Latest & greatest articles for chronic kidney disease

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Top results for chronic kidney disease

61. Determinant factors for chronic kidney disease after partial nephrectomy Full Text available with Trip Pro

Determinant factors for chronic kidney disease after partial nephrectomy The objective of this review is to evaluate the factors that determine the development or deterioration of Chronic Kidney Disease (CKD) after partial nephrectomy (PN). When current literature is reviewed, it is found that factors that influence renal function after partial nephrectomy, are multifactorial. Those are divided into pre-surgical factors, such as hypertension, diabetes mellitus, urolithiasis, obesity, metabolic (...) syndrome among others; intra-surgical factors, like the surgical technique used, the remaining healthy tissue, the experience of the surgeon, the time and type of ischemia among others. Lastly, post-surgical factors, also impose some influence on the post-surgical renal performance. It was also found that minimally invasive surgery, in addition to its known advantages, seems to offer a greater field of action in the future that will allow more nephrons preservation in any future surgical scenario

2018 Oncoscience

62. Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: Synopsis of the Kidney Disease: Improving Global Outcomes 2017 Clinical Practice Guideline Update. Full Text available with Trip Pro

Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: Synopsis of the Kidney Disease: Improving Global Outcomes 2017 Clinical Practice Guideline Update. The Kidney Disease: Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a selective update of the prior CKD-MBD guideline published in 2009. The guideline

2018 Annals of Internal Medicine

63. Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care. Full Text available with Trip Pro

anticoagulation in the preceding 120 days were excluded, as were patients requiring dialysis and recipients of renal transplants.Receipt of an anticoagulant prescription within 60 days of atrial fibrillation diagnosis.Ischaemic stroke, cerebral or gastrointestinal haemorrhage, and all cause mortality.6977 patients with chronic kidney disease and newly diagnosed atrial fibrillation were identified, of whom 2434 were on anticoagulants within 60 days of diagnosis and 4543 were not. 2434 pairs were matched using (...) Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care. To assess the association between anticoagulation, ischaemic stroke, gastrointestinal and cerebral haemorrhage, and all cause mortality in older people with atrial fibrillation and chronic kidney disease.Propensity matched, population based, retrospective cohort analysis from January 2006 through

2018 BMJ

64. Empagliflozin and Clinical Outcomes in Patients With Type 2 Diabetes Mellitus, Established Cardiovascular Disease, and Chronic Kidney Disease Full Text available with Trip Pro

decreases with declining renal function, resulting in less potency for glucose lowering in patients with kidney disease. We investigated the effects of empagliflozin on clinical outcomes in patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney disease.Patients with type 2 diabetes mellitus, established cardiovascular disease, and estimated glomerular filtration rate (eGFR) ≥30 mL·min-1·1.73 m-2 at screening were randomized to receive empagliflozin 10 mg (...) Empagliflozin and Clinical Outcomes in Patients With Type 2 Diabetes Mellitus, Established Cardiovascular Disease, and Chronic Kidney Disease Empagliflozin, a sodium-glucose cotransporter 2 inhibitor, reduced cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus and established cardiovascular disease in the EMPA-REG OUTCOME trial (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients). Urinary glucose excretion with empagliflozin

2018 EvidenceUpdates

65. Risk of stroke and bleeding in patients with heart failure and chronic kidney disease: a nationwide cohort study Full Text available with Trip Pro

Risk of stroke and bleeding in patients with heart failure and chronic kidney disease: a nationwide cohort study The aim of this study was to assess the prognostic value of chronic kidney disease (CKD) in relation to ischaemic stroke, intracranial haemorrhage, major bleeding, and all-cause death in heart failure patients without atrial fibrillation.In this observational cohort study, heart failure patients without atrial fibrillation were identified using Danish nationwide registries. Risk (...) of stroke, major haemorrhage, and death were calculated after 1 and 5 years to compare patients with and without CKD, ±dialysis [dialysis: CKD with renal replacement therapy (CKD-RRT); no dialysis: CKD-no RRT]. A total of 43 199 heart failure patients were included, among which 0.8% had CKD-RRT and 5.9% had CKD-no RRT. When compared with heart failure patients without CKD, both CKD-RRT and CKD-no RRT were associated with a higher 5 year rate of major bleeding (CKD-RRT: adjusted hazard ratio (aHR): 2.91

