Latest & greatest articles for chlorhexidine

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on chlorhexidine or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on chlorhexidine and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for chlorhexidine

101. Systematic review and cost analysis comparing use of chlorhexidine with use of iodine for preoperative skin antisepsis to prevent surgical site infection

Systematic review and cost analysis comparing use of chlorhexidine with use of iodine for preoperative skin antisepsis to prevent surgical site infection Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2010 NHS Economic Evaluation Database.

102. Herbal mouthwash more effective than OTC mouthwash and may be as effective as chlorhexidine rinse.

Herbal mouthwash more effective than OTC mouthwash and may be as effective as chlorhexidine rinse. UTCAT479, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Herbal mouthwash more effective than OTC mouthwash and may be as effective as chlorhexidine rinse Clinical Question Can herbal mouthwash be as effective as OTC mouthwash at preventing gum disease? Clinical Bottom Line In vivo, both herbal mouth and gum therapy (...) and Peridex were significantly more effective at inhibiting microbial growth than Listerine. In vitro, Chlorhexidine rinse was the most effective; herbal rinse was less effective than chlorhexidine but more effective than an essential oil rinse. (See Comments on the CAT below) Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Haffajee/2008 120 inoculated plates In vitro study Key results In vitro, Chlorhexidine

2010 UTHSCSA Dental School CAT Library

103. Chlorhexidine Applications Improve Oral Health of Patients with Down Syndrome

Chlorhexidine Applications Improve Oral Health of Patients with Down Syndrome UTCAT466, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Chlorhexidine Applications Improve Oral Health of Patients with Down Syndrome Clinical Question In a patient with Down Syndrome and poor oral hygiene, will chlorhexidine applications prove more successful at increasing the patient’s overall oral health versus no treatment? Clinical (...) Bottom Line Chlorhexidine applications in a 2% sustained-delivery dosage form along with rinses with 0.2% chlorhexidine mouthwash and brushing with 1% chlorhexidine gel improve the oral health of patients with Down Syndrome. (See Comments on the CAT below) Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Stabholz/1991 30 subjects with Down Syndrome; 10 received placebo, 10 received chlorhexidine solution

2010 UTHSCSA Dental School CAT Library

104. Randomised controlled trial: Preoperative skin cleansing with chlorhexidine-alcohol reduces surgical site infection after clean-contaminated surgery compared with povidone-iodine

Randomised controlled trial: Preoperative skin cleansing with chlorhexidine-alcohol reduces surgical site infection after clean-contaminated surgery compared with povidone-iodine Preoperative skin cleansing with chlorhexidine-alcohol reduces surgical site infection after clean-contaminated surgery compared with povidone-iodine | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser (...) at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Preoperative skin cleansing with chlorhexidine-alcohol reduces

2010 Evidence-Based Nursing

105. Chlorhexidine gel reduces incidence of alveolar osteitis after extraction of the mandibular third molars. Full Text available with Trip Pro

Chlorhexidine gel reduces incidence of alveolar osteitis after extraction of the mandibular third molars. A randomised, prospective clinical trial with parallel groups was carried out in a single centre.The experimental (gel) group (n=41) applied a bioadhesive 0.2% chlorhexidine gel to the wound during the first postoperative week and a control (rinse) group (n=32) used a 0.12% (v/v) chlorhexidine mouthrinse during the first week following third molar extraction. Patients were evaluated (...) on the third and seventh postoperative day.Alveolar osteitis was evaluated according to Blum's criteria..A 70% decrease in postoperative alveolar osteitis in the gel group (P 0.04) was observed. The rinse group had 25% incidence of postoperative alveolar osteitis, whereas the gel group had 7.5%. T equates to a number needed to treat of six (95% confidence interval, 3-144).It was concluded that the topical application of bioadhesive chlorhexidine gel to the surgical wound during the postoperative week may

2009 Evidence-based dentistry Controlled trial quality: uncertain

106. Oropharyngeal cleansing with 0.2% chlorhexidine for prevention of nosocomial pneumonia in critically ill patients: an open-label randomized trial with 0.01% potassium permanganate as control (Abstract)

Oropharyngeal cleansing with 0.2% chlorhexidine for prevention of nosocomial pneumonia in critically ill patients: an open-label randomized trial with 0.01% potassium permanganate as control Oral cleansing with chlorhexidine decreases the incidence of nosocomial pneumonia in patients after cardiac surgery. However, evidence of its benefit in ICU patients is conflicting.Patients admitted to the ICU of an Indian tertiary care teaching hospital were randomized to twice-daily oropharyngeal (...) cleansing with 0.2% chlorhexidine or 0.01% potassium permanganate (control) solution. Effects on the incidence of nosocomial pneumonia during ICU stay (primary outcome) and length of ICU stay and in-hospital mortality (secondary outcomes) were studied.Five hundred twelve patients were randomized to either the chlorhexidine group (n = 250) or the control group (n = 262). Of the 471 subjects who completed the protocol, nosocomial pneumonia developed in 16 of 224 subjects (7.1%) in the chlorhexidine group

