Latest & greatest articles for clonidine

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Top results for clonidine

21. Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials

Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2009 DARE.

22. Clonidine and analgesic duration after popliteal fossa nerve blockade: randomized, double-blind, placebo-controlled study (Abstract)

Clonidine and analgesic duration after popliteal fossa nerve blockade: randomized, double-blind, placebo-controlled study We tested the hypothesis that 100 microg clonidine added to 0.375% bupivacaine would prolong the duration of analgesia from popliteal fossa nerve blockade.Ninety-nine patients scheduled for hospital admission after foot or ankle surgery entered this randomized, double-blind, placebo-controlled trial. Patients received a popliteal fossa block (nerve stimulator technique, via (...) the posterior approach) using 30 mL 0.375% bupivacaine, with epinephrine. Patients were randomized to receive no clonidine, 100 microg clonidine IM, or 100 microg clonidine with bupivacaine for the popliteal block. Patients also received a combined spinal-epidural anesthetic, a saphenous nerve block, and postoperative IV patient-controlled analgesia. The primary outcome was patient-reported duration of analgesia.Duration of analgesia was statistically longer in the block clonidine group (18 +/- 6 h

2008 EvidenceUpdates Controlled trial quality: predicted high

23. Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials

Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials Elia N, Culebras X, Mazza C, Schiffer E, Tramer M R CRD summary The authors concluded that adding clonidine to intrathecal local anaesthetic had beneficial effects (...) on some, but not all measures of motor and sensory block. Adding clonidine reduced intra-operative pain but increased the risk of arterial hypotension. Given the low quality of the included studies and the possibility of publication bias, the reliability of the results is questionable. Authors' objectives To assess the efficacy and harm associated with adding clonidine to intrathecal local anaesthetics for surgery. Searching MEDLINE, EMBASE, CINAHL, BIOSIS Previews, INDMED and Cochrane Central

2008 DARE.

24. Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects Full Text available with Trip Pro

Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal (...) accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects Article Text Therapeutics Review: clonidine is more effective than placebo for long

2006 Evidence-Based Medicine

25. Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trial. Full Text available with Trip Pro

Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trial. Rapid opioid detoxification with opioid antagonist induction using general anesthesia has emerged as an expensive, potentially dangerous, unproven approach to treat opioid dependence.To determine how anesthesia-assisted detoxification with rapid antagonist induction for heroin dependence compared with 2 alternative detoxification and antagonist induction methods.A (...) included if they had an American Society of Anesthesiologists physical status of I or II, were without major comorbid psychiatric illness, and were not dependent on other drugs or alcohol.Anesthesia-assisted rapid opioid detoxification with naltrexone induction, buprenorphine-assisted rapid opioid detoxification with naltrexone induction, and clonidine-assisted opioid detoxification with delayed naltrexone induction.Withdrawal severity scores on objective and subjective scales; proportions of patients

2005 JAMA Controlled trial quality: uncertain

26. Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal Full Text available with Trip Pro

Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our (...) . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Buprenorphine may be more effective than clonidine and other symptomatic medications for short term ambulatory heroin withdrawal

2004 Evidence-Based Mental Health

27. Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature

Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature Efficacy of clonidine for prevention of perioperative myocardial ischemia: a critical appraisal and meta-analysis of the literature Nishina K, Mikawa K, Uesugi T, Obara H, Maekawa M, Kamae I, Nishi N Authors' objectives To determine (...) whether clonidine premedication can reduce the occurrence of peri-operative myocardial ischaemia. Searching MEDLINE was searched from 1980 to 1999 using the following MeSH terms: 'myocardial ischaemia', 'coronary disease', 'myocardial infarction', 'coronary arteriosclerosis', 'coronary thrombosis', 'angina pectoris', 'prospective studies', 'clinical trials', 'randomized controlled trials', 'controlled clinical trials', 'intervention studies'. Only English language articles were considered. Personal

2002 DARE.

28. Clonidine for smoking cessation. Full Text available with Trip Pro

Clonidine for smoking cessation. Clonidine was originally used to lower blood pressure. It acts on the central nervous system and may reduce withdrawal symptoms in various addictive behaviours, including tobacco use.The aim of this review is to determine clonidine's effectiveness in helping smokers to quit.We searched the Cochrane Tobacco Addiction Group trials register. Date of the most recent search: October 1998.We considered randomised trials of clonidine versus placebo with a smoking (...) cessation endpoint assessed at least 12 weeks following the end of treatment.We extracted data in duplicate on the type of subjects, the dose and duration of clonidine therapy, the outcome measures, method of randomisation, and completeness of follow-up. The main outcome measure was abstinence from smoking after at least twelve weeks follow-up in patients smoking at baseline. We used the most rigorous definition of abstinence for each trial, and biochemically validated rates if available. Where

