2019 Key Points for Patients =18 Years of Age: Diagnosis The decision to test children for CDI is complicated given a high rate of asymptomatic carriage, especially in infants 15,000 cells/mm 3 ]) ? Abdominal pain with radiographic evidence of bowel thickening ? Radiographic evidence of toxic megacolon OR 2. Colonoscopic or histopathologic evidence of pseudomembranous colitis. 6 UMHS C. difficile Infection in Adults and Children 12/2019 Table 3A. Classification and Treatment
the quality of all the studies, extracted all relevant data from them, and then combined and summarised the results. The relationship between childhood socioeconomic position and Adverse Childhood Experiences (ACEs) This research set out to better understand the relationship between the socioeconomic circumstances in which children are raised and their risk of experiencing Adverse Childhood Experiences (ACEs). The research was conducted with colleagues at NHS Health Scotland and NHS Greater Glasgow (...) was to better understand this by means of a detailed examination of the evidence. Although a vast amount of research has been published in recent years on the topic of ACEs, remarkably few of these studies have examined the relationship with childhood SEP. We found more evidence of this relationship in the (largely American) literature on the topic of ‘child maltreatment’. Although this is a more specific issue, the definition overlaps considerably with ‘standard’ definitions of ACEs used in different
Plerixafor (Mozobil) - children aged 1 year to <18 years with lymphoma or solid malignant tumours Published 10 February 2020 1 Product update SMC2249 plerixafor 20mg/mL solution for injection (Mozobil®) Sanofi Aventis 10 January 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following an abbreviated (...) submission plerixafor (Mozobil®) is accepted for use within NHSScotland. Indication under review: in combination with granulocyte-colony stimulating factor (G-CSF) to enhance mobilisation of haematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in children aged 1 year to <18 years with lymphoma or solid malignant tumours, either: - pre-emptively, when circulating stem cell count on the predicted day of collection after adequate mobilisation with G-CSF
Voretigene neparvovec (Luxturna) - For the treatment of adult and paediatric patients with vision loss due to inherited retinal dystrophy caused by confirmed biallelic RPE65 mutations www.scottishmedicines.org.uk Assessment explained Medicine: voretigene neparvovec (brand name: Luxturna®) for inherited retinal dystrophy due to biallelic RPE65 mutations Novartis Pharmaceuticals UK Ltd Voretigene neparvovec meets the SMC definition of an ultra-orphan medicine, which is a medicine to treat (...) an extremely rare condition. This document summarises the initial SMC assessment of voretigene neparvovec. What is voretigene neparvovec used for? Voretigene neparvovec is used to treat adults and children with loss of vision due to inherited retinal dystrophy, which is a rare genetic condition that affects the light sensing cells at the back of the eye (retina). Voretigene neparvovec is for use in patients who still have enough working cells left in the retina and when the disease is caused by mutations
Taskforce Charter: National Quality Improvement Taskforce for children and young people’s mental health inpatient services NHS England » Taskforce Charter: National Quality Improvement Taskforce for children and young people’s mental health inpatient services Search Search Menu Taskforce Charter: National Quality Improvement Taskforce for children and young people’s mental health inpatient services Document first published: 24 January 2020 Page updated: 24 January 2020 Topic: , Publication type (...) : This document provides details of our vision is for mental health, learning disability, and autism inpatient services to be delivered to the consistently high standard that children and young people deserve. Document PDF 169 KB 3 pages
Joint AAD-NPF guidelines of care for the management and treatment of psoriasis in pediatric patients Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis in pediatric patients - Journal of the American Academy of Dermatology Email/Username: Password: Remember me Search JAAD & JAAD Case Reports Search Terms Search within Search Volume 82, Issue 1, Pages 161–201 To read this article in full, please review your options (...) for gaining access at the bottom of the page. Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis in pediatric patients x Alan Menter Affiliations Baylor University Medical Center, Dallas, Texas , MD (Co-Chair) a , x Kelly M. Cordoro Affiliations University of California, San Francisco School of Medicine, Department of Dermatology, San Francisco, California , MD b , x Dawn M.R. Davis Affiliations Mayo Clinic, Rochester
. Division of Developmental Medicine, Boston Children’s Hospital, Boston, MA 24 2 7. Departments of Pediatrics and Psychiatry, The Ohio State University College of 1 Medicine, Columbus 2 8. Duke Center for Autism and Brain Development, Duke Institute for Brain Sciences, and 3 Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, 4 Durham, NC 5 9. Northern Michigan Neurology, Traverse City 6 10. Department of Child and Behavioral Sciences, Johns Hopkins University (...) Stephen Ashwal, MD 14 15 16 1. Pediatrics and Developmental Neuroscience Branch, National Institute of Mental Health, 17 NIH, Bethesda, MD 18 2. Department of Neurological Sciences, University of Vermont Medical Center, Burlington 19 3. Department of Pediatric Neurology, McGill University Health Centre, Montréal, Québec, 20 Canada 21 4. Department of Neurology, University of Florida College of Medicine, Gainesville 22 5. Developmental Pediatrics, Our Special KidsPediatric Care, Los Angeles, CA 23 6