2009 EvidenceUpdates Controlled trial quality: predicted high

107. Chlorhexidine maternal-vaginal and neonate body wipes in sepsis and vertical transmission of pathogenic bacteria in South Africa: a randomised, controlled trial. (Abstract)

Chlorhexidine maternal-vaginal and neonate body wipes in sepsis and vertical transmission of pathogenic bacteria in South Africa: a randomised, controlled trial. About 500,000 sepsis-related deaths per year arise in the first 3 days of life. On the basis of results from non-randomised studies, use of vaginal chlorhexidine wipes during labour has been proposed as an intervention for the prevention of early-onset neonatal sepsis in developing countries. We therefore assessed the efficacy (...) of chlorhexidine in early-onset neonatal sepsis and vertical transmission of group B streptococcus.In a trial in Soweto, South Africa, 8011 women (aged 12-51 years) were randomly assigned in a 1:1 ratio to chlorhexidine vaginal wipes or external genitalia water wipes during active labour, and their 8129 newborn babies were assigned to full-body (intervention group) or foot (control group) washes with chlorhexidine at birth, respectively. In a subset of mothers (n=5144), we gathered maternal lower vaginal swabs

2009 Lancet Controlled trial quality: predicted high

108. Intravascular catheter dressings with chlorhexidine-impregnated sponges reduced infections in the ICU

Intravascular catheter dressings with chlorhexidine-impregnated sponges reduced infections in the ICU Intravascular catheter dressings with chlorhexidine-impregnated sponges reduced infections in the ICUCommentary | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Intravascular catheter dressings with chlorhexidine-impregnated sponges reduced infections in the ICUCommentary Article Text Treatment Intravascular catheter dressings

2009 Evidence-Based Nursing

109. Chlorhexidine and Caries Incidence In School-Based Programs

Chlorhexidine and Caries Incidence In School-Based Programs UTCAT452, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Chlorhexidine Does not Reduce Caries Incidence In School-Based Programs Compared with Regular Fluoride Use and Oral Hygiene Clinical Question In school-based programs with children and adolescents, is it more beneficial to use Chlorhexidine to prevent dental caries compared to fluoride treatment (...) ? Clinical Bottom Line In school-based programs, repeated application of chlorhexidine does not lower the caries incidence in young individuals any more than regular fluoride use and oral hygiene practices. (See Comments on the CAT below) Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Ersin/2008 149 eleven to thirteen year olds with high caries risk and low caries incidence Randomized Clinical Trial Key

2009 UTHSCSA Dental School CAT Library

110. Preoperative whole-body bathing with chlorhexidine gluconate for prevention of surgical site infection

Preoperative whole-body bathing with chlorhexidine gluconate for prevention of surgical site infection Preoperative whole-body bathing with chlorhexidine gluconate for prevention of surgical site infection Preoperative whole-body bathing with chlorhexidine gluconate for prevention of surgical site infection Citation Preoperative whole-body bathing with chlorhexidine gluconate for prevention of surgical site infection. Lansdale: HAYES, Inc.. 2009 Authors' objectives

Surgical site infections (...) (SSIs) occur in approximately 2.0% to 3.5% of surgeries and have potentially serious consequences including death. These infections prolong hospitalization and increase costs. Whole-body bathing with an antiseptic such as chlorhexidine gluconate is widely employed before surgery to decrease the number of bacteria on the skin, in an attempt to decrease the incidence of SSIs. Despite their widespread use, it has not been conclusively shown that bathing or showering with these antiseptics actually

2009 Health Technology Assessment (HTA) Database.

111. Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: a randomized controlled trial. Full Text available with Trip Pro

Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: a randomized controlled trial. Use of a chlorhexidine gluconate-impregnated sponge (CHGIS) in intravascular catheter dressings may reduce catheter-related infections (CRIs). Changing catheter dressings every 3 days may be more frequent than necessary.To assess superiority of CHGIS dressings regarding the rate of major CRIs (clinical sepsis with or without

2009 JAMA Controlled trial quality: predicted high

112. Decontamination of the nasopharynx and oropharynx with chlorhexidine reduced nosocomial infections in cardiac surgery

Decontamination of the nasopharynx and oropharynx with chlorhexidine reduced nosocomial infections in cardiac surgery Decontamination of the nasopharynx and oropharynx with chlorhexidine reduced nosocomial infections in cardiac surgery | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username (...) and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Decontamination of the nasopharynx and oropharynx with chlorhexidine reduced nosocomial infections in cardiac surgery Article Text Treatment Decontamination