2000 Cochrane

29. Can clonidine be used in effectively in epidural and intrathecal catheters?

Can clonidine be used in effectively in epidural and intrathecal catheters? Can clonidine be used in effectively in epidural and intrathecal catheters? Can clonidine be used in effectively in epidural and intrathecal catheters? Wasiak J Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Wasiak J. Can clonidine be used in effectively in epidural and intrathecal (...) catheters? Clayton, Victoria: Centre for Clinical Effectiveness (CCE) 2000: 17 Authors' objectives This aim of this report was to assess whether clondine can be used in effectively in epidural and intrathecal catheters. Authors' conclusions - The largest reported experience with clonidine for regional anaesthesia is with epidural administration. - Published reports of epidural clonidine have been in the areas of chronic pain, intra- and post-operative pain, and in obstetric and paediatric populations

2000 Health Technology Assessment (HTA) Database.

30. A meta-analysis of clonidine for symptoms of attention-deficit hyperactivity disorder

A meta-analysis of clonidine for symptoms of attention-deficit hyperactivity disorder Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

1999 DARE.

31. Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects

Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Curatolo M, Petersen-Felix S, Scaramozzino P, Zbinden A M (...) Authors' objectives To assess the effectiveness of adding fentanyl, adrenaline and clonidine to local anaesthetics for intra-operative epidural analgesia not combined with general anaesthesia. Searching MEDLINE (from 1966), Excerpta Medica (from 1974), and the Science Citation Index (from 1980) were searched using the keywords 'anesthetic techniques', 'epidural', fentanyl', 'epinephrine' and 'clonidine'. In addition, the authors' databases, abstracts of anaesthesia meetings (details listed

1998 DARE.

32. Meta-analysis of the efficacy of extradural clonidine to relieve postoperative pain: an impossible task

Meta-analysis of the efficacy of extradural clonidine to relieve postoperative pain: an impossible task Meta-analysis of the efficacy of extradural clonidine to relieve postoperative pain: an impossible task Meta-analysis of the efficacy of extradural clonidine to relieve postoperative pain: an impossible task Armand S, Langlade A, Boutros A, Lobjoit K, Monrigal C, Ramboatiana R, Rauss A, Bonnet F Authors' objectives To assess the efficacy of extradural clonidine in the relief of post-operative (...) pain, to determine whether anti-nociceptive effects and side-effects were dose-related, and to what extent the latter were deleterious. Searching The databases of MEDLINE and Excerpta Medica were searched from 1985 to 1997 using the following headings: regional analgesia; extradural clonidine; postoperative analgesia; and postoperative pain. Citations from articles were cross-referenced with those in the assessor's bibliography and those of the articles under review. Study selection Study designs

1998 DARE.

33. The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia

The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia Imai Y, Mammoto T, Murakami K, Kita T, Sakai T, Kagawa K, Kirita T, Sugimura M, Kishi Y Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion (...) on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of preanaesthetic oral clonidine or diazepam, administered to patients prior to propofol, to induce anaesthesia in minor breast conserving surgery. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised

1998 NHS Economic Evaluation Database.

34. Pharmacy savings generated by preoperative administration of clonidine

Pharmacy savings generated by preoperative administration of clonidine Pharmacy savings generated by preoperative administration of clonidine Pharmacy savings generated by preoperative administration of clonidine Valles J, Samso E, Vilar X, Gallart L, Puig M M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical (...) assessment on the reliability of the study and the conclusions drawn. Health technology Preoperative administration of clonidine in patients undergoing total abdominal hysterectomy with inhalational anaesthesia. Type of intervention Anaesthesia; Treatment. Economic study type Cost-effectiveness analysis. Study population Women undergoing total abdominal hysterectomy (TAH) with inhalational anaesthesia. Setting Secondary care. The economic study was conducted in a university hospital in Barcelona, Spain

1998 NHS Economic Evaluation Database.

35. Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis

Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis Rockemann M G (...) . Epidural bolus clonidine/morphine versus epidural patient-controlled bupivacaine/sufentanil: quality of postoperative analgesia and cost-identification analysis. Anesthesia and Analgesia 1997; 85(4): 864-869 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Adult; Aged; Analgesia, Epidural /economics; Analgesia, Patient-Controlled /economics; Analgesics /administration & Bupivacaine /administration & Clonidine /administration & Female; Health Care Costs; Humans; Male; Middle Aged; Morphine