Beta-lactam allergy in the paediatric population Beta-lactam allergy is commonly diagnosed in paediatric patients, but over 90% of individuals reporting this allergy are able to tolerate the medications prescribed after evaluation by an allergist. Beta-lactam allergy labels are associated with negative clinical and administrative outcomes, including use of less desirable alternative antibiotics, longer hospitalizations, increasing antibiotic-resistant infections, and greater medical costs. Also (...) , children with true IgE-mediated allergy to penicillin medications are often advised to avoid all beta-lactam antibiotics, including cephalosporins, which is likely unnecessary in greater than 97% of those reporting penicillin allergies. Most patients can be safely treated with penicillin or amoxicillin if they do not have a history compatible with IgE-mediated or systemic, delayed reactions such as Stevens-Johnson syndrome (SJS), serum sickness-like reactions, drug reaction with eosinophilia
Dietary intake of sodium by children: Why it matters Dietary sodium is required in very small amounts to support circulating blood volume and blood pressure (BP). Available nutritional surveillance data suggest that most Canadian children consume sodium in excess of their dietary requirements. Approximately 80% of the sodium Canadians consume comes from processed and packaged foods. High sodium intakes in children may be an indicator of poor diet quality. Results from systematic reviews (...) and meta-analyses have demonstrated that decreasing dietary sodium in children leads to small but clinically insignificant decreases in BP. However, population-level strategies to reduce sodium consumption, such as food product reformulation, modifying food procurement processes, and federal healthy eating policies, are important public health initiatives that can produce meaningful reductions in sodium consumption and help to prevent chronic disease in adulthood. Keywords: Blood pressure; Children
Expand Affiliations 1 Centre for International Child Health, University of Melbourne, MCRI, Royal Children's Hospital, Parkville, Australia. 2 Department of Paediatrics, University College Hospital, Ibadan, Nigeria. 3 Department of Paediatrics, University of Ibadan, Ibadan, Nigeria. 4 Nossal Institute for Global Health, University of Melbourne, Parkville, Australia. 5 Ashdown Consultants, Hartfield, England. 6 Biomedical Services, University College Hospital, Ibadan, Nigeria. 7 Asia-Pacific Health (...) , New Vaccines, MCRI, Royal Children's Hospital, Parkville, Australia. 8 Clinical Epidemiology and Biostatistics Unit, MCRI, Royal Children's Hospital, Parkville, Australia. 9 Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Australia. 10 Department of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerland. 11 Bill and Melinda Gates Foundation, Seattle, Washington, United States of America. PMID: 31710601 PMCID: DOI
2019 American Heart Association Focused Update on Pediatric Advanced Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care This 2019 focused update to the American Heart Association pediatric advanced life support guidelines follows the 2018 and 2019 systematic reviews performed by the Pediatric Life Support Task Force of the International Liaison Committee on Resuscitation. It aligns with the continuous evidence (...) review process of the International Liaison Committee on Resuscitation, with updates published when the International Liaison Committee on Resuscitation completes a literature review based on new published evidence. This update provides the evidence review and treatment recommendations for advanced airway management in pediatric cardiac arrest, extracorporeal cardiopulmonary resuscitation in pediatric cardiac arrest, and pediatric targeted temperature management during post-cardiac arrest care
Treatment Effect of Omalizumab on Severe Pediatric Atopic Dermatitis: The ADAPT Randomized Clinical Trial Systemic treatments for severe childhood atopic dermatitis have limited evidence and/or are unlicensed. Despite the efficacy of anti-IgE medication (omalizumab) in the treatment of atopy, no large randomized studies in childhood atopic dermatitis have been published.To determine the effectiveness of omalizumab in treating severe atopic dermatitis in children.The Atopic Dermatitis Anti-IgE (...) -of-life scores were seen in the omalizumab group, as measured by the Children's Dermatology Life Quality Index/Dermatology Life Quality Index (-3.5; 95% CI, -6.4 to -0.5) and Pediatric Allergic Disease Quality of Life Questionnaire score (-0.5; 95% CI, -0.9 to -0.0). Improvements in disease severity occurred despite lower potent topical corticosteroid use in the omalizumab group compared with the placebo group (median [interquartile range (IQR)] percentage of body surface area covered, 16% [10%-46
Asthma: School-Based Self-Management Interventions for Children and Adolescents with Asthma Asthma: School-Based Self-Management | The Community Guide Welcome to The Community Guide! Let us know what you think of the website by completing this . Open Navigation or Search form Search Search The Community Guide You are here » Systematic Review Topic Recommended (strong evidence) July 2019 Audience Adolescents and Young Adults Children/Infants Setting School Strategy Case Management Counseling (...) JL, Hazell J. Randomized controlled trial of a teacher-led asthma education program. Pediatric Pulmonology 2004;38(6):434–42. Horner SD, Fouladi RT. Improvement of rural children’s asthma self-management by lay health educators. Journal of School Health 2008;78(9):506–13. Horner SD, Brown A, Brown SA, Rew DL. Enhancing asthma self-management in rural school-aged children: a randomized controlled trial. Journal of Rural Health 2015;32(3):260–8. Howell KJ. “Quest for the Code”: A Study
European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia This document provides recommendations for monitoring and treatment of children in whom bronchopulmonary dysplasia (BPD) has been established and who have been discharged from the hospital, or who were >36 weeks of postmenstrual age. The guideline was based on predefined Population, Intervention, Comparison and Outcomes (PICO) questions relevant for clinical care, a systematic review (...) in a subgroup only, for example severe BPD or recurrent hospitalisations, and monitoring with lung function in all children. We suggest to give individual advice to parents regarding daycare attendance. With regards to treatment, we suggest the use of bronchodilators in a subgroup only, for example asthma-like symptoms, or reversibility in lung function; no treatment with inhaled or systemic corticosteroids; natural weaning of diuretics by the relative decrease in dose with increasing weight gain