2018 ESC heart failure

66. Impact of neuromuscular electrical stimulation on functional capacity of patients with chronic kidney disease on hemodialysis. Full Text available with Trip Pro

Impact of neuromuscular electrical stimulation on functional capacity of patients with chronic kidney disease on hemodialysis. Literature shows that patients undergoing hemodialysis present poor physical conditioning and low tolerance to exercise. They may also suffer from respiratory dysfunctions. The purpose of this study was to evaluate the effects of neuromuscular electrical stimulation on pulmonary function and functional capacity of patients with chronic kidney disease (...) on hemodialysis.Forty adult patients with chronic kidney disease on hemodialysis were prospectively studied and randomized into two groups (control n = 20 and treatment n = 20). The treatment group underwent bilateral femoral quadriceps muscles electrical stimulation for 30 minutes during hemodialysis, three times per week, for two months. The patients were evaluated by pulmonary function test, maximum respiratory pressures, maximum one-repetition test, and six-minute walk test (6MWT), before and after

2018 Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Controlled trial quality: uncertain

67. Evaluation of an individualized dose titration regimen of patiromer to prevent hyperkalaemia in patients with heart failure and chronic kidney disease Full Text available with Trip Pro

Evaluation of an individualized dose titration regimen of patiromer to prevent hyperkalaemia in patients with heart failure and chronic kidney disease Hyperkalaemia risk precludes optimal renin-angiotensin-aldosterone system inhibitor use in patients with heart failure (HF), particularly those with chronic kidney disease (CKD). Patiromer is a sodium-free, non-absorbed potassium (K+ )-binding polymer approved for the treatment of hyperkalaemia. In PEARL-HF, patiromer 25.2 g (fixed dose (...) ) prevented hyperkalaemia in HF patients with or without CKD initiating spironolactone. The current study evaluated the effectiveness of a lower starting dose of patiromer (16.4 g/day) followed by individualized titration in preventing hyperkalaemia and hypokalaemia when initiating spironolactone.This open-label 8-week study enrolled 63 patients with CKD, serum K+ 4.3-5.1 mEq/L, and chronic HF, who, based on investigator opinion, should receive spironolactone. Eligible patients started spironolactone 25

2018 ESC heart failure Controlled trial quality: uncertain

68. Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease Full Text available with Trip Pro

Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease Cardiovascular disease (CVD) is responsible for the majority of deaths in the developed world. Particularly, in patients with chronic kidney disease (CKD), the imbalance of calcium and phosphate may lead to the acceleration of both vascular and valve inflammation and calcification. One in two patients with CKD are reported as dying from cardiovascular causes due to the resulting acceleration (...) in the development of atherosclerosis plaques. In addition, CKD patients on hemodialysis are prone to aortic valve calcification and often need valve replacement before kidney transplantation. The lysosomal proteases, cathepsins, are composed of 11 cysteine members (cathepsin B, C, F, H, K, L, O, S, V, W, and Z), as well as serine proteases cathepsin A and G, which cleave peptide bonds with serine as the amino acid, and aspartyl proteases D and E, which use an activated water molecule bound to aspartate to break

2018 Frontiers in cardiovascular medicine

69. Renal Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation: Involvement of Chronic Graft-Versus-Host Disease Full Text available with Trip Pro