2008 Evidence-Based Nursing

113. Use of chlorhexidine varnishes in preventing and treating periodontal disease: a review of the literature

Use of chlorhexidine varnishes in preventing and treating periodontal disease: a review of the literature Use of chlorhexidine varnishes in preventing and treating periodontal disease: a review of the literature Use of chlorhexidine varnishes in preventing and treating periodontal disease: a review of the literature Puig Silla M, Montiel Company J M, Almerich Silla, J M CRD summary The authors concluded that chlorhexidine varnish may be of benefit for chronic gingivitis and that high (...) -concentration varnish may help reduce pocket depth following scaling and root planing for chronic periodontitis. Poor reporting of review methods and failure to assess study validity or quantify effect sizes meant that the conclusions may need to be regarded with caution. Authors' objectives To evaluate the effectiveness of chlorhexidine varnishes for preventing and treating periodontal disease. Searching PubMed, EMBASE and The Cochrane Library were searched in June 2007. Search terms were reported. Study

2008 DARE.

114. Oral decontamination with chlorhexidine reduced ventilator associated pneumonia in patients needing mechanical ventilation for 48 hours Full Text available with Trip Pro

Oral decontamination with chlorhexidine reduced ventilator associated pneumonia in patients needing mechanical ventilation for 48 hours Oral decontamination with chlorhexidine reduced ventilator associated pneumonia in patients needing mechanical ventilation for ⩾48 hours | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please (...) see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Oral decontamination with chlorhexidine reduced ventilator associated pneumonia in patients needing mechanical

2008 Evidence-Based Nursing

115. Oral Decontamination with Chlorhexidine Reduces the Incidence of Ventilator-associated Pneumonia.

Oral Decontamination with Chlorhexidine Reduces the Incidence of Ventilator-associated Pneumonia. PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2007 PedsCCM Evidence-Based Journal Club

116. Chlorhexidine varnish has caries-reducing potential. Full Text available with Trip Pro

Chlorhexidine varnish has caries-reducing potential. A double-blind, randomised, placebo-controlled clinical trial was conducted.Children in the test group received 6-monthly applications of a 40% chlorhexidine varnish whereas children in the control group received a placebo varnish, over the course of 2 years. Clinical examination was undertaken at baseline and after 24 months by two calibrated dentists who did not know to which groups children were assigned.Decayed, missing, or primary filled (...) increment of the primary molars was 1.0 dmfs-molar in the test-group children and 1.6 dmfs-molar in the placebo group. The difference of 0.6 tooth surface equated to a 37.3% reduction in caries increment (number-needed-to-treat of 3), and was statistically significant (P 0.036; 95% confidence interval, 0.04-1.16). No side-effects (such as soft-tissue lesions and staining of teeth) were found at the 24-month examination.Six-monthly applications of chlorhexidine varnish were effective in reducing

2007 Evidence-based dentistry Controlled trial quality: predicted high

117. The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: a systematic review of the literature

The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: a systematic review of the literature Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2007 DARE.

118. Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysis

Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2007 DARE.

119. Topical applications of chlorhexidine to the umbilical cord for prevention of omphalitis and neonatal mortality in southern Nepal: a community-based, cluster-randomised trial. Full Text available with Trip Pro

Topical applications of chlorhexidine to the umbilical cord for prevention of omphalitis and neonatal mortality in southern Nepal: a community-based, cluster-randomised trial. Omphalitis contributes to neonatal morbidity and mortality in developing countries. Umbilical cord cleansing with antiseptics might reduce infection and mortality risk, but has not been rigorously investigated.In our community-based, cluster-randomised trial, 413 communities in Sarlahi, Nepal, were randomly assigned (...) to one of three cord-care regimens. 4934 infants were assigned to 4.0% chlorhexidine, 5107 to cleansing with soap and water, and 5082 to dry cord care. In intervention clusters, the newborn cord was cleansed in the home on days 1-4, 6, 8, and 10. In all clusters, the cord was examined for signs of infection (pus, redness, or swelling) on these visits and in follow-up visits on days 12, 14, 21, and 28. Incidence of omphalitis was defined under three sign-based algorithms, with increasing severity

2006 Lancet Controlled trial quality: predicted high

120. Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial. Full Text available with Trip Pro

Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial. Nosocomial infections are an important cause of morbidity and mortality after cardiac surgery. Decolonization of endogenous potential pathogenic microorganisms is important in the prevention of nosocomial infections.To determine the efficacy of perioperative decontamination of the nasopharynx and oropharynx with 0.12 (...) % chlorhexidine gluconate for reduction of nosocomial infection after cardiac surgery.A prospective, randomized, double-blind, placebo-controlled clinical trial conducted at the Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands, between August 1, 2003, and September 1, 2005. Of 991 patients older than 18 years undergoing elective cardiothoracic surgery during the study interval, 954 were eligible for analysis.Oropharyngeal rinse and nasal ointment containing either chlorhexidine gluconate

2006 JAMA Controlled trial quality: predicted high