1997 NHS Economic Evaluation Database.

36. A trial of clonidine to stop smoking. (Abstract)

A trial of clonidine to stop smoking. 2185371 1990 06 07 2016 10 17 0098-7484 263 20 1990 May 23-30 JAMA JAMA A trial of clonidine to stop smoking. 2746-7 eng Clinical Trial Comment Letter Randomized Controlled Trial United States JAMA 7501160 0098-7484 MN3L5RMN02 Clonidine AIM IM JAMA. 1989 Dec 1;262(21):3011-3 2681856 Behavior Therapy Clonidine administration & dosage therapeutic use Double-Blind Method Humans Randomized Controlled Trials as Topic Smoking drug therapy 1990 5 23 1990 5 23 0 1

1990 JAMA Controlled trial quality: uncertain

37. Randomized, controlled trial of clonidine for smoking cessation in a primary care setting. (Abstract)

Randomized, controlled trial of clonidine for smoking cessation in a primary care setting. Clonidine hydrochloride has been reported to reduce tobacco withdrawal symptoms and facilitate smoking cessation. We enrolled 185 subjects, 92 receiving clonidine and 93 receiving placebo, in a randomized, double-blind study of clonidine for smoking cessation in a primary care setting. Clonidine had no demonstrable effect on withdrawal (8 of 11 measures favoring placebo). At 4 weeks, 17 (18%) subjects (...) receiving clonidine had quit compared with 13 (14%) receiving placebo (chi 2 = 0.7; 90% confidence interval of benefit from clonidine, -4% to 13%). At 4 weeks, the mean number of cigarettes smoked was 17.7 for those receiving clonidine and 17.5 for those receiving placebo (t = 0.1; 90% confidence interval of benefit from clonidine, -4.1 to 3.7 cigarettes per day). These results provide little support for a beneficial effect of clonidine on tobacco withdrawal symptoms, quitting, or smoking reduction

1989 JAMA Controlled trial quality: predicted high

38. Lack of benefit of clonidine treatment for short stature in a double-blind, placebo-controlled trial. (Abstract)

Lack of benefit of clonidine treatment for short stature in a double-blind, placebo-controlled trial. Twelve short (more than two standard deviations below the mean height for age), prepubertal children (ten boys, two girls) who had a normal peak growth hormone (GH) response to provocative stimulation with clonidine (more than 10 ng/ml) were enrolled in a double-blind, placebo-controlled, crossover study of the effects of a single, nightly dose of clonidine (0.1 mg/m2 by mouth). The children's (...) mean age was 7.2 years (range 3.6-10.5 years). The results of 6 months of clonidine therapy were compared with those of 6 months of placebo. Clonidine therapy resulted in no significant difference in height standard deviation score, growth velocity, bone age, 24 h integrated GH concentration, peak GH response to clonidine stimulation, levels of insulin-like growth factor 1, or predicted height by the RWT method. In contrast to other studies, this study shows no sustained increases in GH production

1988 Lancet Controlled trial quality: uncertain

39. Heavy smokers, smoking cessation, and clonidine. Results of a double-blind, randomized trial. (Abstract)

Heavy smokers, smoking cessation, and clonidine. Results of a double-blind, randomized trial. Seventy-one heavy smokers who had failed in previous attempts to stop smoking participated in a randomized clinical trial to test the efficacy of clonidine as an aid in smoking cessation. The success rate in clonidine-treated subjects (verified by serum cotinine concentration) was more than twice that in the placebo-treated subjects. When the data were stratified by gender, a strong effect present (...) in women was not apparent in men. After six months, cessation rates remained significantly higher among smokers treated with clonidine than those receiving placebo. The data also revealed an unexpectedly high prevalence (61%) of a history of major depression in this sample and a significant negative effect of such a history on cessation regardless of treatment. These findings, highly suggestive of an important role of clonidine in smoking cessation, warrant further studies to establish the long-term

1988 JAMA Controlled trial quality: uncertain

40. Clonidine blocks acute opiate-withdrawal symptoms. (Abstract)

Clonidine blocks acute opiate-withdrawal symptoms. In a double-blind, placebo-controlled, cross-over trial, clonidine eliminated objective signs and subjective symptoms of opiate withdrawal for 240--360 min in eleven addicts in a hospital setting. In an open pilot study of the effects of clonidine on longer-term opiate abstinence and symptoms, the same patients did well while taking clonidine for one week. There was only one documented instance of heroin use, in a patient who did not take (...) clonidine after hospital discharge. 6 weeks or more after the study, four patients were back on reduced doses of methadone, one was on tricyclic antidepressants, and seven were off of all opiates. All eleven patients were doing well. These data suggest that opiate withdrawal is due to increased neuronal activity in areas such as the locus coeruleus which are regulated by both alpha-2 adrenergic and opiate receptors.

1978 Lancet