Renal Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation: Involvement of Chronic Graft-Versus-Host Disease 29854984 2019 02 26 2468-0249 3 3 2018 May Kidney international reports Kidney Int Rep Renal Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation: Involvement of Chronic Graft-Versus-Host Disease. 743-747 10.1016/j.ekir.2017.12.013 Mii Akiko A Department of Nephrology, Nippon Medical School, Tokyo, Japan. Shimizu Akira A Department of Analytic (...) Human Pathology, Nippon Medical School, Tokyo, Japan. Kaneko Tomohiro T Department of Nephrology, Nippon Medical School, Tokyo, Japan. Nakayama Kazutaka K Department of Hematology, Nippon Medical School, Tokyo, Japan. Yamaguchi Hiroki H Department of Hematology, Nippon Medical School, Tokyo, Japan. Tsuruoka Shuichi S Department of Nephrology, Nippon Medical School, Tokyo, Japan. eng Case Reports 2018 01 05 United States Kidney Int Rep 101684752 2468-0249 2018 6 2 6 0 2018 6 2 6 0 2018 6 2 6 1

2018 Kidney international reports

70. Protective effects of hydrogen sulfide on chronic kidney disease by reducing oxidative stress, inflammation and apoptosis Full Text available with Trip Pro

Protective effects of hydrogen sulfide on chronic kidney disease by reducing oxidative stress, inflammation and apoptosis The current study aimed to examine the renoprotective effects of long-term treatment with sodium hydrosulfide (NaHS), a prominent hydrogen sulfide donor, in 5/6 nephrectomy animal model. Twenty-four rats were randomly divided into 3 groups including sham-operated group (Sham), 5/6-nephrectomized group (5/6 Nx), and NaHS-treated group (5/6Nx+NaHS). NaHS (30 micromol/l (...) ) was added twice daily into the drinking water and renal failure was induced by 5/6 nephrectomy. Twelve weeks after surgical procedure, blood pressure, creatinine clearance (CCr), urine concentration of neutrophil gelatinase associated lipocalin (NGAL) and tissue concentration of malondialdehyde (MDA), superoxide dismutase (SOD), as well as renal morphological changes, apoptosis (cleaved caspase-3) and inflammation (p-NF-κB) were measured. Five-sixth nephrectomy induced severe renal damage as indicated

2018 EXCLI journal

71. Management of Chronic Kidney Disease

with diabetes mellitus and/or hypertension should be screened at least yearly for chronic kidney disease (CKD). • Screening for CKD may be considered for patients with: ? age >65 years old ? obesity ? cardiovascular disease ? metabolic syndrome ? drugs e.g. nephrotoxic drugs, long-term use of proton-pump inhibitors or analgesics ? family history of CKD or hereditary kidney disease ? gout ? multisystem diseases with potential kidney involvement e.g. systemic lupus erythematosus ? structural renal tract (...) Reviewers x Algorithm 1 Screening and Investigations for xi Chronic Kidney Disease in Adults with Diabetes Algorithm 2 Screening and Investigations for xii Chronic Kidney Disease in Adults without Diabetes Algorithm 3 Evaluation of Haematuria in xiii Chronic Kidney Disease in Adults Algorithm 4 Treatment for Chronic Kidney Disease xiv in Adults 1. INTRODUCTION 1 2. RISK FACTORS 2 3 ASSESSMENT 4 3.1 Screening 4 3.2 Renal Function 6 3.3 Renal Ultrasound 7 3.4 Classification 8 4. INTERVENTIONS IN DELAYING

2018 Ministry of Health, Malaysia

72. Comparison of Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Chronic Kidney Disease (Abstract)

Comparison of Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Chronic Kidney Disease There are few data comparing outcomes of transcatheter aortic valve implantation (TAVI) with surgical aortic valve replacement (SAVR) in patients with chronic kidney disease. In this retrospective cohort study using the National Inpatient Sample 2011 to 2014, we included a total of 2,820 TAVI and 4,054 SAVR procedures, representative of 14,039 TAVI and 19,835 SAVR procedures (...) ) compared with SAVR. In conclusion, TAVI may be a preferable approach to SAVR in patients with severe aortic stenosis in the setting of chronic kidney disease.Copyright © 2017 Elsevier Inc. All rights reserved.

2018 EvidenceUpdates

73. Lanthanum carbonate and sevelamer carbonate for hyperphosphataemia in patients with chronic kidney disease

Lanthanum carbonate and sevelamer carbonate for hyperphosphataemia in patients with chronic kidney disease '); } else { document.write(' '); } ACE | Lanthanum carbonate and sevelamer carbonate for treating hyperphosphataemia in patients with chronic kidney disease Search > > Lanthanum carbonate and sevelamer carbonate for treating hyperphosphataemia in patients with chronic kidney disease - Lanthanum carbonate and sevelamer carbonate for treating hyperphosphataemia in patients with chronic (...) kidney disease Published on 1 October 2018 Guidance Recommendations The Ministry of Health's Drug Advisory Committee has recommended: Sevelamer carbonate 800 mg tablet for the treatment of hyperphosphataemia in patients with chronic kidney disease who: have persistent hyperphosphataemia despite optimising treatment with calcium-based phosphate binders; or cannot tolerate calcium-based phosphate binders due to hypercalcaemia. Subsidy status Sevelamer carbonate 800 mg tablet is recommended

2018 Appropriate Care Guides, Agency for Care Effectiveness (Singapore)

74. Whole-Exome Sequencing in Adults With Chronic Kidney Disease: A Pilot Study. Full Text available with Trip Pro

Whole-Exome Sequencing in Adults With Chronic Kidney Disease: A Pilot Study. The utility of whole-exome sequencing (WES) for the diagnosis and management of adult-onset constitutional disorders has not been adequately studied. Genetic diagnostics may be advantageous in adults with chronic kidney disease (CKD), in whom the cause of kidney failure often remains unknown.To study the diagnostic utility of WES in a selected referral population of adults with CKD.Observational cohort.A major academic (...) syndrome characterized by lung, bone marrow, and liver fibrosis; these findings extend the phenotype of PARN mutations to renal fibrosis. In addition, review of the American College of Medical Genetics actionable genes identified a pathogenic BRCA2 mutation in a proband who was diagnosed with breast cancer on follow-up. The results affected clinical management in most identified cases, including initiation of targeted surveillance, familial screening to guide donor selection for transplantation

2017 Annals of Internal Medicine

75. Derivation and External Validation of Prediction Models for Advanced Chronic Kidney Disease Following Acute Kidney Injury. Full Text available with Trip Pro

Derivation and External Validation of Prediction Models for Advanced Chronic Kidney Disease Following Acute Kidney Injury. Some patients will develop chronic kidney disease after a hospitalization with acute kidney injury; however, no risk-prediction tools have been developed to identify high-risk patients requiring follow-up.To derive and validate predictive models for progression of acute kidney injury to advanced chronic kidney disease.Data from 2 population-based cohorts of patients (...) validated with data from a cohort of 2761 patients hospitalized in Ontario, Canada (June 2004-March 2012, with follow-up to March 2013).Demographic, laboratory, and comorbidity variables measured prior to discharge.Advanced chronic kidney disease was defined by a sustained reduction in eGFR less than 30 mL/min/1.73 m2 for at least 3 months during the year after discharge. All participants were followed up for up to 1 year.The participants (mean [SD] age, 66 [15] years in the derivation and internal

2017 JAMA

76. Effect of Sertraline on Depressive Symptoms in Patients With Chronic Kidney Disease Without Dialysis Dependence: The CAST Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Sertraline on Depressive Symptoms in Patients With Chronic Kidney Disease Without Dialysis Dependence: The CAST Randomized Clinical Trial. Major depressive disorder (MDD) is prevalent among patients with chronic kidney disease (CKD) and is associated with morbidity and mortality. The efficacy and adverse events of selective serotonin reuptake inhibitors in these patients are unknown.To determine whether treatment with sertraline improves depressive symptoms in patients with CKD (...) and MDD.The Chronic Kidney Disease Antidepressant Sertraline Trial (CAST) was a randomized, double-blind, placebo-controlled trial involving 201 patients with stage 3, 4, or 5 non-dialysis-dependent CKD, who were enrolled at 3 US medical centers. The Mini Neuropsychiatric Interview was used to establish MDD. The first participant was randomized in March 2010 and the last clinic visit occurred in November 2016.After a 1-week placebo run-in, participants were randomized to sertraline (n = 102) for 12 weeks

2017 JAMA Controlled trial quality: predicted high

77. Do attributes of persons with chronic kidney disease differ in low-income and middle-income countries compared with high-income countries? Evidence from population-based data in six countries Full Text available with Trip Pro

Do attributes of persons with chronic kidney disease differ in low-income and middle-income countries compared with high-income countries? Evidence from population-based data in six countries Kidney biopsies to elucidate the cause of chronic kidney disease (CKD) are performed in a minority of persons with CKD living in high-income countries, since associated conditions-that is, diabetes mellitus, vascular disease or obesity with pre-diabetes, prehypertension or dyslipidaemia-can inform (...) as reference. In the USA, urban India and Moldova, 79.0%-83.9%; in China and Nepal, 62.4%-66.7% and in Nigeria, 51.6% persons with CKD fit one of three established risk profiles. Diabetes was most common in urban India and vascular disease in Moldova (50.7% and 33.2% of persons with CKD in urban India and Moldova, respectively). In Nigeria, 17.8% of persons with CKD without established risk factors had albuminuria ≥300 mg/g, the highest proportion in any country. While the majority of persons with CKD

2017 BMJ global health

78. Afshinnia F, Rajendiran TM, Karnovsky A, et al. Lipidomic Signature of Progression of Chronic Kidney Disease in the Chronic Renal Insufficiency Cohort. Kidney Int Rep. 2016;1:256–268 Full Text available with Trip Pro

Afshinnia F, Rajendiran TM, Karnovsky A, et al. Lipidomic Signature of Progression of Chronic Kidney Disease in the Chronic Renal Insufficiency Cohort. Kidney Int Rep. 2016;1:256–268 [This corrects the article DOI: 10.1016/j.ekir.2016.08.007.].

2017 Kidney international reports

79. A policy model of cardiovascular disease in moderate-to-advanced chronic kidney disease Full Text available with Trip Pro

A policy model of cardiovascular disease in moderate-to-advanced chronic kidney disease To present a long-term policy model of cardiovascular disease (CVD) in moderate-to-advanced chronic kidney disease (CKD).A Markov model with transitions between CKD stages (3B, 4, 5, on dialysis, with kidney transplant) and cardiovascular events (major atherosclerotic events, haemorrhagic stroke, vascular death) was developed with individualised CKD and CVD risks estimated using the 5 years' follow-up data (...) of the 9270 patients with moderate-to-severe CKD in the Study of Heart and Renal Protection (SHARP) and multivariate parametric survival analysis. The model was assessed in three further CKD cohorts and compared with currently used risk scores.Higher age, previous cardiovascular events and advanced CKD were the main contributors to increased individual disease risks. CKD and CVD risks predicted by the state-transition model corresponded well to risks observed in SHARP and external cohorts. The model's

2017 EvidenceUpdates

80. Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease Full Text available with Trip Pro

Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease 28760941 2018 01 29 2018 11 13 1524-4563 70 4 2017 10 Hypertension (Dallas, Tex. : 1979) Hypertension Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease. 687-694 10.1161/HYPERTENSIONAHA.117.08314 Griffin Karen A KA From the Hines VA Hospital, IL; and Loyola University Medical Center, Maywood, IL. kgriffi@lumc.edu. eng R01 DK040426 DK NIDDK NIH HHS United States R01 DK061653 DK NIDDK NIH HHS United (...) States Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review 2017 07 31 United States Hypertension 7906255 0194-911X IM Disease Progression Humans Hypertension complications physiopathology Renal Insufficiency, Chronic etiology physiopathology 2017 8 2 6 0 2018 1 30 6 0 2017 8 2 6 0 ppublish 28760941 HYPERTENSIONAHA.117.08314 10.1161/HYPERTENSIONAHA.117.08314 PMC5599324 NIHMS891429 Curr Opin Nephrol Hypertens. 2012 Jan;21(1):1-6 22048724 Hypertension

2017 Hypertension (Dallas, Tex. : 1979)